JP2016522826A5 - - Google Patents

Info

Publication number

JP2016522826A5

JP2016522826A5 JP2016514042A JP2016514042A JP2016522826A5 JP 2016522826 A5 JP2016522826 A5 JP 2016522826A5 JP 2016514042 A JP2016514042 A JP 2016514042A JP 2016514042 A JP2016514042 A JP 2016514042A JP 2016522826 A5 JP2016522826 A5 JP 2016522826A5

Authority

JP

Japan

Prior art keywords

cancer

pharmaceutically acceptable

acceptable salt

hydroxycyclopentyl

ylamino

Prior art date

2014-05-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000003839 salts Chemical class 0.000 claims description 33
• 238000000034 method Methods 0.000 claims description 30
• 206010028980 Neoplasm Diseases 0.000 claims description 26
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 18
• 201000005202 lung cancer Diseases 0.000 claims description 18
• 208000020816 lung neoplasm Diseases 0.000 claims description 18
• -1 4-((1S) -2,3-dihydro-1H-inden-1-ylamino) -7H-pyrrolo [2,3-d] pyrimidin-7-yl Chemical group 0.000 claims description 16
• 201000010536 head and neck cancer Diseases 0.000 claims description 16
• 208000014829 head and neck neoplasm Diseases 0.000 claims description 16
• FIYXUOWXHWJDAM-UHFFFAOYSA-N methyl sulfamate Chemical compound COS(N)(=O)=O FIYXUOWXHWJDAM-UHFFFAOYSA-N 0.000 claims description 16
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 14
• 229940123237 Taxane Drugs 0.000 claims description 11
• MPUQHZXIXSTTDU-QXGSTGNESA-N sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7-pyrrolo[2,3-d]pyrimidinyl]-2-hydroxycyclopentyl]methyl ester Chemical compound C1[C@H](O)[C@H](COS(=O)(=O)N)C[C@H]1N1C2=NC=NC(N[C@@H]3C4=CC=CC=C4CC3)=C2C=C1 MPUQHZXIXSTTDU-QXGSTGNESA-N 0.000 claims description 10
• 206010005003 Bladder cancer Diseases 0.000 claims description 9
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 9
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 9
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 9
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 9
• 201000004101 esophageal cancer Diseases 0.000 claims description 9
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 9
• 201000002528 pancreatic cancer Diseases 0.000 claims description 9
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 9
• 201000005112 urinary bladder cancer Diseases 0.000 claims description 9
• 206010006187 Breast cancer Diseases 0.000 claims description 8
• 208000026310 Breast neoplasm Diseases 0.000 claims description 8
• 206010009944 Colon cancer Diseases 0.000 claims description 8
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 8
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 8
• 229960004562 carboplatin Drugs 0.000 claims description 8
• 208000029742 colonic neoplasm Diseases 0.000 claims description 8
• 229960003668 docetaxel Drugs 0.000 claims description 8
• 229960001592 paclitaxel Drugs 0.000 claims description 8
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 8
• 239000003814 drug Substances 0.000 claims description 7
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 7
• 229930012538 Paclitaxel Natural products 0.000 claims description 6
• 229960004316 cisplatin Drugs 0.000 claims description 4
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 4
• 108010058566 130-nm albumin-bound paclitaxel Proteins 0.000 claims description 2
• KLNFSAOEKUDMFA-UHFFFAOYSA-N azanide;2-hydroxyacetic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OCC(O)=O KLNFSAOEKUDMFA-UHFFFAOYSA-N 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 229950007221 nedaplatin Drugs 0.000 claims description 2
• 229960001756 oxaliplatin Drugs 0.000 claims description 2
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 2
• 229950005566 picoplatin Drugs 0.000 claims description 2
• IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 claims description 2
• 229960005399 satraplatin Drugs 0.000 claims description 2
• 190014017285 satraplatin Chemical compound 0.000 claims description 2
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
• 210000000481 breast Anatomy 0.000 claims 1
• 210000001072 colon Anatomy 0.000 claims 1
• 210000004072 lung Anatomy 0.000 claims 1
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 6
• 229960005277 gemcitabine Drugs 0.000 description 6
• 239000002246 antineoplastic agent Substances 0.000 description 1
• 201000011510 cancer Diseases 0.000 description 1
• 229940127089 cytotoxic agent Drugs 0.000 description 1
• 239000003112 inhibitor Substances 0.000 description 1