JP2018529687A5 - - Google Patents
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- Publication number
- JP2018529687A5 JP2018529687A5 JP2018514436A JP2018514436A JP2018529687A5 JP 2018529687 A5 JP2018529687 A5 JP 2018529687A5 JP 2018514436 A JP2018514436 A JP 2018514436A JP 2018514436 A JP2018514436 A JP 2018514436A JP 2018529687 A5 JP2018529687 A5 JP 2018529687A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- compound
- formula
- obtaining
- ketone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c(c(F)c1)ccc1F Chemical compound *c(c(F)c1)ccc1F 0.000 description 5
- CEPCPXLLFXPZGW-UHFFFAOYSA-N Nc(c(F)c1)ccc1F Chemical compound Nc(c(F)c1)ccc1F CEPCPXLLFXPZGW-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562220384P | 2015-09-18 | 2015-09-18 | |
| US62/220,384 | 2015-09-18 | ||
| US201662275504P | 2016-01-06 | 2016-01-06 | |
| US62/275,504 | 2016-01-06 | ||
| PCT/US2016/052128 WO2017049080A1 (en) | 2015-09-18 | 2016-09-16 | Antifungal compound process |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529687A JP2018529687A (ja) | 2018-10-11 |
| JP2018529687A5 true JP2018529687A5 (https=) | 2019-09-12 |
| JP6847458B2 JP6847458B2 (ja) | 2021-03-24 |
Family
ID=58289604
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514436A Active JP6847458B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物のプロセス |
| JP2018513603A Pending JP2018532719A (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物および作製方法 |
| JP2018513579A Expired - Fee Related JP6887993B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物調製方法 |
| JP2021083727A Pending JP2021121606A (ja) | 2015-09-18 | 2021-05-18 | 抗真菌化合物および作製方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513603A Pending JP2018532719A (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物および作製方法 |
| JP2018513579A Expired - Fee Related JP6887993B2 (ja) | 2015-09-18 | 2016-09-16 | 抗真菌化合物調製方法 |
| JP2021083727A Pending JP2021121606A (ja) | 2015-09-18 | 2021-05-18 | 抗真菌化合物および作製方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US10513505B2 (https=) |
| EP (3) | EP3349587B1 (https=) |
| JP (4) | JP6847458B2 (https=) |
| KR (3) | KR20180053393A (https=) |
| CN (3) | CN108289457B (https=) |
| AU (3) | AU2016323767B2 (https=) |
| BR (2) | BR112018005194B1 (https=) |
| CA (3) | CA2998808A1 (https=) |
| EA (3) | EA038214B1 (https=) |
| ES (2) | ES2858314T3 (https=) |
| HK (3) | HK1263287A1 (https=) |
| HU (1) | HUE053638T2 (https=) |
| MX (3) | MX391538B (https=) |
| PL (1) | PL3349586T3 (https=) |
| TW (3) | TWI723047B (https=) |
| WO (3) | WO2017049096A1 (https=) |
| ZA (1) | ZA201801404B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015143184A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| EP3119753B1 (en) | 2014-03-19 | 2020-11-04 | Dow AgroSciences LLC | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
| CN109970629B (zh) | 2014-03-19 | 2023-04-11 | 迈科维亚医药公司 | 抗真菌化合物的制备方法 |
| AU2015231216B2 (en) | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| KR102441243B1 (ko) | 2014-03-19 | 2022-09-07 | 브이피에스-3, 엘엘씨 | 2-(2,4-디플루오르페닐)-1,1-디플루오르-1-(5-치환된-피리딘-2-일)-3-(1h-테트라졸-1-일)프로판-2-올 및 이의 제조방법 |
| CA2942936A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| JP6606508B2 (ja) | 2014-03-19 | 2019-11-13 | マイコヴィア ファーマシューティカルズ，インコーポレイテッド | 抗真菌化合物の調製方法 |
| AU2015231275B2 (en) | 2014-03-19 | 2019-03-07 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| JP2017509646A (ja) | 2014-03-19 | 2017-04-06 | ヴィアメット ファーマスーティカルズ，インコーポレイテッド | 抗真菌化合物の調製方法 |
