|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
JP2861087B2
(ja)
*
|
1989-08-08 |
1999-02-24 |
三菱化学株式会社 |
N―アシル‐5‐ピラゾールカルボキサミド類およびこれを有効成分とする殺虫、殺ダニ剤
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
EP1514934B1
(en)
|
1992-02-06 |
2008-12-31 |
Novartis Vaccines and Diagnostics, Inc. |
Biosynthetic binding protein for cancer marker
|
|
IT1255527B
(it)
*
|
1992-09-29 |
1995-11-09 |
Mini Ricerca Scient Tecnolog |
Pirazolcarbossammidi ad attivita' insetticida ed acaricida
|
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
EP0647450A1
(en)
|
1993-09-09 |
1995-04-12 |
BEHRINGWERKE Aktiengesellschaft |
Improved prodrugs for enzyme mediated activation
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
FI973974A7
(fi)
|
1995-04-20 |
1997-10-16 |
Pfizer |
Aryylisulfonyylihydroksaamihappojohdannaisia MMP- ja TNF-inhibiittorei na
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
GB9520822D0
(en)
|
1995-10-11 |
1995-12-13 |
Wellcome Found |
Therapeutically active compounds
|
|
DE69624081T2
(de)
|
1995-12-20 |
2003-06-12 |
Agouron Pharmaceuticals, Inc. |
Matrix-metalloprotease Inhibitoren
|
|
DE19600097C1
(de)
|
1996-01-03 |
1997-07-31 |
Siemens Ag |
Verfahren und Vorrichtung zur Bestimmung einer Flüssigkeitshöhe mit Hilfe von Ultraschallimpulsen
|
|
JP4464466B2
(ja)
|
1996-03-05 |
2010-05-19 |
アストラゼネカ・ユーケイ・リミテッド |
4―アニリノキナゾリン誘導体
|
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
|
AR007857A1
(es)
|
1996-07-13 |
1999-11-24 |
Glaxo Group Ltd |
Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios uso en medicina ycomposiciones farmaceuticas que los contienen.
|
|
CA2260058A1
(en)
|
1996-07-13 |
1998-01-22 |
Kathryn Jane Smith |
Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
HUP9903014A3
(en)
|
1996-07-18 |
2000-08-28 |
Pfizer |
Phosphinate derivatives having matrix metalloprotease inhibitor effect and medicaments containing the same
|
|
IL128189A0
(en)
|
1996-08-23 |
1999-11-30 |
Pfizer |
Arylsulfonylamino hydroxamic acid derivatives
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
ES2224277T3
(es)
|
1997-01-06 |
2005-03-01 |
Pfizer Inc. |
Derivados de sulfonas ciclicas.
|
|
PT977733E
(pt)
|
1997-02-03 |
2003-12-31 |
Pfizer Prod Inc |
Derivados de acido arilsulfonilamino-hidroxamico
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
N−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
IL131123A0
(en)
|
1997-02-11 |
2001-01-28 |
Pfizer |
Arylsulfonyl hydroxamic acid derivatives
|
|
CA2289102A1
(en)
|
1997-05-07 |
1998-11-12 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
|
EP0984692A4
(en)
|
1997-05-30 |
2001-02-21 |
Merck & Co Inc |
ANGIOGENESIS INHIBITORS
|
|
ES2216293T3
(es)
|
1997-08-08 |
2004-10-16 |
Pfizer Products Inc. |
Derivados de acido ariloxiarilsulfonilamino-hidroxamico.
|
|
US6294532B1
(en)
|
1997-08-22 |
2001-09-25 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
|
WO1999016755A1
(en)
|
1997-09-26 |
1999-04-08 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
|
WO1999024440A1
(en)
|
1997-11-11 |
1999-05-20 |
Pfizer Products Inc. |
Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
TR200003514T2
(tr)
|
1998-05-29 |
2002-05-21 |
Sugen Inc. |
Pirol ikame edilmiş 2-indolinon protein kinaz inhibitörleri
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
DK1004578T3
(da)
|
1998-11-05 |
2004-06-28 |
Pfizer Prod Inc |
5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater
|
|
IL143236A0
(en)
|
1998-12-16 |
2002-04-21 |
Warner Lambert Co |
Treatment of arthritis with mek inhibitors
|
|
UA71945C2
(en)
|
1999-01-27 |
2005-01-17 |
Pfizer Prod Inc |
Substituted bicyclic derivatives being used as anticancer agents
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
JP2001172261A
(ja)
*
|
1999-12-20 |
2001-06-26 |
Mitsubishi Chemicals Corp |
ピラゾールカルボン酸アミド類、およびこれを有効成分とする殺虫、殺ダニ剤
|
|
BRPI0117360B8
(pt)
|
2000-02-15 |
2021-07-06 |
Upjohn Co |
inibidores de proteína de quinase de 2-indolinona de pirrol substituído, seus sais e composições farmacêuticas compreendendo os mesmos
|
|
EE05450B1
(et)
|
2000-07-19 |
2011-08-15 |
Warner-Lambert Company |
4-jodofenlaminobenshdroksaamhapete oksgeenitud estrid, nende kristallvormid ja farmatseutilised kompositsioonid ning kasutamine
