CY1123231T1 - Ενωσεις τετραϋδροπυριμιδοδιαζεπινης και τετραϋδροπυριδοδιαζεπινης για θεραπεια πονου και καταστασεων σχετικων με τον πονο - Google Patents

Ενωσεις τετραϋδροπυριμιδοδιαζεπινης και τετραϋδροπυριδοδιαζεπινης για θεραπεια πονου και καταστασεων σχετικων με τον πονο

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Publication number
CY1123231T1
CY1123231T1 CY20201100472T CY201100472T CY1123231T1 CY 1123231 T1 CY1123231 T1 CY 1123231T1 CY 20201100472 T CY20201100472 T CY 20201100472T CY 201100472 T CY201100472 T CY 201100472T CY 1123231 T1 CY1123231 T1 CY 1123231T1
Authority
CY
Cyprus
Prior art keywords
pain
compounds
subunit
voltage
tetrahydropyrimidodiazepine
Prior art date
Application number
CY20201100472T
Other languages
English (en)
Inventor
Félix CUEVAS-CORDOBÉS
Carmen ALMANSA-ROSALES
Original Assignee
Esteve Pharmaceuticals, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Pharmaceuticals, S.A. filed Critical Esteve Pharmaceuticals, S.A.
Publication of CY1123231T1 publication Critical patent/CY1123231T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Abstract

Η παρούσα εφεύρεση αφορά σε νέες ενώσεις του γενικού τύπου (Ι) που παρουσιάζουν μεγάλη συνάφεια και δραστικότητα έναντι της υπομονάδας α2δ περιοριζόμενων από την τάση διαύλων ασβεστίου (VGCC), ειδικώς α2δ-1 υπομονάδα περιοριζόμενων από την τάση διαύλων ασβεστίου ή διπλή δραστικότητα έναντι υπομονάδας α2δ περιοριζόμενων από την τάση διαύλων ασβεστίου (VGCC), ιδιαίτερα α2δ-1 υπομονάδα περιοριζόμενων από την τάση διαύλων ασβεστίου και μεταφορέα νοραδρεναλίνης (NET). Η εφεύρεση επίσης αφορά στη μέθοδο για την παρασκευή των εν λόγω ενώσεων καθώς και συνθέσεων που περιλαμβάνουν αυτές και χρήση αυτών ως φάρμακα. (Ι)
CY20201100472T 2016-05-06 2020-05-25 Ενωσεις τετραϋδροπυριμιδοδιαζεπινης και τετραϋδροπυριδοδιαζεπινης για θεραπεια πονου και καταστασεων σχετικων με τον πονο CY1123231T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16382199 2016-05-06
PCT/EP2017/060780 WO2017191304A1 (en) 2016-05-06 2017-05-05 Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions

Publications (1)

Publication Number Publication Date
CY1123231T1 true CY1123231T1 (el) 2021-10-29

Family

ID=56024209

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100472T CY1123231T1 (el) 2016-05-06 2020-05-25 Ενωσεις τετραϋδροπυριμιδοδιαζεπινης και τετραϋδροπυριδοδιαζεπινης για θεραπεια πονου και καταστασεων σχετικων με τον πονο

Country Status (32)

