ATE371680T1 - Polymerkonjugate - Google Patents

Polymerkonjugate

Info

Publication number
ATE371680T1
ATE371680T1 AT03700372T AT03700372T ATE371680T1 AT E371680 T1 ATE371680 T1 AT E371680T1 AT 03700372 T AT03700372 T AT 03700372T AT 03700372 T AT03700372 T AT 03700372T AT E371680 T1 ATE371680 T1 AT E371680T1
Authority
AT
Austria
Prior art keywords
conjugates
moiety
polydispersity
biologically active
active compounds
Prior art date
Application number
AT03700372T
Other languages
English (en)
Inventor
Andrew Lewis
Original Assignee
Biocompatibles Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles Uk Ltd filed Critical Biocompatibles Uk Ltd
Application granted granted Critical
Publication of ATE371680T1 publication Critical patent/ATE371680T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F246/00—Copolymers in which the nature of only the monomers in minority is defined

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
AT03700372T 2002-01-16 2003-01-16 Polymerkonjugate ATE371680T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02250289 2002-01-16

Publications (1)

Publication Number Publication Date
ATE371680T1 true ATE371680T1 (de) 2007-09-15

Family

ID=27589157

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03700372T ATE371680T1 (de) 2002-01-16 2003-01-16 Polymerkonjugate

Country Status (6)

