JP2021193108A5 - - Google Patents
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- JP2021193108A5 JP2021193108A5 JP2021145468A JP2021145468A JP2021193108A5 JP 2021193108 A5 JP2021193108 A5 JP 2021193108A5 JP 2021145468 A JP2021145468 A JP 2021145468A JP 2021145468 A JP2021145468 A JP 2021145468A JP 2021193108 A5 JP2021193108 A5 JP 2021193108A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- alkyl
- compound according
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023131211A JP2023159230A (ja) | 2016-04-15 | 2023-08-10 | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1606631.8 | 2016-04-15 | ||
| GB201606631 | 2016-04-15 | ||
| GB201619277 | 2016-11-14 | ||
| GB1619277.5 | 2016-11-14 | ||
| JP2018554114A JP6943876B2 (ja) | 2016-04-15 | 2017-04-18 | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554114A Division JP6943876B2 (ja) | 2016-04-15 | 2017-04-18 | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023131211A Division JP2023159230A (ja) | 2016-04-15 | 2023-08-10 | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021193108A JP2021193108A (ja) | 2021-12-23 |
| JP2021193108A5 true JP2021193108A5 (enExample) | 2022-02-08 |
Family
ID=58633035
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554114A Active JP6943876B2 (ja) | 2016-04-15 | 2017-04-18 | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
| JP2021145468A Pending JP2021193108A (ja) | 2016-04-15 | 2021-09-07 | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
| JP2023131211A Pending JP2023159230A (ja) | 2016-04-15 | 2023-08-10 | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018554114A Active JP6943876B2 (ja) | 2016-04-15 | 2017-04-18 | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023131211A Pending JP2023159230A (ja) | 2016-04-15 | 2023-08-10 | Ｒｅｔキナーゼ阻害剤としての複素環化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10954241B2 (enExample) |
| EP (2) | EP3442980B1 (enExample) |
| JP (3) | JP6943876B2 (enExample) |
| KR (3) | KR20240142568A (enExample) |
| CN (2) | CN109195972B (enExample) |
| AU (3) | AU2017250448C1 (enExample) |
| BR (2) | BR122023026297A2 (enExample) |
| CA (1) | CA3020778A1 (enExample) |
| CY (1) | CY1124478T1 (enExample) |
| DK (1) | DK3442980T3 (enExample) |
| ES (1) | ES2886587T3 (enExample) |
| HR (1) | HRP20211362T1 (enExample) |
| HU (1) | HUE056135T2 (enExample) |
| IL (3) | IL297192A (enExample) |
| LT (1) | LT3442980T (enExample) |
| MX (2) | MX387394B (enExample) |
| PL (1) | PL3442980T3 (enExample) |
| PT (1) | PT3442980T (enExample) |
| RS (1) | RS62322B1 (enExample) |
| RU (1) | RU2742115C2 (enExample) |
| SG (2) | SG10201911665UA (enExample) |
| SI (1) | SI3442980T1 (enExample) |
| SM (1) | SMT202100538T1 (enExample) |
| WO (1) | WO2017178844A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2628418T3 (es) | 2010-05-20 | 2017-08-02 | Array Biopharma, Inc. | Compuestos macrocíclicos como inhibidores de la TRK cinasa |
| RS61485B1 (sr) | 2015-07-16 | 2021-03-31 | Array Biopharma Inc | Supstituisana pirazolo [1,5-a] piridinska jedinjenja kao inhibitori ret kinaze |
| IL302209B2 (en) | 2015-11-02 | 2024-06-01 | Blueprint Medicines Corp | Inhibitors of ret |
| LT3442535T (lt) | 2016-04-15 | 2022-10-25 | Cancer Research Technology Limited | Heterocikliniai junginiai kaip ret kinazės inhibitoriai |
| RS62322B1 (sr) * | 2016-04-15 | 2021-10-29 | Cancer Research Tech Ltd | Heterociklična jedinjenja kao inhibitori ret kinaze |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| EP3571203B1 (en) | 2017-01-18 | 2023-06-07 | Array BioPharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| GB201705971D0 (en) | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| JOP20180094A1 (ar) | 2017-10-18 | 2019-04-18 | Hk Inno N Corp | مركب حلقي غير متجانس كمثبط بروتين كيناز |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
