DE602004012713D1 - Konjugationsreaktionen - Google Patents

Konjugationsreaktionen

Info

Publication number
DE602004012713D1
DE602004012713D1 DE602004012713T DE602004012713T DE602004012713D1 DE 602004012713 D1 DE602004012713 D1 DE 602004012713D1 DE 602004012713 T DE602004012713 T DE 602004012713T DE 602004012713 T DE602004012713 T DE 602004012713T DE 602004012713 D1 DE602004012713 D1 DE 602004012713D1
Authority
DE
Germany
Prior art keywords
group
bromo
initiator
methyl
propionic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004012713T
Other languages
English (en)
Other versions
DE602004012713T2 (de
Inventor
Andrew Lennard Lewis
Simon William Leppard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocompatibles UK Ltd
Original Assignee
Biocompatibles UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles UK Ltd filed Critical Biocompatibles UK Ltd
Publication of DE602004012713D1 publication Critical patent/DE602004012713D1/de
Application granted granted Critical
Publication of DE602004012713T2 publication Critical patent/DE602004012713T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F246/00—Copolymers in which the nature of only the monomers in minority is defined
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602004012713T 2003-01-16 2004-01-16 Konjugationsreaktionen Expired - Lifetime DE602004012713T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0301014 2003-01-16
GBGB0301014.7A GB0301014D0 (en) 2003-01-16 2003-01-16 Conjugation reactions
PCT/GB2004/000140 WO2004063237A1 (en) 2003-01-16 2004-01-16 Conjugation reactions

Publications (2)

Publication Number Publication Date
DE602004012713D1 true DE602004012713D1 (de) 2008-05-08
DE602004012713T2 DE602004012713T2 (de) 2009-04-09

Family

ID=9951273

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004012713T Expired - Lifetime DE602004012713T2 (de) 2003-01-16 2004-01-16 Konjugationsreaktionen

Country Status (6)

Country Link
US (2) US8053520B2 (de)
EP (1) EP1592719B1 (de)
AT (1) ATE390447T1 (de)
DE (1) DE602004012713T2 (de)
GB (1) GB0301014D0 (de)
WO (1) WO2004063237A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60315949T2 (de) * 2002-01-16 2008-06-12 Biocompatibles Uk Ltd., Farnham Polymerkonjugate
WO2003074026A1 (en) * 2002-03-07 2003-09-12 Biocompatibles Uk Limited Drug carriers comprising amphiphilic block copolymers
DE60334779D1 (en) 2002-03-07 2010-12-16 Biocompatibles Uk Ltd Mit nucleinsäure complexierte block-copolymere
EP1590388A2 (de) * 2003-02-05 2005-11-02 Biocompatibles UK Limited Blockcopolymere
GB0314472D0 (en) * 2003-06-20 2003-07-23 Warwick Effect Polymers Ltd Polymer
CA2558767A1 (en) * 2004-07-06 2006-01-12 Warwick Effect Polymers Limited Living radical polymerization initiator comprising a functional group capable of reacting with polyeptides or the like, comb polymer obtained therewith, polypeptide conjugates anddrugs obtained therefrom
US20070123646A1 (en) * 2005-09-13 2007-05-31 Lele Bhalchandra S Protein-polymer conjugates and synthesis thereof
EP1988910B1 (de) 2006-02-28 2017-12-06 Kodiak Sciences Inc. Acryloyloxyethylphosphorylcholin-haltige polymerkonjugate und ihre zubereitung
WO2008098930A1 (en) * 2007-02-14 2008-08-21 Biocompatibes Uk Limited Derivatisation of biological molecules
WO2009053700A1 (en) * 2007-10-23 2009-04-30 Cancer Research Technology Limited Modification of nucleic acid-containing biological entities
EP2260873B1 (de) 2009-06-08 2019-07-24 Biocompatibles UK Limited Pcylierung von proteinen
WO2011075185A1 (en) 2009-12-18 2011-06-23 Oligasis Targeted drug phosphorylcholine polymer conjugates
LT2558538T (lt) * 2010-04-15 2019-09-25 Kodiak Sciences Inc. Didelės molekulinės masės polimerai, turintys cviter-joną
DK3041513T3 (da) 2013-09-08 2020-10-26 Kodiak Sciences Inc Zwitterioniske faktor viii-polymerkonjugater
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
WO2016061562A2 (en) 2014-10-17 2016-04-21 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
CN108712911A (zh) 2015-12-30 2018-10-26 科达制药股份有限公司 抗体及其缀合物
MX2020009152A (es) 2018-03-02 2020-11-09 Kodiak Sciences Inc Anticuerpos de il-6 y constructos de fusion y conjugados de los mismos.
CN114786731A (zh) 2019-10-10 2022-07-22 科达制药股份有限公司 治疗眼部病症的方法