| CN108289457B (zh) | 2015-09-18 | 2021-08-06 | 迈科维亚医药公司 | 抗真菌化合物制备方法 |
| CN109666019B (zh) * | 2017-10-14 | 2021-04-06 | 朱允涛 | 一种氘代的氮唑醇类化合物及其制备方法和用途 |
| BR112020009446A2 (pt) | 2017-11-13 | 2020-11-03 | Bayer Aktiengesellschaft | derivados de tetrazólio propila e seu uso como fungicida |
| WO2021188404A1 (en) * | 2020-03-19 | 2021-09-23 | Assia Chemical Industries Ltd | Solid state forms of oteseconazole and process for preparation thereof |
| CN115448848A (zh) * | 2021-06-09 | 2022-12-09 | 苏州盛迪亚生物医药有限公司 | 一种抗真菌化合物制备方法 |
| US20240398773A1 (en) * | 2021-07-22 | 2024-12-05 | Mycovia Pharmaceuticals, Inc. | Compositions comprising oteseconazole |
| CN114573503B (zh) * | 2022-03-28 | 2024-04-09 | 浙江天宇药业股份有限公司 | 一种制备奥特康唑中间体的方法 |
| CN114573557B (zh) * | 2022-03-28 | 2024-03-08 | 浙江天宇药业股份有限公司 | 一种奥特康唑的制备方法 |
| CN116621816B (zh) * | 2022-09-23 | 2025-07-04 | 北京莱瑞森医药科技有限公司 | 一种伏立康唑对映异构对b的拆分方法 |
| TW202423418A (zh) * | 2022-09-30 | 2024-06-16 | 大陸商上海濟煜醫藥科技有限公司 | 雙環類化合物的無定形、結晶固體及其製備方法 |
| CN119798219B (zh) * | 2025-01-13 | 2025-07-18 | 长治医学院 | 一种奥特康唑的制备方法 |
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| DE2854015B2 (de) | 1978-12-14 | 1980-10-09 | Dynamit Nobel Ag, 5210 Troisdorf | Verfahren zur Herstellung von !H-TetrazoI-1-essigsauren und bestimmter Ester derselben |
| EP0069442B1 (en) | 1981-06-06 | 1985-02-20 | Pfizer Limited | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
| CS228931B2 (cs) | 1981-06-06 | 1984-05-14 | Pfizer | Způsob výroby 2-(2,4-difluorfenyl)-l,3-bis(lH-l,2,4-triazol-l-yl)propan- -2-oiu |
| GB8304282D0 (en) | 1983-02-16 | 1983-03-23 | Pfizer Ltd | Antifungal agents |
| US5087240A (en) | 1983-08-18 | 1992-02-11 | Drug Delivery Systems Inc. | Transdermal drug patch with conductive fibers |
| US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
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| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| GB8804164D0 (en) | 1988-02-23 | 1988-03-23 | Tucker J M | Bandage for administering physiologically active compound |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5088977A (en) | 1988-12-21 | 1992-02-18 | Drug Delivery Systems Inc. | Electrical transdermal drug applicator with counteractor and method of drug delivery |
| DK0431519T3 (da) | 1989-12-04 | 1994-07-04 | Searle & Co | System til transdermal indgivelse af albuterol |
| US5352456A (en) | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| DE69228827T2 (de) | 1991-12-18 | 1999-10-21 | Minnesota Mining And Mfg. Co., Saint Paul | Mehrschichtige sperrstrukturen |
| ATE132381T1 (de) | 1992-01-29 | 1996-01-15 | Voelkl Franz Ski | Ballspielschläger, insbesondere tennisschläger |
| JP2000344744A (ja) | 1999-06-04 | 2000-12-12 | Ss Pharmaceut Co Ltd | アセトフェノン誘導体およびその製法 |
| KR20040050906A (ko) * | 2001-10-08 | 2004-06-17 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 모션 추정을 위한 장치 및 방법 |
| JP2004359646A (ja) | 2003-06-09 | 2004-12-24 | Ss Pharmaceut Co Ltd | 抗真菌活性を有する新規アゾール誘導体 |
| US7241800B2 (en) * | 2004-03-17 | 2007-07-10 | Mai De Ltd. | Anhydrous amorphous form of fluvastatin sodium |
| US8198448B2 (en) | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| KR100889937B1 (ko) | 2007-08-06 | 2009-03-20 | 한미약품 주식회사 | 보리코나졸의 제조방법 |
| UA108596C2 (xx) * | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
| KR101109215B1 (ko) | 2009-06-17 | 2012-01-30 | 보령제약 주식회사 | 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법 |
