EA037459B1 - Применение гемцитабин-[фенил-бензокси-l-аланинил]фосфата в комбинации с цисплатином для лечения рака мочевого пузыря или рака желчных путей - Google Patents

Применение гемцитабин-[фенил-бензокси-l-аланинил]фосфата в комбинации с цисплатином для лечения рака мочевого пузыря или рака желчных путей Download PDF

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Publication number
EA037459B1
EA037459B1 EA201891473A EA201891473A EA037459B1 EA 037459 B1 EA037459 B1 EA 037459B1 EA 201891473 A EA201891473 A EA 201891473A EA 201891473 A EA201891473 A EA 201891473A EA 037459 B1 EA037459 B1 EA 037459B1
Authority
EA
Eurasian Patent Office
Prior art keywords
cancer
gemcitabine
cisplatin
phosphate
alaninyl
Prior art date
Application number
EA201891473A
Other languages
English (en)
Russian (ru)
Other versions
EA201891473A1 (ru
Inventor
Хью Гриффит
Original Assignee
НУКАНА ПиЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2015/054158 external-priority patent/WO2017109444A1/en
Priority claimed from GBGB1609770.1A external-priority patent/GB201609770D0/en
Application filed by НУКАНА ПиЭлСи filed Critical НУКАНА ПиЭлСи
Publication of EA201891473A1 publication Critical patent/EA201891473A1/ru
Publication of EA037459B1 publication Critical patent/EA037459B1/ru

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/282Platinum compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201891473A 2015-12-23 2016-12-21 Применение гемцитабин-[фенил-бензокси-l-аланинил]фосфата в комбинации с цисплатином для лечения рака мочевого пузыря или рака желчных путей EA037459B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2015/054158 WO2017109444A1 (en) 2015-12-23 2015-12-23 Combination therapy
GBGB1609770.1A GB201609770D0 (en) 2016-06-03 2016-06-03 Combination therapy
PCT/GB2016/054018 WO2017109486A1 (en) 2015-12-23 2016-12-21 Combination therapy

Publications (2)

Publication Number Publication Date
EA201891473A1 EA201891473A1 (ru) 2019-01-31
EA037459B1 true EA037459B1 (ru) 2021-03-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891473A EA037459B1 (ru) 2015-12-23 2016-12-21 Применение гемцитабин-[фенил-бензокси-l-аланинил]фосфата в комбинации с цисплатином для лечения рака мочевого пузыря или рака желчных путей

Country Status (29)

Country Link
US (2) US20190022117A1 (enExample)
EP (2) EP3738595A1 (enExample)
JP (1) JP6898329B2 (enExample)
KR (1) KR20180096698A (enExample)
CN (1) CN108697725A (enExample)
AU (1) AU2016375861B2 (enExample)
CA (1) CA3008749C (enExample)
CY (1) CY1122835T1 (enExample)
DK (1) DK3393478T3 (enExample)
EA (1) EA037459B1 (enExample)
ES (1) ES2778933T3 (enExample)
HR (1) HRP20200423T1 (enExample)
HU (1) HUE050290T2 (enExample)
IL (1) IL260076A (enExample)
LT (1) LT3393478T (enExample)
MA (1) MA51576A (enExample)
MD (1) MD3393478T2 (enExample)
ME (1) ME03677B (enExample)
MX (1) MX383988B (enExample)
MY (1) MY194629A (enExample)
PH (1) PH12018501339A1 (enExample)
PL (1) PL3393478T3 (enExample)
PT (1) PT3393478T (enExample)
RS (1) RS60211B1 (enExample)
SG (1) SG11201805184TA (enExample)
SI (1) SI3393478T1 (enExample)
SM (1) SMT202000154T1 (enExample)
WO (1) WO2017109486A1 (enExample)
ZA (1) ZA201804155B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3235824B1 (en) 2012-11-16 2019-03-27 University College Cardiff Consultants Limited Mixture of rp/sp gemcitabine-[phenyl-(benzyloxy-l-alaninyl)]-phosphate
HRP20180007T1 (hr) 2014-06-25 2018-02-23 NuCana plc Formulacija koja sadrži gemcitabin-predlijek
PL3160978T3 (pl) 2014-06-25 2020-11-30 NuCana plc Proleki gemcytabiny
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN108135920A (zh) 2015-10-05 2018-06-08 努卡那有限公司 组合疗法
MX386478B (es) 2015-12-11 2025-03-18 Laurus Labs Ltd Sintesis diaestereoselectiva de derivados de fosfato y del profarmaco de gemcitabina nuc-1031.
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012327A2 (en) * 2003-07-21 2005-02-10 University College Cardiff Consultants Limited Nucleotide phosphoramidates as anticancer agents

