JP2018529749A5 - - Google Patents
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- Publication number
- JP2018529749A5 JP2018529749A5 JP2018517702A JP2018517702A JP2018529749A5 JP 2018529749 A5 JP2018529749 A5 JP 2018529749A5 JP 2018517702 A JP2018517702 A JP 2018517702A JP 2018517702 A JP2018517702 A JP 2018517702A JP 2018529749 A5 JP2018529749 A5 JP 2018529749A5
- Authority
- JP
- Japan
- Prior art keywords
- sodium
- iron
- complex
- decanoyl
- dodecanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15188838.5 | 2015-10-07 | ||
| EP15188838 | 2015-10-07 | ||
| PCT/EP2016/074110 WO2017060500A1 (en) | 2015-10-07 | 2016-10-07 | Pharmaceutical formulations for the oral delivery of peptide drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018529749A JP2018529749A (ja) | 2018-10-11 |
| JP2018529749A5 true JP2018529749A5 (https=) | 2019-11-14 |
Family
ID=54292636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517702A Pending JP2018529749A (ja) | 2015-10-07 | 2016-10-07 | ペプチド薬物を経口送達するための医薬製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10905744B2 (https=) |
| EP (1) | EP3359181A1 (https=) |
| JP (1) | JP2018529749A (https=) |
| CN (1) | CN108135962A (https=) |
| AU (1) | AU2016335287A1 (https=) |
| CA (1) | CA2997343A1 (https=) |
| IL (1) | IL258464A (https=) |
| WO (1) | WO2017060500A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2651398T1 (en) | 2010-12-16 | 2018-04-30 | Novo Nordisk A/S | SOLID COMPOSITIONS CONTAINING GLP-1 AGONIST AND SOL N- (8- (2-HYDROXYBENZOIL) AMINO) CAPRICULATE ACIDS |
| PL2696687T3 (pl) | 2011-04-12 | 2017-06-30 | Novo Nordisk A/S | Pochodne podwójnie acylowanej GLP-1 |
| HRP20181447T1 (hr) | 2012-03-22 | 2018-11-02 | Novo Nordisk A/S | Pripravci glp-1 peptida i njihova priprava |
| PT2827845T (pt) | 2012-03-22 | 2019-03-29 | Novo Nordisk As | Composições compreendendo um agente de entrega e sua preparação |
| JP6517690B2 (ja) | 2012-06-20 | 2019-05-22 | ノヴォ ノルディスク アー／エス | ペプチド及び送達剤を含む錠剤製剤 |
| KR102272671B1 (ko) | 2013-05-02 | 2021-07-06 | 노보 노르디스크 에이/에스 | Glp-1 화합물의 경구 투여 |
| KR20180067573A (ko) * | 2015-10-09 | 2018-06-20 | 라디우스 헬쓰, 인코포레이티드 | PTHrP 유사체의 제형, 이의 경피 패취, 및 이의 용도 |
| US10568937B2 (en) | 2016-04-18 | 2020-02-25 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
| CN109381695A (zh) * | 2017-08-09 | 2019-02-26 | 武汉武药科技有限公司 | 一种门冬氨酸帕瑞肽注射液及其制备方法和用途 |
| TWI751379B (zh) * | 2017-09-21 | 2022-01-01 | 奧孟亞股份有限公司 | 用於遞送胜肽之藥物組合物 |
| JP6898518B2 (ja) * | 2018-02-02 | 2021-07-07 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１アゴニスト、ｎ−（８−（２−ヒドロキシベンゾイル）アミノ）カプリル酸の塩及び滑沢剤を含む固形組成物 |
| WO2019193204A1 (en) * | 2018-04-06 | 2019-10-10 | Cyprumed Gmbh | Pharmaceutical compositions for the transmucosal delivery of therapeutic peptides and proteins |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| CA3102509A1 (en) * | 2018-06-10 | 2019-12-19 | Zim Laboratories Limited | Oral mucosal delivery systems comprising monophasic concentrate of teriparatide |
| GB201813678D0 (en) * | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Acylated calcitonin mimetics |
