JP2018529329A5 - - Google Patents
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- JP2018529329A5 JP2018529329A5 JP2018511127A JP2018511127A JP2018529329A5 JP 2018529329 A5 JP2018529329 A5 JP 2018529329A5 JP 2018511127 A JP2018511127 A JP 2018511127A JP 2018511127 A JP2018511127 A JP 2018511127A JP 2018529329 A5 JP2018529329 A5 JP 2018529329A5
- Authority
- JP
- Japan
- Prior art keywords
- utr
- nucleic acid
- acid molecule
- artificial nucleic
- artificial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000007523 nucleic acids Chemical group 0.000 claims 68
- 108020004707 nucleic acids Proteins 0.000 claims 58
- 102000039446 nucleic acids Human genes 0.000 claims 58
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 18
- 230000014616 translation Effects 0.000 claims 17
- 108700026244 Open Reading Frames Proteins 0.000 claims 15
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108020004705 Codon Proteins 0.000 claims 2
- 108091034057 RNA (poly(A)) Proteins 0.000 claims 2
- 108091036066 Three prime untranslated region Proteins 0.000 claims 2
- 108091023045 Untranslated Region Proteins 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000008488 polyadenylation Effects 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102100024948 Aldehyde dehydrogenase family 16 member A1 Human genes 0.000 claims 1
- 102100024426 Dihydropyrimidinase-related protein 2 Human genes 0.000 claims 1
- 108010033040 Histones Proteins 0.000 claims 1
- 101000761405 Homo sapiens Aldehyde dehydrogenase family 16 member A1 Proteins 0.000 claims 1
- 101001053503 Homo sapiens Dihydropyrimidinase-related protein 2 Proteins 0.000 claims 1
- 101001089120 Homo sapiens Proteasome subunit beta type-3 Proteins 0.000 claims 1
- 101100095906 Mus musculus Slfn9 gene Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 101100102675 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) vma-21 gene Proteins 0.000 claims 1
- 102100033755 Proteasome subunit beta type-3 Human genes 0.000 claims 1
- 102000011070 Rab3 Human genes 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000001415 gene therapy Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 108010065559 rab3 GTP-Binding Proteins Proteins 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021132110A JP7245878B2 (ja) | 2015-08-28 | 2021-08-16 | 人工核酸分子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2015001755 | 2015-08-28 | ||
| EPPCT/EP2015/001755 | 2015-08-28 | ||
| PCT/EP2016/001417 WO2017036580A1 (en) | 2015-08-28 | 2016-08-22 | Artificial nucleic acid molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132110A Division JP7245878B2 (ja) | 2015-08-28 | 2021-08-16 | 人工核酸分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529329A JP2018529329A (ja) | 2018-10-11 |
| JP2018529329A5 true JP2018529329A5 (enExample) | 2019-09-05 |
| JP7304155B2 JP7304155B2 (ja) | 2023-07-06 |
Family
ID=54064264
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018511127A Active JP7304155B2 (ja) | 2015-08-28 | 2016-08-22 | 人工核酸分子 |
| JP2021132110A Active JP7245878B2 (ja) | 2015-08-28 | 2021-08-16 | 人工核酸分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132110A Active JP7245878B2 (ja) | 2015-08-28 | 2021-08-16 | 人工核酸分子 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12258567B2 (enExample) |
| EP (2) | EP3341482B1 (enExample) |
| JP (2) | JP7304155B2 (enExample) |
| KR (1) | KR102645398B1 (enExample) |
| CN (2) | CN114381470A (enExample) |
| AU (1) | AU2016316439B2 (enExample) |
| CA (1) | CA2992801A1 (enExample) |
| DK (1) | DK3341482T3 (enExample) |
| ES (1) | ES2924739T3 (enExample) |
| MX (1) | MX395421B (enExample) |
| SG (1) | SG10201913629VA (enExample) |
| WO (1) | WO2017036580A1 (enExample) |
Families Citing this family (127)
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| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2012116714A1 (en) | 2011-03-02 | 2012-09-07 | Curevac Gmbh | Vaccination in elderly patients |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| WO2013120497A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein |
| RU2658490C2 (ru) | 2012-03-27 | 2018-06-21 | Кьюрвак Аг | Искусственные молекулы нуклеиновых кислот для улучшенной экспрессии белков или пептидов |
