AU2016375861B2 - Combination therapy - Google Patents

Combination therapy Download PDF

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Publication number
AU2016375861B2
AU2016375861B2 AU2016375861A AU2016375861A AU2016375861B2 AU 2016375861 B2 AU2016375861 B2 AU 2016375861B2 AU 2016375861 A AU2016375861 A AU 2016375861A AU 2016375861 A AU2016375861 A AU 2016375861A AU 2016375861 B2 AU2016375861 B2 AU 2016375861B2
Authority
AU
Australia
Prior art keywords
cancer
gemcitabine
phosphate
alaninyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016375861A
Other languages
English (en)
Other versions
AU2016375861A1 (en
Inventor
Hugh GRIFFITH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nucana PLC
Original Assignee
Nucana PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2015/054158 external-priority patent/WO2017109444A1/en
Priority claimed from GBGB1609770.1A external-priority patent/GB201609770D0/en
Application filed by Nucana PLC filed Critical Nucana PLC
Publication of AU2016375861A1 publication Critical patent/AU2016375861A1/en
Application granted granted Critical
Publication of AU2016375861B2 publication Critical patent/AU2016375861B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2016375861A 2015-12-23 2016-12-21 Combination therapy Ceased AU2016375861B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/GB2015/054158 WO2017109444A1 (en) 2015-12-23 2015-12-23 Combination therapy
AUPCT/GB2015/054158 2015-12-23
GBGB1609770.1A GB201609770D0 (en) 2016-06-03 2016-06-03 Combination therapy
GB1609770.1 2016-06-03
PCT/GB2016/054018 WO2017109486A1 (en) 2015-12-23 2016-12-21 Combination therapy

Publications (2)

Publication Number Publication Date
AU2016375861A1 AU2016375861A1 (en) 2018-07-05
AU2016375861B2 true AU2016375861B2 (en) 2021-12-23

Family

ID=57681677

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016375861A Ceased AU2016375861B2 (en) 2015-12-23 2016-12-21 Combination therapy

Country Status (29)

Country Link
US (2) US20190022117A1 (enExample)
EP (2) EP3738595A1 (enExample)
JP (1) JP6898329B2 (enExample)
KR (1) KR20180096698A (enExample)
CN (1) CN108697725A (enExample)
AU (1) AU2016375861B2 (enExample)
CA (1) CA3008749C (enExample)
CY (1) CY1122835T1 (enExample)
DK (1) DK3393478T3 (enExample)
EA (1) EA037459B1 (enExample)
ES (1) ES2778933T3 (enExample)
HR (1) HRP20200423T1 (enExample)
HU (1) HUE050290T2 (enExample)
IL (1) IL260076A (enExample)
LT (1) LT3393478T (enExample)
MA (1) MA51576A (enExample)
MD (1) MD3393478T2 (enExample)
ME (1) ME03677B (enExample)
MX (1) MX383988B (enExample)
MY (1) MY194629A (enExample)
PH (1) PH12018501339A1 (enExample)
PL (1) PL3393478T3 (enExample)
PT (1) PT3393478T (enExample)
RS (1) RS60211B1 (enExample)
SG (1) SG11201805184TA (enExample)
SI (1) SI3393478T1 (enExample)
SM (1) SMT202000154T1 (enExample)
WO (1) WO2017109486A1 (enExample)
ZA (1) ZA201804155B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013346515B2 (en) 2012-11-16 2017-05-25 NuCana plc Process for preparing nucleoside prodrugs
EA033046B1 (ru) 2014-06-25 2019-08-30 НУКАНА ПиЭлСи Состав, содержащий пролекарство гемцитабина
RS60968B1 (sr) 2014-06-25 2020-11-30 NuCana plc Prolekovi gemcitabina
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
PH12018500691B1 (en) 2015-10-05 2022-08-10 NuCana plc Combination therapy
CA3007347C (en) 2015-12-11 2020-08-04 NuCana plc Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012327A2 (en) * 2003-07-21 2005-02-10 University College Cardiff Consultants Limited Nucleotide phosphoramidates as anticancer agents
WO2016181093A1 (en) * 2015-05-14 2016-11-17 Nucana Biomed Limited Cancer treatments

