JP6877407B2 - Ｎｔｒｋ関連障害の治療に有用な化合物および組成物 - Google Patents

Ｎｔｒｋ関連障害の治療に有用な化合物および組成物 Download PDF

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JP6877407B2
JP6877407B2 JP2018510406A JP2018510406A JP6877407B2 JP 6877407 B2 JP6877407 B2 JP 6877407B2 JP 2018510406 A JP2018510406 A JP 2018510406A JP 2018510406 A JP2018510406 A JP 2018510406A JP 6877407 B2 JP6877407 B2 JP 6877407B2
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JP2018528200A5 (enExample
JP2018528200A (ja
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スティーブン マーク ウェングロウスキー，
スティーブン マーク ウェングロウスキー，
ナターシャ ブルージマンス，
ナターシャ ブルージマンス，
チャンドラセカール ブイ． ミドゥトゥル，
チャンドラセカール ブイ． ミドゥトゥル，
ニール ジュニア ビフルコ，
ニール ジュニア ビフルコ，
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ブループリント メディシンズ コーポレイション
ブループリント メディシンズ コーポレイション
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2018510406A 2015-08-26 2016-08-25 Ｎｔｒｋ関連障害の治療に有用な化合物および組成物 Expired - Fee Related JP6877407B2 (ja)

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US201562210264P 2015-08-26 2015-08-26
US62/210,264 2015-08-26
PCT/US2016/048698 WO2017035354A1 (en) 2015-08-26 2016-08-25 Compounds and compositions useful for treating disorders related to ntrk

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JP2018528200A JP2018528200A (ja) 2018-09-27
JP2018528200A5 JP2018528200A5 (enExample) 2019-09-12
JP6877407B2 true JP6877407B2 (ja) 2021-05-26

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US (2) US10017512B2 (enExample)
EP (1) EP3341374A1 (enExample)
JP (1) JP6877407B2 (enExample)
KR (1) KR20180043810A (enExample)
CN (1) CN108137607B (enExample)
AR (1) AR105836A1 (enExample)
AU (1) AU2016311426B2 (enExample)
BR (1) BR112018003588A2 (enExample)
CA (1) CA2995997A1 (enExample)
HK (1) HK1255330A1 (enExample)
IL (1) IL257702A (enExample)
MX (1) MX2018002407A (enExample)
PH (1) PH12018500397A1 (enExample)
RU (1) RU2744974C2 (enExample)
TW (1) TW201713665A (enExample)
WO (1) WO2017035354A1 (enExample)
ZA (1) ZA201801881B (enExample)

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Publication number Publication date
RU2744974C2 (ru) 2021-03-17
AU2016311426B2 (en) 2021-05-20
IL257702A (en) 2018-04-30
ZA201801881B (en) 2019-05-29
US20190169194A1 (en) 2019-06-06
PH12018500397A1 (en) 2018-08-29
RU2018110379A3 (enExample) 2019-12-26
US11046697B2 (en) 2021-06-29
CN108137607A (zh) 2018-06-08
WO2017035354A1 (en) 2017-03-02
BR112018003588A2 (pt) 2018-09-25
RU2018110379A (ru) 2019-09-27
KR20180043810A (ko) 2018-04-30
MX2018002407A (es) 2018-11-29
JP2018528200A (ja) 2018-09-27
CN108137607B (zh) 2021-04-06
EP3341374A1 (en) 2018-07-04
CA2995997A1 (en) 2017-03-02
US20170066773A1 (en) 2017-03-09
AU2016311426A1 (en) 2018-04-05
AR105836A1 (es) 2017-11-15
US10017512B2 (en) 2018-07-10
TW201713665A (zh) 2017-04-16
HK1255330A1 (zh) 2019-08-16

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