JP2014516968A5 - - Google Patents
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- Publication number
- JP2014516968A5 JP2014516968A5 JP2014511589A JP2014511589A JP2014516968A5 JP 2014516968 A5 JP2014516968 A5 JP 2014516968A5 JP 2014511589 A JP2014511589 A JP 2014511589A JP 2014511589 A JP2014511589 A JP 2014511589A JP 2014516968 A5 JP2014516968 A5 JP 2014516968A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- salt
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(*)NP(COCc1ccccc1)(Oc1ccccc1)=O Chemical compound CC(*)NP(COCc1ccccc1)(Oc1ccccc1)=O 0.000 description 4
- RRUSGPITJKSLPR-UHFFFAOYSA-N CC(NC(COC)(C[O]=C)O)[Mn] Chemical compound CC(NC(COC)(C[O]=C)O)[Mn] RRUSGPITJKSLPR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488133P | 2011-05-19 | 2011-05-19 | |
| US61/488,133 | 2011-05-19 | ||
| PCT/US2012/038615 WO2012159047A1 (en) | 2011-05-19 | 2012-05-18 | Processes and intermediates for preparing anti-hiv agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016005955A Division JP6282295B2 (ja) | 2011-05-19 | 2016-01-15 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014516968A JP2014516968A (ja) | 2014-07-17 |
| JP2014516968A5 true JP2014516968A5 (https=) | 2015-07-02 |
| JP5951757B2 JP5951757B2 (ja) | 2016-07-13 |
Family
ID=46208163
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511589A Active JP5951757B2 (ja) | 2011-05-19 | 2012-05-18 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2016005955A Active JP6282295B2 (ja) | 2011-05-19 | 2016-01-15 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2017019959A Active JP6621772B2 (ja) | 2011-05-19 | 2017-02-06 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2019017324A Pending JP2019089808A (ja) | 2011-05-19 | 2019-02-01 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016005955A Active JP6282295B2 (ja) | 2011-05-19 | 2016-01-15 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2017019959A Active JP6621772B2 (ja) | 2011-05-19 | 2017-02-06 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
| JP2019017324A Pending JP2019089808A (ja) | 2011-05-19 | 2019-02-01 | 抗ｈｉｖ剤を調製するためのプロセスおよび中間体 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8987437B2 (https=) |
| EP (3) | EP3199537B1 (https=) |
| JP (4) | JP5951757B2 (https=) |
| AR (1) | AR086492A1 (https=) |
| AU (4) | AU2012255029B2 (https=) |
| CA (1) | CA2835932C (https=) |
| ES (2) | ES2629913T3 (https=) |
| PT (2) | PT3199537T (https=) |
| TW (1) | TWI635093B (https=) |
| WO (1) | WO2012159047A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI635093B (zh) | 2011-05-19 | 2018-09-11 | 基利科學股份有限公司 | 用於製備抗ｈｉｖ藥劑的方法與中間物 |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| WO2018064071A1 (en) | 2016-09-27 | 2018-04-05 | Gilead Sciences, Inc. | Therapeutic compositions for treatment of human immunodeficiency virus |
| SI3661937T1 (sl) | 2017-08-01 | 2021-11-30 | Gilead Sciences, Inc. | Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| CN112175003B (zh) * | 2019-07-01 | 2022-02-15 | 上海医药工业研究院 | 一种苯基氢膦酸酯及其中间体的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US599431A (en) | 1898-02-22 | Clothes-wringer | ||
| GB835785A (en) * | 1956-04-30 | 1960-05-25 | Victor Chemical Works | Method of making diaryl phosphites |
| MX3898E (es) * | 1975-12-29 | 1981-09-10 | Monsanto Co | Procedimiento mejorado para la preparacion de triesteres de n-fosfonometilglicina |
| US4198355A (en) | 1977-03-28 | 1980-04-15 | Mobil Oil Corporation | Preparation of tertiary alkylphosphorodichloridite derivatives |