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
EA201491629A1 (ru) * 2012-08-13 2015-08-31 Регулон, Инк. Способы лечения рака с использованием липоплатина
JP6420247B2 (ja) * 2012-11-13 2018-11-07 ボーイエン セラピューティクス，インコーポレイティド ゲムシタビンプロドラッグ及びその使用
PH12018500691B1 (en) * 2015-10-05 2022-08-10 NuCana plc Combination therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012327A2 (en) * 2003-07-21 2005-02-10 University College Cardiff Consultants Limited Nucleotide phosphoramidates as anticancer agents
WO2016181093A1 (en) * 2015-05-14 2016-11-17 Nucana Biomed Limited Cancer treatments

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Ghazaly, E. et al., "ProGem1: A Phase I/II study of a first-in-class nucleotide analogue Acelarin (NUC-1031) in patients with advanced solid tumors", 2014 ASCO Annual Meeting <URL: https://www.nucana.com/downloads/Nucana2014ASCOPoster.pdf> *
Slusarczyk, M. et al., JOURNAL OF MEDICINAL CHEMISTRY, 28 January 2014, vol. 57, no. 4, doi:10.1021/jm401853a, pages 1531-1542 *
The Christie NHS Foundation Trust, "ABC-08: Phase Ib Trial of Acelarin in Combination With Cisplatin in Locally Advanced/ Metastatic Biliary Tract Cancers (ABC-08)", ClinicalTrials.gov, Identifier: NCT02351765, 30 January 2015 *

Also Published As

Publication number Publication date
US20190022117A1 (en) 2019-01-24
JP2019509253A (ja) 2019-04-04
MX2018007772A (es) 2019-07-04
WO2017109486A1 (en) 2017-06-29
SMT202000154T1 (it) 2020-05-08
HK1255110A1 (en) 2019-08-02
US20230149436A1 (en) 2023-05-18
ME03677B (me) 2020-10-20
KR20180096698A (ko) 2018-08-29
EA201891473A1 (ru) 2019-01-31
MA51576A (fr) 2020-11-18
PH12018501339A1 (en) 2019-02-18
ZA201804155B (en) 2021-06-30
LT3393478T (lt) 2020-04-10
DK3393478T3 (da) 2020-03-23
MY194629A (en) 2022-12-07
EP3738595A1 (en) 2020-11-18
CY1122835T1 (el) 2021-05-05
MX383988B (es) 2025-03-14
CA3008749C (en) 2024-01-02
MD3393478T2 (ro) 2020-04-30
PL3393478T3 (pl) 2020-07-13
BR112018012956A2 (pt) 2019-01-08
PT3393478T (pt) 2020-03-24
JP6898329B2 (ja) 2021-07-07
CN108697725A (zh) 2018-10-23
CA3008749A1 (en) 2017-06-29
SG11201805184TA (en) 2018-07-30
RS60211B1 (sr) 2020-06-30
HRP20200423T1 (hr) 2020-09-04
SI3393478T1 (sl) 2020-07-31
HUE050290T2 (hu) 2020-11-30
IL260076A (en) 2018-07-31
EP3393478A1 (en) 2018-10-31
ES2778933T3 (es) 2020-08-12
EA037459B1 (ru) 2021-03-30
EP3393478B1 (en) 2020-03-04
AU2016375861A1 (en) 2018-07-05

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired
NA Applications received for extensions of time, section 223

Free format text: AN APPLICATION TO EXTEND THE TIME FROM 21 DEC 2022 TO 21 AUG 2023 IN WHICH TO PAY A RENEWAL FEE HAS BEEN FILED

NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO PAY A RENEWAL FEE HAS BEEN EXTENDED TO 21 AUG 2023

MK14 Patent ceased section 143(a) (annual fees not paid) or expired