JP2023537943A5 - - Google Patents
Info
- Publication number
- JP2023537943A5 JP2023537943A5 JP2023509499A JP2023509499A JP2023537943A5 JP 2023537943 A5 JP2023537943 A5 JP 2023537943A5 JP 2023509499 A JP2023509499 A JP 2023509499A JP 2023509499 A JP2023509499 A JP 2023509499A JP 2023537943 A5 JP2023537943 A5 JP 2023537943A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- rnai construct
- sense strand
- antisense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025282055A JP2026049002A (ja) | 2020-08-13 | 2025-12-25 | ＭＡＲＣ１発現を阻害するためのＲＮＡｉコンストラクト及び方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063065190P | 2020-08-13 | 2020-08-13 | |
| US63/065,190 | 2020-08-13 | ||
| US202163214016P | 2021-06-23 | 2021-06-23 | |
| US63/214,016 | 2021-06-23 | ||
| PCT/US2021/045784 WO2022036126A2 (en) | 2020-08-13 | 2021-08-12 | RNAi CONSTRUCTS AND METHODS FOR INHIBITING MARC1 EXPRESSION |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025282055A Division JP2026049002A (ja) | 2020-08-13 | 2025-12-25 | ＭＡＲＣ１発現を阻害するためのＲＮＡｉコンストラクト及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023537943A JP2023537943A (ja) | 2023-09-06 |
| JP2023537943A5 true JP2023537943A5 (https=) | 2024-08-21 |
Family
ID=77640774
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023509499A Pending JP2023537943A (ja) | 2020-08-13 | 2021-08-12 | ＭＡＲＣ１発現を阻害するためのＲＮＡｉコンストラクト及び方法 |
| JP2025282055A Pending JP2026049002A (ja) | 2020-08-13 | 2025-12-25 | ＭＡＲＣ１発現を阻害するためのＲＮＡｉコンストラクト及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025282055A Pending JP2026049002A (ja) | 2020-08-13 | 2025-12-25 | ＭＡＲＣ１発現を阻害するためのＲＮＡｉコンストラクト及び方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20220047621A1 (https=) |
| EP (1) | EP4196584A2 (https=) |
| JP (2) | JP2023537943A (https=) |
| KR (1) | KR20230046319A (https=) |
| CN (1) | CN116194119A (https=) |
| AU (1) | AU2021326521A1 (https=) |
| CA (1) | CA3190868A1 (https=) |
| CL (1) | CL2023000407A1 (https=) |
| CO (1) | CO2023002966A2 (https=) |
| CR (1) | CR20230126A (https=) |
| IL (1) | IL300360A (https=) |
| JO (1) | JOP20230030A1 (https=) |
| MX (1) | MX2023001786A (https=) |
| PE (1) | PE20230993A1 (https=) |
| TW (1) | TW202221124A (https=) |
| UY (1) | UY39382A (https=) |
| WO (1) | WO2022036126A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220264823A1 (en) * | 2021-02-24 | 2022-08-25 | Syngenta Crop Protection Ag | Soybean variety |
| US20220338438A1 (en) * | 2021-04-21 | 2022-10-27 | Syngenta Crop Protection Ag | A soybean variety |
| EP4347820A1 (en) * | 2021-05-28 | 2024-04-10 | Novo Nordisk A/S | Compositions and methods for inhibiting mitochondria amidoxime reducing component 1 (marc1) expression |
| CA3225054A1 (en) * | 2021-07-08 | 2023-02-12 | Sun Woo Hong | Rnai agent targeting marc1 gene, and use thereof |
| US20230240232A1 (en) * | 2022-01-28 | 2023-08-03 | Pioneer Hi-Bred International, Inc. | Soybean variety 5psym14 |
| US20230240241A1 (en) * | 2022-01-28 | 2023-08-03 | Pioneer Hi-Bred International, Inc. | Soybean variety 5pryl83 |
| US20230255169A1 (en) * | 2022-02-16 | 2023-08-17 | Syngenta Crop Protection Ag | Soybean variety |
| CN120322552A (zh) * | 2022-07-27 | 2025-07-15 | e-生物有限公司 | 核酸化合物 |
| US20240268301A1 (en) * | 2023-02-10 | 2024-08-15 | Pioneer Hi-Bred International, Inc. | Soybean variety 5ptcn76 |
| KR20250137186A (ko) * | 2023-03-08 | 2025-09-17 | 올릭스 주식회사 | 비만의 예방 또는 치료용 RNAi 제제 및 이를 이용한 병용 요법 |
| EP4680249A1 (en) * | 2023-03-16 | 2026-01-21 | Arrowhead Pharmaceuticals, Inc. | Rnai agents for inhibiting expression of mitochondrial amidoxime reducing component 1 (marc1), pharmaceutical compositions thereof, and methods of use |
| WO2024222898A1 (zh) * | 2023-04-28 | 2024-10-31 | 北京福元医药股份有限公司 | 用于抑制marc1基因表达的双链核糖核酸及其修饰物、缀合物和用途 |
| US20250268171A1 (en) * | 2024-02-28 | 2025-08-28 | Pioneer Hi-Bred International, Inc. | Soybean variety 5ppzm06 |
| US20250268198A1 (en) * | 2024-02-28 | 2025-08-28 | Pioneer Hi-Bred International, Inc. | Soybean variety 5pgbu05 |
| US20250268178A1 (en) * | 2024-02-28 | 2025-08-28 | Pioneer Hi-Bred International, Inc. | Soybean variety 5peve11 |
| US20250268175A1 (en) * | 2024-02-28 | 2025-08-28 | Pioneer Hi-Bred International, Inc. | Soybean variety 5paks02 |
| US20250268190A1 (en) * | 2024-02-28 | 2025-08-28 | Pioneer Hi-Bred International, Inc. | Soybean variety 5phsb14 |
