ME03726B - Jedinjenja tetrahidropirimidodiazepina i tetrahidropirido-diazepina za lečenje bola i stanja povezanih sa bolom - Google Patents

Jedinjenja tetrahidropirimidodiazepina i tetrahidropirido-diazepina za lečenje bola i stanja povezanih sa bolom

Info

Publication number
ME03726B
ME03726B MEP-2020-101A MEP2020101A ME03726B ME 03726 B ME03726 B ME 03726B ME P2020101 A MEP2020101 A ME P2020101A ME 03726 B ME03726 B ME 03726B
Authority
ME
Montenegro
Prior art keywords
pain
tetrahydropyrimidodiazepine
tetrahydropyridodiazepine
compounds
related conditions
Prior art date
Application number
MEP-2020-101A
Other languages
German (de)
English (en)
French (fr)
Inventor
Félix Cuevas-Cordobés
Carmen Almansa-Rosales
Original Assignee
Esteve Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Pharmaceuticals Sa filed Critical Esteve Pharmaceuticals Sa
Publication of ME03726B publication Critical patent/ME03726B/me

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MEP-2020-101A 2016-05-06 2017-05-05 Jedinjenja tetrahidropirimidodiazepina i tetrahidropirido-diazepina za lečenje bola i stanja povezanih sa bolom ME03726B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16382199 2016-05-06
EP17721680.1A EP3452475B1 (en) 2016-05-06 2017-05-05 Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions
PCT/EP2017/060780 WO2017191304A1 (en) 2016-05-06 2017-05-05 Tetrahydropyrimidodiazepine and tetrahydropyridodiazepine compounds for treating pain and pain related conditions

Publications (1)

Publication Number Publication Date
ME03726B true ME03726B (me) 2021-01-20

Family

ID=56024209

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2020-101A ME03726B (me) 2016-05-06 2017-05-05 Jedinjenja tetrahidropirimidodiazepina i tetrahidropirido-diazepina za lečenje bola i stanja povezanih sa bolom

Country Status (32)

Country Link
US (1) US10590140B2 (me)
EP (1) EP3452475B1 (me)
JP (1) JP6926197B2 (me)
KR (1) KR20190024876A (me)
CN (1) CN109526220B (me)
AR (1) AR108387A1 (me)
AU (1) AU2017260305B2 (me)
BR (1) BR112018072755A2 (me)
CA (1) CA3023379A1 (me)
CO (1) CO2018012002A2 (me)
CY (1) CY1123231T1 (me)
DK (1) DK3452475T3 (me)
ES (1) ES2789676T3 (me)
HR (1) HRP20200668T1 (me)
HU (1) HUE051829T2 (me)
IL (1) IL262825A (me)
LT (1) LT3452475T (me)
ME (1) ME03726B (me)
MX (1) MX2018013471A (me)
MY (1) MY196791A (me)
PH (1) PH12018502337A1 (me)
PL (1) PL3452475T3 (me)
PT (1) PT3452475T (me)
RS (1) RS60528B1 (me)
RU (1) RU2018141084A (me)
SG (1) SG11201809799WA (me)
SI (1) SI3452475T1 (me)
TN (1) TN2018000372A1 (me)
TW (1) TWI736619B (me)
UA (1) UA123789C2 (me)
WO (1) WO2017191304A1 (me)
ZA (1) ZA201807653B (me)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3697754A1 (en) * 2017-10-16 2020-08-26 Esteve Pharmaceuticals, S.A. Propanamine derivatives for treating pain and pain related conditions
KR20200097694A (ko) * 2017-10-27 2020-08-19 에스테베 파마슈티칼스 에스에이 통증 및 통증 관련 상태를 치료하기 위한 신규한 알콕시아미노 유도체
AR113910A1 (es) * 2017-12-04 2020-06-24 Esteve Pharmaceuticals Sa Derivados de o-fenoxi y o-benciloxipropilamino con actividad contra el dolor
WO2019115008A1 (en) * 2017-12-12 2019-06-20 Esteve Pharmaceuticals, S.A. Dialkylaminoarylpiperidinyl-o-phenoxy and o-benzyloxypropylamino derivatives having multimodal activity against pain
WO2019149919A1 (en) * 2018-02-05 2019-08-08 Esteve Pharmaceuticals, S.A. Aminopropoxypiperidinylamido derivatives having multimodal activity against pain
WO2020089263A1 (en) * 2018-10-31 2020-05-07 Esteve Pharmaceuticals, S.A. Optionally nitrogenated isoquinolin-1(2h)-ones and 1h-isochromen- 1-ones for treating pain and pain related conditions
AR116972A1 (es) * 2018-11-02 2021-06-30 Esteve Pharmaceuticals Sa Derivados de alcoxiaminopiridina para tratar dolor y estados relacionados con dolor
JP2022506378A (ja) * 2018-11-02 2022-01-17 エステベ ファーマシューティカルズ,ソシエダッド アノニマ 疼痛及び疼痛に関連する状態を処置するための新規なテトラヒドロピリミドジアゼピン及びテトラヒドロピリドジアゼピン化合物
US20220204481A1 (en) * 2019-02-28 2022-06-30 Osaka University Protein and/or peptide modification molecule

