RU2744974C2 - Соединения и композиции, применяемые для лечения расстройств, связанных с ntrk - Google Patents
Соединения и композиции, применяемые для лечения расстройств, связанных с ntrk Download PDFInfo
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- RU2744974C2 RU2744974C2 RU2018110379A RU2018110379A RU2744974C2 RU 2744974 C2 RU2744974 C2 RU 2744974C2 RU 2018110379 A RU2018110379 A RU 2018110379A RU 2018110379 A RU2018110379 A RU 2018110379A RU 2744974 C2 RU2744974 C2 RU 2744974C2
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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| US9499522B2 (en) | 2013-03-15 | 2016-11-22 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| BR112016008541B1 (pt) | 2013-10-17 | 2022-11-22 | Blueprint Medicines Corporation | Composto ou sal farmaceuticamente aceitável, uso do mesmo para tratar mastocistose, tumor do estroma gastrointestinal e leucemia, e composição farmacêutica |
| AU2014339972B9 (en) | 2013-10-25 | 2019-05-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| KR20180048635A (ko) | 2015-07-24 | 2018-05-10 | 블루프린트 메디신즈 코포레이션 | Kit 및 pdgfr에 관련된 장애를 치료하는데 유용한 조성물 |
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| IL302209B2 (en) | 2015-11-02 | 2024-06-01 | Blueprint Medicines Corp | Inhibitors of ret |
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| WO2017161269A1 (en) | 2016-03-17 | 2017-09-21 | Blueprint Medicines Corporation | Inhibitors of ret receptor tyrosine kinases |
| EP4285996A3 (en) | 2016-04-15 | 2024-01-10 | Blueprint Medicines Corporation | Inhibitors of activin receptor-like kinase |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| US10035789B2 (en) | 2016-07-27 | 2018-07-31 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| US11040979B2 (en) | 2017-03-31 | 2021-06-22 | Blueprint Medicines Corporation | Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR |
| CN113735881A (zh) | 2017-08-23 | 2021-12-03 | 正大天晴药业集团股份有限公司 | 含有氨基吡唑并嘧啶的大环化合物及其药物组合物和用途 |
| CN111566102B (zh) | 2017-10-18 | 2023-09-08 | 缆图药品公司 | 作为激活素受体样激酶抑制剂的取代的吡咯并吡啶 |
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| CN111971287B (zh) * | 2018-03-28 | 2023-06-02 | 重庆复尚源创医药技术有限公司 | 作为trk激酶抑制剂的大环化合物 |
| PT3773589T (pt) | 2018-04-03 | 2024-02-06 | Blueprint Medicines Corp | Inibidor de ret para utilização no tratamento de cancro com alteração de ret |
| KR20220012221A (ko) * | 2019-02-27 | 2022-02-03 | 페로 테라퓨틱스 인코포레이티드 | 페롭토시스 유도 활성을 갖는 화합물 및 이의 사용 방법 |
| EP3856341B1 (en) | 2019-04-12 | 2023-09-06 | Blueprint Medicines Corporation | Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making |
| JP7787812B2 (ja) * | 2019-11-25 | 2025-12-17 | アルカームス インコーポレーテッド | 置換大環状化合物および関連する治療方法 |
| CA3183728A1 (en) | 2020-05-29 | 2021-12-02 | Blueprint Medicines Corporation | Solid forms of pralsetinib |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| CN113408945B (zh) * | 2021-07-15 | 2023-03-24 | 广西中烟工业有限责任公司 | 一种烤烟纯度的检测方法、装置、电子设备及存储介质 |
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-
2016
- 2016-08-25 RU RU2018110379A patent/RU2744974C2/ru active
- 2016-08-25 EP EP16763630.7A patent/EP3341374A1/en not_active Withdrawn
- 2016-08-25 MX MX2018002407A patent/MX2018002407A/es unknown
- 2016-08-25 KR KR1020187008146A patent/KR20180043810A/ko not_active Withdrawn
- 2016-08-25 CA CA2995997A patent/CA2995997A1/en not_active Abandoned
- 2016-08-25 WO PCT/US2016/048698 patent/WO2017035354A1/en not_active Ceased
- 2016-08-25 BR BR112018003588A patent/BR112018003588A2/pt not_active IP Right Cessation
- 2016-08-25 AU AU2016311426A patent/AU2016311426B2/en not_active Expired - Fee Related
- 2016-08-25 HK HK18114466.6A patent/HK1255330A1/zh unknown
- 2016-08-25 JP JP2018510406A patent/JP6877407B2/ja not_active Expired - Fee Related
- 2016-08-25 CN CN201680060799.0A patent/CN108137607B/zh not_active Expired - Fee Related
- 2016-08-26 AR ARP160102616A patent/AR105836A1/es unknown
- 2016-08-26 TW TW105127561A patent/TW201713665A/zh unknown
- 2016-08-26 US US15/248,207 patent/US10017512B2/en active Active
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2018
- 2018-02-22 PH PH12018500397A patent/PH12018500397A1/en unknown
- 2018-02-25 IL IL257702A patent/IL257702A/en unknown
- 2018-03-20 ZA ZA2018/01881A patent/ZA201801881B/en unknown
- 2018-07-03 US US16/027,166 patent/US11046697B2/en active Active
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Also Published As
| Publication number | Publication date |
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| MX2018002407A (es) | 2018-11-29 |
| JP6877407B2 (ja) | 2021-05-26 |
| IL257702A (en) | 2018-04-30 |
| AU2016311426A1 (en) | 2018-04-05 |
| ZA201801881B (en) | 2019-05-29 |
| HK1255330A1 (zh) | 2019-08-16 |
| BR112018003588A2 (pt) | 2018-09-25 |
| PH12018500397A1 (en) | 2018-08-29 |
| JP2018528200A (ja) | 2018-09-27 |
| CN108137607B (zh) | 2021-04-06 |
| CA2995997A1 (en) | 2017-03-02 |
| AU2016311426B2 (en) | 2021-05-20 |
| RU2018110379A3 (enExample) | 2019-12-26 |
| US20190169194A1 (en) | 2019-06-06 |
| CN108137607A (zh) | 2018-06-08 |
| KR20180043810A (ko) | 2018-04-30 |
| US11046697B2 (en) | 2021-06-29 |
| AR105836A1 (es) | 2017-11-15 |
| US10017512B2 (en) | 2018-07-10 |
| RU2018110379A (ru) | 2019-09-27 |
| WO2017035354A1 (en) | 2017-03-02 |
| TW201713665A (zh) | 2017-04-16 |
| US20170066773A1 (en) | 2017-03-09 |
| EP3341374A1 (en) | 2018-07-04 |
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