JP2019509253A5 - - Google Patents
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- Publication number
- JP2019509253A5 JP2019509253A5 JP2018532746A JP2018532746A JP2019509253A5 JP 2019509253 A5 JP2019509253 A5 JP 2019509253A5 JP 2018532746 A JP2018532746 A JP 2018532746A JP 2018532746 A JP2018532746 A JP 2018532746A JP 2019509253 A5 JP2019509253 A5 JP 2019509253A5
- Authority
- JP
- Japan
- Prior art keywords
- phosphate
- alaninyl
- benzoxy
- gemcitabine
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910019142 PO4 Inorganic materials 0.000 claims 23
- 239000010452 phosphate Substances 0.000 claims 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 22
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 22
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 8
- 239000002246 antineoplastic agent Substances 0.000 claims 7
- 229910052697 platinum Inorganic materials 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 229960004316 cisplatin Drugs 0.000 claims 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 claims 3
- 229950005566 picoplatin Drugs 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- YMOXEIOKAJSRQX-QPPQHZFASA-N Gemcitabine triphosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 YMOXEIOKAJSRQX-QPPQHZFASA-N 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 229940041181 antineoplastic drug Drugs 0.000 claims 2
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 208000007666 Klatskin Tumor Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 201000007434 ampulla of Vater carcinoma Diseases 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000009036 biliary tract cancer Diseases 0.000 claims 1
- 208000011825 carcinoma of the ampulla of vater Diseases 0.000 claims 1
- NHTKGYOMICWFQZ-BBOXMAMFSA-N fosgemcitabine palabenamide Chemical compound C[C@H](N[P@](=O)(OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)C(F)(F)[C@@H]1O)OC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1 NHTKGYOMICWFQZ-BBOXMAMFSA-N 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 208000018060 hilar cholangiocarcinoma Diseases 0.000 claims 1
- 201000007450 intrahepatic cholangiocarcinoma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2015/054158 WO2017109444A1 (en) | 2015-12-23 | 2015-12-23 | Combination therapy |
| GBPCT/GB2015/054158 | 2015-12-23 | ||
| GBGB1609770.1A GB201609770D0 (en) | 2016-06-03 | 2016-06-03 | Combination therapy |
| GB1609770.1 | 2016-06-03 | ||
| PCT/GB2016/054018 WO2017109486A1 (en) | 2015-12-23 | 2016-12-21 | Combination therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509253A JP2019509253A (ja) | 2019-04-04 |
| JP2019509253A5 true JP2019509253A5 (enExample) | 2020-01-09 |
| JP6898329B2 JP6898329B2 (ja) | 2021-07-07 |
Family
ID=57681677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018532746A Active JP6898329B2 (ja) | 2015-12-23 | 2016-12-21 | 併用療法 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20190022117A1 (enExample) |
| EP (2) | EP3738595A1 (enExample) |
| JP (1) | JP6898329B2 (enExample) |
| KR (1) | KR20180096698A (enExample) |
| CN (1) | CN108697725A (enExample) |
| AU (1) | AU2016375861B2 (enExample) |
| CA (1) | CA3008749C (enExample) |
| CY (1) | CY1122835T1 (enExample) |
| DK (1) | DK3393478T3 (enExample) |
| EA (1) | EA037459B1 (enExample) |
| ES (1) | ES2778933T3 (enExample) |
| HR (1) | HRP20200423T1 (enExample) |
| HU (1) | HUE050290T2 (enExample) |
| IL (1) | IL260076A (enExample) |
| LT (1) | LT3393478T (enExample) |
| MA (1) | MA51576A (enExample) |
| MD (1) | MD3393478T2 (enExample) |
| ME (1) | ME03677B (enExample) |
| MX (1) | MX383988B (enExample) |
| MY (1) | MY194629A (enExample) |
| PH (1) | PH12018501339A1 (enExample) |
