JP2018537400A5 - - Google Patents
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- JP2018537400A5 JP2018537400A5 JP2018511202A JP2018511202A JP2018537400A5 JP 2018537400 A5 JP2018537400 A5 JP 2018537400A5 JP 2018511202 A JP2018511202 A JP 2018511202A JP 2018511202 A JP2018511202 A JP 2018511202A JP 2018537400 A5 JP2018537400 A5 JP 2018537400A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 1025
- 239000000427 antigen Substances 0.000 claims description 196
- 102000036639 antigens Human genes 0.000 claims description 196
- 108091007433 antigens Proteins 0.000 claims description 196
- 239000012634 fragment Substances 0.000 claims description 180
- 238000006467 substitution reaction Methods 0.000 claims description 53
- 238000007792 addition Methods 0.000 claims description 48
- 238000012217 deletion Methods 0.000 claims description 48
- 230000037430 deletion Effects 0.000 claims description 48
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 23
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 22
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 17
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims description 15
- 230000001404 mediated effect Effects 0.000 claims description 12
- 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 claims description 11
- 208000026278 immune system disease Diseases 0.000 claims description 10
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- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 239000002773 nucleotide Substances 0.000 claims description 7
- 125000003729 nucleotide group Chemical group 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 208000023275 Autoimmune disease Diseases 0.000 claims description 4
- 102000043131 MHC class II family Human genes 0.000 claims description 4
- 108091054438 MHC class II family Proteins 0.000 claims description 4
- 230000006044 T cell activation Effects 0.000 claims description 4
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- 150000001413 amino acids Chemical class 0.000 claims description 4
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims description 4
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- 229940056913 eftilagimod alfa Drugs 0.000 claims description 4
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- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims description 2
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- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims description 2
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims description 2
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- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
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- 241000721454 Pemphigus Species 0.000 claims description 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 2
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- 208000006011 Stroke Diseases 0.000 claims description 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims description 2
- 208000031737 Tissue Adhesions Diseases 0.000 claims description 2
- 206010052779 Transplant rejections Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 206010047115 Vasculitis Diseases 0.000 claims description 2
- 230000001270 agonistic effect Effects 0.000 claims description 2
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- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims description 2
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- 230000024279 bone resorption Effects 0.000 claims description 2
- 210000003169 central nervous system Anatomy 0.000 claims description 2
- 230000015271 coagulation Effects 0.000 claims description 2
- 238000005345 coagulation Methods 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 238000010494 dissociation reaction Methods 0.000 claims description 2
- 230000005593 dissociations Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 206010014599 encephalitis Diseases 0.000 claims description 2
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- 210000003780 hair follicle Anatomy 0.000 claims description 2
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- 201000008482 osteoarthritis Diseases 0.000 claims description 2
- 201000001245 periodontitis Diseases 0.000 claims description 2
- 210000001428 peripheral nervous system Anatomy 0.000 claims description 2
- 206010034674 peritonitis Diseases 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 201000000306 sarcoidosis Diseases 0.000 claims description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 2
- 230000035755 proliferation Effects 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 208000003807 Graves Disease Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 8
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 7
- 230000006052 T cell proliferation Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000023328 Basedow disease Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 description 1
- 241001024304 Mino Species 0.000 description 1
- 208000004362 Penile Induration Diseases 0.000 description 1
- 208000020758 Peyronie disease Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000025020 negative regulation of T cell proliferation Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021041608A JP2021097706A (ja) | 2015-09-02 | 2021-03-15 | 抗ｌａｇ−３抗体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1515572.4 | 2015-09-02 | ||
