JP2010520289A5 - - Google Patents

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Publication number
JP2010520289A5
JP2010520289A5 JP2009552757A JP2009552757A JP2010520289A5 JP 2010520289 A5 JP2010520289 A5 JP 2010520289A5 JP 2009552757 A JP2009552757 A JP 2009552757A JP 2009552757 A JP2009552757 A JP 2009552757A JP 2010520289 A5 JP2010520289 A5 JP 2010520289A5
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JP
Japan
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composition
cancer
item
therapy
rapamycin
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JP2009552757A
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English (en)
Japanese (ja)
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JP2010520289A (ja
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Priority claimed from PCT/US2008/003096 external-priority patent/WO2008109163A1/en
Publication of JP2010520289A publication Critical patent/JP2010520289A/ja
Publication of JP2010520289A5 publication Critical patent/JP2010520289A5/ja
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JP2009552757A 2007-03-07 2008-03-07 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子 Withdrawn JP2010520289A (ja)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US90578707P 2007-03-07 2007-03-07
US90576707P 2007-03-07 2007-03-07
US90566907P 2007-03-07 2007-03-07
US90573407P 2007-03-07 2007-03-07
US90566307P 2007-03-07 2007-03-07
US90575007P 2007-03-07 2007-03-07
US90573507P 2007-03-07 2007-03-07
US90567207P 2007-03-07 2007-03-07
US90566207P 2007-03-07 2007-03-07
US92324807P 2007-04-13 2007-04-13
US92345607P 2007-04-13 2007-04-13
PCT/US2008/003096 WO2008109163A1 (en) 2007-03-07 2008-03-07 Nanoparticle comprising rapamycin and albumin as anticancer agent

Related Child Applications (1)

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JP2013223132A Division JP6348698B2 (ja) 2007-03-07 2013-10-28 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子

Publications (2)

Publication Number Publication Date
JP2010520289A JP2010520289A (ja) 2010-06-10
JP2010520289A5 true JP2010520289A5 (enExample) 2011-04-28

Family

ID=39562000

Family Applications (6)

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JP2009552757A Withdrawn JP2010520289A (ja) 2007-03-07 2008-03-07 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子
JP2013223132A Active JP6348698B2 (ja) 2007-03-07 2013-10-28 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子
JP2015202611A Withdrawn JP2016011309A (ja) 2007-03-07 2015-10-14 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子
JP2017093894A Active JP6544812B2 (ja) 2007-03-07 2017-05-10 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子
JP2018127659A Pending JP2018150381A (ja) 2007-03-07 2018-07-04 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子
JP2019185794A Pending JP2020002177A (ja) 2007-03-07 2019-10-09 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子

Family Applications After (5)

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JP2013223132A Active JP6348698B2 (ja) 2007-03-07 2013-10-28 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子
JP2015202611A Withdrawn JP2016011309A (ja) 2007-03-07 2015-10-14 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子
JP2017093894A Active JP6544812B2 (ja) 2007-03-07 2017-05-10 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子
JP2018127659A Pending JP2018150381A (ja) 2007-03-07 2018-07-04 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子
JP2019185794A Pending JP2020002177A (ja) 2007-03-07 2019-10-09 抗癌剤としてラパマイシンおよびアルブミンを含むナノ粒子

Country Status (24)

