JP2018528200A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018528200A5 JP2018528200A5 JP2018510406A JP2018510406A JP2018528200A5 JP 2018528200 A5 JP2018528200 A5 JP 2018528200A5 JP 2018510406 A JP2018510406 A JP 2018510406A JP 2018510406 A JP2018510406 A JP 2018510406A JP 2018528200 A5 JP2018528200 A5 JP 2018528200A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- independently
- acceptable salt
- cycloalkyl
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562210264P | 2015-08-26 | 2015-08-26 | |
| US62/210,264 | 2015-08-26 | ||
| PCT/US2016/048698 WO2017035354A1 (en) | 2015-08-26 | 2016-08-25 | Compounds and compositions useful for treating disorders related to ntrk |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528200A JP2018528200A (ja) | 2018-09-27 |
| JP2018528200A5 true JP2018528200A5 (enExample) | 2019-09-12 |
| JP6877407B2 JP6877407B2 (ja) | 2021-05-26 |
Family
ID=56896780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510406A Expired - Fee Related JP6877407B2 (ja) | 2015-08-26 | 2016-08-25 | Ｎｔｒｋ関連障害の治療に有用な化合物および組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10017512B2 (enExample) |
| EP (1) | EP3341374A1 (enExample) |
| JP (1) | JP6877407B2 (enExample) |
| KR (1) | KR20180043810A (enExample) |
| CN (1) | CN108137607B (enExample) |
| AR (1) | AR105836A1 (enExample) |
| AU (1) | AU2016311426B2 (enExample) |
| BR (1) | BR112018003588A2 (enExample) |
| CA (1) | CA2995997A1 (enExample) |
| HK (1) | HK1255330A1 (enExample) |
| IL (1) | IL257702A (enExample) |
| MX (1) | MX2018002407A (enExample) |
| PH (1) | PH12018500397A1 (enExample) |
| RU (1) | RU2744974C2 (enExample) |
| TW (1) | TW201713665A (enExample) |
| WO (1) | WO2017035354A1 (enExample) |
| ZA (1) | ZA201801881B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2019102203A (ru) | 2012-07-11 | 2019-03-05 | Блюпринт Медсинс Корпорейшн | Ингибиторы рецептора фактора роста фибробластов |
| US9499522B2 (en) | 2013-03-15 | 2016-11-22 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| WO2015057873A1 (en) | 2013-10-17 | 2015-04-23 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| PT3395814T (pt) | 2013-10-25 | 2022-07-27 | Blueprint Medicines Corp | Inibidores do recetor do fator de crescimento de fibroblastos |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| AU2016297754A1 (en) | 2015-07-24 | 2018-02-15 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to KIT and PDGFR |
| AU2016311426B2 (en) | 2015-08-26 | 2021-05-20 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to NTRK |
| TWI757256B (zh) | 2015-11-02 | 2022-03-11 | 美商纜圖藥品公司 | 轉染過程重排之抑制劑 |
| EP3377497A1 (en) | 2015-11-19 | 2018-09-26 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| TW201738228A (zh) | 2016-03-17 | 2017-11-01 | 藍圖醫藥公司 | Ｒｅｔ之抑制劑 |
| EP3442977B1 (en) | 2016-04-15 | 2023-06-28 | Blueprint Medicines Corporation | Inhibitors of activin receptor-like kinase |
| US10227329B2 (en) | 2016-07-22 | 2019-03-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
| WO2018183712A1 (en) | 2017-03-31 | 2018-10-04 | Blueprint Medicines Corporation | Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr |
| PL3674307T3 (pl) | 2017-08-23 | 2023-11-27 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Związek makrocykliczny zawierający ugrupowanie aminopirazolu i pirymidyny oraz kompozycja farmaceutyczna i i ch zastosowanie |
| US11236086B2 (en) | 2017-10-18 | 2022-02-01 | Blueprint Medicines Corporation | Substituted pyrrolopyridines as inhibitors of activin receptor-like kinase |
| WO2019152982A1 (en) * | 2018-02-05 | 2019-08-08 | Shenzhen Ionova Life Science Co., Ltd. | Heterobicyclic compounds as ep4 antagonists |
| AU2019241260B2 (en) * | 2018-03-28 | 2022-06-16 | Fochon Biosciences, Ltd. | Macrocyclic compounds as TRK kinases inhibitors |
| JP7422084B2 (ja) | 2018-04-03 | 2024-01-25 | ブループリント メディシンズ コーポレイション | Ｒｅｔ変化を有する癌の処置において使用するためのｒｅｔ阻害剤 |
