JP2019503653A5 - - Google Patents
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- JP2019503653A5 JP2019503653A5 JP2018524760A JP2018524760A JP2019503653A5 JP 2019503653 A5 JP2019503653 A5 JP 2019503653A5 JP 2018524760 A JP2018524760 A JP 2018524760A JP 2018524760 A JP2018524760 A JP 2018524760A JP 2019503653 A5 JP2019503653 A5 JP 2019503653A5
- Authority
- JP
- Japan
- Prior art keywords
- promoter
- vector
- foreign dna
- cells
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091028043 Nucleic acid sequence Proteins 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 12
- 241000700605 Viruses Species 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 150000007523 nucleic acids Chemical group 0.000 claims 7
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 241000701022 Cytomegalovirus Species 0.000 claims 4
- 101000834253 Gallus gallus Actin, cytoplasmic 1 Proteins 0.000 claims 4
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 claims 4
- 102000011755 Phosphoglycerate Kinase Human genes 0.000 claims 4
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 claims 4
- 102000008579 Transposases Human genes 0.000 claims 4
- 108010020764 Transposases Proteins 0.000 claims 4
- 102000010292 Peptide Elongation Factor 1 Human genes 0.000 claims 3
- 108010077524 Peptide Elongation Factor 1 Proteins 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 230000010354 integration Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 206010010144 Completed suicide Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 241000714474 Rous sarcoma virus Species 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- 229920006317 cationic polymer Polymers 0.000 claims 1
- 238000000975 co-precipitation Methods 0.000 claims 1
- 102000003675 cytokine receptors Human genes 0.000 claims 1
- 108010057085 cytokine receptors Proteins 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 238000004520 electroporation Methods 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000012212 insulator Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000003584 silencer Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562267270P | 2015-12-14 | 2015-12-14 | |
| US62/267,270 | 2015-12-14 | ||
| PCT/CN2016/109510 WO2017101749A1 (en) | 2015-12-14 | 2016-12-12 | Transposon system, kit comprising the same, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019503653A JP2019503653A (ja) | 2019-02-14 |
| JP2019503653A5 true JP2019503653A5 (enExample) | 2020-12-17 |
| JP6956416B2 JP6956416B2 (ja) | 2021-11-02 |
Family
ID=59055731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018524760A Active JP6956416B2 (ja) | 2015-12-14 | 2016-12-12 | トランスポゾン系、それを含むキット及びそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11345926B2 (enExample) |
| JP (1) | JP6956416B2 (enExample) |
| KR (1) | KR102249982B1 (enExample) |
| CN (1) | CN108474005B (enExample) |
| AU (1) | AU2016373365B2 (enExample) |
| CA (1) | CA3004665C (enExample) |
| MX (1) | MX380289B (enExample) |
| MY (1) | MY184126A (enExample) |
| NZ (1) | NZ742068A (enExample) |
| TW (1) | TWI609960B (enExample) |
| WO (1) | WO2017101749A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US20190119636A1 (en) | 2017-10-23 | 2019-04-25 | Poseida Therapeutics, Inc. | Modified stem cell memory t cells, methods of making and methods of using same |
| KR102523318B1 (ko) | 2016-12-16 | 2023-04-18 | 비-모젠 바이오테크놀로지스, 인크. | 증진된 ｈＡＴ 패밀리 트랜스포존 매개 유전자 전달 및 연관된 조성물, 시스템, 및 방법 |
| US11278570B2 (en) | 2016-12-16 | 2022-03-22 | B-Mogen Biotechnologies, Inc. | Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods |
| EP3810764A2 (en) | 2018-06-21 | 2021-04-28 | B-Mogen Biotechnologies, Inc. | Enhanced hat family transposon-mediated gene transfer and associated compositions, systems, and methods |
| US20220042038A1 (en) * | 2018-12-20 | 2022-02-10 | Poseida Therapeutics, Inc. | Nanotransposon compositions and methods of use |
| AU2020290790A1 (en) * | 2019-06-11 | 2022-01-27 | Universitat Pompeu Fabra | Targeted gene editing constructs and methods of using the same |
| JP7693253B2 (ja) * | 2021-07-09 | 2025-06-17 | ネオジェンティーシ― コーポレーション | トランスポゾンシステムおよびその用途 |
| WO2023060589A1 (zh) * | 2021-10-15 | 2023-04-20 | 深圳市深研生物科技有限公司 | 多转座子系统 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6962810B2 (en) | 2000-10-31 | 2005-11-08 | University Of Notre Dame Du Lac | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector piggyBac |
| US20100154070A1 (en) * | 2005-05-14 | 2010-06-17 | Tian Xu | PiggyBac as a Tool for Genetic Manipulation and Analysis in Vertebrates |
| US20090042297A1 (en) * | 2007-06-01 | 2009-02-12 | George Jr Alfred L | Piggybac transposon-based vectors and methods of nucleic acid integration |
| KR20080041146A (ko) * | 2007-12-13 | 2008-05-09 | 푸단 유니버시티 | 척추동물에서의 유전자 조작 및 분석을 위한 도구로서의피기백 |
| SG174155A1 (en) | 2009-02-25 | 2011-10-28 | Univ Johns Hopkins | Piggybac transposon variants and methods of use |
| DE102011118018B4 (de) | 2011-10-25 | 2017-10-26 | Plasmidfactory Gmbh & Co. Kg | Minicircles mit Transpositionskassetten und ihre Verwendung zur Transformation von Zellen |
| US10398787B2 (en) * | 2012-10-26 | 2019-09-03 | Vrije Universiteit Brussel | Vectors for liver-directed gene therapy of hemophilia and methods and use thereof |
| CN102943092B (zh) | 2012-11-20 | 2014-12-10 | 西北农林科技大学 | 一种通用型PiggyBac转座子转基因载体及其制备方法 |
| KR20150085846A (ko) * | 2012-11-20 | 2015-07-24 | 제이.알.심프롯캄패니 | Tal-매개 전이 DNA 삽입방법 |
| CN104342453A (zh) * | 2013-08-06 | 2015-02-11 | 深圳先进技术研究院 | 含基因工程抗体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用 |
| EP3119896B1 (en) | 2014-03-21 | 2022-03-23 | The Sydney Children's Hospitals Network (Randwick and Westmead) | Stable gene transfer to proliferating cells |
| CA3246595A1 (en) * | 2014-04-09 | 2025-07-08 | Dna Twopointo Inc | Enhanced polynucleotide constructs for eukaryotic gene expression |
| SG11201608393TA (en) * | 2014-04-10 | 2016-11-29 | Seattle Children S Hospital Dba Seattle Children S Res Inst | Transgene genetic tags and methods of use |
-
2016
- 2016-12-12 NZ NZ742068A patent/NZ742068A/en unknown
- 2016-12-12 TW TW105141119A patent/TWI609960B/zh active
- 2016-12-12 KR KR1020187017078A patent/KR102249982B1/ko active Active
- 2016-12-12 MX MX2018007203A patent/MX380289B/es unknown
- 2016-12-12 MY MYPI2018701786A patent/MY184126A/en unknown
- 2016-12-12 CA CA3004665A patent/CA3004665C/en active Active
- 2016-12-12 WO PCT/CN2016/109510 patent/WO2017101749A1/en not_active Ceased
- 2016-12-12 US US15/766,707 patent/US11345926B2/en active Active
- 2016-12-12 AU AU2016373365A patent/AU2016373365B2/en active Active
- 2016-12-12 JP JP2018524760A patent/JP6956416B2/ja active Active
- 2016-12-12 CN CN201680071463.4A patent/CN108474005B/zh active Active
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