JP2018533973A5 - - Google Patents

Info

Publication number

JP2018533973A5

JP2018533973A5 JP2018536085A JP2018536085A JP2018533973A5 JP 2018533973 A5 JP2018533973 A5 JP 2018533973A5 JP 2018536085 A JP2018536085 A JP 2018536085A JP 2018536085 A JP2018536085 A JP 2018536085A JP 2018533973 A5 JP2018533973 A5 JP 2018533973A5

Authority

JP

Japan

Prior art keywords

antibody

antigen

binding fragment

seq

amino acid

Prior art date

2016-09-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 239000000427 antigen Substances 0.000 claims description 355
• 102000036639 antigens Human genes 0.000 claims description 355
• 108091007433 antigens Proteins 0.000 claims description 355
• 239000012634 fragment Substances 0.000 claims description 355
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 140
• 101710089372 Programmed cell death protein 1 Proteins 0.000 claims description 30
• 239000002157 polynucleotide Substances 0.000 claims description 16
• 102000040430 polynucleotide Human genes 0.000 claims description 16
• 108091033319 polynucleotide Proteins 0.000 claims description 16
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 13
• 239000003795 chemical substances by application Substances 0.000 claims description 6
• 150000001875 compounds Chemical class 0.000 claims description 6
• 239000002773 nucleotide Substances 0.000 claims description 4
• 125000003729 nucleotide group Chemical group 0.000 claims description 4
• 102000004190 Enzymes Human genes 0.000 claims description 3
• 108090000790 Enzymes Proteins 0.000 claims description 3
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 3
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 3
• 239000002738 chelating agent Substances 0.000 claims description 3
• 239000007850 fluorescent dye Substances 0.000 claims description 3
• 239000002184 metal Substances 0.000 claims description 3
• 239000000203 mixture Substances 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
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• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 4
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