MD3393478T2 - Terapie combinată - Google Patents

Terapie combinată Download PDF

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Publication number
MD3393478T2
MD3393478T2 MDE20181039T MDE20181039T MD3393478T2 MD 3393478 T2 MD3393478 T2 MD 3393478T2 MD E20181039 T MDE20181039 T MD E20181039T MD E20181039 T MDE20181039 T MD E20181039T MD 3393478 T2 MD3393478 T2 MD 3393478T2
Authority
MD
Moldova
Prior art keywords
cancer
gemcitabine
phenyl
benzoxy
phosphate
Prior art date
Application number
MDE20181039T
Other languages
English (en)
Romanian (ro)
Inventor
Hugh Griffith
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2015/054158 external-priority patent/WO2017109444A1/en
Priority claimed from GBGB1609770.1A external-priority patent/GB201609770D0/en
Application filed by NuCana plc filed Critical NuCana plc
Publication of MD3393478T2 publication Critical patent/MD3393478T2/ro

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/282Platinum compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MDE20181039T 2015-12-23 2016-12-21 Terapie combinată MD3393478T2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2015/054158 WO2017109444A1 (en) 2015-12-23 2015-12-23 Combination therapy
GBGB1609770.1A GB201609770D0 (en) 2016-06-03 2016-06-03 Combination therapy
PCT/GB2016/054018 WO2017109486A1 (en) 2015-12-23 2016-12-21 Combination therapy

Publications (1)

Publication Number Publication Date
MD3393478T2 true MD3393478T2 (ro) 2020-04-30

Family

ID=57681677

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20181039T MD3393478T2 (ro) 2015-12-23 2016-12-21 Terapie combinată

Country Status (29)

Country Link
US (2) US20190022117A1 (enExample)
EP (2) EP3738595A1 (enExample)
JP (1) JP6898329B2 (enExample)
KR (1) KR20180096698A (enExample)
CN (1) CN108697725A (enExample)
AU (1) AU2016375861B2 (enExample)
CA (1) CA3008749C (enExample)
CY (1) CY1122835T1 (enExample)
DK (1) DK3393478T3 (enExample)
EA (1) EA037459B1 (enExample)
ES (1) ES2778933T3 (enExample)
HR (1) HRP20200423T1 (enExample)
HU (1) HUE050290T2 (enExample)
IL (1) IL260076A (enExample)
LT (1) LT3393478T (enExample)
MA (1) MA51576A (enExample)
MD (1) MD3393478T2 (enExample)
ME (1) ME03677B (enExample)
MX (1) MX383988B (enExample)
MY (1) MY194629A (enExample)
PH (1) PH12018501339A1 (enExample)
PL (1) PL3393478T3 (enExample)
PT (1) PT3393478T (enExample)
RS (1) RS60211B1 (enExample)
SG (1) SG11201805184TA (enExample)
SI (1) SI3393478T1 (enExample)
SM (1) SMT202000154T1 (enExample)
WO (1) WO2017109486A1 (enExample)
ZA (1) ZA201804155B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3235824B1 (en) 2012-11-16 2019-03-27 University College Cardiff Consultants Limited Mixture of rp/sp gemcitabine-[phenyl-(benzyloxy-l-alaninyl)]-phosphate
HRP20180007T1 (hr) 2014-06-25 2018-02-23 NuCana plc Formulacija koja sadrži gemcitabin-predlijek
PL3160978T3 (pl) 2014-06-25 2020-11-30 NuCana plc Proleki gemcytabiny
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
CN108135920A (zh) 2015-10-05 2018-06-08 努卡那有限公司 组合疗法
MX386478B (es) 2015-12-11 2025-03-18 Laurus Labs Ltd Sintesis diaestereoselectiva de derivados de fosfato y del profarmaco de gemcitabina nuc-1031.
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
KR20150044838A (ko) * 2012-08-13 2015-04-27 레귤론, 인코퍼레이티드. 리포플라틴을 이용한 암 치료방법
WO2014078295A1 (en) * 2012-11-13 2014-05-22 BoYen Therapeutics, Inc. Gemcitabine prodrugs and uses thereof
LT3197456T (lt) * 2015-05-14 2018-07-10 NuCana plc Vėžio gydymas
CN108135920A (zh) * 2015-10-05 2018-06-08 努卡那有限公司 组合疗法

Also Published As

Publication number Publication date
HRP20200423T1 (hr) 2020-09-04
MX2018007772A (es) 2019-07-04
MA51576A (fr) 2020-11-18
MX383988B (es) 2025-03-14
CA3008749C (en) 2024-01-02
EP3738595A1 (en) 2020-11-18
DK3393478T3 (da) 2020-03-23
BR112018012956A2 (pt) 2019-01-08
EA037459B1 (ru) 2021-03-30
US20230149436A1 (en) 2023-05-18
PT3393478T (pt) 2020-03-24
LT3393478T (lt) 2020-04-10
ME03677B (me) 2020-10-20
SI3393478T1 (sl) 2020-07-31
IL260076A (en) 2018-07-31
AU2016375861A1 (en) 2018-07-05
CY1122835T1 (el) 2021-05-05
KR20180096698A (ko) 2018-08-29
AU2016375861B2 (en) 2021-12-23
EA201891473A1 (ru) 2019-01-31
RS60211B1 (sr) 2020-06-30
CA3008749A1 (en) 2017-06-29
PL3393478T3 (pl) 2020-07-13
SMT202000154T1 (it) 2020-05-08
ZA201804155B (en) 2021-06-30
HK1255110A1 (en) 2019-08-02
HUE050290T2 (hu) 2020-11-30
JP6898329B2 (ja) 2021-07-07
EP3393478A1 (en) 2018-10-31
MY194629A (en) 2022-12-07
CN108697725A (zh) 2018-10-23
WO2017109486A1 (en) 2017-06-29
EP3393478B1 (en) 2020-03-04
PH12018501339A1 (en) 2019-02-18
JP2019509253A (ja) 2019-04-04
ES2778933T3 (es) 2020-08-12
US20190022117A1 (en) 2019-01-24
SG11201805184TA (en) 2018-07-30

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Legal Events

Date Code Title Description
MM4A Patent for invention definitely lapsed due to non-payment of fees