| PT3773589T (pt) | 2018-04-03 | 2024-02-06 | Blueprint Medicines Corp | Inibidor de ret para utilização no tratamento de cancro com alteração de ret |
| EP3774797B1 (en) * | 2018-04-05 | 2025-11-19 | Merck Patent GmbH | Heteroaryl compounds as type ii irak inhibitors and uses hereof |
| JP2022500383A (ja) | 2018-09-10 | 2022-01-04 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての縮合複素環式化合物 |
| KR20210125471A (ko) | 2018-10-05 | 2021-10-18 | 안나푸르나 바이오, 인코포레이티드 | Apj 수용체 활성과 관련된 병태를 치료하기 위한 화합물 및 조성물 |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| US12297197B2 (en) * | 2019-04-03 | 2025-05-13 | Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory | Pyrazolopyridine compound as RET inhibitor and application thereof |
| CN113490670B (zh) * | 2019-08-05 | 2023-06-02 | 北京志健金瑞生物医药科技有限公司 | 含氮多环稠环类化合物,其药物组合物、制备方法和用途 |
| JP7461605B2 (ja) * | 2020-02-20 | 2024-04-04 | 広州白雲山医薬集団股▲フン▼有限公司白雲山制薬総廠 | キノリン系化合物 |
| EP4146654A1 (en) * | 2020-05-07 | 2023-03-15 | Adorx therapeutics Limited | Antagonists of the adenosine a2a receptor |
| CA3183728A1 (en) | 2020-05-29 | 2021-12-02 | Blueprint Medicines Corporation | Solid forms of pralsetinib |
| CN113214294A (zh) * | 2020-06-10 | 2021-08-06 | 深圳铂立健医药有限公司 | 三环化合物、药物组合物及其应用 |
| KR20230104781A (ko) | 2020-10-05 | 2023-07-10 | 인라이븐 테라퓨틱스, 인크. | Bcr-abl 티로신 키나아제의 억제를 위한 5- 및 6-아자인돌 화합물 |
| EP4267559A1 (en) * | 2020-12-22 | 2023-11-01 | Gilead Sciences, Inc. | Substituted indole compounds |
| US20250002471A1 (en) * | 2020-12-22 | 2025-01-02 | Gilead Sciences, Inc. | 6-substituted indole compounds |
| TWI861488B (zh) | 2021-04-16 | 2024-11-11 | 美商基利科學股份有限公司 | 噻吩并吡咯化合物 |
| CN113248518B (zh) * | 2021-06-21 | 2022-03-25 | 山东大学 | 嘧啶哌嗪类衍生物及其制备方法与应用 |
| AU2022341114A1 (en) | 2021-09-10 | 2024-02-29 | Gilead Sciences, Inc. | Thienopyrrole compounds |
| WO2023064843A1 (en) | 2021-10-15 | 2023-04-20 | Stemline Therapeutics, Inc. | Inhibitors of mutant ret kinases for use in treating cancer |
| WO2024151519A2 (en) * | 2023-01-09 | 2024-07-18 | University Of Florida Research Foundatin, Incorporated | Pparg modulators |
| AU2024320585A1 (en) * | 2023-08-09 | 2025-10-02 | Daewoong Pharmaceutical Co., Ltd. | Novel compound, and pharmaceutical composition for prevention or treatment of cancer or tumors comprising same |
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| EP0322779A3 (en) | 1987-12-29 | 1991-05-08 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzolactam compounds and pharmaceutical uses thereof |
| US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| CA2369895C (en) * | 1999-01-11 | 2010-12-21 | Princeton University | High affinity inhibitors for target validation and uses thereof |
| US7119200B2 (en) * | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7429596B2 (en) | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
| EP1831225A2 (en) | 2004-11-19 | 2007-09-12 | The Regents of the University of California | Anti-inflammatory pyrazolopyrimidines |
| EP1853261B1 (de) | 2005-03-03 | 2017-01-11 | Universität des Saarlandes | Selektive hemmstoffe humaner corticoidsynthasen |
| AU2006316605B2 (en) | 2005-11-17 | 2012-04-26 | Osi Pharmaceuticals, Inc. | Fused bicyclic mTOR inhibitors |
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| PT2496567T (pt) | 2009-11-05 | 2017-11-15 | Rhizen Pharmaceuticals S A | Novos moduladores de quinase benzopiran |