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TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
KR20150044838A (ko) * 2012-08-13 2015-04-27 레귤론, 인코퍼레이티드. 리포플라틴을 이용한 암 치료방법
WO2014078295A1 (en) * 2012-11-13 2014-05-22 BoYen Therapeutics, Inc. Gemcitabine prodrugs and uses thereof
LT3197456T (lt) * 2015-05-14 2018-07-10 NuCana plc Vėžio gydymas
CN108135920A (zh) * 2015-10-05 2018-06-08 努卡那有限公司 组合疗法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012327A2 (en) * 2003-07-21 2005-02-10 University College Cardiff Consultants Limited Nucleotide phosphoramidates as anticancer agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BROWN J, SMITH J A, RAMONDETTA L M, SOOD A K, RAMIREZ P T, COLEMAN R L, LEVENBACK C F, MUNSELL M F, JUNG M, WOLF J K: "Combination of gemcitabine and cisplatin is highly active in women with endometrial carcinoma: results of a prospective phase 2 trial.", CANCER, AMERICAN CANCER SOCIETY , PHILADELPHIA , PA, US, vol. 116, no. 21, 1 November 2010 (2010-11-01), US, pages 4973 - 4979, XP002755733, ISSN: 0008-543X, DOI: 10.1002/cncr.25498 *
CHEW H K, DOROSHOW J H, FRANKEL P, MARGOLIN K A, SOMLO G, LENZ H J, GORDON M, ZHANG W, YANG D, RUSSELL C, SPICER D, SYNOLD T, BAYE: "Phase II studies of gemcitabine and cisplatin in heavily and minimally pretreated metastatic breast cancer.", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, vol. 27, no. 13, 1 May 2009 (2009-05-01), US, pages 2163 - 2169, XP002755734, ISSN: 0732-183X, DOI: 10.1200/JCO.2008.17.4839 *
LUIZ GUSTAVO OLIVEIRA BRITO; JURANDYR MOREIRA DE ANDRADE; THIAGO LINS-ALMEIDA; FÁBIO EDUARDO ZOLA; MARIANA NOVAES PINHEIRO; HEITOR: "Safety and efficacy of gemcitabine plus cisplatin combination in pretreated metastatic breast cancer patients", MEDICAL ONCOLOGY, SPRINGER-VERLAG, NEW YORK, vol. 29, no. 1, 25 January 2011 (2011-01-25), New York, pages 33 - 38, XP035012885, ISSN: 1559-131X, DOI: 10.1007/s12032-010-9793-8 *
MAGDALENA SLUSARCZYK, MONICA HUERTA LOPEZ, JAN BALZARINI, MALCOLM MASON, WEN G. JIANG, SARAH BLAGDEN, EMELY THOMPSON, ESSAM GHAZAL: "Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 57, no. 4, 27 February 2014 (2014-02-27), pages 1531 - 1542, XP055205033, ISSN: 00222623, DOI: 10.1021/jm401853a *

Also Published As

Publication number Publication date
HRP20200423T1 (hr) 2020-09-04
MX2018007772A (es) 2019-07-04
MA51576A (fr) 2020-11-18
MX383988B (es) 2025-03-14
CA3008749C (en) 2024-01-02
EP3738595A1 (en) 2020-11-18
DK3393478T3 (da) 2020-03-23
BR112018012956A2 (pt) 2019-01-08
US20230149436A1 (en) 2023-05-18
PT3393478T (pt) 2020-03-24
LT3393478T (lt) 2020-04-10
ME03677B (me) 2020-10-20
SI3393478T1 (sl) 2020-07-31
IL260076A (en) 2018-07-31
MD3393478T2 (ro) 2020-04-30
AU2016375861A1 (en) 2018-07-05
CY1122835T1 (el) 2021-05-05
KR20180096698A (ko) 2018-08-29
AU2016375861B2 (en) 2021-12-23
EA201891473A1 (ru) 2019-01-31
RS60211B1 (sr) 2020-06-30
CA3008749A1 (en) 2017-06-29
PL3393478T3 (pl) 2020-07-13
SMT202000154T1 (it) 2020-05-08
ZA201804155B (en) 2021-06-30
HK1255110A1 (en) 2019-08-02
HUE050290T2 (hu) 2020-11-30
JP6898329B2 (ja) 2021-07-07
EP3393478A1 (en) 2018-10-31
MY194629A (en) 2022-12-07
CN108697725A (zh) 2018-10-23
WO2017109486A1 (en) 2017-06-29
EP3393478B1 (en) 2020-03-04
PH12018501339A1 (en) 2019-02-18
JP2019509253A (ja) 2019-04-04
ES2778933T3 (es) 2020-08-12
US20190022117A1 (en) 2019-01-24
SG11201805184TA (en) 2018-07-30

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