EA202191629A1 - Конструкции для rnai, предназначенные для подавления экспрессии pnpla3 - Google Patents

Конструкции для rnai, предназначенные для подавления экспрессии pnpla3

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Publication number
EA202191629A1
EA202191629A1 EA202191629A EA202191629A EA202191629A1 EA 202191629 A1 EA202191629 A1 EA 202191629A1 EA 202191629 A EA202191629 A EA 202191629A EA 202191629 A EA202191629 A EA 202191629A EA 202191629 A1 EA202191629 A1 EA 202191629A1
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EA
Eurasian Patent Office
Prior art keywords
pnpla3
rnai
suppress expression
constructions designed
designed
Prior art date
Application number
EA202191629A
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English (en)
Inventor
Ингрид Рулифсон
Джастин К. Мюррей
Майкл Оллманн
Оливер Хоманн
Original Assignee
Эмджен Инк.
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Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA202191629A1 publication Critical patent/EA202191629A1/ru

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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Abstract

Настоящее изобретение относится к конструкциям для RNAi, предназначенным для снижения экспрессии гена PNPLA3. Также описаны способы применения таких конструкций для RNAi с целью лечения или предупреждения заболевания печени, представляющего собой неалкогольную жировую болезнь печени (NAFLD).
EA202191629A 2018-12-10 2019-12-10 Конструкции для rnai, предназначенные для подавления экспрессии pnpla3 EA202191629A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862777714P 2018-12-10 2018-12-10
PCT/US2019/065481 WO2020123508A2 (en) 2018-12-10 2019-12-10 Rnai constructs for inhibiting pnpla3 expression and methods of use thereof

Publications (1)

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EA202191629A1 true EA202191629A1 (ru) 2021-09-03

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Country Link
US (1) US20220017906A1 (ru)
EP (1) EP3894555A2 (ru)
JP (1) JP2022511550A (ru)
KR (1) KR20210102932A (ru)
CN (1) CN113166761A (ru)
AR (1) AR117297A1 (ru)
AU (1) AU2019396419A1 (ru)
BR (1) BR112021011061A2 (ru)
CA (1) CA3121510A1 (ru)
CL (1) CL2021001489A1 (ru)
CO (1) CO2021008997A2 (ru)
CR (1) CR20210371A (ru)
EA (1) EA202191629A1 (ru)
IL (1) IL283473A (ru)
JO (1) JOP20210142A1 (ru)
MX (1) MX2021006784A (ru)
PE (1) PE20211225A1 (ru)
SG (1) SG11202105711SA (ru)
TW (1) TW202039843A (ru)
UY (1) UY38503A (ru)
WO (1) WO2020123508A2 (ru)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
TW202300645A (zh) * 2021-04-14 2023-01-01 美商戴瑟納製藥股份有限公司 用於調節ｐｎｐｌａ３表現之組合物及方法
TW202317762A (zh) * 2021-06-02 2023-05-01 美商艾拉倫製藥股份有限公司 含有類ＰＡＴＡＴＩＮ磷脂酶結構域３（ＰＮＰＬＡ３）的ｉＲＮＡ組成物及其使用方法
CA3230222A1 (en) * 2021-09-01 2023-03-09 Leonid Beigelman Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
WO2024023256A1 (en) * 2022-07-27 2024-02-01 E-Therapeutics Plc Nucleic acid compounds

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WO2020123508A2 (en) 2020-06-18
TW202039843A (zh) 2020-11-01
UY38503A (es) 2020-06-30
WO2020123508A3 (en) 2020-08-13
CA3121510A1 (en) 2020-06-18
PE20211225A1 (es) 2021-07-06
BR112021011061A2 (pt) 2021-08-31
KR20210102932A (ko) 2021-08-20
US20220017906A1 (en) 2022-01-20
JOP20210142A1 (ar) 2023-01-30
AU2019396419A1 (en) 2021-06-17
EP3894555A2 (en) 2021-10-20
SG11202105711SA (en) 2021-06-29
CR20210371A (es) 2021-08-27
IL283473A (en) 2021-07-29
MX2021006784A (es) 2021-07-15
CL2021001489A1 (es) 2022-01-07
JP2022511550A (ja) 2022-01-31
AR117297A1 (es) 2021-07-28
CN113166761A (zh) 2021-07-23
CO2021008997A2 (es) 2021-07-30

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