TNSN96141A1 - Formulations pharmaceutiques et procede pour leur production - Google Patents
Formulations pharmaceutiques et procede pour leur productionInfo
- Publication number
- TNSN96141A1 TNSN96141A1 TNTNSN96141A TNSN96141A TNSN96141A1 TN SN96141 A1 TNSN96141 A1 TN SN96141A1 TN TNSN96141 A TNTNSN96141 A TN TNSN96141A TN SN96141 A TNSN96141 A TN SN96141A TN SN96141 A1 TNSN96141 A1 TN SN96141A1
- Authority
- TN
- Tunisia
- Prior art keywords
- formulation
- production
- pharmaceutical formulations
- administration
- hydroxypropylmethylcellulose
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L’INVENTION CONCERNE UNE FORMULATION PHARMACEUTIQUE A LIBERATION CONTROLEE POUR L’ADMINISTRATION ORALE. CETTE FORMULATION CONSISTE EN UN COMPOSE MEDICAMENTEUX ACTIF, UN POLYMERE D’OXYDE D’ETHYLENE DE BAS POIDS MOLECULAIRE, DE L’HYDROXYPROPYLMETHYLCELLULOSE, DES EXCIPIENTS DE COMPRESSION ET, FACULTATIVEMENT, UN OU PLUSIEURS POLYMERES ENTERIQUES. APPLICATION : OBTENTION DE FORMULATION A VITESSE CONSTANTE DE LIBERATION POUR L'ADMINISTRATION DE DIVERS MEDICAMENTS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9523752.5A GB9523752D0 (en) | 1995-11-21 | 1995-11-21 | Pharmaceutical formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN96141A1 true TNSN96141A1 (fr) | 2005-03-15 |
Family
ID=10784188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN96141A TNSN96141A1 (fr) | 1995-11-21 | 1996-11-20 | Formulations pharmaceutiques et procede pour leur production |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP0862437A1 (fr) |
JP (1) | JPH10513481A (fr) |
KR (1) | KR19990071505A (fr) |
CN (1) | CN1215993A (fr) |
AP (1) | AP718A (fr) |
AR (1) | AR004335A1 (fr) |
AU (1) | AU709560B2 (fr) |
BG (1) | BG102438A (fr) |
BR (1) | BR9611626A (fr) |
CA (1) | CA2232715A1 (fr) |
CO (1) | CO4480020A1 (fr) |
CZ (1) | CZ155498A3 (fr) |
GB (1) | GB9523752D0 (fr) |
HR (1) | HRP960554A2 (fr) |
HU (1) | HUP9903734A3 (fr) |
IS (1) | IS4706A (fr) |
MA (1) | MA26410A1 (fr) |
MX (1) | MX9804008A (fr) |
NO (1) | NO982302L (fr) |
NZ (1) | NZ322053A (fr) |
OA (1) | OA10687A (fr) |
PE (1) | PE22898A1 (fr) |
PL (1) | PL326981A1 (fr) |
SK (1) | SK63098A3 (fr) |
TN (1) | TNSN96141A1 (fr) |
TR (1) | TR199800902T2 (fr) |
WO (1) | WO1997018814A1 (fr) |
YU (1) | YU62096A (fr) |
ZA (1) | ZA969722B (fr) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1282248A (zh) * | 1997-12-16 | 2001-01-31 | 辉瑞产品公司 | 阳萎的联合治疗 |
AP1224A (en) | 1998-03-19 | 2003-11-14 | Bristol Myers Squibb Co | Biphasic controlled release delivery system for high solubility pharmaceuticals and method. |
GT199900061A (es) * | 1998-05-15 | 2000-10-14 | Pfizer | Formulaciones farmaceuticas. |
EP0987020A1 (fr) * | 1998-09-04 | 2000-03-22 | Pharma Pass LLC | Composition contenant du metoprolol et procédé de préparation |
EP0974343B1 (fr) * | 1998-07-22 | 2004-09-29 | Pharma Pass II LLC | Procédé de préparation d'une composition solide contentant du metoprolol |
CO5140079A1 (es) * | 1998-10-14 | 2002-03-22 | Novartis Ag | Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo |
UA67802C2 (uk) * | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції |
US20030059467A1 (en) * | 2001-09-14 | 2003-03-27 | Pawan Seth | Pharmaceutical composition comprising doxasozin |
US7612112B2 (en) | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
US6723340B2 (en) * | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
US8329217B2 (en) | 2001-11-06 | 2012-12-11 | Osmotica Kereskedelmi Es Szolgaltato Kft | Dual controlled release dosage form |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
WO2005037247A2 (fr) * | 2003-10-17 | 2005-04-28 | Ranbaxy Laboratories Limited | Formulations matricielles de doxazosine a administration orale |