Country Link
US (2) US8048408B2 (de)
EP (1) EP1465933B1 (de)
AT (1) ATE371680T1 (de)
DE (1) DE60315949T2 (de)
ES (1) ES2291613T3 (de)
WO (1) WO2003062290A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE371680T1 (de) 2002-01-16 2007-09-15 Biocompatibles Uk Ltd Polymerkonjugate
WO2003074026A1 (en) 2002-03-07 2003-09-12 Biocompatibles Uk Limited Drug carriers comprising amphiphilic block copolymers
US8182802B2 (en) 2002-03-07 2012-05-22 Biocompatibles Uk Limited Composition of polymers
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
US7820753B2 (en) * 2003-02-05 2010-10-26 Biocompatibles Uk Limited Block copolymers
GB0314472D0 (en) 2003-06-20 2003-07-23 Warwick Effect Polymers Ltd Polymer
US7786213B2 (en) * 2003-10-15 2010-08-31 The Regents Of The University Of California Biomacromolecule polymer conjugates
PT1701940E (pt) * 2003-12-23 2008-07-30 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-benzil-amina como ssri
CA2558767A1 (en) * 2004-07-06 2006-01-12 Warwick Effect Polymers Limited Living radical polymerization initiator comprising a functional group capable of reacting with polyeptides or the like, comb polymer obtained therewith, polypeptide conjugates anddrugs obtained therefrom
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
US7629473B2 (en) * 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) * 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
LT1988910T (lt) 2006-02-28 2018-01-10 Kodiak Sciences Inc. Akriloiloksietilfosforilcholiną turintys polimero konjugatai ir jų gavimo būdas
US8216582B2 (en) * 2006-06-23 2012-07-10 Alethia Biotherapeutics Inc. Polynucleotides and polypeptide sequences involved in cancer
JP2008060540A (ja) * 2006-08-03 2008-03-13 Seiko Epson Corp 電子デバイスの製造方法、電子デバイスおよび電子機器
JP5570809B2 (ja) 2006-09-01 2014-08-13 ノボ ノルディスク ヘルス ケア アーゲー 修飾タンパク質
US8575397B2 (en) 2007-02-14 2013-11-05 Biocompatibles Uk Limited Derivatisation of biological molecules
WO2009108806A1 (en) 2008-02-27 2009-09-03 Novo Nordisk A/S Conjugated factor viii molecules
MX336869B (es) 2008-11-03 2016-02-04 Alethia Biotherapeutics Inc Anticuerpos que bloquean espicificamente la actividad biologica de un antigeno de tumor.
DK2260873T3 (da) 2009-06-08 2019-09-16 Biocompatibles Uk Ltd Pcylering af proteiner
US8765432B2 (en) 2009-12-18 2014-07-01 Oligasis, Llc Targeted drug phosphorylcholine polymer conjugates
EP2536753B1 (de) 2010-02-16 2017-12-20 Novo Nordisk A/S Faktor-VIII-Moleküle mit reduzierter VWF-Bindung
EP2571487B1 (de) * 2010-05-21 2023-01-04 Siemens Healthcare Diagnostics Inc. Zwitterionische reagenzien
PL3173427T3 (pl) 2011-03-31 2019-11-29 Adc Therapeutics Sa Przeciwciała przeciwko antygenowi związanemu z nerkami 1 i ich fragmenty wiążące antygen
JP6352806B2 (ja) 2011-09-23 2018-07-04 ノヴォ ノルディスク アー／エス 新規のグルカゴン類似体
PT2802351T (pt) 2012-01-09 2019-06-27 Adc Therapeutics Sa Agentes para o tratamento de cancro da mama triplo negativo
ES2879430T3 (es) * 2012-11-15 2021-11-22 Apellis Pharmaceuticals Inc Análogos de compstatina de acción prolongada y composiciones y métodos relacionados
CN105307672B (zh) 2013-04-18 2021-01-05 诺和诺德股份有限公司 用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂
HUE052447T2 (hu) 2013-09-08 2021-04-28 Kodiak Sciences Inc A VIII. tényezõs zwitterionos polimer konjugációk
US9309336B2 (en) 2013-11-27 2016-04-12 King Fahd University Of Petroleum And Minerals Synthesis and antiscalant behavior of a novel polyzwitterionic acid
JP2017525656A (ja) 2014-06-04 2017-09-07 ノヴォ ノルディスク アー／エス 医療用のｇｌｐ−１／グルカゴン受容体コアゴニスト
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
CN107208076A (zh) 2014-10-17 2017-09-26 科达制药 丁酰胆碱酯酶两性离子聚合物缀合物
AU2016381964B2 (en) 2015-12-30 2024-02-15 Kodiak Sciences Inc. Antibodies and conjugates thereof
CN112203679A (zh) 2018-03-02 2021-01-08 科达制药股份有限公司 Il-6抗体及其融合构建体和缀合物
CN114786731A (zh) 2019-10-10 2022-07-22 科达制药股份有限公司 治疗眼部病症的方法
EP4199934A4 (de) * 2020-08-21 2024-09-04 Univ Texas Funktionelle ionisierbare phospholipide