| WO2010146113A1 (en) | 2009-06-18 | 2010-12-23 | Basf Se | Antifungal 1, 2, 4-triazolyl derivatives having a 5- sulfur substituent |
| AU2011242562B2 (en) | 2010-04-24 | 2016-10-13 | Mycovia Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| KR20140040235A (ko) | 2011-06-19 | 2014-04-02 | 비아멧 파마슈티컬즈, 인코포레이티드 | 금속효소 억제제 화합물 |
| AU2012273100B2 (en) | 2011-06-19 | 2017-05-25 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| US8940735B2 (en) | 2011-06-23 | 2015-01-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| TW201329025A (zh) | 2011-11-01 | 2013-07-16 | Astex Therapeutics Ltd | 醫藥化合物 |
| IN2014MN01378A (https=) | 2011-12-11 | 2015-07-03 | Viamet Pharmaceuticals Inc | |
| WO2013109998A1 (en) | 2012-01-20 | 2013-07-25 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| US9414596B2 (en) | 2012-01-20 | 2016-08-16 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| KR20210033067A (ko) * | 2012-06-04 | 2021-03-25 | 파마싸이클릭스 엘엘씨 | 브루톤 타이로신 키나아제 저해제의 결정 형태 |
| KR20140012226A (ko) * | 2012-07-18 | 2014-02-03 | 엘지전자 주식회사 | 태양전지 모듈 |
| US20150246898A1 (en) | 2012-09-12 | 2015-09-03 | Dow Agrosciences Llc | Metalloenzyme inhibitor compounds |
| AU2014209107B2 (en) | 2013-01-28 | 2018-04-12 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| WO2014165861A1 (en) | 2013-04-05 | 2014-10-09 | The Regents Of The University Of California | Metal-catalyzed coupling of aryl and vinyl halides with alpha, alpha-difluorocarbonyl compounds |
| US9447073B2 (en) | 2013-05-28 | 2016-09-20 | Viamet Pharmaceuticals, Inc. | Fungicidal compositions |
| AU2014278172B2 (en) * | 2013-06-12 | 2018-08-09 | Mycovia Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| JP2017509646A (ja) | 2014-03-19 | 2017-04-06 | ヴィアメット ファーマスーティカルズ，インコーポレイテッド | 抗真菌化合物の調製方法 |
| US9802914B2 (en) | 2014-03-19 | 2017-10-31 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942936A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| EP3119753B1 (en) | 2014-03-19 | 2020-11-04 | Dow AgroSciences LLC | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
| AU2015231216B2 (en) | 2014-03-19 | 2019-04-04 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| CN109970629B (zh) * | 2014-03-19 | 2023-04-11 | 迈科维亚医药公司 | 抗真菌化合物的制备方法 |
| WO2015143184A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| KR102441243B1 (ko) | 2014-03-19 | 2022-09-07 | 브이피에스-3, 엘엘씨 | 2-(2,4-디플루오르페닐)-1,1-디플루오르-1-(5-치환된-피리딘-2-일)-3-(1h-테트라졸-1-일)프로판-2-올 및 이의 제조방법 |
| AU2015231275B2 (en) | 2014-03-19 | 2019-03-07 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| JP6606508B2 (ja) | 2014-03-19 | 2019-11-13 | マイコヴィア ファーマシューティカルズ，インコーポレイテッド | 抗真菌化合物の調製方法 |
| KR102603277B1 (ko) | 2015-03-19 | 2023-11-17 | 마이코비아 파마슈티컬즈, 인코포레이티드 | 항진균성 화합물 및 이의 제조 방법 |
| CR20170574A (es) | 2015-05-18 | 2018-07-19 | Viamet Pharmaceuticals Inc | Compuestos antifíngicos |
| CN108289457B (zh) | 2015-09-18 | 2021-08-06 | 迈科维亚医药公司 | 抗真菌化合物制备方法 |
| EP3377480A4 (en) | 2015-11-17 | 2019-04-10 | Dow AgroSciences LLC | 4 - ((6- (2,4-DIFLUROPHENYL) -1,1-difluoro-2-hydroxy-3- (1H-1,2,4-triazol-1-YL) PROPYL) PYRIDINE-3-YL) OXY ) BENZONITRILE AND METHOD OF PREPARING THEREOF |
| TWI679198B (zh) | 2015-11-17 | 2019-12-11 | 美商陶氏益農有限責任公司 | 製備４-（（６-（２-（２，４-二氟苯基）-１，１-二氟-２-羥基-３-（１ｈ-１，２，４-三唑-１-基）丙基）吡啶-３-基）氧基）苄腈之方法 |
| AR106729A1 (es) | 2015-11-17 | 2018-02-14 | Viamet Pharmaceuticals Inc | 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación |
