CN112584849A - 包含核酸及car修饰的免疫细胞的治疗剂及其应用 - Google Patents

包含核酸及car修饰的免疫细胞的治疗剂及其应用 Download PDF

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CN112584849A
CN112584849A CN201980052439.XA CN201980052439A CN112584849A CN 112584849 A CN112584849 A CN 112584849A CN 201980052439 A CN201980052439 A CN 201980052439A CN 112584849 A CN112584849 A CN 112584849A
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cancer
seq
tumor
amino acid
tag
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胡放
陈璨
肖�琳
傅瑾
张蓉
蔡金露
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Hangzhou Converd Co Ltd
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Hangzhu Youshan Biotechnology Co ltd
Hangzhou Converd Co Ltd
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Abstract

涉及包含核酸及CAR修饰的免疫细胞的治疗剂及应用。所述治疗剂包含第一组合物和第二组合物，第一组合物包含用于导入肿瘤细胞和/或癌细胞的、具有标记性多肽编码序列的核酸；所述标记性多肽具有可操作地连接的胞外抗原决定区、间隔部分和跨膜部分，能够经表达而修饰在所述肿瘤细胞和/或癌细胞的表面；所述胞外抗原决定区的氨基酸序列含有一个或多个抗原表位多肽的氨基酸序列；其中在自然状态下，哺乳动物细胞膜蛋白或分泌蛋白的氨基酸序列不含有所述抗原表位多肽的氨基酸序列；所述第二组合物包含嵌合抗原受体修饰的免疫细胞；所述嵌合抗原受体修饰的免疫细胞能够特异性识别并结合所述标记性多肽的所述胞外抗原决定区。实现了协同疗效。

Description

PCT国内申请，说明书已公开。

Claims (59)

  1. PCT国内申请，权利要求书已公开。
CN201980052439.XA 2018-08-24 2019-08-26 包含核酸及car修饰的免疫细胞的治疗剂及其应用 Pending CN112584849A (zh)

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