| SG11201506052PA (en) | 2013-02-22 | 2015-09-29 | Curevac Gmbh | Combination of vaccination and inhibition of the pd-1 pathway |
| BR112016003361A2 (pt) | 2013-08-21 | 2017-11-21 | Curevac Ag | vacina do vírus sincicial respiratório (rsv) |
| CN105517569A (zh) | 2013-08-21 | 2016-04-20 | 库瑞瓦格股份公司 | 狂犬病疫苗 |
| AU2014310935B2 (en) | 2013-08-21 | 2019-11-21 | CureVac SE | Combination vaccine |
| WO2015062738A1 (en) | 2013-11-01 | 2015-05-07 | Curevac Gmbh | Modified rna with decreased immunostimulatory properties |
| CA2935878C (en) | 2014-03-12 | 2023-05-02 | Curevac Ag | Combination of vaccination and ox40 agonists |
| CA2953341C (en) | 2014-06-25 | 2023-01-24 | Acuitas Therapeutics Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| EP4023755B1 (en) | 2014-12-12 | 2023-04-26 | CureVac SE | Artificial nucleic acid molecules for improved protein expression |
| EP4353257A3 (en) | 2015-04-13 | 2024-08-07 | CureVac Manufacturing GmbH | Method for producing rna compositions |
| US10780054B2 (en) | 2015-04-17 | 2020-09-22 | Curevac Real Estate Gmbh | Lyophilization of RNA |
| WO2016176330A1 (en) | 2015-04-27 | 2016-11-03 | The Trustees Of The University Of Pennsylvania | Nucleoside-modified rna for inducing an adaptive immune response |
| WO2016174271A1 (en) | 2015-04-30 | 2016-11-03 | Curevac Ag | Immobilized poly(n)polymerase |
| WO2016180430A1 (en) | 2015-05-08 | 2016-11-17 | Curevac Ag | Method for producing rna |
| DK3294326T3 (da) | 2015-05-15 | 2021-05-31 | Curevac Ag | Prime-boost-regimer indbefattende indgivelse af mindst én mrna-konstruktion |
| CN107530448A (zh) | 2015-05-20 | 2018-01-02 | 库瑞瓦格股份公司 | 包含长链rna的干粉组合物 |
| WO2016184575A1 (en) | 2015-05-20 | 2016-11-24 | Curevac Ag | Dry powder composition comprising long-chain rna |
| EP4098743A1 (en) | 2015-05-29 | 2022-12-07 | CureVac AG | Method for adding cap structures to rna using immobilized enzymes |
| DK3303583T3 (da) | 2015-05-29 | 2020-07-13 | Curevac Real Estate Gmbh | Fremgangsmåde til fremstilling og oprensning af rna, omfattende mindst et trin til tangential-flow-filtrering |
| HUE067372T2 (hu) | 2015-06-29 | 2024-10-28 | Acuitas Therapeutics Inc | Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására |
| US10501768B2 (en) | 2015-07-13 | 2019-12-10 | Curevac Ag | Method of producing RNA from circular DNA and corresponding template DNA |
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| CN108368028B (zh) | 2015-10-28 | 2021-09-03 | 爱康泰生治疗公司 | 用于递送核酸的新型脂质和脂质纳米颗粒制剂 |
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| US12612654B2 (en) | 2016-02-12 | 2026-04-28 | CureVac SE | Method for analyzing RNA |
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| WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| EP4233898A3 (en) | 2016-05-04 | 2023-11-01 | CureVac SE | Influenza mrna vaccines |
| WO2017212009A1 (en) | 2016-06-09 | 2017-12-14 | Curevac Ag | Hybrid carriers for nucleic acid cargo |
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-
2016
- 2016-08-22 US US15/755,739 patent/US12258567B2/en active Active
- 2016-08-22 KR KR1020187008732A patent/KR102645398B1/ko active Active
- 2016-08-22 AU AU2016316439A patent/AU2016316439B2/en active Active
- 2016-08-22 DK DK16759979.4T patent/DK3341482T3/da active
- 2016-08-22 EP EP16759979.4A patent/EP3341482B1/en active Active
- 2016-08-22 SG SG10201913629VA patent/SG10201913629VA/en unknown
- 2016-08-22 JP JP2018511127A patent/JP7304155B2/ja active Active
- 2016-08-22 ES ES16759979T patent/ES2924739T3/es active Active
- 2016-08-22 WO PCT/EP2016/001417 patent/WO2017036580A1/en not_active Ceased
- 2016-08-22 MX MX2018001040A patent/MX395421B/es unknown
- 2016-08-22 CN CN202210036661.4A patent/CN114381470A/zh active Pending
- 2016-08-22 EP EP22176444.2A patent/EP4108774A1/en active Pending
- 2016-08-22 CA CA2992801A patent/CA2992801A1/en active Pending
- 2016-08-22 CN CN201680049973.1A patent/CN108026537B/zh active Active
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- 2025-01-16 US US19/026,182 patent/US20250171789A1/en active Pending
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