JP2018527367A5 - - Google Patents
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- JP2018527367A5 JP2018527367A5 JP2018513579A JP2018513579A JP2018527367A5 JP 2018527367 A5 JP2018527367 A5 JP 2018527367A5 JP 2018513579 A JP2018513579 A JP 2018513579A JP 2018513579 A JP2018513579 A JP 2018513579A JP 2018527367 A5 JP2018527367 A5 JP 2018527367A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- formula
- compound
- acid
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c1cnc(C(C(c(c(F)c2)ccc2F)=O)(F)F)cc1 Chemical compound *c1cnc(C(C(c(c(F)c2)ccc2F)=O)(F)F)cc1 0.000 description 2
- UDGASIIGNCBLSI-PMERELPUSA-N N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@](C[n]3nnnc3)(c(c(F)c3)ccc3F)O)(F)F)cc2)cc1 Chemical compound N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@](C[n]3nnnc3)(c(c(F)c3)ccc3F)O)(F)F)cc2)cc1 UDGASIIGNCBLSI-PMERELPUSA-N 0.000 description 2
- LBBHRBLMMYBWEM-VGFJAJBZSA-N N#Cc1ccc(COC(C=C2)=CC=CC2C#Cc2cnc(C([C@@](C[n]3nnnc3)(c(c(F)c3)ccc3F)O)(F)F)cc2)cc1 Chemical compound N#Cc1ccc(COC(C=C2)=CC=CC2C#Cc2cnc(C([C@@](C[n]3nnnc3)(c(c(F)c3)ccc3F)O)(F)F)cc2)cc1 LBBHRBLMMYBWEM-VGFJAJBZSA-N 0.000 description 1
- JFHOATHDSUPBNY-SSEXGKCCSA-N N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@@H](c(c(F)c3)ccc3F)/[O]=C/[n]3nnnc3)(F)F)cc2)cc1 Chemical compound N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@@H](c(c(F)c3)ccc3F)/[O]=C/[n]3nnnc3)(F)F)cc2)cc1 JFHOATHDSUPBNY-SSEXGKCCSA-N 0.000 description 1
- UDGASIIGNCBLSI-SSEXGKCCSA-N N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@@](C[n]3nnnc3)(c(c(F)c3)ccc3F)O)(F)F)cc2)cc1 Chemical compound N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@@](C[n]3nnnc3)(c(c(F)c3)ccc3F)O)(F)F)cc2)cc1 UDGASIIGNCBLSI-SSEXGKCCSA-N 0.000 description 1
- RKDYIOGHCIESBV-MUUNZHRXSA-N N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@H](C[n]3nnnc3)c(ccc(F)c3)c3F)(F)F)cc2)cc1 Chemical compound N#Cc1ccc(COc(cc2)ccc2C#Cc2cnc(C([C@H](C[n]3nnnc3)c(ccc(F)c3)c3F)(F)F)cc2)cc1 RKDYIOGHCIESBV-MUUNZHRXSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220384P | 2015-09-18 | 2015-09-18 | |
| US62/220,384 | 2015-09-18 | ||
| US201662275504P | 2016-01-06 | 2016-01-06 | |
| US62/275,504 | 2016-01-06 | ||
| PCT/US2016/052151 WO2017049096A1 (en) | 2015-09-18 | 2016-09-16 | Antifungal compound process |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527367A JP2018527367A (ja) | 2018-09-20 |
| JP2018527367A5 true JP2018527367A5 (https=) | 2019-07-25 |
| JP6887993B2 JP6887993B2 (ja) | 2021-06-16 |
Family
ID=58289604
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514436A Active JP6847458B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物のプロセス |
| JP2018513579A Expired - Fee Related JP6887993B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物調製方法 |
| JP2018513603A Pending JP2018532719A (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物および作製方法 |
| JP2021083727A Pending JP2021121606A (ja) | 2015-09-18 | 2021-05-18 | 抗真菌化合物および作製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514436A Active JP6847458B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物のプロセス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513603A Pending JP2018532719A (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物および作製方法 |
| JP2021083727A Pending JP2021121606A (ja) | 2015-09-18 | 2021-05-18 | 抗真菌化合物および作製方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10513505B2 (https=) |
| EP (3) | EP3349753A4 (https=) |
| JP (4) | JP6847458B2 (https=) |