| CA3112060A1 (en) * | 2018-10-12 | 2020-04-16 | Advanced Accelerator Applications International Sa | Pharmaceutical composition comprising a radiolabeled gprp antagonist and a surfactant |
| WO2020180534A1 (en) | 2019-03-01 | 2020-09-10 | President And Fellows Of Harvard College | Methods and compositions for protein delivery |
| KR20210137373A (ko) * | 2019-03-08 | 2021-11-17 | 안야 바이오팜 인코포레이티드 | 부갑상샘 호르몬 유사체의 경구 제제 및 치료 |
| CN111714643A (zh) * | 2019-03-22 | 2020-09-29 | 约翰霍普金斯大学 | 一种单宁酸/Fe3+纳米颗粒体系、药物递送方法 |
| GB201906917D0 (en) * | 2019-05-16 | 2019-07-03 | Intract Pharma Ltd | Novel compositions |
| CN112057619A (zh) * | 2019-06-10 | 2020-12-11 | 苏州兰鼎生物制药有限公司 | 一种具有降血糖作用的药物组合物 |
| TW202143997A (zh) * | 2020-03-18 | 2021-12-01 | 大陸商四川海思科製藥有限公司 | 口服藥物組合物 |
| US20210315930A1 (en) * | 2020-04-14 | 2021-10-14 | David A. Cuddeback | Nutraceutical composition for multimodal prophylaxis against and treatment of viral and bacterial infection and inflammation |
| CN114306917A (zh) * | 2021-01-12 | 2022-04-12 | 广州新济药业科技有限公司 | 可溶性微针贴片及其制备方法 |
| FR3120189B1 (fr) | 2021-03-01 | 2024-11-29 | Farid Bennis | Composition pharmaceutique pour une administration par voie orale d’un agoniste du récepteur du GLP-1 |
| CN113117050B (zh) * | 2021-05-06 | 2022-04-26 | 合肥天汇孵化科技有限公司 | 多肽组合物及其用途 |
| AU2022386166A1 (en) | 2021-11-10 | 2024-06-20 | I2O Therapeutics, Inc. | Ionic liquid compositions |
| WO2024043867A1 (en) * | 2022-08-20 | 2024-02-29 | Sinapu Llc | C60 histidine carnosine fumarates and use |
| CN115321657B (zh) * | 2022-08-31 | 2023-10-03 | 四川农业大学 | 一种疏水壳聚糖-聚合氯化铝Hmcs-PAC复合絮凝剂及其制备与应用 |
| WO2024077409A1 (en) * | 2022-10-09 | 2024-04-18 | Guangzhou Dazhou Biomedicine Ltd. | Oral delivery of therapeutic agents |
| WO2025046590A1 (en) * | 2023-08-30 | 2025-03-06 | Entera Bio Ltd. | Formulations for oral administration of active agents |
| US12377156B2 (en) | 2023-10-24 | 2025-08-05 | Neuvian Ip Holdings, Llc | Compositions and methods for treatment of wounds and inflammatory skin conditions |
| US20250235509A1 (en) * | 2024-01-23 | 2025-07-24 | Men Hwei Tsai | Formulation and Method of Preparing Glucagon-like Peptide-1 (GLP-1) for Oral Administration |
| WO2025188317A1 (en) * | 2024-03-08 | 2025-09-12 | Neuvian Skincare Llc | Compositions and methods for hair treatment |
| US12409204B1 (en) | 2024-03-08 | 2025-09-09 | Neuvian Ip Holdings, Llc | Compositions and methods for hair treatment |
| WO2025251740A1 (en) * | 2024-06-03 | 2025-12-11 | Shenzhen Oralead Pharma Co., LTD. | Oral polypeptide composition |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK39892D0 (da) | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
| US5661130A (en) | 1993-06-24 | 1997-08-26 | The Uab Research Foundation | Absorption enhancers for drug administration |
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| CN1228708A (zh) | 1996-09-04 | 1999-09-15 | 有限会社多特 | 经口给药用含肽药物组合物 |
| US5773647A (en) | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| JP2002506792A (ja) | 1998-02-27 | 2002-03-05 | ノボ ノルディスク アクティーゼルスカブ | Ｎ末端修飾ｇｌｐ−１誘導体 |