Country Link
US (7) US8911786B2 (enExample)
EP (4) EP3417859A1 (enExample)
JP (6) JP2010520289A (enExample)
KR (5) KR101943230B1 (enExample)
CN (1) CN104814930B (enExample)
AU (1) AU2008223334B2 (enExample)
BR (1) BRPI0808635B1 (enExample)
CA (3) CA2680207C (enExample)
CY (3) CY1120555T1 (enExample)
DK (3) DK2481409T3 (enExample)
ES (3) ES2686150T3 (enExample)
HR (3) HRP20181159T1 (enExample)
HU (3) HUE039643T2 (enExample)
IL (2) IL200755A (enExample)
LT (3) LT2481402T (enExample)
MX (2) MX2009009537A (enExample)
NZ (2) NZ711695A (enExample)
PL (3) PL2131821T3 (enExample)
PT (3) PT2481402T (enExample)
RU (3) RU2483714C2 (enExample)
SI (3) SI2131821T1 (enExample)
UA (1) UA118645C2 (enExample)
WO (1) WO2008109163A1 (enExample)
ZA (1) ZA200906342B (enExample)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
EP1585548B1 (en) 2002-12-09 2018-06-27 Abraxis BioScience, LLC Compositions and methods of delivery of pharmacological agents
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
SI3248600T1 (sl) 2005-02-18 2020-09-30 Abraxis Bioscience, Llc Kombinacije in načini dajanja terapevtskih sredstev in kombinacijska terapija
PL1931321T3 (pl) 2005-08-31 2019-08-30 Abraxis Bioscience, Llc Kompozycje zawierające słabo rozpuszczalne w wodzie środki farmaceutyczne i środki przeciwdrobnoustrojowe
EP3470071A1 (en) 2006-12-14 2019-04-17 Abraxis BioScience, LLC Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane
LT2481402T (lt) * 2007-03-07 2018-10-25 Abraxis Bioscience, Llc Nanodalelė, apimanti rapamiciną ir albuminą, kaip priešvėžinį agentą
CA2686736A1 (en) * 2007-05-03 2008-11-13 Abraxis Bioscience, Llc Nanoparticle compositions comprising rapamycin for treating pulmonary hypertension
WO2008150532A1 (en) * 2007-06-01 2008-12-11 Abraxis Bioscience, Llc Methods and compositions for treating recurrent cancer
US20100048913A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
CA2721153C (en) * 2008-04-10 2018-10-02 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
EP2309990B2 (en) 2008-06-16 2017-03-15 Pfizer Inc. Drug loaded polymeric nanoparticles and methods of making and using same
WO2010005725A2 (en) 2008-06-16 2010-01-14 Bind Biosciences, Inc. Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
MX2011005667A (es) * 2008-11-28 2011-06-16 Novartis Ag Combinacion farmaceutica que comprende un inhibidor de hsp90 y un inhibidor de mtor.
JP2012512175A (ja) 2008-12-15 2012-05-31 バインド バイオサイエンシズ インコーポレイテッド 治療薬を徐放するための長時間循環性ナノ粒子
WO2010091306A1 (en) 2009-02-05 2010-08-12 Tokai Pharmaceuticals Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
KR20130128018A (ko) * 2009-04-10 2013-11-25 하이얀 치 새로운 노화 방지 물질 및 그 확인 방법
MX378130B (es) 2009-04-15 2025-03-10 Abraxis Bioscience Llc Métodos y composiciones de nanopartículas sin priones.
US10391059B2 (en) 2009-11-11 2019-08-27 Rapamycin Holdings, Inc. Oral rapamycin nanoparticle preparations and use
US8357401B2 (en) 2009-12-11 2013-01-22 Bind Biosciences, Inc. Stable formulations for lyophilizing therapeutic particles