Country Link
US (1) US10590140B2 (el)
EP (1) EP3452475B1 (el)
JP (1) JP6926197B2 (el)
KR (1) KR20190024876A (el)
CN (1) CN109526220B (el)
AR (1) AR108387A1 (el)
AU (1) AU2017260305B2 (el)
BR (1) BR112018072755A2 (el)
CA (1) CA3023379A1 (el)
CO (1) CO2018012002A2 (el)
CY (1) CY1123231T1 (el)
DK (1) DK3452475T3 (el)
ES (1) ES2789676T3 (el)
HR (1) HRP20200668T1 (el)
HU (1) HUE051829T2 (el)
IL (1) IL262825A (el)
LT (1) LT3452475T (el)
ME (1) ME03726B (el)
MX (1) MX2018013471A (el)
MY (1) MY196791A (el)
PH (1) PH12018502337A1 (el)
PL (1) PL3452475T3 (el)
PT (1) PT3452475T (el)
RS (1) RS60528B1 (el)
RU (1) RU2018141084A (el)
SG (1) SG11201809799WA (el)
SI (1) SI3452475T1 (el)
TN (1) TN2018000372A1 (el)
TW (1) TWI736619B (el)
UA (1) UA123789C2 (el)
WO (1) WO2017191304A1 (el)
ZA (1) ZA201807653B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019076904A1 (en) * 2017-10-16 2019-04-25 Esteve Pharmaceuticals, S.A. PROPANAMINE DERIVATIVES FOR THE TREATMENT OF PAIN AND PAIN DISEASES ASSOCIATED WITH PAIN
SG11202003599UA (en) * 2017-10-27 2020-05-28 Esteve Pharmaceuticals Sa New alcoxyamino derivatives for treating pain and pain related conditions
WO2019110137A1 (en) * 2017-12-04 2019-06-13 Esteve Pharmaceuticals, S.A. O-phenoxy and o-benzyloxypropylamino derivatives having activity against pain
WO2019115008A1 (en) * 2017-12-12 2019-06-20 Esteve Pharmaceuticals, S.A. Dialkylaminoarylpiperidinyl-o-phenoxy and o-benzyloxypropylamino derivatives having multimodal activity against pain
WO2019149919A1 (en) * 2018-02-05 2019-08-08 Esteve Pharmaceuticals, S.A. Aminopropoxypiperidinylamido derivatives having multimodal activity against pain
WO2020089263A1 (en) * 2018-10-31 2020-05-07 Esteve Pharmaceuticals, S.A. Optionally nitrogenated isoquinolin-1(2h)-ones and 1h-isochromen- 1-ones for treating pain and pain related conditions
WO2020089477A1 (en) * 2018-11-02 2020-05-07 Esteve Pharmaceuticals, S.A. New alcoxyaminopyridine derivatives for treating pain and pain related conditions
US20210395254A1 (en) * 2018-11-02 2021-12-23 Esteve Pharmaceuticals, S.A. New tetrahydropyrimidodiazepin and tetrahydropyridodiazepin compounds for treating pain and pain related conditions
WO2020175680A1 (ja) * 2019-02-28 2020-09-03 国立大学法人大阪大学 タンパク質及び／又はペプチド修飾用分子

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2002026732A1 (ja) * 2000-09-27 2004-07-08 味の素株式会社 ベンゾジアゼピン誘導体
AU2003239752A1 (en) 2002-06-27 2004-01-19 Warner-Lambert Company Llc Use of an alpha2delta ligand such as gabapentin or pregabalin for treating ttention deficit hyperactivity disorder
US20070197510A1 (en) * 2004-03-10 2007-08-23 Kazuyuki Ohmoto Nitriles and medicinal compositions containing the same as the active ingredient
ES2351367T3 (es) * 2006-02-14 2011-02-03 Vertex Pharmaceuticals Incorporated Dihidrodiazepinas útiles como inhibidores de proteína quinasas.
TW200914457A (en) 2007-05-31 2009-04-01 Kyowa Hakko Kogyo Kk Pyrimidodiazepinone derivative
UY32622A (es) * 2009-05-12 2010-12-31 Astrazeneca Ab Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)

Also Published As

Publication number Publication date
PT3452475T (pt) 2020-05-05
CA3023379A1 (en) 2017-11-09
RS60528B1 (sr) 2020-08-31
EP3452475A1 (en) 2019-03-13
ME03726B (me) 2021-01-20
MY196791A (en) 2023-05-03
WO2017191304A1 (en) 2017-11-09
UA123789C2 (uk) 2021-06-02
IL262825A (en) 2018-12-31
EP3452475B1 (en) 2020-02-26
CN109526220A (zh) 2019-03-26
HUE051829T2 (hu) 2021-03-29
JP6926197B2 (ja) 2021-08-25
JP2019515039A (ja) 2019-06-06
ES2789676T3 (es) 2020-10-26
MX2018013471A (es) 2019-06-06
TWI736619B (zh) 2021-08-21
AU2017260305A1 (en) 2018-12-13
PL3452475T3 (pl) 2020-08-24
RU2018141084A3 (el) 2020-06-11
LT3452475T (lt) 2020-05-11
PH12018502337A1 (en) 2019-07-08
KR20190024876A (ko) 2019-03-08
SG11201809799WA (en) 2018-12-28
ZA201807653B (en) 2019-06-26
US20190144455A1 (en) 2019-05-16
US10590140B2 (en) 2020-03-17
HRP20200668T1 (hr) 2020-10-16
TW201808955A (zh) 2018-03-16
CN109526220B (zh) 2021-12-21
AR108387A1 (es) 2018-08-15
DK3452475T3 (da) 2020-04-27
SI3452475T1 (sl) 2020-07-31
BR112018072755A2 (pt) 2019-02-19
CO2018012002A2 (es) 2019-04-30
AU2017260305B2 (en) 2021-04-01
TN2018000372A1 (en) 2020-06-15
RU2018141084A (ru) 2020-06-08

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