| JP2003522099A (ja) | 1998-02-27 | 2003-07-22 | ノボ ノルディスク アクティーゼルスカブ | 遅延作用プロファイルを有するｇｌｐ−１のｇｌｐ−１誘導体及びエキセンジン |
| EP1061946B1 (en) | 1998-02-27 | 2004-04-28 | Novo Nordisk A/S | Glp-1 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates |
| WO1999043706A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Derivatives of glp-1 analogs |
| ES2235854T3 (es) | 1999-04-05 | 2005-07-16 | Emisphere Technologies, Inc. | Sales disodicas, monohidratos y solvatos etanolicos para aportar agentes activos. |
| ATE267582T1 (de) | 2000-01-20 | 2004-06-15 | Basilea Pharmaceutica Ag | Nasal verabreichbare cyclische antimykotische peptidzusammensetzungen |
| US6248360B1 (en) | 2000-06-21 | 2001-06-19 | International Health Management Associates, Inc. | Complexes to improve oral absorption of poorly absorbable antibiotics |
| US20030017195A1 (en) | 2001-07-20 | 2003-01-23 | Samir Mitragotri | Method for oral drug delivery |
| KR20040058324A (ko) | 2001-11-26 | 2004-07-03 | 다이이찌 산토리 파마 가부시키가이샤 | 경비흡수용 의약 조성물 |
| WO2004024225A1 (en) | 2002-09-16 | 2004-03-25 | Zicam, Llc. | System and method for delivering a composition to the nasal membrane |
| BR122019021416A2 (https=) | 2003-09-19 | 2019-12-21 | ||
| ATE461217T1 (de) | 2003-12-18 | 2010-04-15 | Novo Nordisk As | Glp-1-verbindungen |
| EP1696962A2 (en) | 2003-12-18 | 2006-09-06 | Novo Nordisk A/S | Novel glp-1 analogues linked to albumin-like agents |
| EA018643B1 (ru) | 2004-02-23 | 2013-09-30 | Цайтэн Чжан | Раствор металлсодержащего хелатного полимера и его применение (варианты) |
| CA2572770A1 (en) | 2004-07-08 | 2006-01-19 | Novo-Nordisk A/S | Polypeptide protracting tags comprising a tetrazole moiety |
| JP2006028031A (ja) * | 2004-07-12 | 2006-02-02 | Ltt Bio-Pharma Co Ltd | 経粘膜吸収用薬物封入ナノ粒子 |
| RU2527893C2 (ru) | 2004-07-19 | 2014-09-10 | Биокон Лимитед | Инсулин-олигомерные конъюгаты, их препараты и применения |
| EP1781257B1 (en) | 2004-08-13 | 2018-12-19 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
| JP5066448B2 (ja) | 2004-09-03 | 2012-11-07 | 協和発酵バイオ株式会社 | 口内炎の予防または治療のための組成物および方法 |
| WO2006037810A2 (en) | 2004-10-07 | 2006-04-13 | Novo Nordisk A/S | Protracted glp-1 compounds |
| US8030273B2 (en) | 2004-10-07 | 2011-10-04 | Novo Nordisk A/S | Protracted exendin-4 compounds |
| US8603972B2 (en) | 2005-03-18 | 2013-12-10 | Novo Nordisk A/S | Extended GLP-1 compounds |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| WO2007025332A1 (en) | 2005-08-29 | 2007-03-08 | Dia-B Tech Limited | A peptide and zinc ion composition for treating diabetes and enhancing immune function |
| WO2007029238A2 (en) | 2005-09-06 | 2007-03-15 | Oramed Pharmaceuticals, Inc. | Methods and compositions for oral administration of proteins |
| WO2007041481A1 (en) | 2005-09-29 | 2007-04-12 | Biodel, Inc. | Rapid acting and prolonged acting insulin preparations |
| CN101309668A (zh) | 2005-11-30 | 2008-11-19 | 健乐克斯医药公司 | 经口吸收的药物制剂和用药方法 |
| WO2008023050A1 (en) | 2006-08-25 | 2008-02-28 | Novo Nordisk A/S | Acylated exendin-4 compounds |
