|
US4099012A
(en)
|
1975-08-28 |
1978-07-04 |
Ciba-Geigy Corporation |
2-pyrazolyl-benzophenones
|
|
US4481142A
(en)
|
1979-02-07 |
1984-11-06 |
Hoffmann-La Roche Inc. |
Pyrimido-2-benzazepines
|
|
FR2450833A1
(fr)
|
1979-02-07 |
1980-10-03 |
Hoffmann La Roche |
Derives de benzazepine
|
|
US4469633A
(en)
|
1980-05-16 |
1984-09-04 |
Hoffmann-La Roche Inc. |
N-oxides of 5-oxo-1-phenyl-2-benzazepines
|
|
EP0273697A3
(en)
|
1986-12-30 |
1989-11-29 |
Merck & Co. Inc. |
2-benzazepines with 5- and 6- membered heterocyclic rings
|
|
US5166151A
(en)
|
1988-03-25 |
1992-11-24 |
Merck & Co., Inc. |
2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
|
|
US5210082A
(en)
|
1991-05-16 |
1993-05-11 |
Merck & Co., Inc. |
2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
CN1084747C
(zh)
|
1996-03-08 |
2002-05-15 |
曾尼卡有限公司 |
作为神经活性剂的吡咯并苯并氮杂䓬衍生物
|
|
JP2001507349A
(ja)
|
1996-12-23 |
2001-06-05 |
セルテック セラピューティックス リミテッド |
縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
|
|
GB9713087D0
(en)
|
1997-06-20 |
1997-08-27 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
CN1155599C
(zh)
|
1997-09-29 |
2004-06-30 |
明治制果株式会社 |
三环三唑并苯并氮杂�衍生物、用于制备该衍生物的方法和抗变态反应剂
|
|
US6277844B1
(en)
|
1998-09-14 |
2001-08-21 |
Sydney Spector |
Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
|
|
US6417207B1
(en)
|
1999-05-12 |
2002-07-09 |
Nitromed, Inc. |
Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
|
|
HUP0400639A3
(en)
|
2000-12-21 |
2010-03-29 |
Vertex Pharma |
Pyrazole compounds useful as protein kinase inhibitors and pharmaceutical compositions containing them
|
|
US6686352B2
(en)
|
2001-05-18 |
2004-02-03 |
Hoffmann-La Roche Inc. |
Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
|
|
BR0211729A
(pt)
|
2001-08-09 |
2004-08-24 |
Actelion Pharmaceuticals Ltd |
Compostos, composições farmacêuticas, processo para fabricar compostos, uso de um ou mais compostos, e, processo para fabricar composições farmacêuticas
|
|
MY141867A
(en)
|
2002-06-20 |
2010-07-16 |
Vertex Pharma |
Substituted pyrimidines useful as protein kinase inhibitors
|
|
GB0226583D0
(en)
|
2002-11-14 |
2002-12-18 |
Cyclacel Ltd |
Compounds
|
|
PT1578755E
(pt)
|
2002-12-24 |
2007-10-19 |
Astrazeneca Ab |
Derivados de fosfonooxiquinazolina e sua utilização farmacêutica
|
|
US20060264493A1
(en)
|
2003-02-17 |
2006-11-23 |
Ermes Vanotti |
Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
TWI372050B
(en)
|
2003-07-03 |
2012-09-11 |
Astex Therapeutics Ltd |
(morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
|
|
GB0315657D0
(en)
|
2003-07-03 |
2003-08-13 |
Astex Technology Ltd |
Pharmaceutical compounds
|
|
US7141568B2
(en)
|
2003-07-09 |
2006-11-28 |
Pfizer Italia S.R.L. |
Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
|
|
DK1663242T3
(da)
|
2003-08-07 |
2011-08-01 |
Rigel Pharmaceuticals Inc |
2,4-Pyrimidindiamin-forbindelser og anvendelse som antiproliferative midler
|
|
CN1897950A
(zh)
|
2003-10-14 |
2007-01-17 |
惠氏公司 |
稠合芳基和杂芳基衍生物及其使用方法
|
|
ES2299080T3
(es)
|
2004-05-14 |
2008-05-16 |
Millennium Pharmaceuticals, Inc. |
Compuestos y metodos para inhibir la progresion mitotica mediante la inhibicion de quinasas aurora.
