CY1122835T1 - Συνδυαστικη θεραπεια - Google Patents

Συνδυαστικη θεραπεια

Info

Publication number
CY1122835T1
CY1122835T1 CY20201100245T CY201100245T CY1122835T1 CY 1122835 T1 CY1122835 T1 CY 1122835T1 CY 20201100245 T CY20201100245 T CY 20201100245T CY 201100245 T CY201100245 T CY 201100245T CY 1122835 T1 CY1122835 T1 CY 1122835T1
Authority
CY
Cyprus
Prior art keywords
alaninyl
phosphate
combined therapy
cancer
lipoplatin
Prior art date
Application number
CY20201100245T
Other languages
Greek (el)
English (en)
Inventor
Hugh GRIFFITH
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2015/054158 external-priority patent/WO2017109444A1/en
Priority claimed from GBGB1609770.1A external-priority patent/GB201609770D0/en
Application filed by NuCana plc filed Critical NuCana plc
Publication of CY1122835T1 publication Critical patent/CY1122835T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/282Platinum compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CY20201100245T 2015-12-23 2020-03-17 Συνδυαστικη θεραπεια CY1122835T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2015/054158 WO2017109444A1 (en) 2015-12-23 2015-12-23 Combination therapy
GBGB1609770.1A GB201609770D0 (en) 2016-06-03 2016-06-03 Combination therapy
PCT/GB2016/054018 WO2017109486A1 (en) 2015-12-23 2016-12-21 Combination therapy

Publications (1)

Publication Number Publication Date
CY1122835T1 true CY1122835T1 (el) 2021-05-05

Family

ID=57681677

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100245T CY1122835T1 (el) 2015-12-23 2020-03-17 Συνδυαστικη θεραπεια

Country Status (29)

Country Link
US (2) US20190022117A1 (enExample)
EP (2) EP3393478B1 (enExample)
JP (1) JP6898329B2 (enExample)
KR (1) KR20180096698A (enExample)
CN (1) CN108697725A (enExample)
AU (1) AU2016375861B2 (enExample)
CA (1) CA3008749C (enExample)
CY (1) CY1122835T1 (enExample)
DK (1) DK3393478T3 (enExample)
EA (1) EA037459B1 (enExample)
ES (1) ES2778933T3 (enExample)
HR (1) HRP20200423T1 (enExample)
HU (1) HUE050290T2 (enExample)
IL (1) IL260076A (enExample)
LT (1) LT3393478T (enExample)
MA (1) MA51576A (enExample)
MD (1) MD3393478T2 (enExample)
ME (1) ME03677B (enExample)
MX (1) MX383988B (enExample)
MY (1) MY194629A (enExample)
PH (1) PH12018501339A1 (enExample)
PL (1) PL3393478T3 (enExample)
PT (1) PT3393478T (enExample)
RS (1) RS60211B1 (enExample)
SG (1) SG11201805184TA (enExample)
SI (1) SI3393478T1 (enExample)
SM (1) SMT202000154T1 (enExample)
WO (1) WO2017109486A1 (enExample)
ZA (1) ZA201804155B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3150616T (pt) 2012-11-16 2017-06-09 Univ College Cardiff Consultants Ltd Mistura de rp/sp gencitabina-[fenil-(benziloxi-l-alaninil)]-fosfato
HUE053240T2 (hu) 2014-06-25 2021-06-28 NuCana plc Gemcitabin prodrugok
PL3119794T3 (pl) 2014-06-25 2018-04-30 NuCana plc Preparat zawierający prolek gemcytabiny
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
PH12018500691B1 (en) 2015-10-05 2022-08-10 NuCana plc Combination therapy
SMT202100665T1 (it) 2015-12-11 2022-03-21 NuCana plc Sintesi diastereoselettiva di derivati di fosfato e del profarmaco di gemcitabina nuc-1031
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
SG11201501147WA (en) * 2012-08-13 2015-04-29 Regulon Inc Methods for treatment of cancer using lipoplatin
US8956613B2 (en) * 2012-11-13 2015-02-17 BoYen Therapeutics, Inc. Gemcitabine prodrugs and uses thereof
RS57371B1 (sr) * 2015-05-14 2018-08-31 NuCana plc Tretman kancera
PH12018500691B1 (en) * 2015-10-05 2022-08-10 NuCana plc Combination therapy

Also Published As

Publication number Publication date
PL3393478T3 (pl) 2020-07-13
HK1255110A1 (en) 2019-08-02
KR20180096698A (ko) 2018-08-29
SG11201805184TA (en) 2018-07-30
RS60211B1 (sr) 2020-06-30
ZA201804155B (en) 2021-06-30
CA3008749C (en) 2024-01-02
ES2778933T3 (es) 2020-08-12
DK3393478T3 (da) 2020-03-23
BR112018012956A2 (pt) 2019-01-08
CN108697725A (zh) 2018-10-23
US20190022117A1 (en) 2019-01-24
WO2017109486A1 (en) 2017-06-29
HUE050290T2 (hu) 2020-11-30
AU2016375861B2 (en) 2021-12-23
JP6898329B2 (ja) 2021-07-07
HRP20200423T1 (hr) 2020-09-04
PT3393478T (pt) 2020-03-24
MA51576A (fr) 2020-11-18
EA037459B1 (ru) 2021-03-30
JP2019509253A (ja) 2019-04-04
EP3393478A1 (en) 2018-10-31
US20230149436A1 (en) 2023-05-18
SMT202000154T1 (it) 2020-05-08
MY194629A (en) 2022-12-07
PH12018501339A1 (en) 2019-02-18
EA201891473A1 (ru) 2019-01-31
MX383988B (es) 2025-03-14
MX2018007772A (es) 2019-07-04
SI3393478T1 (sl) 2020-07-31
MD3393478T2 (ro) 2020-04-30
LT3393478T (lt) 2020-04-10
AU2016375861A1 (en) 2018-07-05
CA3008749A1 (en) 2017-06-29
ME03677B (me) 2020-10-20
EP3393478B1 (en) 2020-03-04
EP3738595A1 (en) 2020-11-18
IL260076A (en) 2018-07-31

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