| EP2190872B1 (en) | 2007-09-05 | 2018-03-14 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
| WO2009030771A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| US20100292133A1 (en) | 2007-09-05 | 2010-11-18 | Novo Nordisk A/S | Truncated glp-1 derivaties and their therapeutical use |
| PE20110543A1 (es) | 2008-08-15 | 2011-08-04 | Ironwood Pharmaceuticals Inc | Formulacion solida oral que comprende linaclotida, cation de calcio y leucina |
| RU2548807C2 (ru) | 2009-05-20 | 2015-04-20 | Торэй Индастриз, Инк. | Пептиды, проникающие в клетку |
| CA2770077A1 (en) | 2009-08-06 | 2011-02-10 | Ironwood Pharmaceuticals, Inc. | Formulations comprising linaclotide |
| MX2012001691A (es) * | 2009-08-12 | 2012-02-29 | Forest Lab Holdings Ltd | Composiciones de linaclotida que se desintegran oralmente. |
| JP6016234B2 (ja) | 2009-09-30 | 2016-10-26 | ティオマトリックス・フォルシュンクス・ウント・べラートゥンクス・ゲーエムベーハー | ビタミンｂ部分構造を持つ粘膜付着性ポリマー |
| US20110311621A1 (en) | 2010-03-16 | 2011-12-22 | Paul Salama | Pharmaceutical compositions and methods of delvery |
| CN102970864A (zh) | 2010-04-21 | 2013-03-13 | 那挪玛加医药有限公司 | 纳米颗粒药物组合物 |
| CN103347532A (zh) | 2011-02-04 | 2013-10-09 | 爱奇司治疗公司 | 口服可生物利用肽药物组合物及其方法 |
| EP2696847A1 (en) | 2011-04-14 | 2014-02-19 | Novo Nordisk A/S | Fatty acid acylated amino acids for oral peptide delivery |
| EP2717858B1 (en) | 2011-06-10 | 2018-08-08 | Aquestive Therapeutics, Inc. | Combination peptide-nanoparticles and delivery systems incorporating same |
| US20130004590A1 (en) | 2011-06-28 | 2013-01-03 | Lin Connie B | Zinc oxide/acid containing compositions and methods for treating and/or preventing enzymatic irritation |
| HRP20181447T1 (hr) | 2012-03-22 | 2018-11-02 | Novo Nordisk A/S | Pripravci glp-1 peptida i njihova priprava |
| IN2014MN02304A (https=) | 2012-05-03 | 2015-08-07 | Zealand Pharma As | |
| US20150174076A1 (en) | 2012-06-14 | 2015-06-25 | Entrega, Inc. | Mucoadhesive devices for delivery of active agents |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| US10570184B2 (en) | 2014-06-04 | 2020-02-25 | Novo Nordisk A/S | GLP-1/glucagon receptor co-agonists for medical use |
| ES2630106T3 (es) | 2014-10-07 | 2017-08-18 | Cyprumed Gmbh | Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos |
| WO2018065634A1 (en) | 2016-10-07 | 2018-04-12 | Cyprumed Gmbh | Pharmaceutical compositions for the nasal delivery of peptide or protein drugs |
-
2016
- 2016-10-07 JP JP2018517702A patent/JP2018529749A/ja active Pending
- 2016-10-07 WO PCT/EP2016/074110 patent/WO2017060500A1/en not_active Ceased
- 2016-10-07 US US15/766,546 patent/US10905744B2/en active Active
- 2016-10-07 AU AU2016335287A patent/AU2016335287A1/en not_active Abandoned
- 2016-10-07 EP EP16779074.0A patent/EP3359181A1/en not_active Withdrawn
- 2016-10-07 CN CN201680057777.9A patent/CN108135962A/zh active Pending
- 2016-10-07 CA CA2997343A patent/CA2997343A1/en not_active Abandoned
-
2018
- 2018-03-29 IL IL258464A patent/IL258464A/en unknown
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