| GBGB1515572.4A GB201515572D0 (en) | 2015-09-02 | 2015-09-02 | Anti-LAG-3 antibodies |
| GBGB1612437.2A GB201612437D0 (en) | 2016-07-18 | 2016-07-18 | Anti-lag-3 antibodies |
| GB1612437.2 | 2016-07-18 | ||
| PCT/EP2016/070664 WO2017037203A1 (en) | 2015-09-02 | 2016-09-01 | Anti-LAG-3 Antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021041608A Division JP2021097706A (ja) | 2015-09-02 | 2021-03-15 | 抗ｌａｇ−３抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537400A JP2018537400A (ja) | 2018-12-20 |
| JP2018537400A5 true JP2018537400A5 (cg-RX-API-DMAC7.html) | 2019-10-17 |
| JP7074341B2 JP7074341B2 (ja) | 2022-05-24 |
Family
ID=56852278
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511202A Active JP7074341B2 (ja) | 2015-09-02 | 2016-09-01 | 抗ｌａｇ－３抗体 |
| JP2021041608A Pending JP2021097706A (ja) | 2015-09-02 | 2021-03-15 | 抗ｌａｇ−３抗体 |
| JP2022113055A Withdrawn JP2022137218A (ja) | 2015-09-02 | 2022-07-14 | 抗ｌａｇ－３抗体 |
| JP2024092967A Pending JP2024116273A (ja) | 2015-09-02 | 2024-06-07 | 抗ｌａｇ－３抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021041608A Pending JP2021097706A (ja) | 2015-09-02 | 2021-03-15 | 抗ｌａｇ−３抗体 |
| JP2022113055A Withdrawn JP2022137218A (ja) | 2015-09-02 | 2022-07-14 | 抗ｌａｇ－３抗体 |
| JP2024092967A Pending JP2024116273A (ja) | 2015-09-02 | 2024-06-07 | 抗ｌａｇ－３抗体 |
Country Status (20)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| WO2017037203A1 (en) * | 2015-09-02 | 2017-03-09 | Immutep S.A.S. | Anti-LAG-3 Antibodies |
| EP3954709A1 (en) | 2015-10-02 | 2022-02-16 | F. Hoffmann-La Roche AG | Bispecific antibodies specific for pd1 and tim3 |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| TWI843168B (zh) | 2016-10-11 | 2024-05-21 | 美商艾吉納斯公司 | 抗ｌａｇ－３抗體及其使用方法 |
| UA125700C2 (uk) | 2017-04-03 | 2022-05-18 | Ф. Хоффманн-Ля Рош Аг | Імунокон'югати антитіла до pd-1 з мутантом il-2 |
| MA49038B1 (fr) | 2017-04-05 | 2025-01-31 | F. Hoffmann-La Roche Ag | Anticorps bispécifiques se liant particulièrement à pd1 et lag3 |
| CA3053360A1 (en) * | 2017-04-05 | 2018-10-11 | F. Hoffmann-La Roche Ag | Anti-lag3 antibodies |
| EP3615572A1 (en) * | 2017-04-27 | 2020-03-04 | Tesaro Inc. | Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| JP7382232B2 (ja) | 2017-05-02 | 2023-11-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤 |
| MX2019012076A (es) | 2017-05-30 | 2019-12-09 | Bristol Myers Squibb Co | Composiciones que comprenden un anticuerpo anti gen-3 de activacion del linfocito (lag-3) o un anticuerpo anti-lag-3 y un anticuerpo anti muerte celular programada 1 (pd-1) o anti ligando 1 de muerte celular programada (pd-l1). |
| DK3631454T3 (da) | 2017-05-30 | 2023-12-04 | Bristol Myers Squibb Co | Behandling af lag-3 positive tumorer |
| JP2020536495A (ja) * | 2017-08-30 | 2020-12-17 | フェインズ セラピューティクス，インコーポレーテッド | 抗ｌａｇ−３抗体及びその使用 |
| TWI869334B (zh) * | 2017-12-22 | 2025-01-11 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種ｌａｇ-３抗體醫藥組成物及其用途 |
| WO2019129137A1 (zh) * | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| CN109970856B (zh) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| JP7438180B2 (ja) | 2018-03-20 | 2024-02-26 | ウーシー バイオロジクス アイルランド リミテッド | 新規抗ｌａｇ－３抗体ポリペプチド |
| WO2019186559A1 (en) * | 2018-03-27 | 2019-10-03 | Raz Yirmiya | Microglia modulators for use in treatment of depression |
| CN110343178B (zh) * | 2018-04-03 | 2022-07-22 | 上海开拓者生物医药有限公司 | 抗人lag-3单克隆抗体及其应用 |
| CN110606892B (zh) * | 2018-06-14 | 2023-09-26 | 华博生物医药技术（上海）有限公司 | 一种高亲和力高生物活性的lag-3抗体及其应用 |
| MX2021005394A (es) | 2018-11-07 | 2021-07-06 | Merck Sharp & Dohme Llc | Co-formulaciones de anticuerpos anti-gen de activacion de linfocitos 3 (anti-lag3) y anticuerpos anti-muerte programada-1 (anti-pd-1). |
| CN111620949A (zh) * | 2019-02-28 | 2020-09-04 | 三生国健药业（上海）股份有限公司 | 结合人lag-3的抗体、其制备方法和用途 |
| GB201906127D0 (en) | 2019-05-01 | 2019-06-12 | Immutep S A | Assays |
| GB201906118D0 (en) | 2019-05-01 | 2019-06-12 | Immutep S A | Anti-LAG-3 binding molecules |
| MX2021013815A (es) | 2019-05-13 | 2021-12-14 | Regeneron Pharma | Combinacion de inhibidores de pd-1 e inhibidores de lag-3 para mejorar la eficacia en el tratamiento contra el cancer. |
| JP7684656B2 (ja) * | 2019-06-11 | 2025-05-28 | 小野薬品工業株式会社 | 免疫抑制剤 |
| CN115666648A (zh) * | 2020-04-03 | 2023-01-31 | 索伦托药业有限公司 | 结合lag3的工程化抗体 |
| EP4157879A4 (en) * | 2020-05-27 | 2024-06-19 | Agilent Technologies, Inc. | Anti-human lag-3 antibodies and their use in immunohistochemistry (ihc) |
| JP7788447B2 (ja) | 2020-08-13 | 2025-12-18 | ブリストル－マイヤーズ スクイブ カンパニー | 目的の細胞を標的とするためのｉｌ－２の向け直し方法 |
| CN114621345B (zh) * | 2020-12-10 | 2022-11-29 | 北京东方百泰生物科技股份有限公司 | 一种抗lag-3的单克隆抗体、其抗原结合片段及其应用 |
| EP4658687A1 (en) | 2023-01-31 | 2025-12-10 | University of Rochester | Immune checkpoint blockade therapy for treating staphylococcus aureus infections |
| WO2024192033A1 (en) | 2023-03-13 | 2024-09-19 | Regeneron Pharmaceuticals, Inc. | Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating melanoma |
| WO2025106736A2 (en) | 2023-11-15 | 2025-05-22 | Regeneron Pharmaceuticals, Inc. | Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating lung cancer |
| US20250197493A1 (en) | 2023-12-13 | 2025-06-19 | Eli Lilly And Company | Lag-3 agonist antibodies |
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