WO2011084513A2 (en) 2009-12-15 2011-07-14 Bind Biosciences, Inc. Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers
KR101267813B1 (ko) 2009-12-30 2013-06-04 주식회사 삼양바이오팜 향상된 수용해도를 갖는 라파마이신 함유 고분자나노입자 주사제형 조성물 및 그 제조방법, 및 방사선 요법과 병용하기 위한 항암 조성물
GB2478556A (en) * 2010-03-09 2011-09-14 Myrovlytis Technology Ventures Ltd A composition for use in the treatment of Birt-Hogg-Dubô sydrome
PT2552438T (pt) 2010-03-26 2016-07-07 Abraxis Bioscience Llc Métodos de tratamento de carcinoma hepatocelular
AU2011232862B2 (en) 2010-03-29 2016-03-03 Abraxis Bioscience, Llc Methods of enhancing drug delivery and effectiveness of therapeutic agents
EP3141245A1 (en) 2010-03-29 2017-03-15 Abraxis BioScience, LLC Methods of treating cancer
WO2011133668A2 (en) * 2010-04-20 2011-10-27 President And Fellows Of Harvard College Methods and compositions for the treatment of cancer
BR112012030909A2 (pt) 2010-06-04 2020-08-18 Abraxis Bioscience, Llc métodos de tratamento de câncer pancreático
WO2012054564A2 (en) * 2010-10-19 2012-04-26 The Curators Of The University Of Missouri Anti-vegf antibody/fragment conjugated gold nanoparticles, and fabrication and therapeutic methods
US8691777B2 (en) 2011-01-27 2014-04-08 Emory University Combination therapy
AU2012249371B2 (en) 2011-04-28 2017-06-08 Abraxis Bioscience, Llc Intravascular delivery of nanoparticle compositions and uses thereof
JP6491879B2 (ja) 2011-04-29 2019-03-27 セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. 制御性b細胞を誘導するための寛容原性合成ナノキャリア
LT2707030T (lt) 2011-05-09 2020-07-10 Mayo Foundation For Medical Education And Research Vėžio gydymas
RU2705998C2 (ru) 2011-12-14 2019-11-13 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Применение полимерных эксципиентов для лиофилизации или заморозки частиц
WO2013148158A1 (en) * 2012-03-30 2013-10-03 President And Fellows Of Harvard College Laser-actuated therapeutic nanoparticles
AU2013274101B2 (en) 2012-06-15 2017-09-07 The Brigham And Women's Hospital, Inc. Compositions for treating cancer and methods for making the same
CA2881818A1 (en) * 2012-08-21 2014-02-27 Genesys Research Institute Compositions and methods for treating or preventing anthracycline induced cardiotoxicity
PT2895156T (pt) 2012-09-17 2019-06-28 Pfizer Processo para a preparação de nanopartículas terapêuticas
SG11201502008WA (en) * 2012-09-17 2015-04-29 Bind Therapeutics Inc Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
EP2903610B1 (en) 2012-10-01 2021-11-03 Mayo Foundation For Medical Education And Research Cancer treatments
US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
EP2941301A4 (en) * 2013-01-03 2016-08-17 Univ Texas RAPAMYCIN ANALOGUE TREATED ON PROTEASOME FUNCTION IN THE TREATMENT OF CANCER
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
US10172789B2 (en) 2013-01-24 2019-01-08 Palvella Therapeutics Llc Compositions for transdermal delivery of mTOR inhibitors
US10744110B2 (en) 2013-03-12 2020-08-18 Abraxis Bioscience, Llc Methods of treating lung cancer