US20050255157A1 (en) * | 2004-05-11 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Sustained release, mucoadhesive vaginal pharmaceutical compositions |
KR100574554B1 (ko) * | 2004-05-28 | 2006-04-27 | 한미약품 주식회사 | 니아신의 경구투여용 서방성 조성물 |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
KR100679111B1 (ko) * | 2004-11-20 | 2007-02-07 | 대우약품공업주식회사 | 독사조신을 포함하는 서방성 정제 |
BRPI0614870A2 (pt) * | 2005-08-22 | 2011-04-19 | Novartis Ag | composições farmacêuticas |
US20090176882A1 (en) | 2008-12-09 | 2009-07-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
CN101489560B (zh) | 2006-04-26 | 2015-11-25 | 苏佩努斯制药公司 | 具有s形释放曲线的奥卡西平控释制剂 |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
NZ619413A (en) | 2006-05-04 | 2015-08-28 | Boehringer Ingelheim Int | Polymorphs of a dpp-iv enzyme inhibitor |
EP1852108A1 (fr) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | Compositions d'inhibiteurs de la DPP IV |
CN100396282C (zh) * | 2006-07-25 | 2008-06-25 | 山东省医药工业研究所 | 甲磺酸多沙唑嗪缓释胶囊及制备方法 |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
AU2009223061B2 (en) | 2008-03-11 | 2014-10-09 | Depomed Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
KR101004205B1 (ko) * | 2008-12-17 | 2010-12-24 | 동아제약주식회사 | 유데나필 함유 서방성 제제를 제조하기 위한 제어방출 조성물 |
PL2395983T3 (pl) | 2009-02-13 | 2020-09-07 | Boehringer Ingelheim International Gmbh | Kompozycja farmaceutyczna zawierająca inhibitor sglt2, inhibitor dpp-iv i ewentualnie dalszy środek przeciwcukrzycowy oraz jej zastosowania |
US8828953B2 (en) | 2009-04-20 | 2014-09-09 | NaZura BioHealth, Inc. | Chemosensory receptor ligand-based therapies |
US9901551B2 (en) | 2009-04-20 | 2018-02-27 | Ambra Bioscience Llc | Chemosensory receptor ligand-based therapies |
CA2758976C (fr) | 2009-04-20 | 2015-02-03 | Alain Baron | Therapies a base de ligand de recepteur chimiosensible |
JP2013512229A (ja) | 2009-11-27 | 2013-04-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 遺伝子型が同定された糖尿病患者のリナグリプチン等のddp−iv阻害薬による治療 |
US20110150989A1 (en) * | 2009-12-22 | 2011-06-23 | Mallinkckrodt Inc. | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
BR112012028136A2 (pt) | 2010-05-05 | 2016-08-09 | Boehringer Ingelheim Int | terapia de combinaçao |
MY161846A (en) | 2010-07-09 | 2017-05-15 | James Trinca Green | Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin |
SG189444A1 (en) | 2010-10-19 | 2013-05-31 | Elcelyx Therapeutics Inc | Chemosensory receptor ligand-based therapies |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
SI2661266T1 (sl) | 2011-01-07 | 2021-01-29 | Anji Pharma (Us) Llc | Terapije, na osnovi kemosenzoričnih receptorskih ligandov |
CN102058555A (zh) * | 2011-01-13 | 2011-05-18 | 北京汇诚瑞祥医药技术有限公司 | 一种多沙唑嗪控释片 |
AR085689A1 (es) | 2011-03-07 | 2013-10-23 | Boehringer Ingelheim Int | Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2 |
CN102188431A (zh) * | 2011-05-09 | 2011-09-21 | 浙江九旭药业有限公司 | 甲磺酸多沙唑嗪缓释片及其制备方法 |
US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
US8658631B1 (en) | 2011-05-17 | 2014-02-25 | Mallinckrodt Llc | Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia |
US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
WO2013158928A2 (fr) | 2012-04-18 | 2013-10-24 | Elcelyx Therapeutics, Inc. | Thérapies à base de ligand de récepteur chimiosensoriels |
EP3685839A1 (fr) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin pour son utilisation dans le traitement de l'albuminurie et des maladies liees au rein |
WO2013174767A1 (fr) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires |
CN105431144A (zh) | 2013-06-05 | 2016-03-23 | 思康脑侒股份有限公司 | 阿坎酸制剂、使用阿坎酸制剂的方法以及包含阿坎酸制剂的组合 |
EP3110449B1 (fr) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Utilisation médicale d'un inhibiteur de dpp-4 |