|
|
JP4812763B2
(ja)
|
2004-05-18 |
2011-11-09 |
ライジェル ファーマシューティカルズ， インコーポレイテッド |
シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途
|
|
JP2008505167A
(ja)
|
2004-07-05 |
2008-02-21 |
アステックス、セラピューティックス、リミテッド |
医薬組成物
|
|
ATE485300T1
(de)
|
2004-07-16 |
2010-11-15 |
Sunesis Pharmaceuticals Inc |
Als aurora-kinase-inhibitoren nutzbare thienopyrimidine
|
|
DK1812581T3
(da)
|
2004-11-15 |
2009-05-11 |
Rigel Pharmaceuticals Inc |
Fremgangsmåde til fremstilling af optisk aktive N-carbamat-beskyttede beta-lactamer ved optisk oplösning under anvendelse af en candida antarctica lipase
|
|
GB2420559B
(en)
|
2004-11-15 |
2008-08-06 |
Rigel Pharmaceuticals Inc |
Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
|
|
WO2006055831A2
(en)
|
2004-11-17 |
2006-05-26 |
Miikana Therapeutics, Inc. |
Kinase inhibitors
|
|
US8110573B2
(en)
|
2004-12-30 |
2012-02-07 |
Astex Therapeutics Limited |
Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases
|
|
US20080312223A1
(en)
|
2004-12-30 |
2008-12-18 |
Astex Therapeutics Limited |
Thiazole And Isothiazole Derivatives That Modulate The Activity Of CDK, GSK And Aurora Kinases
|
|
US20100160324A1
(en)
|
2004-12-30 |
2010-06-24 |
Astex Therapeutics Limited |
Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
|
|
WO2006070202A1
(en)
|
2004-12-30 |
2006-07-06 |
Astex Therapeutics Limited |
Pyrazole derivatives having kinase modulating activity
|
|
US7485661B2
(en)
|
2005-01-18 |
2009-02-03 |
Pfizer Italia S.R.L. |
Heterobicyclic pyrazole derivatives as kinase inhibitors
|
|
ES2535854T3
(es)
|
2005-09-30 |
2015-05-18 |
Miikana Therapeutics, Inc. |
Compuestos de pirazol sustituidos
|
|
CN101316597B
(zh)
|
2005-11-03 |
2013-04-17 |
顶点医药品公司 |
用作激酶抑制剂的氨基嘧啶
|
|
SI1962830T1
(sl)
|
2005-12-23 |
2013-07-31 |
Glaxosmithkline Llc |
Azaindolni inhibitorji kinaz Aurora
|
|
TW200808311A
(en)
|
2006-03-30 |
2008-02-16 |
Nerviano Medical Sciences Srl |
Use of a kinase inhibitor for the treatment of particular resistant tumors
|
|
WO2007129062A1
(en)
|
2006-05-08 |
2007-11-15 |
Astex Therapeutics Limited |
Pharmaceutical combinations of diazole derivatives for cancer treatment
|
|
WO2007132221A1
(en)
|
2006-05-12 |
2007-11-22 |
Cyclacel Limited |
Combined anticancer pyrimidine-thiazole aurora kinase inhibitors
|
|
WO2007132220A1
(en)
|
2006-05-12 |
2007-11-22 |
Cyclacel Limited |
Combination of a 2-substituted-4-heter0aryl-pyrimidine amine with a cytotoxic drug and use thereof in the treatment of a proliferative disorder
|
|
GB0609530D0
(en)
|
2006-05-12 |
2006-06-21 |
Cyclacel Ltd |
Combination
|
|
EP2054413A2
(en)
|
2006-08-09 |
2009-05-06 |
Millennium Pharmaceuticals, Inc. |
Pyridobenzazepine compounds and methods for inhibiting mitotic progression
|
|
CL2007003244A1
(es)
|
2006-11-16 |
2008-04-04 |
Millennium Pharm Inc |
Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
|
|
WO2009114703A2
(en)
|
2008-03-12 |
2009-09-17 |
Fox Chase Cancer Center |
Combination therapy for the treatment of cancer
|
|
JO3635B1
(ar)
|
2009-05-18 |
2020-08-27 |
Millennium Pharm Inc |
مركبات صيدلانية صلبة وطرق لانتاجها
|
|
JO3434B1
(ar)
|
2009-07-31 |
2019-10-20 |
Millennium Pharm Inc |
مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
|
|
US8653064B2
(en)
|
2010-02-19 |
2014-02-18 |
Millennium Pharmaceuticals, Inc. |
Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-D][2]benzazepin-2-yl]amino}-2-methoxybenzoate
|
|
UY34114A
(es)
*
|
2011-06-03 |
2013-01-03 |
Millennium Pharm Inc |
Combinación de inhibidores de mek e inhibidores selectivos de la quiinasa aurora a
|
|
JP2018524292A
(ja)
|
2015-07-21 |
2018-08-30 |
ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
オーロラキナーゼインヒビターと化学療法剤の投与
|