CA2903548A1 (en) * 2013-03-14 2014-09-25 Abraxis Bioscience, Llc Methods of treating bladder cancer
BR112015023098A2 (pt) 2013-03-14 2017-07-18 Univ Jefferson agentes de infrarregulação do receptor de andrógeno e usos dos mesmos
WO2014144405A1 (en) * 2013-03-15 2014-09-18 The Board Of Regents Of The University Of Texas System Use of mtor inhibitors for prevention of neuroendocrine tumor development and growth
KR101329646B1 (ko) 2013-05-02 2013-11-14 주식회사 지니스 표적지향증폭형 항암나노입자 및 이의 제조방법
CA2910579C (en) * 2013-05-03 2023-09-26 Selecta Biosciences, Inc. Dosing combinations for reducing undesired humoral immune responses
EA201592106A3 (ru) * 2013-05-03 2016-08-31 Селекта Байосайенсиз, Инк. Локальное сопутствующее введение толерогенных синтетических наноносителей для снижения гиперчувствительности типа i и гиперчувствительности типа iv
KR20160058774A (ko) 2013-08-12 2016-05-25 토카이 파마슈티컬, 아이엔씨. 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커
EP3311845B1 (en) 2013-09-16 2020-01-15 Astrazeneca AB Therapeutic polymeric nanoparticles and methods of making and using same
US20160271072A1 (en) * 2013-10-22 2016-09-22 The University Of North Carolina At Chapel Hill Polymer nanoparticles containing multiple agents and methods thereof
HUP1400075A2 (hu) 2014-02-14 2015-08-28 Druggability Technologies Ip Holdco Jersey Ltd Sirolimus és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói
JP6348616B2 (ja) 2014-03-14 2018-06-27 ファイザー・インク 治療剤を含む治療用ナノ粒子ならびにその製造および使用方法
US20160250351A1 (en) 2014-06-13 2016-09-01 Mayo Foundation For Medical Education And Research Treating Lymphomas
AU2015277494A1 (en) 2014-06-16 2017-01-12 Mayo Foundation For Medical Education And Research Treating myelomas
KR20240123409A (ko) 2014-09-07 2024-08-13 셀렉타 바이오사이언시즈, 인크. 유전자 편집 항-바이러스 전달 벡터 면역 반응을 약화시키기 위한 방법 및 조성물
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
WO2016172069A1 (en) * 2015-04-20 2016-10-27 Washington State University Methods of treating inflammation associated airway diseases and viral infections
US20160346221A1 (en) 2015-06-01 2016-12-01 Autotelic Llc Phospholipid-coated therapeutic agent nanoparticles and related methods
JP6871919B2 (ja) 2015-06-16 2021-05-19 ナノファギックス エルエルシー 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法
KR102606071B1 (ko) * 2015-06-29 2023-11-27 아브락시스 바이오사이언스, 엘엘씨 상피양 세포 종양을 치료하는 방법
CA2990705A1 (en) * 2015-06-29 2017-01-05 Abraxis Bioscience, Llc Methods of treating hematological malignancy using nanoparticle mtor inhibitor combination therapy
AU2016287508B2 (en) * 2015-06-29 2021-10-14 Abraxis Bioscience, Llc Methods of treating solid tumors using nanoparticle MTOR inhibitor combination therapy
IL256326B2 (en) * 2015-06-29 2024-09-01 Abraxis Bioscience Llc Biomarkers for nanoparticle compositions
TW201707725A (zh) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 載體-抗體組合物及其製造及使用方法
CN114796130B (zh) * 2015-08-18 2023-10-20 梅约医学教育与研究基金会 载体结合剂组合物及其制备和使用方法
TW201713360A (en) 2015-10-06 2017-04-16 Mayo Foundation Methods of treating cancer using compositions of antibodies and carrier proteins