| AU2020228056A1 (en) * | 2019-02-27 | 2021-09-16 | Ferro Therapeutics, Inc. | Compounds with ferroptosis inducing activity and methods of their use |
| SMT202300447T1 (it) | 2019-04-12 | 2024-01-10 | Blueprint Medicines Corp | Forme cristalline di (s)-1-(4-fluorofenil)-1-(2-(4-(6-(1-metil-1h-pirazol-4-yl)pirrolo[2,1-f][1,2,4]triazin-4-il)piperazinil)-pirimidin-5-il)etan-1-ammina e metodi di produzione |
| NZ787541A (en) * | 2019-11-25 | 2025-10-31 | Alkermes Inc | Substituted macrocyclic compounds and related methods of treatment |
| CA3183728A1 (en) | 2020-05-29 | 2021-12-02 | Blueprint Medicines Corporation | Solid forms of pralsetinib |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| CN113408945B (zh) * | 2021-07-15 | 2023-03-24 | 广西中烟工业有限责任公司 | 一种烤烟纯度的检测方法、装置、电子设备及存储介质 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU720135B2 (en) * | 1996-10-02 | 2000-05-25 | Novartis Ag | Pyrimidine derivatives and processes for the preparation thereof |
| EP2194058B1 (en) | 2002-09-04 | 2013-11-27 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidines suitable for the treatment of cancer diseases |
| US7329662B2 (en) | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
| AR048518A1 (es) * | 2004-04-02 | 2006-05-03 | Osi Pharm Inc | Inhibidores heterobiciclicos de proteina quinasas sustituidos con anillos 6,6 -biciclicos |
| JP5213229B2 (ja) * | 2004-04-23 | 2013-06-19 | エグゼリクシス， インコーポレイテッド | キナーゼ調節因子および使用方法 |
| WO2009032703A1 (en) * | 2007-08-28 | 2009-03-12 | Irm Llc | 2- (het) arylamino-6-aminopyridine derivatives and fused forms thereof as anaplastic lymphoma kinase inhibitors |
| KR101853026B1 (ko) | 2008-10-22 | 2018-04-27 | 어레이 바이오파마 인크. | ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５ａ］ 피리미딘 화합물 |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| JP2013525481A (ja) * | 2010-05-05 | 2013-06-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | ＰＫＣ−θインヒビターとして有用な４置換ピラゾロピリミジン |
| UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| CN102241678B (zh) | 2011-04-26 | 2014-10-29 | 辽宁利锋科技开发有限公司 | 含有脂环结构化合物的抗肿瘤作用与应用 |
| RU2019102203A (ru) | 2012-07-11 | 2019-03-05 | Блюпринт Медсинс Корпорейшн | Ингибиторы рецептора фактора роста фибробластов |
| US20150218652A1 (en) * | 2012-08-31 | 2015-08-06 | The Regents Of The Unversity Of Colorado, A Body Corporate | Methods for diagnosis and treatment of cancer |
| CN104837832B (zh) | 2012-10-05 | 2019-04-26 | 里格尔药品股份有限公司 | Gdf-8抑制剂 |
| WO2014071358A2 (en) | 2012-11-05 | 2014-05-08 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof |
| TWI629266B (zh) | 2012-12-28 | 2018-07-11 | 藍印藥品公司 | 纖維母細胞生長因子受體之抑制劑 |
| EP2951175B1 (en) * | 2013-02-01 | 2017-10-04 | Bayer Pharma Aktiengesellschaft | Substituted pyrazolopyrimidinylamino-indazoles |
| CN103965199B (zh) | 2013-02-02 | 2017-07-07 | 广东东阳光药业有限公司 | 一种芳杂环化合物、包含它的药物组合物及其用途 |
| MY182036A (en) | 2013-02-21 | 2021-01-18 | Sunshine Lake Pharma Co Ltd | Heteroaromatic compounds as pi3 kinase modulators |
| US10035801B2 (en) | 2013-03-13 | 2018-07-31 | Genentech, Inc. | Pyrazolo compounds and uses thereof |
| US9499522B2 (en) | 2013-03-15 | 2016-11-22 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| GB2515785A (en) * | 2013-07-03 | 2015-01-07 | Redx Pharma Ltd | Compounds |
| US9334263B2 (en) | 2013-10-17 | 2016-05-10 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| WO2015057873A1 (en) | 2013-10-17 | 2015-04-23 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| PT3395814T (pt) | 2013-10-25 | 2022-07-27 | Blueprint Medicines Corp | Inibidores do recetor do fator de crescimento de fibroblastos |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| ES2759240T3 (es) | 2014-04-08 | 2020-05-08 | Rigel Pharmaceuticals Inc | Compuestos de piridina 2,3-disustituidos como inhibidores de TGF-beta |