| KR (3) | KR20180052755A (https=) |
| CN (3) | CN108347949B (https=) |
| AU (3) | AU2016323767B2 (https=) |
| BR (2) | BR112018005194B1 (https=) |
| CA (3) | CA2998805C (https=) |
| EA (3) | EA038214B1 (https=) |
| ES (2) | ES2821021T3 (https=) |
| HK (3) | HK1258863A1 (https=) |
| HU (1) | HUE053638T2 (https=) |
| MX (3) | MX2018003284A (https=) |
| PL (1) | PL3349586T3 (https=) |
| TW (3) | TWI730986B (https=) |
| WO (3) | WO2017049196A1 (https=) |
| ZA (1) | ZA201801404B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015231226B2 (en) | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942936A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| ES2800905T3 (es) | 2014-03-19 | 2021-01-05 | Mycovia Pharmaceuticals Inc | Procedimiento para compuesto antifúngico |
| BR112016021257B1 (pt) | 2014-03-19 | 2021-03-02 | Viamet Pharmaceuticals (NC), Inc. | 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos |
| CA2942972A1 (en) | 2014-03-19 | 2015-09-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antifungal compound process |
| JP6633539B2 (ja) * | 2014-03-19 | 2020-01-22 | ダウ アグロサイエンシィズ エルエルシー | ２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−１−（５−置換−ピリジン−２−イル）−３−（１ｈ−テトラゾール−１−イル）プロパン−２−オールおよびその調製工程 |
| CA2942231A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| JP6572234B2 (ja) | 2014-03-19 | 2019-09-04 | ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド | 抗真菌化合物の調製方法 |
| AU2015231275B2 (en) | 2014-03-19 | 2019-03-07 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| JP6847458B2 (ja) | 2015-09-18 | 2021-03-24 | マイコヴィア ファーマシューティカルズ，インコーポレイテッド | 抗真菌化合物のプロセス |
| CN109666019B (zh) * | 2017-10-14 | 2021-04-06 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
| US11213031B2 (en) | 2017-11-13 | 2022-01-04 | Bayer Aktiengesellschaft | Tetrazolylpropyl derivatives and their use as fungicides |
| WO2021188404A1 (en) * | 2020-03-19 | 2021-09-23 | Assia Chemical Industries Ltd | Solid state forms of oteseconazole and process for preparation thereof |
| WO2023003554A1 (en) * | 2021-07-22 | 2023-01-26 | Mycovia Pharmaceuticals, Inc. | Compositions comprising oteseconazole |
| CN114573503B (zh) * | 2022-03-28 | 2024-04-09 | 浙江天宇药业股份有限公司 | 一种制备奥特康唑中间体的方法 |
| CN114573557B (zh) * | 2022-03-28 | 2024-03-08 | 浙江天宇药业股份有限公司 | 一种奥特康唑的制备方法 |
| CN116621816B (zh) * | 2022-09-23 | 2025-07-04 | 北京莱瑞森医药科技有限公司 | 一种伏立康唑对映异构对b的拆分方法 |
| WO2024067784A1 (zh) * | 2022-09-30 | 2024-04-04 | 上海济煜医药科技有限公司 | 双环类化合物的无定形、结晶固体及其制备方法 |
| CN119798219B (zh) * | 2025-01-13 | 2025-07-18 | 长治医学院 | 一种奥特康唑的制备方法 |
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| DE2854015B2 (de) | 1978-12-14 | 1980-10-09 | Dynamit Nobel Ag, 5210 Troisdorf | Verfahren zur Herstellung von !H-TetrazoI-1-essigsauren und bestimmter Ester derselben |
| EP0069442B1 (en) | 1981-06-06 | 1985-02-20 | Pfizer Limited | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
| CS228931B2 (cs) | 1981-06-06 | 1984-05-14 | Pfizer | Způsob výroby 2-(2,4-difluorfenyl)-l,3-bis(lH-l,2,4-triazol-l-yl)propan- -2-oiu |
| GB8304282D0 (en) | 1983-02-16 | 1983-03-23 | Pfizer Ltd | Antifungal agents |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
| US5163899A (en) | 1987-03-20 | 1992-11-17 | Drug Delivery Systems Inc. | Transdermal drug delivery system |
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| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