US10765665B2 (en) 2015-11-24 2020-09-08 Melin Jeffrey Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases
US20220280233A1 (en) * 2015-12-23 2022-09-08 Theromics, Inc. Devices, methods, and compositions for thermal acceleration and drug delivery
US11571469B2 (en) 2016-01-07 2023-02-07 Mayo Foundation For Medical Education And Research Methods of treating cancer with interferon wherein the cancer cells are HLA negative or have reduced HLA expression
US10774110B2 (en) 2016-02-04 2020-09-15 The Johns Hopkins University Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof
JP7104627B2 (ja) * 2016-02-04 2022-07-21 ザ・ジョンズ・ホプキンス・ユニバーシティ ラパグルチン(rapaglutins)、glutの新規阻害剤及びその使用
WO2017139698A1 (en) 2016-02-12 2017-08-17 Mayo Foundation For Medical Education And Research Hematologic cancer treatments
US11585805B2 (en) 2016-02-19 2023-02-21 Nantcell, Inc. Methods of immunogenic modulation
US10064855B2 (en) 2016-03-08 2018-09-04 Los Gatos Pharmaceuticals, Inc. Composite nanoparticles and uses thereof
AU2017238119A1 (en) 2016-03-21 2018-10-11 Mayo Foundation For Medical Education And Research Methods for reducing toxicity of a chemotherapeutic drug
CA3018340A1 (en) 2016-03-21 2017-09-28 Mayo Foundation For Medical Education And Research Methods for improving the therapeutic index for a chemotherapeutic drug
US10618969B2 (en) 2016-04-06 2020-04-14 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
US10894960B2 (en) 2016-08-30 2021-01-19 Children's Hospital Medical Center Compositions and methods for nucleic acid transfer
CA3035377A1 (en) 2016-09-01 2018-03-08 Mayo Foundation For Medical Education And Research Nanoparticle compositions for targeting t-cell cancers
KR20220151022A (ko) 2016-09-01 2022-11-11 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 암 치료용 담체-pd-l1 결합제 조성물
US11590098B2 (en) 2016-09-06 2023-02-28 Mayo Foundation For Medical Education And Research Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins
EP3509643A1 (en) 2016-09-06 2019-07-17 Mayo Foundation for Medical Education and Research Paclitaxel-albumin-binding agent compositions and methods for using and making the same
EP3510048A1 (en) 2016-09-06 2019-07-17 Mayo Foundation for Medical Education and Research Methods of treating pd-l1 expressing cancer
MX389962B (es) * 2016-09-28 2025-03-20 Abraxis Bioscience Llc Metodos para tratar trastornos mitocondriales y metabolicos.
CN110520097B (zh) 2017-01-06 2023-10-27 帕尔维拉治疗股份有限公司 Mtor抑制剂的无水组合物及其使用方法
US11013731B2 (en) 2017-01-06 2021-05-25 Santen Pharmaceutical Co., Ltd. Intratumoral administration of sirolimus for treatment of prostate cancer
ES3036482T3 (en) 2017-03-11 2025-09-19 Cartesian Therapeutics Inc Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
US12411144B2 (en) 2017-03-22 2025-09-09 Children's Hospital Medical Center Compositions and methods for treatment of lung function
US10806801B2 (en) 2017-06-07 2020-10-20 National Cheng Kung University Pharmaceutical composition and methods for using the same
