CN108137607B - 适用于治疗与ntrk相关的病症的化合物和组合物 - Google Patents

适用于治疗与ntrk相关的病症的化合物和组合物 Download PDF

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Publication number
CN108137607B
CN108137607B CN201680060799.0A CN201680060799A CN108137607B CN 108137607 B CN108137607 B CN 108137607B CN 201680060799 A CN201680060799 A CN 201680060799A CN 108137607 B CN108137607 B CN 108137607B
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CN108137607A (zh
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史蒂文·M·翁劳斯基
娜塔莎·布鲁杰孟
昌德拉塞卡·V·曼德拉
尼尔·比富尔科
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Cable Chart Pharmaceutical Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680060799.0A 2015-08-26 2016-08-25 适用于治疗与ntrk相关的病症的化合物和组合物 Expired - Fee Related CN108137607B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562210264P 2015-08-26 2015-08-26
US62/210,264 2015-08-26
PCT/US2016/048698 WO2017035354A1 (en) 2015-08-26 2016-08-25 Compounds and compositions useful for treating disorders related to ntrk

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CN108137607A CN108137607A (zh) 2018-06-08
CN108137607B true CN108137607B (zh) 2021-04-06

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US (2) US10017512B2 (enExample)
EP (1) EP3341374A1 (enExample)
JP (1) JP6877407B2 (enExample)
KR (1) KR20180043810A (enExample)
CN (1) CN108137607B (enExample)
AR (1) AR105836A1 (enExample)
AU (1) AU2016311426B2 (enExample)
BR (1) BR112018003588A2 (enExample)
CA (1) CA2995997A1 (enExample)
HK (1) HK1255330A1 (enExample)
IL (1) IL257702A (enExample)
MX (1) MX2018002407A (enExample)
PH (1) PH12018500397A1 (enExample)
RU (1) RU2744974C2 (enExample)
TW (1) TW201713665A (enExample)
WO (1) WO2017035354A1 (enExample)
ZA (1) ZA201801881B (enExample)

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Publication number Publication date
MX2018002407A (es) 2018-11-29
JP6877407B2 (ja) 2021-05-26
IL257702A (en) 2018-04-30
AU2016311426A1 (en) 2018-04-05
ZA201801881B (en) 2019-05-29
HK1255330A1 (zh) 2019-08-16
BR112018003588A2 (pt) 2018-09-25
PH12018500397A1 (en) 2018-08-29
JP2018528200A (ja) 2018-09-27
CA2995997A1 (en) 2017-03-02
AU2016311426B2 (en) 2021-05-20
RU2744974C2 (ru) 2021-03-17
RU2018110379A3 (enExample) 2019-12-26
US20190169194A1 (en) 2019-06-06
CN108137607A (zh) 2018-06-08
KR20180043810A (ko) 2018-04-30
US11046697B2 (en) 2021-06-29
AR105836A1 (es) 2017-11-15
US10017512B2 (en) 2018-07-10
RU2018110379A (ru) 2019-09-27
WO2017035354A1 (en) 2017-03-02
TW201713665A (zh) 2017-04-16
US20170066773A1 (en) 2017-03-09
EP3341374A1 (en) 2018-07-04

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