CN105616378A (zh) * | 2014-10-31 | 2016-06-01 | 康普药业股份有限公司 | 一种氟康唑胶囊及其制备方法 |
MX2018015089A (es) | 2016-06-10 | 2019-05-13 | Boehringer Ingelheim Int | Combinacion de linagliptina y metformina. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1198386B (it) * | 1982-07-06 | 1988-12-21 | Lepetit Spa | Un prodotto a rilascio protratto contenente il suloctidile |
US4765989A (en) * | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
US4837111A (en) * | 1988-03-21 | 1989-06-06 | Alza Corporation | Dosage form for dispensing drug for human therapy |
IL92966A (en) * | 1989-01-12 | 1995-07-31 | Pfizer | Hydrogel-operated release devices |
WO1992001445A1 (fr) * | 1990-07-23 | 1992-02-06 | Alza Corporation | Appareil osmotique pour la bouche liberant de la nicotine |
-
1995
- 1995-11-21 GB GBGB9523752.5A patent/GB9523752D0/en active Pending
-
1996
- 1996-11-11 PL PL96326981A patent/PL326981A1/xx unknown
- 1996-11-11 CA CA002232715A patent/CA2232715A1/fr not_active Abandoned
- 1996-11-11 NZ NZ322053A patent/NZ322053A/xx unknown
- 1996-11-11 JP JP9519364A patent/JPH10513481A/ja active Pending
- 1996-11-11 CZ CZ981554A patent/CZ155498A3/cs unknown
- 1996-11-11 AU AU75721/96A patent/AU709560B2/en not_active Ceased
- 1996-11-11 CN CN96198486A patent/CN1215993A/zh active Pending
- 1996-11-11 WO PCT/EP1996/005020 patent/WO1997018814A1/fr not_active Application Discontinuation
- 1996-11-11 EP EP96938215A patent/EP0862437A1/fr not_active Withdrawn
- 1996-11-11 SK SK630-98A patent/SK63098A3/sk unknown
- 1996-11-11 KR KR1019980703777A patent/KR19990071505A/ko not_active Application Discontinuation
- 1996-11-11 BR BR9611626A patent/BR9611626A/pt not_active Application Discontinuation
- 1996-11-11 HU HU9903734A patent/HUP9903734A3/hu unknown
- 1996-11-11 TR TR1998/00902T patent/TR199800902T2/xx unknown
- 1996-11-20 TN TNTNSN96141A patent/TNSN96141A1/fr unknown
- 1996-11-20 AR ARP960105252A patent/AR004335A1/es unknown
- 1996-11-20 YU YU62096A patent/YU62096A/sh unknown
- 1996-11-20 MA MA24397A patent/MA26410A1/fr unknown
- 1996-11-20 ZA ZA9609722A patent/ZA969722B/xx unknown
- 1996-11-20 PE PE1996000831A patent/PE22898A1/es not_active Application Discontinuation
- 1996-11-21 AP APAP/P/1996/000883A patent/AP718A/en active
- 1996-11-21 HR HR9523752.5A patent/HRP960554A2/hr not_active Application Discontinuation
- 1996-11-21 CO CO96061449A patent/CO4480020A1/es unknown
-
1998
- 1998-03-31 IS IS4706A patent/IS4706A/is unknown
- 1998-05-08 BG BG102438A patent/BG102438A/xx unknown
- 1998-05-19 OA OA9800058A patent/OA10687A/en unknown
- 1998-05-20 MX MX9804008A patent/MX9804008A/es unknown
- 1998-05-20 NO NO982302A patent/NO982302L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
YU62096A (sh) | 1999-03-04 |
SK63098A3 (en) | 1999-05-07 |
CA2232715A1 (fr) | 1997-05-29 |
BG102438A (en) | 1999-01-29 |
NO982302L (no) | 1998-07-17 |
CN1215993A (zh) | 1999-05-05 |
OA10687A (en) | 2002-11-27 |
TR199800902T2 (xx) | 1998-09-21 |
KR19990071505A (ko) | 1999-09-27 |
NO982302D0 (no) | 1998-05-20 |
GB9523752D0 (en) | 1996-01-24 |
HUP9903734A2 (hu) | 2000-03-28 |
JPH10513481A (ja) | 1998-12-22 |
IS4706A (is) | 1998-03-31 |
CO4480020A1 (es) | 1997-07-09 |
CZ155498A3 (cs) | 1999-03-17 |
AP718A (en) | 1999-01-06 |
WO1997018814A1 (fr) | 1997-05-29 |
AU7572196A (en) | 1997-06-11 |
AR004335A1 (es) | 1998-11-04 |
PE22898A1 (es) | 1998-05-07 |
HRP960554A2 (en) | 1998-02-28 |
MX9804008A (es) | 1998-09-30 |
AU709560B2 (en) | 1999-09-02 |
AP9600883A0 (en) | 1997-01-31 |
EP0862437A1 (fr) | 1998-09-09 |
BR9611626A (pt) | 1999-06-01 |
MA26410A1 (fr) | 2004-12-20 |
NZ322053A (en) | 1999-11-29 |
HUP9903734A3 (en) | 2000-04-28 |
ZA969722B (en) | 1998-05-20 |
PL326981A1 (en) | 1998-11-09 |
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