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260373A (en) * 1987-03-13 1993-11-09 Repligen Corporation Immobilized immunoglobulin-binding proteins
AU2825689A (en) * 1987-12-09 1989-07-05 Medical Research Council Polymers and polymer-peptide conjugates
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
SE466754B (sv) * 1990-09-13 1992-03-30 Berol Nobel Ab Saett att kovalent binda biopolymerer till hydrofila ytor
US5286846A (en) * 1991-06-14 1994-02-15 The Government Of The United States Of America As Represented By The Dept. Of Health And Human Services Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
JP3030086B2 (ja) 1991-07-05 2000-04-10 バイオコンパテイブルズ・リミテツド ポリマーの表面コーティング
JPH05220218A (ja) 1992-02-13 1993-08-31 Norio Nakabayashi 抗血栓性再生セルロース系膜及びその製造方法
IL104734A0 (en) * 1993-02-15 1993-06-10 Univ Bar Ilan Bioactive conjugates of cellulose with amino compounds
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
WO1996016680A1 (en) * 1994-11-30 1996-06-06 Amur Research Corp. Phosphocholine drug derivatives
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5763548A (en) 1995-03-31 1998-06-09 Carnegie-Mellon University (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization
US5807937A (en) * 1995-11-15 1998-09-15 Carnegie Mellon University Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
EP0906342B2 (de) * 1996-06-12 2015-02-11 Warwick Effect Polymers Limited Polymerisation-katalysator und -verfahren
AU4892897A (en) * 1996-09-17 1998-04-14 Amur Pharmaceuticals, Inc. Phospholipid drug derivatives
US5830432A (en) 1997-03-31 1998-11-03 Amur Pharmacuticals, Inc. Phospholipid drug derivatives
EP0922446A1 (de) * 1997-12-03 1999-06-16 Applied Research Systems Ars Holding N.V. Lösungsphase Verfahrung zur ortspezifischer Herstellung von GRF-PEG Konjugaten
US6642318B1 (en) * 1997-12-18 2003-11-04 E. I. Du Pont De Nemours And Company Polymerization process with living characteristics and polymers made therefrom
US6251382B1 (en) * 1998-04-17 2001-06-26 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
JP4145403B2 (ja) * 1998-09-29 2008-09-03 日油株式会社 免疫学的活性物質測定用高分子／酵素結合体
EP1128784B1 (de) * 1998-11-13 2003-07-23 Biocompatibles UK Limited Therapeutische anwendung von polymeren
CA2377739A1 (en) * 1999-07-02 2001-01-11 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
US8106098B2 (en) * 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
US7160924B2 (en) * 2002-07-19 2007-01-09 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
US6803438B1 (en) * 1999-09-08 2004-10-12 Polytherics Limited Uniform molecular weight polymers
GB9924502D0 (en) 1999-10-15 1999-12-15 Biocompatibles Ltd Polymer blend materials
DE60010644T2 (de) * 2000-02-07 2005-05-19 Biocompatibles Uk Ltd., Farnham Silizium enthaltende Verbindungen hergestellt durch Michael Addition als Monomere und Macromere
JP2001316361A (ja) * 2000-05-01 2001-11-13 Ethyl Corp スクシンイミド−酸化合物およびそれの誘導体
AU2001274146A1 (en) * 2000-05-29 2001-12-11 Bio Merieux Biocompatible polymer for fixing biological ligands
DE60129148T2 (de) * 2000-10-06 2008-02-28 Biocompatibles Uk Ltd., Farnham Zwitterionische polymere
US6652886B2 (en) * 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
JP4577747B2 (ja) * 2001-06-05 2010-11-10 和光純薬工業株式会社 免疫学的測定法用凝集促進剤
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US6908963B2 (en) * 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
CA2466027C (en) * 2001-11-07 2013-01-08 Nektar Therapeutics Al, Corporation Branched polymers and their conjugates
DE60315949T2 (de) * 2002-01-16 2008-06-12 Biocompatibles Uk Ltd., Farnham Polymerkonjugate
DE60334779D1 (en) * 2002-03-07 2010-12-16 Biocompatibles Uk Ltd Mit nucleinsäure complexierte block-copolymere
WO2003074026A1 (en) * 2002-03-07 2003-09-12 Biocompatibles Uk Limited Drug carriers comprising amphiphilic block copolymers
AU2003281060A1 (en) * 2002-07-16 2004-02-02 Rensselaer Polytechnic Institute Process for conversion of phenols to carboxamides via the succinimide esters
JP2004075823A (ja) * 2002-08-15 2004-03-11 Fuji Xerox Co Ltd 非架橋重合体粒子の製造方法
US7556969B2 (en) * 2002-12-19 2009-07-07 Northeastern University Intensified neutral loss tags and use thereof in mass spectrometry
EP1590388A2 (de) * 2003-02-05 2005-11-02 Biocompatibles UK Limited Blockcopolymere
JP2006517995A (ja) * 2003-02-19 2006-08-03 ファルマシア・コーポレーション 活性化されたポリエチレングリコールエステル類
WO2004075923A2 (en) * 2003-02-26 2004-09-10 Nektar Therapeutics Al, Corporation Polymer-factor viii moiety conjugates
GB0314472D0 (en) * 2003-06-20 2003-07-23 Warwick Effect Polymers Ltd Polymer
BRPI0412671A (pt) * 2003-08-08 2006-10-03 Fresenius Kabi De Gmbh conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima
WO2005039641A2 (en) * 2003-10-15 2005-05-06 The Regents Of The University Of California Biomacromolecule polymer conjugates
US7179874B2 (en) * 2003-11-21 2007-02-20 Chia Nan University Of Pharmacy And Science Biodegradable cationic polymer
US7365127B2 (en) * 2005-02-04 2008-04-29 Enzon Pharmaceuticals, Inc. Process for the preparation of polymer conjugates
US20070123646A1 (en) * 2005-09-13 2007-05-31 Lele Bhalchandra S Protein-polymer conjugates and synthesis thereof
EP1988910B1 (de) * 2006-02-28 2017-12-06 Kodiak Sciences Inc. Acryloyloxyethylphosphorylcholin-haltige polymerkonjugate und ihre zubereitung

Also Published As

Publication number Publication date
ATE390447T1 (de) 2008-04-15
EP1592719A1 (de) 2005-11-09
DE602004012713T2 (de) 2009-04-09
WO2004063237A1 (en) 2004-07-29
US20060135714A1 (en) 2006-06-22
US20120016082A1 (en) 2012-01-19
US8445612B2 (en) 2013-05-21
EP1592719B1 (de) 2008-03-26
GB0301014D0 (en) 2003-02-19
US8053520B2 (en) 2011-11-08

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