| US5459256A (en) * | 1987-04-17 | 1995-10-17 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Lipophilic, aminohydrolase-activated prodrugs |
| HU906976D0 (en) | 1989-11-13 | 1991-05-28 | Bristol Myers Squibb Co | Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues |
| US5672697A (en) * | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| US20020119443A1 (en) * | 2000-07-21 | 2002-08-29 | Gilead Sciences, Inc. | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
| WO2003091264A2 (en) | 2002-04-26 | 2003-11-06 | Gilead Sciences, Inc. | Non nucleoside reverse transcriptase inhibitors |
| EA014685B1 (ru) * | 2003-04-25 | 2010-12-30 | Джилид Сайэнс, Инк. | Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе |
| JP2010535701A (ja) * | 2003-04-25 | 2010-11-25 | ギリアード サイエンシーズ， インコーポレイテッド | 抗癌ホスホネートアナログ |
| RS51974B (sr) * | 2004-07-16 | 2012-02-29 | Gilead Sciences Inc. | Antivirusna jedinjenja |
| AU2005330489B2 (en) | 2004-07-27 | 2011-08-25 | Gilead Sciences, Inc. | Nucleoside phosphonate conjugates as anti HIV agents |
| EP1906971A2 (en) | 2005-07-27 | 2008-04-09 | Gilead Sciences, Inc. | Antiviral compounds |
| WO2007109005A2 (en) * | 2006-03-17 | 2007-09-27 | Invista Technologies S.A R.L. | Method for the purification of triorganophosphites by treatment with a basic additive |
| WO2008100447A2 (en) | 2007-02-09 | 2008-08-21 | Gilead Sciences, Inc. | Nucleoside analogs for antiviral treatment |
| US8658617B2 (en) * | 2008-07-08 | 2014-02-25 | Gilead Sciences, Inc. | Salts of HIV inhibitor compounds |
| US9790252B2 (en) * | 2009-07-01 | 2017-10-17 | Cornell University | 2-fluorinated riboses and arabinoses and methods of use and synthesis |
| TWI635093B (zh) | 2011-05-19 | 2018-09-11 | 基利科學股份有限公司 | 用於製備抗ｈｉｖ藥劑的方法與中間物 |
-
2012
- 2012-05-18 TW TW101117811A patent/TWI635093B/zh active
- 2012-05-18 ES ES12725570.1T patent/ES2629913T3/es active Active
- 2012-05-18 WO PCT/US2012/038615 patent/WO2012159047A1/en not_active Ceased
- 2012-05-18 PT PT16204289T patent/PT3199537T/pt unknown
- 2012-05-18 EP EP16204289.9A patent/EP3199537B1/en active Active
- 2012-05-18 ES ES16204289T patent/ES2700470T3/es active Active
- 2012-05-18 EP EP18200819.3A patent/EP3450438A1/en not_active Withdrawn
- 2012-05-18 EP EP12725570.1A patent/EP2710019B1/en active Active
- 2012-05-18 US US13/475,569 patent/US8987437B2/en active Active
- 2012-05-18 CA CA2835932A patent/CA2835932C/en active Active
- 2012-05-18 AU AU2012255029A patent/AU2012255029B2/en active Active
- 2012-05-18 JP JP2014511589A patent/JP5951757B2/ja active Active
- 2012-05-18 PT PT127255701T patent/PT2710019T/pt unknown
- 2012-05-18 AR ARP120101777A patent/AR086492A1/es unknown
-
2015
- 2015-02-05 US US14/615,357 patent/US9296779B2/en active Active
-
2016
- 2016-01-15 JP JP2016005955A patent/JP6282295B2/ja active Active
- 2016-02-17 US US15/046,399 patent/US9783567B2/en active Active
- 2016-07-26 AU AU2016208292A patent/AU2016208292B2/en active Active
-
2017
- 2017-02-06 JP JP2017019959A patent/JP6621772B2/ja active Active
- 2017-09-06 US US15/697,136 patent/US10196419B2/en active Active
-
2018
- 2018-02-01 AU AU2018200776A patent/AU2018200776B2/en active Active
- 2018-12-20 US US16/226,811 patent/US20190359644A1/en not_active Abandoned
-
2019
- 2019-02-01 JP JP2019017324A patent/JP2019089808A/ja active Pending
- 2019-09-09 AU AU2019226278A patent/AU2019226278A1/en not_active Abandoned
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