CL2023000407A1 - Construcciones de iarn y métodos para inhibir la expresión de marc1 - Google Patents

Construcciones de iarn y métodos para inhibir la expresión de marc1

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Publication number
CL2023000407A1
CL2023000407A1 CL2023000407A CL2023000407A CL2023000407A1 CL 2023000407 A1 CL2023000407 A1 CL 2023000407A1 CL 2023000407 A CL2023000407 A CL 2023000407A CL 2023000407 A CL2023000407 A CL 2023000407A CL 2023000407 A1 CL2023000407 A1 CL 2023000407A1
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CL
Chile
Prior art keywords
marc1
expression
methods
constructs
iarn
Prior art date
Application number
CL2023000407A
Other languages
English (en)
Inventor
K Murray Justin
HOMANN Oliver
Zhang Jun
C Long Jason
Meade Bryan
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Amgen Inc
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Publication date
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Publication of CL2023000407A1 publication Critical patent/CL2023000407A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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Abstract

La presente invención se refiere a construcciones de iARN para reducir la expresión del gen MARC1. También se describen métodos para usar dichas construcciones de iARN para tratar o prevenir la fibrosis hepática y las esteatosis hepáticas, tales como la esteatosis hepática no alcohólica y la esteatohepatitis no alcohólica.
CL2023000407A 2020-08-13 2023-02-09 Construcciones de iarn y métodos para inhibir la expresión de marc1 CL2023000407A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063065190P 2020-08-13 2020-08-13
US202163214016P 2021-06-23 2021-06-23

Publications (1)

Publication Number Publication Date
CL2023000407A1 true CL2023000407A1 (es) 2023-09-29

Family

ID=77640774

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Application Number Title Priority Date Filing Date
CL2023000407A CL2023000407A1 (es) 2020-08-13 2023-02-09 Construcciones de iarn y métodos para inhibir la expresión de marc1

Country Status (16)

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US (1) US20220047621A1 (es)
EP (1) EP4196584A2 (es)
JP (1) JP2023537943A (es)
KR (1) KR20230046319A (es)
CN (1) CN116194119A (es)
AU (1) AU2021326521A1 (es)
CA (1) CA3190868A1 (es)
CL (1) CL2023000407A1 (es)
CO (1) CO2023002966A2 (es)
CR (1) CR20230126A (es)
IL (1) IL300360A (es)
MX (1) MX2023001786A (es)
PE (1) PE20230993A1 (es)
TW (1) TW202221124A (es)
UY (1) UY39382A (es)
WO (1) WO2022036126A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024023262A2 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc Nucleic acid compounds

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PE20230993A1 (es) 2023-06-23
US20220047621A1 (en) 2022-02-17
TW202221124A (zh) 2022-06-01
CN116194119A (zh) 2023-05-30
UY39382A (es) 2022-02-25
WO2022036126A3 (en) 2022-04-21
MX2023001786A (es) 2023-03-10
CA3190868A1 (en) 2022-02-17
WO2022036126A2 (en) 2022-02-17
KR20230046319A (ko) 2023-04-05
CO2023002966A2 (es) 2023-03-17
AU2021326521A1 (en) 2023-03-09
IL300360A (en) 2023-04-01
CR20230126A (es) 2023-05-03
EP4196584A2 (en) 2023-06-21
JP2023537943A (ja) 2023-09-06

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