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260373A (en) 1987-03-13 1993-11-09 Repligen Corporation Immobilized immunoglobulin-binding proteins
JPH03503047A (ja) 1987-12-09 1991-07-11 スリーアイ・リサーチ・エクスプロイテーション・リミテッド ポリマーおよびポリマー‐ペプチド複合体
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
SE466754B (sv) 1990-09-13 1992-03-30 Berol Nobel Ab Saett att kovalent binda biopolymerer till hydrofila ytor
US5286846A (en) 1991-06-14 1994-02-15 The Government Of The United States Of America As Represented By The Dept. Of Health And Human Services Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
AU666485B2 (en) * 1991-07-05 1996-02-15 Biocompatibles Uk Limited Polymeric surface coatings
JPH05220218A (ja) * 1992-02-13 1993-08-31 Norio Nakabayashi 抗血栓性再生セルロース系膜及びその製造方法
IL104734A0 (en) 1993-02-15 1993-06-10 Univ Bar Ilan Bioactive conjugates of cellulose with amino compounds
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
EP0796112A4 (de) * 1994-11-30 1999-12-01 Amur Research Corp Phosphocholin-arzneistoffderivate
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5763548A (en) 1995-03-31 1998-06-09 Carnegie-Mellon University (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization
TW517067B (en) 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
ATE207082T1 (de) * 1996-06-12 2001-11-15 Univ Warwick Polymerisation-katalysator und -verfahren
CA2266404A1 (en) * 1996-09-17 1998-03-26 Amur Pharmaceuticals, Inc. Phospholipid drug derivatives
US5830432A (en) * 1997-03-31 1998-11-03 Amur Pharmacuticals, Inc. Phospholipid drug derivatives
EP0922446A1 (de) 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Lösungsphase Verfahrung zur ortspezifischer Herstellung von GRF-PEG Konjugaten
US6251382B1 (en) 1998-04-17 2001-06-26 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US6562330B1 (en) * 1998-11-13 2003-05-13 Biocompatibles Limited Therapeutic use of polymers
ATE323113T1 (de) 1999-07-02 2006-04-15 Symyx Technologies Inc Polymerverzweigungen zur immobilisierung von molekülen auf oberflächen oder substraten, wobei die polymere wasserlösliche oder wasserdispergierbare segmente und sonden aufweisen
WO2001018080A1 (en) 1999-09-08 2001-03-15 School Of Pharmacy, University Of London Uniform molecular weight polymers
GB9924502D0 (en) * 1999-10-15 1999-12-15 Biocompatibles Ltd Polymer blend materials
ATE266668T1 (de) 2000-02-07 2004-05-15 Biocompatibles Uk Ltd Silizium enthaltende verbindungen hergestellt durch michael addition als monomere und macromere
DE60119318T2 (de) 2000-05-29 2007-05-03 Bio Merieux Biokompatible polymere für die bindung von biologischen liganden
AU2001292092A1 (en) * 2000-10-06 2002-04-15 Biocompatibles Uk Limited Zwitterionic polymers
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
JP4577747B2 (ja) 2001-06-05 2010-11-10 和光純薬工業株式会社 免疫学的測定法用凝集促進剤
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
ATE371680T1 (de) 2002-01-16 2007-09-15 Biocompatibles Uk Ltd Polymerkonjugate
WO2003074026A1 (en) 2002-03-07 2003-09-12 Biocompatibles Uk Limited Drug carriers comprising amphiphilic block copolymers
US8182802B2 (en) 2002-03-07 2012-05-22 Biocompatibles Uk Limited Composition of polymers
GB0301014D0 (en) 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
US7820753B2 (en) 2003-02-05 2010-10-26 Biocompatibles Uk Limited Block copolymers
BRPI0407511A (pt) 2003-02-19 2006-02-14 Pharmacia Corp ésteres de polietilenoglicol ativados
CA2788505C (en) 2003-02-26 2018-09-04 Nektar Therapeutics Polymer-factor viii moiety conjugates
BRPI0412671A (pt) 2003-08-08 2006-10-03 Fresenius Kabi De Gmbh conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima
US7786213B2 (en) 2003-10-15 2010-08-31 The Regents Of The University Of California Biomacromolecule polymer conjugates
US7179874B2 (en) 2003-11-21 2007-02-20 Chia Nan University Of Pharmacy And Science Biodegradable cationic polymer
US7365127B2 (en) 2005-02-04 2008-04-29 Enzon Pharmaceuticals, Inc. Process for the preparation of polymer conjugates
US20070123646A1 (en) 2005-09-13 2007-05-31 Lele Bhalchandra S Protein-polymer conjugates and synthesis thereof

Also Published As

Publication number Publication date
ES2291613T3 (es) 2008-03-01
US20050123501A1 (en) 2005-06-09
DE60315949D1 (de) 2007-10-11
US8431113B2 (en) 2013-04-30
WO2003062290A1 (en) 2003-07-31
EP1465933A1 (de) 2004-10-13
DE60315949T2 (de) 2008-06-12
US20120016085A1 (en) 2012-01-19
US8048408B2 (en) 2011-11-01
EP1465933B1 (de) 2007-08-29

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