SG11201809799WA - Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions - Google Patents
Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditionsInfo
- Publication number
- SG11201809799WA SG11201809799WA SG11201809799WA SG11201809799WA SG11201809799WA SG 11201809799W A SG11201809799W A SG 11201809799WA SG 11201809799W A SG11201809799W A SG 11201809799WA SG 11201809799W A SG11201809799W A SG 11201809799WA SG 11201809799W A SG11201809799W A SG 11201809799WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- subunit
- compounds
- voltage
- pain
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/191304 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CO7D 471/04 (2006.01) A61K 31/551 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, CO7D 487/04 (2006.01) A61P 29/00 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, C07D 498/10 (2006.01) A61P 25/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/EP2017/060780 Published: — with international search report (Art. 21(3)) (22) International Filing Date: 05 May 2017 (05.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16382199.4 06 May 2016 (06.05.2016) EP (71) Applicant: LABORATORIOS DEL DR. ESTEVE, S.A. [ES/ES]; Avda. Mare de Deu de Montserrat, 221, 08041 BARCELONA (ES). (72) Inventors: CUEVAS-CORDOBES, Felix; Pza. Her- — mano Ramon Quiroga 2, 4F, 28340 VALDEMORO (Madrid) (ES). ALMANSA-ROSALES, Carmen; c/ — Teodora Lamadrid, n° 41, Ent 4', 08022 BARCELONA = (ES). = Agent: CARPINTERO LOPEZ, Francisco; Herrero & (74) — Asociados, S.L., Cedaceros, 1, 28014 MADRID (ES). — Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (81) — = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = = = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, — TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = Title: TETRAHYDROPYRIMIDODIAZEPINE AND TETRAHYDROPYRIDODIAZEPINE COMPOUNDS FOR TREATING (54) 1-1 PAIN AND PAIN RELATED CONDITIONS (57) : The present invention relates to new compounds of general formu- 71' en \ la (I) that show great affinity and activity towards the subunit GCS of voltage-gat- ed calcium channels (VGCC), especially a28-1 subunit of voltage-gated calcium __--y 1-1 N\-- '' ''''. 1 channels or dual activity towards subunit GCS of voltage-gated calcium channels 01 N (I) (VGCC), especially ct28-1 subunit of voltage gated calcium channels, and nora- 1-1 drenaline transporter (NET). The invention is also related to the process for the .--\". IN 1-1 NiiVx R2 preparation of said compounds as well as to compositions comprising them, and © ei i to their use as medicaments. (I) C
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382199 | 2016-05-06 | ||
| PCT/EP2017/060780 WO2017191304A1 (en) | 2016-05-06 | 2017-05-05 | Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201809799WA true SG11201809799WA (en) | 2018-12-28 |
Family
ID=56024209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201809799WA SG11201809799WA (en) | 2016-05-06 | 2017-05-05 | Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US10590140B2 (en) |
| EP (1) | EP3452475B1 (en) |
| JP (1) | JP6926197B2 (en) |
| KR (1) | KR20190024876A (en) |
| CN (1) | CN109526220B (en) |
| AR (1) | AR108387A1 (en) |
| AU (1) | AU2017260305B2 (en) |
| BR (1) | BR112018072755A2 (en) |
| CA (1) | CA3023379A1 (en) |
| CO (1) | CO2018012002A2 (en) |
| CY (1) | CY1123231T1 (en) |
| DK (1) | DK3452475T3 (en) |
| ES (1) | ES2789676T3 (en) |
| HR (1) | HRP20200668T1 (en) |
| HU (1) | HUE051829T2 (en) |
| IL (1) | IL262825A (en) |
| LT (1) | LT3452475T (en) |
| ME (1) | ME03726B (en) |
| MX (1) | MX2018013471A (en) |
| MY (1) | MY196791A (en) |
| PH (1) | PH12018502337A1 (en) |
| PL (1) | PL3452475T3 (en) |
| PT (1) | PT3452475T (en) |
| RS (1) | RS60528B1 (en) |
| RU (1) | RU2018141084A (en) |
| SG (1) | SG11201809799WA (en) |
| SI (1) | SI3452475T1 (en) |
| TN (1) | TN2018000372A1 (en) |
| TW (1) | TWI736619B (en) |
| UA (1) | UA123789C2 (en) |
| WO (1) | WO2017191304A1 (en) |
| ZA (1) | ZA201807653B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111225901B (en) | 2017-10-16 | 2023-07-04 | 埃斯特韦制药股份公司 | Propylamine derivatives for the treatment of pain and pain-related disorders |
| CA3084425A1 (en) * | 2017-10-27 | 2019-05-02 | Esteve Pharmaceuticals, S.A. | New alcoxyamino derivatives for treating pain and pain related conditions |