WO2019073371A1 (en) 2017-10-11 2019-04-18 Wockhardt Limited PHARMACEUTICAL COMPOSITION COMPRISING ALBUMIN-LIPID HYBRID NANOPARTICLES
MX2020006042A (es) * 2017-12-19 2020-10-20 Abraxis Bioscience Llc Metodos de tratamiento de cancer de colon usando terapia combinada de inhibidor del objetivo mamifero de la rapamicina (mtor) en nanoparticulas.
US20200316037A1 (en) * 2017-12-21 2020-10-08 The Angiogenesis Foundation Compositions and methods for treating neoplasia
WO2019162048A1 (en) 2018-02-23 2019-08-29 Biotronik Ag Parenteral formulation materials and methods for 40-o-cyclic hydrocarbon esters and related structures
KR102837015B1 (ko) * 2018-03-20 2025-07-23 아브락시스 바이오사이언스, 엘엘씨 mTOR 억제제 및 알부민의 나노입자의 투여를 통한 중추 신경계 장애의 치료 방법
WO2019226685A1 (en) 2018-05-22 2019-11-28 Abraxis Bioscience, Llc Methods and compositions for treating pulmonary hypertension
JP2021530463A (ja) 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク. mTOR阻害剤の無水組成物および使用方法
CA3133988A1 (en) * 2019-03-19 2020-09-24 Abraxis Bioscience, Llc Subcutaneous administration of nanoparticles comprising an mtor inhibitor and albumin for treatment of diseases
EP3999153A4 (en) * 2019-07-16 2023-08-16 The Regents Of The University Of Michigan Composite drug particles and uses thereof
CA3158764A1 (en) 2019-10-28 2021-05-06 Abraxis Bioscience, Llc Pharmaceutical compositions of albumin and rapamycin
CN114945358A (zh) * 2019-11-11 2022-08-26 阿布拉科斯生物科学有限公司 用于纳米颗粒组合物的生物标记
KR102641217B1 (ko) * 2019-12-24 2024-02-29 (주)아이엠지티 항암제가 코팅된 알부민 나노입자 및 이의 제조방법
KR102517033B1 (ko) 2020-07-15 2023-04-03 성균관대학교산학협력단 엔도텔린 수용체 길항제를 봉입한 나노입자 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물
AU2021397776A1 (en) * 2020-12-10 2023-06-22 Children's Hospital Medical Center Enhanced nanoparticle delivery systems
US12245355B2 (en) 2021-02-19 2025-03-04 Mevion Medical Systems, Inc. Gantry for a particle therapy system
US20240226104A1 (en) * 2021-04-20 2024-07-11 The Regents Of The University Of Michigan Pi3k inhibitors, nanoformulations, and uses thereof
KR102837034B1 (ko) 2022-09-28 2025-07-22 충남대학교산학협력단 피로인산티아민 알부민 나노클러스터를 포함하는 항암치료용 조성물 및 이의 제조방법
WO2024081674A1 (en) 2022-10-11 2024-04-18 Aadi Bioscience, Inc. Combination therapies for the treatment of cancer
CN116271067A (zh) * 2023-03-20 2023-06-23 山东大学齐鲁医院 一种基于hsp90抑制剂白蛋白纳米药物及其制备方法与应用
WO2024228964A1 (en) 2023-04-30 2024-11-07 Aadi Bioscience, Inc. Treatments comprising an mtor inhibitor nanoparticle composition
WO2024243413A1 (en) 2023-05-24 2024-11-28 Aadi Bioscience, Inc. Combination therapy with a mtor inhibitor and a multi-tyrosine kinase inhibitor for treating soft tissue sarcoma
WO2025034870A1 (en) 2023-08-08 2025-02-13 Aadi Bioscience, Inc. Combination of nab-sirolimus and an estrogen suppresor for use in the treatment of hormone-dependent cancers
WO2025049962A1 (en) 2023-08-31 2025-03-06 Aadi Bioscience, Inc. Combination cancer treatments with a composition comprising an mtor pathway inhibitor
WO2025129108A1 (en) 2023-12-14 2025-06-19 Aadi Bioscience, Inc. Methods of treating a cancer in an individual

