JP2018532719A5 - - Google Patents
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- JP2018532719A5 JP2018532719A5 JP2018513603A JP2018513603A JP2018532719A5 JP 2018532719 A5 JP2018532719 A5 JP 2018532719A5 JP 2018513603 A JP2018513603 A JP 2018513603A JP 2018513603 A JP2018513603 A JP 2018513603A JP 2018532719 A5 JP2018532719 A5 JP 2018532719A5
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- polymorph
- butanol
- powder
- ray diffraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002904 solvent Substances 0.000 claims 21
- 238000000034 method Methods 0.000 claims 17
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 8
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 6
- 238000000634 powder X-ray diffraction Methods 0.000 claims 6
- 239000004215 Carbon black (E152) Substances 0.000 claims 5
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229930195733 hydrocarbon Natural products 0.000 claims 5
- 150000002430 hydrocarbons Chemical group 0.000 claims 5
- 239000011877 solvent mixture Substances 0.000 claims 5
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 4
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 4
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical group CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 238000001938 differential scanning calorimetry curve Methods 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 239000011343 solid material Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- UAEPNZWRGJTJPN-UHFFFAOYSA-N methylcyclohexane Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- MQWCXKGKQLNYQG-UHFFFAOYSA-N 4-methylcyclohexan-1-ol Chemical compound CC1CCC(O)CC1 MQWCXKGKQLNYQG-UHFFFAOYSA-N 0.000 claims 1
- 229940125898 compound 5 Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- UDGASIIGNCBLSI-PMERELPUSA-N N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@](C[n]3nnnc3)(c(c(F)c3)ccc3F)O)(F)F)cc2)cc1 Chemical compound N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@](C[n]3nnnc3)(c(c(F)c3)ccc3F)O)(F)F)cc2)cc1 UDGASIIGNCBLSI-PMERELPUSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021083727A JP2021121606A (ja) | 2015-09-18 | 2021-05-18 | 抗真菌化合物および作製方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220384P | 2015-09-18 | 2015-09-18 | |
| US62/220,384 | 2015-09-18 | ||
| US201662275504P | 2016-01-06 | 2016-01-06 | |
| US62/275,504 | 2016-01-06 | ||
| PCT/US2016/052300 WO2017049196A1 (en) | 2015-09-18 | 2016-09-16 | Antifungal compounds and processes for making |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083727A Division JP2021121606A (ja) | 2015-09-18 | 2021-05-18 | 抗真菌化合物および作製方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018532719A JP2018532719A (ja) | 2018-11-08 |
| JP2018532719A5 true JP2018532719A5 (enExample) | 2019-07-25 |
Family
ID=58289604
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514436A Active JP6847458B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物のプロセス |
| JP2018513579A Expired - Fee Related JP6887993B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物調製方法 |
| JP2018513603A Pending JP2018532719A (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物および作製方法 |
| JP2021083727A Pending JP2021121606A (ja) | 2015-09-18 | 2021-05-18 | 抗真菌化合物および作製方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514436A Active JP6847458B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物のプロセス |
| JP2018513579A Expired - Fee Related JP6887993B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物調製方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083727A Pending JP2021121606A (ja) | 2015-09-18 | 2021-05-18 | 抗真菌化合物および作製方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10513505B2 (enExample) |
| EP (3) | EP3349586B1 (enExample) |
| JP (4) | JP6847458B2 (enExample) |
| KR (3) | KR102798709B1 (enExample) |
| CN (3) | CN108289457B (enExample) |
| AU (3) | AU2016324148B2 (enExample) |
| BR (2) | BR112018005194B1 (enExample) |
| CA (3) | CA2998805C (enExample) |
| EA (3) | EA037521B1 (enExample) |
| ES (2) | ES2858314T3 (enExample) |
| HK (3) | HK1258863A1 (enExample) |