| US9688680B2 (en) | 2014-08-04 | 2017-06-27 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| PL3233863T3 (pl) | 2014-12-15 | 2024-11-12 | Cmg Pharmaceutical Co., Ltd. | Związki heteroarylowe ze skondensowanymi pierścieniami i ich zastosowanie jako inhibitorów trk |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| CN107531666A (zh) | 2015-02-20 | 2018-01-02 | 里格尔药品股份有限公司 | Gdf‑8抑制剂 |
| AU2016297754A1 (en) | 2015-07-24 | 2018-02-15 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to KIT and PDGFR |
| AU2016311426B2 (en) | 2015-08-26 | 2021-05-20 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to NTRK |
| TWI757256B (zh) | 2015-11-02 | 2022-03-11 | 美商纜圖藥品公司 | 轉染過程重排之抑制劑 |
| EP3377497A1 (en) | 2015-11-19 | 2018-09-26 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| TW201738228A (zh) | 2016-03-17 | 2017-11-01 | 藍圖醫藥公司 | Ｒｅｔ之抑制劑 |
| EP3442977B1 (en) | 2016-04-15 | 2023-06-28 | Blueprint Medicines Corporation | Inhibitors of activin receptor-like kinase |
| US10227329B2 (en) | 2016-07-22 | 2019-03-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
| US20190192522A1 (en) | 2016-09-08 | 2019-06-27 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor 4 in combination with cyclin-dependent kinase inhibitors |
| CN107844168B (zh) | 2017-11-23 | 2020-12-01 | 英业达科技有限公司 | 主板组件及其卡扣装置 |
-
2016
- 2016-08-25 AU AU2016311426A patent/AU2016311426B2/en not_active Expired - Fee Related
- 2016-08-25 MX MX2018002407A patent/MX2018002407A/es unknown
- 2016-08-25 HK HK18114466.6A patent/HK1255330A1/zh unknown
- 2016-08-25 KR KR1020187008146A patent/KR20180043810A/ko not_active Withdrawn
- 2016-08-25 BR BR112018003588A patent/BR112018003588A2/pt not_active IP Right Cessation
- 2016-08-25 WO PCT/US2016/048698 patent/WO2017035354A1/en not_active Ceased
- 2016-08-25 JP JP2018510406A patent/JP6877407B2/ja not_active Expired - Fee Related
- 2016-08-25 RU RU2018110379A patent/RU2744974C2/ru active
- 2016-08-25 CN CN201680060799.0A patent/CN108137607B/zh not_active Expired - Fee Related
- 2016-08-25 CA CA2995997A patent/CA2995997A1/en not_active Abandoned
- 2016-08-25 EP EP16763630.7A patent/EP3341374A1/en not_active Withdrawn
- 2016-08-26 AR ARP160102616A patent/AR105836A1/es unknown
- 2016-08-26 TW TW105127561A patent/TW201713665A/zh unknown
- 2016-08-26 US US15/248,207 patent/US10017512B2/en active Active
-
2018
- 2018-02-22 PH PH12018500397A patent/PH12018500397A1/en unknown
- 2018-02-25 IL IL257702A patent/IL257702A/en unknown
- 2018-03-20 ZA ZA2018/01881A patent/ZA201801881B/en unknown
- 2018-07-03 US US16/027,166 patent/US11046697B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018528200A5 (enExample) | ||
| RU2018110379A (ru) | Соединения и композиции, применяемые для лечения расстройств, связанных с ntrk | |
| JP2013541561A5 (enExample) | ||
| JP2010501572A5 (enExample) | ||
| JP2013522292A5 (enExample) | ||
| JP2017537080A5 (enExample) | ||
| JP2019532084A5 (enExample) | ||
| FI4355749T3 (fi) | Trisyklisiä parp1:n estäjiä ja niiden käyttötapoja | |
| EA201391324A1 (ru) | Бис(фторалкил)-1,4-бензодиазепиноновые соединения | |
| BR112014027190A2 (pt) | pirrolobenzodiazepinas | |
| JP2019529500A5 (enExample) | ||
| JP2019535720A5 (enExample) | ||
| JP2019514863A5 (enExample) | ||
| JP2019514955A5 (enExample) | ||
| PH12017502334A1 (en) | Polycyclic amide derivative as cdk9 inhibitors | |
| UY32251A (es) | Compuestos quimicos | |
| HK1246645A1 (zh) | 细胞周期蛋白依赖性激酶的抑制剂 | |
| WO2016105528A3 (en) | Inhibitors of cyclin-dependent kinase 7 (cdk7) | |
| JP2015506985A5 (enExample) | ||
| JP2013502423A5 (enExample) | ||
| CA2593428A1 (en) | Pyrrolopyrazoles, potent kinase inhibitors | |
| JP2012153722A5 (enExample) | ||
| RU2012105914A (ru) | Эффективные низкомолекулярные ингибиторы аутофагии и способ их применения | |
| PH12017501989A1 (en) | Heteroaryl derivative or pharmaceutically acceptable salt thereof, preparation method therefor, and pharmaceutical composition for preventing or treating diseases associated with pi3 kinases, containing same as active ingredient | |
| EA201001126A1 (ru) | Пирролопиримидины и пирролопиридины |