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| EP0431519B1 (en) | 1989-12-04 | 1994-06-15 | G.D. Searle & Co. | System for transdermal albuterol administration |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| DE69228827T2 (de) | 1991-12-18 | 1999-10-21 | Minnesota Mining And Mfg. Co., Saint Paul | Mehrschichtige sperrstrukturen |
| EP0553769B1 (de) | 1992-01-29 | 1996-01-03 | FRANZ VÖLKL GmbH & CO. SKI UND TENNIS SPORTARTIKELFABRIK KG | Ballspielschläger, insbesondere Tennisschläger |
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| KR100889937B1 (ko) | 2007-08-06 | 2009-03-20 | 한미약품 주식회사 | 보리코나졸의 제조방법 |
| UA108596C2 (xx) * | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
| KR101109215B1 (ko) | 2009-06-17 | 2012-01-30 | 보령제약 주식회사 | 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법 |
| JP2012530111A (ja) | 2009-06-18 | 2012-11-29 | ビーエーエスエフ ソシエタス・ヨーロピア | ５−硫黄置換基を有する抗菌類性１，２，４−トリアゾリル誘導体 |
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| IN2014MN00093A (https=) | 2011-06-19 | 2015-06-19 | Viamet Pharmaceuticals Inc | |
| EA025266B1 (ru) | 2011-06-23 | 2016-12-30 | Ваймет Фармасьютикалс, Инк. | Соединения, ингибирующие металлоферменты |
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| US9598340B2 (en) | 2013-04-05 | 2017-03-21 | The Regents Of The University Of California | Metal-catalyzed coupling of aryl and vinyl halides with alpha, alpha-difluorocarbonyl compounds |
| HK1223093A1 (zh) | 2013-05-28 | 2017-07-21 | Viamet Pharmaceuticals (NC), Inc. | 杀真菌组合物 |
| US9688671B2 (en) | 2013-06-12 | 2017-06-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| JP6633539B2 (ja) | 2014-03-19 | 2020-01-22 | ダウ アグロサイエンシィズ エルエルシー | ２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−１−（５−置換−ピリジン−２−イル）−３−（１ｈ−テトラゾール−１−イル）プロパン−２−オールおよびその調製工程 |
| JP2017512777A (ja) * | 2014-03-19 | 2017-05-25 | ヴィアメット ファーマスーティカルズ，インコーポレイテッド | 抗真菌化合物の調製方法 |
| AU2015231226B2 (en) * | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942972A1 (en) | 2014-03-19 | 2015-09-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antifungal compound process |
| JP6572234B2 (ja) * | 2014-03-19 | 2019-09-04 | ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド | 抗真菌化合物の調製方法 |
| ES2800905T3 (es) | 2014-03-19 | 2021-01-05 | Mycovia Pharmaceuticals Inc | Procedimiento para compuesto antifúngico |
| BR112016021257B1 (pt) | 2014-03-19 | 2021-03-02 | Viamet Pharmaceuticals (NC), Inc. | 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos |
| CA2942936A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942231A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| AU2015231275B2 (en) | 2014-03-19 | 2019-03-07 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| RS63566B1 (sr) | 2015-03-19 | 2022-10-31 | Mycovia Pharmaceuticals Inc | Antifungalna jedinjenja i procesi izrade |
| AU2016265932B2 (en) | 2015-05-18 | 2020-10-08 | Viamet Pharmaceuticals (NC), Inc. | Antifungal compounds |
| JP6847458B2 (ja) | 2015-09-18 | 2021-03-24 | マイコヴィア ファーマシューティカルズ，インコーポレイテッド | 抗真菌化合物のプロセス |
| AR106729A1 (es) | 2015-11-17 | 2018-02-14 | Viamet Pharmaceuticals Inc | 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación |
| TWI679198B (zh) | 2015-11-17 | 2019-12-11 | 美商陶氏益農有限責任公司 | 製備４-（（６-（２-（２，４-二氟苯基）-１，１-二氟-２-羥基-３-（１ｈ-１，２，４-三唑-１-基）丙基）吡啶-３-基）氧基）苄腈之方法 |
| KR20180100313A (ko) | 2015-11-17 | 2018-09-10 | 다우 아그로사이언시즈 엘엘씨 | 4-((6-(2-(2,4-디플루오로페닐)-1,1-디플루오로-2-히드록시-3-(1h-1,2,4-트리아졸-1-일)프로필)피리딘-3-일)옥시)벤조니트릴 및 제조방법 |
| US20180370946A1 (en) | 2015-11-17 | 2018-12-27 | Dow Agrosciences Llc | 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation |
| KR102240920B1 (ko) | 2015-12-30 | 2021-04-16 | 브이피에스-3, 엘엘씨 | 금속 효소 억제 화합물 |
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2016
- 2016-09-16 JP JP2018514436A patent/JP6847458B2/ja active Active
- 2016-09-16 BR BR112018005194-2A patent/BR112018005194B1/pt not_active IP Right Cessation
- 2016-09-16 CN CN201680066541.1A patent/CN108347949B/zh not_active Expired - Fee Related
- 2016-09-16 AU AU2016323767A patent/AU2016323767B2/en active Active
- 2016-09-16 EP EP16847471.6A patent/EP3349753A4/en not_active Withdrawn
- 2016-09-16 HK HK19101335.1A patent/HK1258863A1/zh unknown
- 2016-09-16 MX MX2018003284A patent/MX2018003284A/es unknown
- 2016-09-16 WO PCT/US2016/052300 patent/WO2017049196A1/en not_active Ceased
- 2016-09-16 KR KR1020187010879A patent/KR20180052755A/ko not_active Ceased
- 2016-09-16 EA EA201890522A patent/EA038214B1/ru unknown
- 2016-09-16 EA EA201890752A patent/EA036098B1/ru not_active IP Right Cessation
- 2016-09-16 WO PCT/US2016/052128 patent/WO2017049080A1/en not_active Ceased
- 2016-09-16 HK HK19101334.2A patent/HK1258862A1/zh unknown
- 2016-09-16 US US15/760,812 patent/US10513505B2/en active Active
- 2016-09-16 CA CA2998805A patent/CA2998805C/en active Active
- 2016-09-16 AU AU2016323782A patent/AU2016323782B2/en not_active Ceased
- 2016-09-16 ES ES16847394T patent/ES2821021T3/es active Active
- 2016-09-16 PL PL16847379T patent/PL3349586T3/pl unknown
- 2016-09-16 US US15/760,917 patent/US10308632B2/en active Active
- 2016-09-16 JP JP2018513579A patent/JP6887993B2/ja not_active Expired - Fee Related
- 2016-09-16 CN CN201680061980.3A patent/CN108289457B/zh active Active
- 2016-09-16 KR KR1020187010880A patent/KR102798709B1/ko active Active
- 2016-09-16 US US15/760,738 patent/US10464921B2/en active Active
- 2016-09-16 EA EA201890751A patent/EA037521B1/ru not_active IP Right Cessation
- 2016-09-16 CN CN201680066558.7A patent/CN108348511A/zh active Pending
- 2016-09-16 WO PCT/US2016/052151 patent/WO2017049096A1/en not_active Ceased
- 2016-09-16 EP EP16847379.1A patent/EP3349586B1/en active Active
- 2016-09-16 HU HUE16847379A patent/HUE053638T2/hu unknown
- 2016-09-16 CA CA2998808A patent/CA2998808A1/en active Pending
- 2016-09-16 ES ES16847379T patent/ES2858314T3/es active Active
- 2016-09-16 AU AU2016324148A patent/AU2016324148B2/en not_active Ceased
- 2016-09-16 BR BR112018005198-5A patent/BR112018005198A2/pt not_active Application Discontinuation
- 2016-09-16 KR KR1020187010867A patent/KR20180053393A/ko not_active Ceased
- 2016-09-16 JP JP2018513603A patent/JP2018532719A/ja active Pending
- 2016-09-16 MX MX2018003357A patent/MX391538B/es unknown
- 2016-09-16 MX MX2018003280A patent/MX391539B/es unknown
- 2016-09-16 CA CA2998807A patent/CA2998807A1/en active Pending
- 2016-09-16 HK HK18115458.3A patent/HK1263287A1/zh unknown
- 2016-09-16 EP EP16847394.0A patent/EP3349587B1/en active Active
- 2016-09-19 TW TW105130167A patent/TWI730986B/zh not_active IP Right Cessation
- 2016-09-19 TW TW105130166A patent/TWI723047B/zh active
- 2016-09-19 TW TW105130165A patent/TWI766842B/zh not_active IP Right Cessation
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2018
- 2018-02-28 ZA ZA2018/01404A patent/ZA201801404B/en unknown
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2019
- 2019-07-01 US US16/458,252 patent/US10836740B2/en active Active
-
2021
- 2021-05-18 JP JP2021083727A patent/JP2021121606A/ja active Pending
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