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| US9765037B2 (en) | 2010-01-28 | 2017-09-19 | University Of Washington Through Its Center For Commercialization | Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases |
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| TWI592411B (zh) | 2011-02-23 | 2017-07-21 | 英特爾立秦有限責任公司 | 激酶抑制劑之組合及其用途 |
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| KR20180109842A (ko) * | 2015-09-16 | 2018-10-08 | 록쏘 온콜로지, 인코포레이티드 | 화합물 |
| WO2017160717A2 (en) | 2016-03-15 | 2017-09-21 | Memorial Sloan Kettering Cancer Center | Method of treating diseases using kinase modulators |
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-
2017
- 2017-04-18 RS RS20211115A patent/RS62322B1/sr unknown
- 2017-04-18 US US16/093,854 patent/US10954241B2/en active Active
- 2017-04-18 SM SM20210538T patent/SMT202100538T1/it unknown
- 2017-04-18 EP EP17719687.0A patent/EP3442980B1/en active Active
- 2017-04-18 PL PL17719687T patent/PL3442980T3/pl unknown
- 2017-04-18 IL IL297192A patent/IL297192A/en unknown
- 2017-04-18 BR BR122023026297-2A patent/BR122023026297A2/pt not_active Application Discontinuation
- 2017-04-18 LT LTEPPCT/GB2017/051076T patent/LT3442980T/lt unknown
- 2017-04-18 CN CN201780031509.4A patent/CN109195972B/zh active Active
- 2017-04-18 SG SG10201911665UA patent/SG10201911665UA/en unknown
- 2017-04-18 HR HRP20211362TT patent/HRP20211362T1/hr unknown
- 2017-04-18 SI SI201730892T patent/SI3442980T1/sl unknown
- 2017-04-18 EP EP21172597.3A patent/EP3960180A1/en active Pending
- 2017-04-18 KR KR1020247030356A patent/KR20240142568A/ko not_active Withdrawn
- 2017-04-18 WO PCT/GB2017/051076 patent/WO2017178844A1/en not_active Ceased
- 2017-04-18 KR KR1020187032842A patent/KR102390578B1/ko active Active
- 2017-04-18 HU HUE17719687A patent/HUE056135T2/hu unknown
- 2017-04-18 PT PT177196870T patent/PT3442980T/pt unknown
- 2017-04-18 JP JP2018554114A patent/JP6943876B2/ja active Active
- 2017-04-18 BR BR112018071097-0A patent/BR112018071097B1/pt active IP Right Grant
- 2017-04-18 CA CA3020778A patent/CA3020778A1/en active Pending
- 2017-04-18 IL IL289793A patent/IL289793B2/en unknown
- 2017-04-18 RU RU2018138471A patent/RU2742115C2/ru active
- 2017-04-18 MX MX2018012609A patent/MX387394B/es unknown
- 2017-04-18 CN CN202211269931.2A patent/CN115650985B/zh active Active
- 2017-04-18 DK DK17719687.0T patent/DK3442980T3/da active
- 2017-04-18 SG SG11201808878UA patent/SG11201808878UA/en unknown
- 2017-04-18 ES ES17719687T patent/ES2886587T3/es active Active
- 2017-04-18 AU AU2017250448A patent/AU2017250448C1/en active Active
- 2017-04-18 KR KR1020227013172A patent/KR102706837B1/ko active Active
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2018
- 2018-10-07 IL IL262185A patent/IL262185B/en unknown
- 2018-10-15 MX MX2021013110A patent/MX2021013110A/es unknown
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2020
- 2020-08-18 AU AU2020220079A patent/AU2020220079B2/en active Active
-
2021
- 2021-02-02 US US17/165,151 patent/US11548896B2/en active Active
- 2021-09-06 CY CY20211100784T patent/CY1124478T1/el unknown
- 2021-09-07 JP JP2021145468A patent/JP2021193108A/ja active Pending
-
2022
- 2022-06-06 AU AU2022203916A patent/AU2022203916A1/en not_active Abandoned
- 2022-11-22 US US17/992,049 patent/US20230339954A1/en not_active Abandoned
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2023
- 2023-08-10 JP JP2023131211A patent/JP2023159230A/ja active Pending
-
2024
- 2024-12-03 US US18/967,321 patent/US20250236624A1/en active Pending
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