| EP3377475A4 (en) | 2015-11-17 | 2019-04-10 | Dow Agrosciences Llc | 4 - ((6-2- (2,4-difluorophenyl) -1,1-difluoro-2-hydroxy-3- (1H-1,2,4-triazol-1-YL) PROPYL) PYRIDINE-3-YL ) OXY) BENZONITRIL AND METHOD OF PREPARING THEREOF |
| EA038421B1 (ru) | 2015-12-30 | 2021-08-26 | ВиПиЭс-3, ИНК. | Соединения, ингибирующие металлоферменты |
-
2016
- 2016-09-16 CN CN201680061980.3A patent/CN108289457B/zh active Active
- 2016-09-16 BR BR112018005194-2A patent/BR112018005194B1/pt not_active IP Right Cessation
- 2016-09-16 EP EP16847394.0A patent/EP3349587B1/en active Active
- 2016-09-16 PL PL16847379T patent/PL3349586T3/pl unknown
- 2016-09-16 AU AU2016323767A patent/AU2016323767B2/en active Active
- 2016-09-16 EP EP16847471.6A patent/EP3349753A4/en not_active Withdrawn
- 2016-09-16 JP JP2018514436A patent/JP6847458B2/ja active Active
- 2016-09-16 ES ES16847379T patent/ES2858314T3/es active Active
- 2016-09-16 CA CA2998808A patent/CA2998808A1/en active Pending
- 2016-09-16 WO PCT/US2016/052151 patent/WO2017049096A1/en not_active Ceased
- 2016-09-16 KR KR1020187010867A patent/KR20180053393A/ko not_active Ceased
- 2016-09-16 BR BR112018005198-5A patent/BR112018005198A2/pt not_active Application Discontinuation
- 2016-09-16 KR KR1020187010879A patent/KR20180052755A/ko not_active Ceased
- 2016-09-16 EA EA201890522A patent/EA038214B1/ru unknown
- 2016-09-16 US US15/760,812 patent/US10513505B2/en active Active
- 2016-09-16 CA CA2998807A patent/CA2998807A1/en active Pending
- 2016-09-16 MX MX2018003357A patent/MX391538B/es unknown
- 2016-09-16 WO PCT/US2016/052128 patent/WO2017049080A1/en not_active Ceased
- 2016-09-16 JP JP2018513603A patent/JP2018532719A/ja active Pending
- 2016-09-16 AU AU2016323782A patent/AU2016323782B2/en not_active Ceased
- 2016-09-16 KR KR1020187010880A patent/KR102798709B1/ko active Active
- 2016-09-16 CA CA2998805A patent/CA2998805C/en active Active
- 2016-09-16 EP EP16847379.1A patent/EP3349586B1/en active Active
- 2016-09-16 US US15/760,738 patent/US10464921B2/en active Active
- 2016-09-16 EA EA201890751A patent/EA037521B1/ru not_active IP Right Cessation
- 2016-09-16 WO PCT/US2016/052300 patent/WO2017049196A1/en not_active Ceased
- 2016-09-16 CN CN201680066558.7A patent/CN108348511A/zh active Pending
- 2016-09-16 HU HUE16847379A patent/HUE053638T2/hu unknown
- 2016-09-16 AU AU2016324148A patent/AU2016324148B2/en not_active Ceased
- 2016-09-16 MX MX2018003280A patent/MX391539B/es unknown
- 2016-09-16 ES ES16847394T patent/ES2821021T3/es active Active
- 2016-09-16 HK HK18115458.3A patent/HK1263287A1/zh unknown
- 2016-09-16 HK HK19101335.1A patent/HK1258863A1/zh unknown
- 2016-09-16 US US15/760,917 patent/US10308632B2/en active Active
- 2016-09-16 MX MX2018003284A patent/MX2018003284A/es unknown
- 2016-09-16 CN CN201680066541.1A patent/CN108347949B/zh not_active Expired - Fee Related
- 2016-09-16 EA EA201890752A patent/EA036098B1/ru not_active IP Right Cessation
- 2016-09-16 JP JP2018513579A patent/JP6887993B2/ja not_active Expired - Fee Related
- 2016-09-16 HK HK19101334.2A patent/HK1258862A1/zh unknown
- 2016-09-19 TW TW105130166A patent/TWI723047B/zh active
- 2016-09-19 TW TW105130165A patent/TWI766842B/zh not_active IP Right Cessation
- 2016-09-19 TW TW105130167A patent/TWI730986B/zh not_active IP Right Cessation
-
2018
- 2018-02-28 ZA ZA2018/01404A patent/ZA201801404B/en unknown
-
2019
- 2019-07-01 US US16/458,252 patent/US10836740B2/en active Active
-
2021
- 2021-05-18 JP JP2021083727A patent/JP2021121606A/ja active Pending
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