| TW201938154A (en) * | 2017-12-04 | 2019-10-01 | 西班牙商艾斯提夫製藥股份有限公司 | O-phenoxy and o-benzyloxypropylamino derivatives having activity against pain |
| WO2019115008A1 (en) * | 2017-12-12 | 2019-06-20 | Esteve Pharmaceuticals, S.A. | Dialkylaminoarylpiperidinyl-o-phenoxy and o-benzyloxypropylamino derivatives having multimodal activity against pain |
| WO2019149919A1 (en) * | 2018-02-05 | 2019-08-08 | Esteve Pharmaceuticals, S.A. | Aminopropoxypiperidinylamido derivatives having multimodal activity against pain |
| WO2020089263A1 (en) * | 2018-10-31 | 2020-05-07 | Esteve Pharmaceuticals, S.A. | Optionally nitrogenated isoquinolin-1(2h)-ones and 1h-isochromen- 1-ones for treating pain and pain related conditions |
| EP3873902A1 (en) * | 2018-11-02 | 2021-09-08 | Esteve Pharmaceuticals, S.A. | New tetrahydropyrimidodiazepin and tetrahydropyridodiazepin compounds for treating pain and pain related conditions |
| AR116972A1 (en) * | 2018-11-02 | 2021-06-30 | Esteve Pharmaceuticals Sa | ALCOXYAMINOPYRIDINE DERIVATIVES TO TREAT PAIN AND PAIN RELATED STATES |
| EP3932912A4 (en) * | 2019-02-28 | 2022-09-07 | Osaka University | Protein and/or peptide modification molecule |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1476446A (en) * | 2000-09-27 | 2004-02-18 | ֮����ʽ���� | Benzodiazepine derivative |
| AU2003239752A1 (en) | 2002-06-27 | 2004-01-19 | Warner-Lambert Company Llc | Use of an alpha2delta ligand such as gabapentin or pregabalin for treating ttention deficit hyperactivity disorder |
| JPWO2005085210A1 (en) * | 2004-03-10 | 2008-01-17 | 小野薬品工業株式会社 | Nitrile compound and pharmaceutical composition containing the compound as an active ingredient |
| CN101420955B (en) * | 2006-02-14 | 2013-07-17 | 沃泰克斯药物股份有限公司 | Dihydrodiazepines useful as inhibitors of protein kinases |
| TW200914457A (en) * | 2007-05-31 | 2009-04-01 | Kyowa Hakko Kogyo Kk | Pyrimidodiazepinone derivative |
| UY32622A (en) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | NEW COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES RELATED TO AB (BETA) |
-
2017
- 2017-05-05 SI SI201730239T patent/SI3452475T1/en unknown
- 2017-05-05 JP JP2019510471A patent/JP6926197B2/en active Active
- 2017-05-05 EP EP17721680.1A patent/EP3452475B1/en active Active
- 2017-05-05 HU HUE17721680A patent/HUE051829T2/en unknown
- 2017-05-05 MX MX2018013471A patent/MX2018013471A/en unknown
- 2017-05-05 ES ES17721680T patent/ES2789676T3/en active Active
- 2017-05-05 RU RU2018141084A patent/RU2018141084A/en unknown
- 2017-05-05 WO PCT/EP2017/060780 patent/WO2017191304A1/en unknown
- 2017-05-05 TN TNP/2018/000372A patent/TN2018000372A1/en unknown
- 2017-05-05 CA CA3023379A patent/CA3023379A1/en not_active Abandoned
- 2017-05-05 SG SG11201809799WA patent/SG11201809799WA/en unknown
- 2017-05-05 TW TW106114980A patent/TWI736619B/en not_active IP Right Cessation
- 2017-05-05 DK DK17721680.1T patent/DK3452475T3/en active
- 2017-05-05 RS RS20200595A patent/RS60528B1/en unknown
- 2017-05-05 US US16/098,244 patent/US10590140B2/en active Active
- 2017-05-05 AR ARP170101172A patent/AR108387A1/en unknown
- 2017-05-05 LT LTEP17721680.1T patent/LT3452475T/en unknown
- 2017-05-05 UA UAA201811326A patent/UA123789C2/en unknown
- 2017-05-05 AU AU2017260305A patent/AU2017260305B2/en not_active Ceased
- 2017-05-05 PT PT177216801T patent/PT3452475T/en unknown
- 2017-05-05 PL PL17721680T patent/PL3452475T3/en unknown
- 2017-05-05 MY MYPI2018704135A patent/MY196791A/en unknown
- 2017-05-05 BR BR112018072755-5A patent/BR112018072755A2/en not_active IP Right Cessation
- 2017-05-05 ME MEP-2020-101A patent/ME03726B/en unknown
- 2017-05-05 CN CN201780042378.XA patent/CN109526220B/en active Active
- 2017-05-05 KR KR1020187032195A patent/KR20190024876A/en not_active Application Discontinuation
-
2018
- 2018-11-06 PH PH12018502337A patent/PH12018502337A1/en unknown
- 2018-11-06 IL IL262825A patent/IL262825A/en unknown
- 2018-11-14 ZA ZA2018/07653A patent/ZA201807653B/en unknown
- 2018-11-29 CO CONC2018/0012002A patent/CO2018012002A2/en unknown
-
2020
- 2020-04-26 HR HRP20200668TT patent/HRP20200668T1/en unknown
- 2020-05-25 CY CY20201100472T patent/CY1123231T1/en unknown
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