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03002649A (es) * 2000-09-27 2003-09-25 Ajinomoto Kk Derivado de benzodiazepina.
AU2003239752A1 (en) 2002-06-27 2004-01-19 Warner-Lambert Company Llc Use of an alpha2delta ligand such as gabapentin or pregabalin for treating ttention deficit hyperactivity disorder
JPWO2005085210A1 (ja) * 2004-03-10 2008-01-17 小野薬品工業株式会社 ニトリル化合物およびその化合物を有効成分として含有する医薬組成物
ZA200806871B (en) * 2006-02-14 2009-10-28 Vertex Pharma Dihydrodiazepines useful as inhibitors of protein kinases
TW200914457A (en) * 2007-05-31 2009-04-01 Kyowa Hakko Kogyo Kk Pyrimidodiazepinone derivative
UY32622A (es) * 2009-05-12 2010-12-31 Astrazeneca Ab Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)

Also Published As

Publication number Publication date
TW201808955A (zh) 2018-03-16
PT3452475T (pt) 2020-05-05
PL3452475T3 (pl) 2020-08-24
SI3452475T1 (sl) 2020-07-31
AU2017260305A1 (en) 2018-12-13
CN109526220A (zh) 2019-03-26
EP3452475B1 (en) 2020-02-26
SG11201809799WA (en) 2018-12-28
AR108387A1 (es) 2018-08-15
DK3452475T3 (da) 2020-04-27
JP6926197B2 (ja) 2021-08-25
EP3452475A1 (en) 2019-03-13
CY1123231T1 (el) 2021-10-29
UA123789C2 (uk) 2021-06-02
HUE051829T2 (hu) 2021-03-29
ES2789676T3 (es) 2020-10-26
LT3452475T (lt) 2020-05-11
CA3023379A1 (en) 2017-11-09
WO2017191304A1 (en) 2017-11-09
CN109526220B (zh) 2021-12-21
US20190144455A1 (en) 2019-05-16
HRP20200668T1 (hr) 2020-10-16
MX2018013471A (es) 2019-06-06
TWI736619B (zh) 2021-08-21
US10590140B2 (en) 2020-03-17
BR112018072755A2 (pt) 2019-02-19
JP2019515039A (ja) 2019-06-06
KR20190024876A (ko) 2019-03-08
RU2018141084A3 (me) 2020-06-11
MY196791A (en) 2023-05-03
PH12018502337A1 (en) 2019-07-08
RU2018141084A (ru) 2020-06-08
AU2017260305B2 (en) 2021-04-01
TN2018000372A1 (en) 2020-06-15
CO2018012002A2 (es) 2019-04-30
ZA201807653B (en) 2019-06-26
IL262825A (en) 2018-12-31
RS60528B1 (sr) 2020-08-31

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