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206018A (en) * 1978-11-03 1993-04-27 Ayerst, Mckenna & Harrison, Inc. Use of rapamycin in treatment of tumors
US5540931A (en) 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5665383A (en) 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US20030068362A1 (en) 1993-02-22 2003-04-10 American Bioscience, Inc. Methods and formulations for the delivery of pharmacologically active agents
DK0693924T4 (da) 1993-02-22 2008-08-04 Abraxis Bioscience Inc Fremgangsmåde til (in vivo) levering af biologiske materialer og sammensætninger, der er egnede dertil
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6528067B1 (en) 1993-02-22 2003-03-04 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US5362478A (en) 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5650156A (en) 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5665382A (en) 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5997904A (en) 1993-02-22 1999-12-07 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US20070116761A1 (en) 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
EP1683517A1 (en) 1996-08-19 2006-07-26 American Bioscience, Inc. Methods for the production of protein particles useful for delivery of pharmacological agents
US20070092563A1 (en) 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20030199425A1 (en) 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
NZ502500A (en) 1997-06-27 2002-03-28 Vivorx Pharmaceuticals Inc Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
AU777528B2 (en) 1999-04-22 2004-10-21 Abraxis Bioscience, Llc Long term administration of pharmacologically active agents
CA2684454A1 (en) 1999-05-21 2000-11-18 American Bioscience, Llc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
GB0008785D0 (en) * 2000-04-10 2000-05-31 Novartis Ag Organic compounds
ITMI20001107A1 (it) 2000-05-18 2001-11-18 Acs Dobfar Spa Metodo per il trattamento di tumori solici mediante microparticelle di albumina incorporanti paclitaxel
EP2762140B1 (en) * 2001-02-19 2017-03-22 Novartis AG Treatment of solid brain tumours with a rapamycin derivative
EP1385551B1 (en) 2001-04-06 2008-09-03 Wyeth Antineoplastic combinations comprising cci-779 (rapamycin derivative) together with gemcitabine or fluorouracil
EA007530B1 (ru) * 2001-06-01 2006-10-27 Уайт Противоопухолевые комбинации
US20030054042A1 (en) 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
JP4212921B2 (ja) * 2002-03-29 2009-01-21 独立行政法人科学技術振興機構 抗体を提示するタンパク質中空ナノ粒子を用いる治療薬剤およびタンパク質中空ナノ粒子
WO2003086178A2 (en) 2002-04-11 2003-10-23 Children's Medical Center Corporation Methods for inhibiting vascular hyperpermeability
US20040126400A1 (en) * 2002-05-03 2004-07-01 Iversen Patrick L. Delivery of therapeutic compounds via microparticles or microbubbles
EP1585548B1 (en) 2002-12-09 2018-06-27 Abraxis BioScience, LLC Compositions and methods of delivery of pharmacological agents
KR20150108943A (ko) 2002-12-09 2015-09-30 아브락시스 바이오사이언스, 엘엘씨 약리학적 물질의 조성물 및 그 전달방법
AU2003293529A1 (en) 2002-12-16 2004-07-29 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
US20050119330A1 (en) 2003-03-17 2005-06-02 Kao Peter N. Use of antiproliferative agents in the treatment and prevention of pulmonary proliferative vascular diseases
US20050038498A1 (en) 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20050152979A1 (en) 2003-09-05 2005-07-14 Cell Therapeutics, Inc. Hydrophobic drug compositions containing reconstitution enhancer
DE10347994A1 (de) 2003-10-15 2005-06-16 Pari GmbH Spezialisten für effektive Inhalation Wässrige Aerosol-Zubereitung
MXPA06013191A (es) * 2004-05-14 2007-07-24 Abraxis Bioscience Inc Metodos de tratamiento que utilizan proteinas que enlazan albumina como objetivos.
BRPI0511262A (pt) 2004-05-17 2007-11-27 Novartis Ag combinação de compostos orgánicos
EP1793803B1 (en) * 2004-10-01 2012-11-07 Ramscor, Inc. Conveniently implantable sustained release drug compositions
WO2006053754A1 (en) 2004-11-19 2006-05-26 Novartis Ag COMBINATIONS OF ANTI-ATHEROSCLEROTIC PEPTIDES AND AN mTOR INHIBITING AGENT AND THEIR METHODS OF USE
