EA202091520A1 - Композиции на основе irna против бокса-1 высокомобильной группы (hmgb1) и способы их применения - Google Patents

Композиции на основе irna против бокса-1 высокомобильной группы (hmgb1) и способы их применения

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Publication number
EA202091520A1
EA202091520A1 EA202091520A EA202091520A EA202091520A1 EA 202091520 A1 EA202091520 A1 EA 202091520A1 EA 202091520 A EA202091520 A EA 202091520A EA 202091520 A EA202091520 A EA 202091520A EA 202091520 A1 EA202091520 A1 EA 202091520A1
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Eurasian Patent Office
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hmgb1
irna
application
based compositions
mobile group
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EA202091520A
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English (en)
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Грегори Хинкл
Фредерик Тремблэй
Джеймс Д. Макайнинч
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Элнилэм Фармасьютикалз, Инк.
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Publication of EA202091520A1 publication Critical patent/EA202091520A1/ru

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Abstract

Настоящее изобретение относится к средствам для RNAi, например к средствам на основе двухнитевой РНК (dsRNA), целенаправленно воздействующим на ген HMGB1. Настоящее изобретение также относится к способам применения таких средств для RNAi для подавления экспрессии гена HMGB1 и способам предупреждения и лечения связанных с HMGB1 нарушений, например метаболического нарушения или неалкогольной жировой болезни печени, например неалкогольного стеатогепатита (NASH).
EA202091520A 2017-12-18 2018-12-18 Композиции на основе irna против бокса-1 высокомобильной группы (hmgb1) и способы их применения EA202091520A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762599860P 2017-12-18 2017-12-18
PCT/US2018/066126 WO2019126097A1 (en) 2017-12-18 2018-12-18 High mobility group box-1 (hmgb1) irna compositions and methods of use thereof

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EA202091520A1 true EA202091520A1 (ru) 2020-10-05

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EA202091520A EA202091520A1 (ru) 2017-12-18 2018-12-18 Композиции на основе irna против бокса-1 высокомобильной группы (hmgb1) и способы их применения

Country Status (13)

Country Link
US (1) US20200308588A1 (ru)
EP (1) EP3728593A1 (ru)
JP (1) JP2021508491A (ru)
KR (1) KR20200110655A (ru)
CN (1) CN111727252A (ru)
AU (1) AU2018388484A1 (ru)
BR (1) BR112020012088A2 (ru)
CA (1) CA3086343A1 (ru)
EA (1) EA202091520A1 (ru)
IL (1) IL275249A (ru)
MX (1) MX2020006012A (ru)
WO (1) WO2019126097A1 (ru)
ZA (1) ZA202003954B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL295086A (en) 2017-06-29 2022-09-01 Dicerna Pharmaceuticals Inc Compositions and methods for inhibiting expression of hmgb1
JP7455433B2 (ja) * 2020-04-22 2024-03-26 チュラーロンコーン ユニバーシティー Ｄｎａを回復する及びｄｎａ損傷を防止する組成物及び方法
AU2021466375A1 (en) * 2021-09-30 2024-04-11 Niigata University Drug for treating fatty liver and non-alcoholic steatohepatitis
CN117264954A (zh) * 2022-09-20 2023-12-22 北京福元医药股份有限公司 用于抑制hmgb1基因表达的双链核糖核酸及其修饰物、缀合物和用途

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