BR112020009152A2 - ácidos nucleicos para inibição da expressão de lpa em uma célula - Google Patents

ácidos nucleicos para inibição da expressão de lpa em uma célula Download PDF

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Publication number
BR112020009152A2
BR112020009152A2 BR112020009152-9A BR112020009152A BR112020009152A2 BR 112020009152 A2 BR112020009152 A2 BR 112020009152A2 BR 112020009152 A BR112020009152 A BR 112020009152A BR 112020009152 A2 BR112020009152 A2 BR 112020009152A2
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Brazil
Prior art keywords
strand
nucleic acid
nucleotides
modified
seq
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BR112020009152-9A
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English (en)
Portuguese (pt)
Inventor
Sibylle DAMES
Steffen Schubert
Stephan Tenbaum
Christian Frauendorf
Lucas Bethge
Judith HAUPTMANN
Adrien WEINGÄRTNER
David Anthony Rider
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Silence Therapeutics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from EP17201449.0A external-priority patent/EP3483270A1/en
Application filed by Silence Therapeutics Gmbh filed Critical Silence Therapeutics Gmbh
Publication of BR112020009152A2 publication Critical patent/BR112020009152A2/pt

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549Sugars, nucleosides, nucleotides or nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3222'-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/344Position-specific modifications, e.g. on every purine, at the 3'-end
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate

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  • Health & Medical Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112020009152-9A 2017-11-13 2018-11-13 ácidos nucleicos para inibição da expressão de lpa em uma célula BR112020009152A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17201449.0A EP3483270A1 (en) 2017-11-13 2017-11-13 Products and compositions
EP17201449.0 2017-11-13
EP18179175.7 2018-06-21
EP18179175.7A EP3483271A3 (en) 2017-11-13 2018-06-21 Products and compositions
GB201815915 2018-09-28
GB1815915.2 2018-09-28
PCT/EP2018/081106 WO2019092283A1 (en) 2017-11-13 2018-11-13 Nucleic acids for inhibiting expression of lpa in a cell

Publications (1)

Publication Number Publication Date
BR112020009152A2 true BR112020009152A2 (pt) 2020-10-27

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BR112020009152-9A BR112020009152A2 (pt) 2017-11-13 2018-11-13 ácidos nucleicos para inibição da expressão de lpa em uma célula

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US (3) US11319537B2 (https=)
EP (2) EP3710586B1 (https=)
JP (1) JP7245254B2 (https=)
KR (1) KR102553382B1 (https=)
CN (2) CN111465694A (https=)
AU (1) AU2018363840B2 (https=)
BR (1) BR112020009152A2 (https=)
CA (1) CA3081905C (https=)
DK (1) DK3710586T3 (https=)
ES (1) ES2938193T3 (https=)
FI (1) FI3710586T3 (https=)
HR (1) HRP20230127T1 (https=)
HU (1) HUE061265T2 (https=)
IL (1) IL274503B2 (https=)
LT (1) LT3710586T (https=)
MX (1) MX2020004897A (https=)
PL (1) PL3710586T3 (https=)
RS (1) RS63955B1 (https=)
SG (1) SG11202003230UA (https=)
SI (1) SI3710586T1 (https=)
WO (1) WO2019092283A1 (https=)
ZA (1) ZA202003371B (https=)

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KR102812602B1 (ko) 2020-08-05 2025-05-28 다이서나 파마수이티컬, 인크. Lpa 발현을 저해하기 위한 조성물 및 방법
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US20220290144A1 (en) 2022-09-15
US11319537B2 (en) 2022-05-03
EP4219716A2 (en) 2023-08-02
US12054717B2 (en) 2024-08-06
IL274503A (en) 2020-06-30
CN111465694A (zh) 2020-07-28
KR20200088392A (ko) 2020-07-22
AU2018363840B2 (en) 2022-09-29
US20240327843A1 (en) 2024-10-03
IL274503B2 (en) 2024-10-01
EP3710586B1 (en) 2022-11-23
EP3710586A1 (en) 2020-09-23
HUE061265T2 (hu) 2023-06-28
US20210123048A1 (en) 2021-04-29
KR102553382B1 (ko) 2023-07-07
RS63955B1 (sr) 2023-02-28
SG11202003230UA (en) 2020-05-28
AU2018363840A1 (en) 2020-04-16
PL3710586T3 (pl) 2023-03-20
MX2020004897A (es) 2020-10-05
FI3710586T3 (fi) 2023-03-02
HRP20230127T1 (hr) 2023-03-31
DK3710586T3 (da) 2023-01-23
CA3081905C (en) 2023-10-03
WO2019092283A1 (en) 2019-05-16
CA3081905A1 (en) 2019-05-16
ES2938193T3 (es) 2023-04-05
CN119120476A (zh) 2024-12-13
LT3710586T (lt) 2023-02-27
JP7245254B2 (ja) 2023-03-23
IL274503B1 (en) 2024-06-01
SI3710586T1 (sl) 2023-03-31
JP2021502120A (ja) 2021-01-28
EP4219716A3 (en) 2024-03-27
ZA202003371B (en) 2023-08-30

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]