| HU (1) | HUE053638T2 (enExample) |
| MX (3) | MX2018003284A (enExample) |
| PL (1) | PL3349586T3 (enExample) |
| TW (3) | TWI766842B (enExample) |
| WO (3) | WO2017049080A1 (enExample) |
| ZA (1) | ZA201801404B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2942976C (en) | 2014-03-19 | 2022-05-10 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| MX382905B (es) * | 2014-03-19 | 2025-03-13 | Viamet Pharmaceuticals Nc Inc | 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. |
| MX371291B (es) | 2014-03-19 | 2020-01-24 | Viamet Pharmaceuticals Nc Inc | 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procedimientos para su preparacion. |
| AU2015231226B2 (en) | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| JP2017509646A (ja) | 2014-03-19 | 2017-04-06 | ヴィアメット ファーマスーティカルズ，インコーポレイテッド | 抗真菌化合物の調製方法 |
| AU2015231220B2 (en) | 2014-03-19 | 2019-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antifungal compound process |
| EP3119764B1 (en) | 2014-03-19 | 2019-04-17 | Viamet Pharmaceuticals (NC), Inc. | Antifungal compound process |
| CA2942231A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| AU2015231208B2 (en) | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| MX2018003284A (es) | 2015-09-18 | 2018-08-23 | Vps 3 Inc | Compuestos antifungicos y procesos para hacerlos. |
| CN109666019B (zh) * | 2017-10-14 | 2021-04-06 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
| JP2021502402A (ja) | 2017-11-13 | 2021-01-28 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | テトラゾリルプロピル誘導体および殺真菌剤としてのそれらの使用 |
| WO2021188404A1 (en) * | 2020-03-19 | 2021-09-23 | Assia Chemical Industries Ltd | Solid state forms of oteseconazole and process for preparation thereof |
| CN117915913A (zh) * | 2021-07-22 | 2024-04-19 | 迈科维亚医药公司 | 包含奥特康唑的组合物 |
| CN114573503B (zh) * | 2022-03-28 | 2024-04-09 | 浙江天宇药业股份有限公司 | 一种制备奥特康唑中间体的方法 |
| CN114573557B (zh) * | 2022-03-28 | 2024-03-08 | 浙江天宇药业股份有限公司 | 一种奥特康唑的制备方法 |
| CN116621816B (zh) * | 2022-09-23 | 2025-07-04 | 北京莱瑞森医药科技有限公司 | 一种伏立康唑对映异构对b的拆分方法 |
| CN119855811A (zh) * | 2022-09-30 | 2025-04-18 | 上海济煜医药科技有限公司 | 双环类化合物的无定形、结晶固体及其制备方法 |
| CN119798219B (zh) * | 2025-01-13 | 2025-07-18 | 长治医学院 | 一种奥特康唑的制备方法 |
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| JP2017509646A (ja) | 2014-03-19 | 2017-04-06 | ヴィアメット ファーマスーティカルズ，インコーポレイテッド | 抗真菌化合物の調製方法 |
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-
2016
- 2016-09-16 MX MX2018003284A patent/MX2018003284A/es unknown
- 2016-09-16 US US15/760,812 patent/US10513505B2/en active Active
- 2016-09-16 JP JP2018514436A patent/JP6847458B2/ja active Active
- 2016-09-16 EP EP16847379.1A patent/EP3349586B1/en active Active
- 2016-09-16 AU AU2016324148A patent/AU2016324148B2/en not_active Ceased
- 2016-09-16 HK HK19101335.1A patent/HK1258863A1/zh unknown
- 2016-09-16 KR KR1020187010880A patent/KR102798709B1/ko active Active
- 2016-09-16 CN CN201680061980.3A patent/CN108289457B/zh active Active
- 2016-09-16 EA EA201890751A patent/EA037521B1/ru not_active IP Right Cessation
- 2016-09-16 EA EA201890522A patent/EA038214B1/ru unknown
- 2016-09-16 EA EA201890752A patent/EA036098B1/ru not_active IP Right Cessation
- 2016-09-16 US US15/760,738 patent/US10464921B2/en active Active
- 2016-09-16 KR KR1020187010867A patent/KR20180053393A/ko not_active Ceased
- 2016-09-16 HU HUE16847379A patent/HUE053638T2/hu unknown
- 2016-09-16 PL PL16847379T patent/PL3349586T3/pl unknown
- 2016-09-16 MX MX2018003280A patent/MX391539B/es unknown
- 2016-09-16 CN CN201680066541.1A patent/CN108347949B/zh not_active Expired - Fee Related
- 2016-09-16 CA CA2998805A patent/CA2998805C/en active Active
- 2016-09-16 WO PCT/US2016/052128 patent/WO2017049080A1/en not_active Ceased
- 2016-09-16 CN CN201680066558.7A patent/CN108348511A/zh active Pending
- 2016-09-16 AU AU2016323782A patent/AU2016323782B2/en not_active Ceased
- 2016-09-16 CA CA2998807A patent/CA2998807A1/en active Pending
- 2016-09-16 EP EP16847394.0A patent/EP3349587B1/en active Active
- 2016-09-16 US US15/760,917 patent/US10308632B2/en active Active
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