US7862588B2 (en) * 2005-02-18 2011-01-04 Samy Abdou Devices and methods for dynamic fixation of skeletal structure
US20070166388A1 (en) 2005-02-18 2007-07-19 Desai Neil P Combinations and modes of administration of therapeutic agents and combination therapy
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
EP1861070B1 (en) 2005-02-18 2018-01-17 Abraxis BioScience, LLC Drugs with improved hydrophobicity for incorporation in medical devices
SI3248600T1 (sl) 2005-02-18 2020-09-30 Abraxis Bioscience, Llc Kombinacije in načini dajanja terapevtskih sredstev in kombinacijska terapija
CN101175481A (zh) 2005-03-17 2008-05-07 伊兰制药国际有限公司 纳米颗粒免疫抑制化合物的可注射的组合物
DE102005016873A1 (de) * 2005-04-12 2006-10-19 Magforce Nanotechnologies Ag Nanopartikel-Wirstoff-Konjugate
WO2006113579A2 (en) * 2005-04-16 2006-10-26 Michigan State University Tumor inhibition by modulating sprouty expression or activity
AU2006247473A1 (en) 2005-05-16 2006-11-23 Novartis Ag The use of rapamycin derivatives for the treatment and/or prevention of cardiovascular disorders
PL1931321T3 (pl) 2005-08-31 2019-08-30 Abraxis Bioscience, Llc Kompozycje zawierające słabo rozpuszczalne w wodzie środki farmaceutyczne i środki przeciwdrobnoustrojowe
EP3527202A1 (en) 2005-08-31 2019-08-21 Abraxis BioScience, LLC Compositions and methods for preparation of poorly water soluble drugs with increased stability
US20070148251A1 (en) * 2005-12-22 2007-06-28 Hossainy Syed F A Nanoparticle releasing medical devices
EP2056812A1 (en) 2006-08-31 2009-05-13 Abraxis BioScience, LLC Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases
US20080280987A1 (en) 2006-08-31 2008-11-13 Desai Neil P Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases
US20100112077A1 (en) 2006-11-06 2010-05-06 Abraxis Bioscience, Llc Nanoparticles of paclitaxel and albumin in combination with bevacizumab against cancer
EP3470071A1 (en) 2006-12-14 2019-04-17 Abraxis BioScience, LLC Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane
LT2481402T (lt) 2007-03-07 2018-10-25 Abraxis Bioscience, Llc Nanodalelė, apimanti rapamiciną ir albuminą, kaip priešvėžinį agentą
CA2686736A1 (en) 2007-05-03 2008-11-13 Abraxis Bioscience, Llc Nanoparticle compositions comprising rapamycin for treating pulmonary hypertension
WO2008150532A1 (en) 2007-06-01 2008-12-11 Abraxis Bioscience, Llc Methods and compositions for treating recurrent cancer
CA2721153C (en) 2008-04-10 2018-10-02 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
MX2011006167A (es) 2008-12-11 2011-07-28 Abraxis Bioscience Llc Combinaciones y modos de administracion de agentes terapeuticos y terapia de combinacion.
JP5725563B2 (ja) 2009-03-13 2015-05-27 アブラクシス バイオサイエンス, エルエルシー チオコルヒチン誘導体との組み合わせ療法
CA2758200A1 (en) 2009-04-10 2010-10-14 Abraxis Bioscience, Llc Nanoparticle formulations and uses thereof
MX378130B (es) 2009-04-15 2025-03-10 Abraxis Bioscience Llc Métodos y composiciones de nanopartículas sin priones.
MX340670B (es) 2009-08-25 2016-07-20 Abraxis Bioscience Llc * Terapia combinada con composiciones de nanoparticulas de taxano e inhibidores de hedgehog.
US9775819B2 (en) 2009-09-16 2017-10-03 R.P. Scherer Technologies, Llc Oral solid dosage form containing nanoparticles and process of formulating the same using fish gelatin
PT2552438T (pt) 2010-03-26 2016-07-07 Abraxis Bioscience Llc Métodos de tratamento de carcinoma hepatocelular
EP3141245A1 (en) 2010-03-29 2017-03-15 Abraxis BioScience, LLC Methods of treating cancer
AU2011232862B2 (en) 2010-03-29 2016-03-03 Abraxis Bioscience, Llc Methods of enhancing drug delivery and effectiveness of therapeutic agents
ES2639038T3 (es) 2010-06-02 2017-10-25 Abraxis Bioscience, Llc Métodos para el tratamiento de cáncer de vejiga
BR112012030909A2 (pt) * 2010-06-04 2020-08-18 Abraxis Bioscience, Llc métodos de tratamento de câncer pancreático
US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
CA2903548A1 (en) * 2013-03-14 2014-09-25 Abraxis Bioscience, Llc Methods of treating bladder cancer

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