|
|
US6638926B2
(en)
*
|
2000-09-15 |
2003-10-28 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6660731B2
(en)
|
2000-09-15 |
2003-12-09 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
EP1384714A1
(en)
*
|
2001-04-06 |
2004-01-28 |
Nihon Nohyaku Co., Ltd. |
Pyrazolecarboxamide derivative, intermediate therefor, and pest control agent containing the same as active ingredient
|
|
JP2002363164A
(ja)
*
|
2001-04-06 |
2002-12-18 |
Mitsubishi Chemicals Corp |
ピラゾールカルボキサミド類、その中間体およびこれを有効成分とする有害生物防除剤
|
|
JP4575667B2
(ja)
|
2002-03-08 |
2010-11-04 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
医薬として有用な大環状化合物
|
|
PL401638A1
(pl)
|
2002-03-13 |
2013-05-27 |
Array Biopharma Inc. |
N3 alkilowane pochodne benzimidazolu jako inhibitory MEK
|
|
JP2007524596A
(ja)
|
2003-02-28 |
2007-08-30 |
トランスフォーム・ファーマシューティカルズ・インコーポレイテッド |
共結晶医薬組成物
|
|
US20070060589A1
(en)
*
|
2004-12-21 |
2007-03-15 |
Purandare Ashok V |
Inhibitors of protein arginine methyl transferases
|
|
CN101189228A
(zh)
*
|
2005-04-08 |
2008-05-28 |
辉瑞产品有限公司 |
用作i型甘氨酸转运抑制剂的二环[3.1.0]杂芳酰胺
|
|
CA2609394A1
(en)
*
|
2005-05-23 |
2006-11-30 |
Masaki Takagi |
Pyrazole compound and therapeutic agent for diabetes comprising the same
|
|
EP1912636B1
(en)
|
2005-07-21 |
2014-06-25 |
Ardea Biosciences, Inc. |
N-(arylamino)-sulfonamide inhibitors of mek
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
US8552050B2
(en)
|
2007-08-16 |
2013-10-08 |
Beth Israel Deaconess Medical Center |
Activators of pyruvate kinase M2 and methods of treating disease
|
|
JPWO2009028280A1
(ja)
*
|
2007-08-29 |
2010-11-25 |
三井化学アグロ株式会社 |
ピラゾールカルボン酸誘導体及びその製造方法、並びに殺菌剤
|
|
EP2205242B1
(en)
|
2007-09-12 |
2015-04-15 |
Genentech, Inc. |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
JP5348725B2
(ja)
|
2007-10-25 |
2013-11-20 |
ジェネンテック, インコーポレイテッド |
チエノピリミジン化合物の製造方法
|
|
ES2620634T3
(es)
*
|
2008-10-09 |
2017-06-29 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Activadores de piruvato quinasa humana
|
|
JP5584696B2
(ja)
*
|
2008-11-17 |
2014-09-03 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Mmp−13阻害剤として有用なヘテロアリールジアミド化合物
|
|
US20110263647A1
(en)
|
2009-01-15 |
2011-10-27 |
Amgen Inc. |
Fluoroisoquinoline substituted thiazole compounds and methods of use
|
|
CN102448951B
(zh)
*
|
2009-04-06 |
2017-05-10 |
安吉奥斯医药品有限公司 |
丙酮酸激酶m2调节剂、治疗组合物和相关使用方法
|
|
EP2427441B1
(en)
|
2009-05-04 |
2016-12-14 |
Agios Pharmaceuticals, Inc. |
Pkm2 activators for use in the treatment of cancer
|
|
US8349832B2
(en)
|
2009-09-02 |
2013-01-08 |
Canthera Therapeutics |
Compounds and compositions for treating cancer
|
|
WO2011069298A1
(en)
*
|
2009-12-11 |
2011-06-16 |
F. Hoffmann-La Roche Ag |
Novel cyclopropane indolinone derivatives
|
|
CN105482129B
(zh)
|
2010-09-30 |
2018-07-27 |
黄奇英 |
抗癌萃取物及化合物
|
|
WO2012056319A1
(en)
|
2010-10-27 |
2012-05-03 |
Dynamix Pharmaceuticals Ltd. |
Sulfonamides for the modulation of pkm2
|
|
EP2651898B1
(en)
*
|
2010-12-17 |
2015-12-09 |
Agios Pharmaceuticals, Inc. |
Novel n-(4-(azetidine-1-carbonyl)phenyl)-(hetero-)arylsulfonamide derivatives as pyruvate kinase m2 (pmk2) modulators
|
|
US9328077B2
(en)
|
2010-12-21 |
2016-05-03 |
Agios Pharmaceuticals, Inc |
Bicyclic PKM2 activators
|
|
TWI549947B
(zh)
|
2010-12-29 |
2016-09-21 |
阿吉歐斯製藥公司 |
治療化合物及組成物
|
|
EP2497775A1
(en)
|
2011-03-11 |
2012-09-12 |
Ruprecht-Karls-Universität Heidelberg |
Ferrocene-based compounds and their use as ROS regulating prodrugs
|
|
WO2012160447A1
(en)
*
|
2011-05-25 |
2012-11-29 |
Dynamix Pharmaceuticals Ltd. |
3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases
|
|
WO2013005157A1
(en)
|
2011-07-05 |
2013-01-10 |
Lupin Limited |
Sulfone derivatives and their use as pkm2 modulators for the treatment of cancer
|
|
DK2909181T3
(da)
*
|
2012-10-16 |
2017-11-20 |
Tolero Pharmaceuticals Inc |
PKM2-modulatorer og fremgangsmåder til anvendelse deraf
|
|
CN104822672B
(zh)
|
2012-11-08 |
2018-08-28 |
安吉奥斯医药品有限公司 |
治疗性化合物和组合物以及其作为pkm2调节剂的用途
|
|
US9447054B2
(en)
|
2014-01-15 |
2016-09-20 |
Korea Institute Of Radiological & Medical Sciences |
Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient
|