| PL (1) | PL3393478T3 (enExample) |
| PT (1) | PT3393478T (enExample) |
| RS (1) | RS60211B1 (enExample) |
| SG (1) | SG11201805184TA (enExample) |
| SI (1) | SI3393478T1 (enExample) |
| SM (1) | SMT202000154T1 (enExample) |
| WO (1) | WO2017109486A1 (enExample) |
| ZA (1) | ZA201804155B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3235824B1 (en) | 2012-11-16 | 2019-03-27 | University College Cardiff Consultants Limited | Mixture of rp/sp gemcitabine-[phenyl-(benzyloxy-l-alaninyl)]-phosphate |
| HRP20180007T1 (hr) | 2014-06-25 | 2018-02-23 | NuCana plc | Formulacija koja sadrži gemcitabin-predlijek |
| PL3160978T3 (pl) | 2014-06-25 | 2020-11-30 | NuCana plc | Proleki gemcytabiny |
| GB201417644D0 (en) | 2014-10-06 | 2014-11-19 | Nucana Biomed Ltd | Method of separating phosphate diastereoisomers |
| CN108135920A (zh) | 2015-10-05 | 2018-06-08 | 努卡那有限公司 | 组合疗法 |
| MX386478B (es) | 2015-12-11 | 2025-03-18 | Laurus Labs Ltd | Sintesis diaestereoselectiva de derivados de fosfato y del profarmaco de gemcitabina nuc-1031. |
| GB201522771D0 (en) | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Crystalline form of a phosphate derivative |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0317009D0 (en) * | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
| KR20150044838A (ko) * | 2012-08-13 | 2015-04-27 | 레귤론, 인코퍼레이티드. | 리포플라틴을 이용한 암 치료방법 |
| WO2014078295A1 (en) * | 2012-11-13 | 2014-05-22 | BoYen Therapeutics, Inc. | Gemcitabine prodrugs and uses thereof |
| LT3197456T (lt) * | 2015-05-14 | 2018-07-10 | NuCana plc | Vėžio gydymas |
| CN108135920A (zh) * | 2015-10-05 | 2018-06-08 | 努卡那有限公司 | 组合疗法 |
-
2016
- 2016-12-21 EP EP20160070.7A patent/EP3738595A1/en not_active Withdrawn
- 2016-12-21 US US16/065,498 patent/US20190022117A1/en not_active Abandoned
- 2016-12-21 MD MDE20181039T patent/MD3393478T2/ro not_active IP Right Cessation
- 2016-12-21 EA EA201891473A patent/EA037459B1/ru unknown
- 2016-12-21 WO PCT/GB2016/054018 patent/WO2017109486A1/en not_active Ceased
- 2016-12-21 ES ES16820005T patent/ES2778933T3/es active Active
- 2016-12-21 CN CN201680082464.9A patent/CN108697725A/zh active Pending
- 2016-12-21 HR HRP20200423TT patent/HRP20200423T1/hr unknown
- 2016-12-21 MY MYPI2018001015A patent/MY194629A/en unknown
- 2016-12-21 MA MA051576A patent/MA51576A/fr unknown
- 2016-12-21 JP JP2018532746A patent/JP6898329B2/ja active Active
- 2016-12-21 AU AU2016375861A patent/AU2016375861B2/en not_active Ceased
- 2016-12-21 KR KR1020187020533A patent/KR20180096698A/ko not_active Ceased
- 2016-12-21 LT LTEP16820005.3T patent/LT3393478T/lt unknown
- 2016-12-21 DK DK16820005.3T patent/DK3393478T3/da active
- 2016-12-21 EP EP16820005.3A patent/EP3393478B1/en active Active
- 2016-12-21 RS RS20200297A patent/RS60211B1/sr unknown
- 2016-12-21 PT PT168200053T patent/PT3393478T/pt unknown
- 2016-12-21 ME MEP-2020-56A patent/ME03677B/me unknown
- 2016-12-21 MX MX2018007772A patent/MX383988B/es unknown
- 2016-12-21 PL PL16820005T patent/PL3393478T3/pl unknown
- 2016-12-21 SI SI201630680T patent/SI3393478T1/sl unknown
- 2016-12-21 CA CA3008749A patent/CA3008749C/en active Active
- 2016-12-21 HU HUE16820005A patent/HUE050290T2/hu unknown
- 2016-12-21 SM SM20200154T patent/SMT202000154T1/it unknown
- 2016-12-21 SG SG11201805184TA patent/SG11201805184TA/en unknown
-
2018
- 2018-06-17 IL IL260076A patent/IL260076A/en unknown
- 2018-06-21 ZA ZA2018/04155A patent/ZA201804155B/en unknown
- 2018-06-21 PH PH12018501339A patent/PH12018501339A1/en unknown
-
2020
- 2020-03-17 CY CY20201100245T patent/CY1122835T1/el unknown
-
2022
- 2022-06-21 US US17/845,878 patent/US20230149436A1/en not_active Abandoned
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