| US20250268197A1 (en) * | 2024-02-28 | 2025-08-28 | Pioneer Hi-Bred International, Inc. | Soybean variety 5pysg46 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5840710A (en) | 1994-12-09 | 1998-11-24 | Genzyme Corporation | Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules |
| US7422902B1 (en) | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US5976567A (en) | 1995-06-07 | 1999-11-02 | Inex Pharmaceuticals Corp. | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
| CA2294988C (en) | 1997-07-01 | 2015-11-24 | Isis Pharmaceuticals Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
| US7491805B2 (en) | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
| US6693187B1 (en) | 2000-10-17 | 2004-02-17 | Lievre Cornu Llc | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge |
| US20030130186A1 (en) | 2001-07-20 | 2003-07-10 | Chandra Vargeese | Conjugates and compositions for cellular delivery |
| US7109165B2 (en) | 2001-05-18 | 2006-09-19 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US9181551B2 (en) * | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| CA2487274A1 (en) | 2002-05-06 | 2003-11-13 | Nucleonics Inc. | Spermine chemically linked to lipids and cell-specific targeting molecules as a transfection agent |
| ES2702942T3 (es) | 2003-04-17 | 2019-03-06 | Alnylam Pharmaceuticals Inc | Agentes de ARNi modificados |
| US8017762B2 (en) | 2003-04-17 | 2011-09-13 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
| US7851615B2 (en) | 2003-04-17 | 2010-12-14 | Alnylam Pharmaceuticals, Inc. | Lipophilic conjugated iRNA agents |
| US7723509B2 (en) | 2003-04-17 | 2010-05-25 | Alnylam Pharmaceuticals | IRNA agents with biocleavable tethers |
| CA2685127C (en) | 2007-04-23 | 2019-01-08 | Alnylam Pharmaceuticals, Inc. | Glycoconjugates of rna interference agents |
| WO2009073809A2 (en) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| WO2009099991A2 (en) * | 2008-01-31 | 2009-08-13 | The Brigham And Women's Hospital, Inc. | Treatment of cancer |
| AR090905A1 (es) | 2012-05-02 | 2014-12-17 | Merck Sharp & Dohme | Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica |
| DK2992098T3 (da) * | 2013-05-01 | 2019-06-17 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression |
| EP3564374A1 (en) | 2013-06-21 | 2019-11-06 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulation of target nucleic acids |
| DK3569711T3 (da) * | 2014-12-15 | 2021-02-22 | Dicerna Pharmaceuticals Inc | Ligandmodificerede dobbeltstrengede nukleinsyrer |
| EP3356415B1 (en) | 2015-09-29 | 2024-05-01 | Amgen Inc. | Asgr inhibitors for reduzing cholesterol levels |
| US10835581B2 (en) * | 2017-11-28 | 2020-11-17 | University of Pittsburgh—of the Commonwealth System of Higher Education | Method of treating insulin resistance |
| WO2020123410A1 (en) | 2018-12-10 | 2020-06-18 | Amgen Inc. | CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF |
| US20230183707A1 (en) * | 2020-05-21 | 2023-06-15 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting marc1 gene expression |
-
2021
- 2021-08-12 KR KR1020237008366A patent/KR20230046319A/ko active Pending
- 2021-08-12 CA CA3190868A patent/CA3190868A1/en active Pending
- 2021-08-12 CN CN202180055964.4A patent/CN116194119A/zh active Pending
- 2021-08-12 US US17/401,114 patent/US20220047621A1/en active Pending
- 2021-08-12 AU AU2021326521A patent/AU2021326521A1/en active Pending
- 2021-08-12 CR CR20230126A patent/CR20230126A/es unknown
- 2021-08-12 EP EP21766066.1A patent/EP4196584A2/en active Pending
- 2021-08-12 PE PE2023000271A patent/PE20230993A1/es unknown
- 2021-08-12 IL IL300360A patent/IL300360A/en unknown
- 2021-08-12 WO PCT/US2021/045784 patent/WO2022036126A2/en not_active Ceased
- 2021-08-12 JP JP2023509499A patent/JP2023537943A/ja active Pending
- 2021-08-12 MX MX2023001786A patent/MX2023001786A/es unknown
- 2021-08-13 TW TW110129910A patent/TW202221124A/zh unknown
- 2021-08-13 UY UY0001039382A patent/UY39382A/es unknown
-
2023
- 2023-02-09 CL CL2023000407A patent/CL2023000407A1/es unknown
- 2023-02-12 JO JOJO/P/2023/0030A patent/JOP20230030A1/ar unknown
- 2023-03-10 CO CONC2023/0002966A patent/CO2023002966A2/es unknown
-
2025
- 2025-12-25 JP JP2025282055A patent/JP2026049002A/ja active Pending
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