JP2020520385A5 - - Google Patents

Info

Publication number

JP2020520385A5

JP2020520385A5 JP2020514327A JP2020514327A JP2020520385A5 JP 2020520385 A5 JP2020520385 A5 JP 2020520385A5 JP 2020514327 A JP2020514327 A JP 2020514327A JP 2020514327 A JP2020514327 A JP 2020514327A JP 2020520385 A5 JP2020520385 A5 JP 2020520385A5

Authority

JP

Japan

Prior art keywords

cancer

compound

paclitaxel

combination

carboplatin

Prior art date

2018-05-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 40
• 206010028980 Neoplasm Diseases 0.000 claims 27
• 201000011510 cancer Diseases 0.000 claims 27
• 229960001592 paclitaxel Drugs 0.000 claims 21
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 21
• 229930012538 Paclitaxel Natural products 0.000 claims 19
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 14
• 229960004562 carboplatin Drugs 0.000 claims 14
• 239000003795 chemical substances by application Substances 0.000 claims 14
• 206010014733 Endometrial cancer Diseases 0.000 claims 9
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 9
• 229960004316 cisplatin Drugs 0.000 claims 9
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 9
• 229960005277 gemcitabine Drugs 0.000 claims 8
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 8
• 201000005249 lung adenocarcinoma Diseases 0.000 claims 6
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 5
• 229960003668 docetaxel Drugs 0.000 claims 5
• 206010006187 Breast cancer Diseases 0.000 claims 4
• 208000026310 Breast neoplasm Diseases 0.000 claims 4
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
• 239000002246 antineoplastic agent Substances 0.000 claims 4
• 208000006990 cholangiocarcinoma Diseases 0.000 claims 4
• 229940127089 cytotoxic agent Drugs 0.000 claims 4
• 201000005202 lung cancer Diseases 0.000 claims 4
• 208000020816 lung neoplasm Diseases 0.000 claims 4
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 4
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
• 201000002528 pancreatic cancer Diseases 0.000 claims 4
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 4
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
• 206010029260 Neuroblastoma Diseases 0.000 claims 3
• 229940079593 drug Drugs 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 206010041823 squamous cell carcinoma Diseases 0.000 claims 3
• 108010058566 130-nm albumin-bound paclitaxel Proteins 0.000 claims 2
• AFDSETGKYZMEEA-HZJYTTRNSA-N 2-hydroxylinoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCC(O)C(O)=O AFDSETGKYZMEEA-HZJYTTRNSA-N 0.000 claims 2
• 229940125664 ABTL0812 Drugs 0.000 claims 2
• 206010004593 Bile duct cancer Diseases 0.000 claims 2
• 201000009030 Carcinoma Diseases 0.000 claims 2
• 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
• 208000026900 bile duct neoplasm Diseases 0.000 claims 2
• 208000037828 epithelial carcinoma Diseases 0.000 claims 2
• 208000005017 glioblastoma Diseases 0.000 claims 2
• 238000001802 infusion Methods 0.000 claims 2
• 239000003978 infusion fluid Substances 0.000 claims 2
• QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims 2
• 229960005079 pemetrexed Drugs 0.000 claims 2
• 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
• 206010041067 Small cell lung cancer Diseases 0.000 claims 1
• 208000009956 adenocarcinoma Diseases 0.000 claims 1
• 201000010536 head and neck cancer Diseases 0.000 claims 1
• 208000014829 head and neck neoplasm Diseases 0.000 claims 1
• 229960001756 oxaliplatin Drugs 0.000 claims 1
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
• 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
• 159000000000 sodium salts Chemical class 0.000 claims 1
• 229960000303 topotecan Drugs 0.000 claims 1
• UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1