MD3393478T2 - Terapie combinată - Google Patents

Terapie combinată Download PDF

Info

Publication number
MD3393478T2
MD3393478T2 MDE20181039T MDE20181039T MD3393478T2 MD 3393478 T2 MD3393478 T2 MD 3393478T2 MD E20181039 T MDE20181039 T MD E20181039T MD E20181039 T MDE20181039 T MD E20181039T MD 3393478 T2 MD3393478 T2 MD 3393478T2
Authority
MD
Moldova
Prior art keywords
cancer
gemcitabine
phenyl
benzoxy
phosphate
Prior art date
Application number
MDE20181039T
Other languages
English (en)
Romanian (ro)
Inventor
Hugh Griffith
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2015/054158 external-priority patent/WO2017109444A1/en
Priority claimed from GBGB1609770.1A external-priority patent/GB201609770D0/en
Application filed by NuCana plc filed Critical NuCana plc
Publication of MD3393478T2 publication Critical patent/MD3393478T2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MDE20181039T 2015-12-23 2016-12-21 Terapie combinată MD3393478T2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/GB2015/054158 WO2017109444A1 (en) 2015-12-23 2015-12-23 Combination therapy
GBGB1609770.1A GB201609770D0 (en) 2016-06-03 2016-06-03 Combination therapy
PCT/GB2016/054018 WO2017109486A1 (en) 2015-12-23 2016-12-21 Combination therapy

Publications (1)

Publication Number Publication Date
MD3393478T2 true MD3393478T2 (ro) 2020-04-30

Family

ID=57681677

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20181039T MD3393478T2 (ro) 2015-12-23 2016-12-21 Terapie combinată

Country Status (29)

Country Link
US (2) US20190022117A1 (enExample)
EP (2) EP3738595A1 (enExample)
JP (1) JP6898329B2 (enExample)
KR (1) KR20180096698A (enExample)
CN (1) CN108697725A (enExample)
AU (1) AU2016375861B2 (enExample)
CA (1) CA3008749C (enExample)
CY (1) CY1122835T1 (enExample)
DK (1) DK3393478T3 (enExample)
EA (1) EA037459B1 (enExample)
ES (1) ES2778933T3 (enExample)
HR (1) HRP20200423T1 (enExample)
HU (1) HUE050290T2 (enExample)
IL (1) IL260076A (enExample)
LT (1) LT3393478T (enExample)
MA (1) MA51576A (enExample)
MD (1) MD3393478T2 (enExample)
ME (1) ME03677B (enExample)
MX (1) MX383988B (enExample)
MY (1) MY194629A (enExample)
PH (1) PH12018501339A1 (enExample)
PL (1) PL3393478T3 (enExample)
PT (1) PT3393478T (enExample)
RS (1) RS60211B1 (enExample)
SG (1) SG11201805184TA (enExample)
SI (1) SI3393478T1 (enExample)
SM (1) SMT202000154T1 (enExample)
WO (1) WO2017109486A1 (enExample)
ZA (1) ZA201804155B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013346515B2 (en) 2012-11-16 2017-05-25 NuCana plc Process for preparing nucleoside prodrugs
EA033046B1 (ru) 2014-06-25 2019-08-30 НУКАНА ПиЭлСи Состав, содержащий пролекарство гемцитабина
RS60968B1 (sr) 2014-06-25 2020-11-30 NuCana plc Prolekovi gemcitabina
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
PH12018500691B1 (en) 2015-10-05 2022-08-10 NuCana plc Combination therapy
CA3007347C (en) 2015-12-11 2020-08-04 NuCana plc Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
EA201491629A1 (ru) * 2012-08-13 2015-08-31 Регулон, Инк. Способы лечения рака с использованием липоплатина
JP6420247B2 (ja) * 2012-11-13 2018-11-07 ボーイエン セラピューティクス,インコーポレイティド ゲムシタビンプロドラッグ及びその使用
CN107835687A (zh) * 2015-05-14 2018-03-23 努卡那有限公司 癌症治疗
PH12018500691B1 (en) * 2015-10-05 2022-08-10 NuCana plc Combination therapy

Also Published As

Publication number Publication date
US20190022117A1 (en) 2019-01-24
JP2019509253A (ja) 2019-04-04
MX2018007772A (es) 2019-07-04
WO2017109486A1 (en) 2017-06-29
SMT202000154T1 (it) 2020-05-08
HK1255110A1 (en) 2019-08-02
US20230149436A1 (en) 2023-05-18
ME03677B (me) 2020-10-20
KR20180096698A (ko) 2018-08-29
EA201891473A1 (ru) 2019-01-31
MA51576A (fr) 2020-11-18
PH12018501339A1 (en) 2019-02-18
ZA201804155B (en) 2021-06-30
LT3393478T (lt) 2020-04-10
DK3393478T3 (da) 2020-03-23
MY194629A (en) 2022-12-07
EP3738595A1 (en) 2020-11-18
CY1122835T1 (el) 2021-05-05
AU2016375861B2 (en) 2021-12-23
MX383988B (es) 2025-03-14
CA3008749C (en) 2024-01-02
PL3393478T3 (pl) 2020-07-13
BR112018012956A2 (pt) 2019-01-08
PT3393478T (pt) 2020-03-24
JP6898329B2 (ja) 2021-07-07
CN108697725A (zh) 2018-10-23
CA3008749A1 (en) 2017-06-29
SG11201805184TA (en) 2018-07-30
RS60211B1 (sr) 2020-06-30
HRP20200423T1 (hr) 2020-09-04
SI3393478T1 (sl) 2020-07-31
HUE050290T2 (hu) 2020-11-30
IL260076A (en) 2018-07-31
EP3393478A1 (en) 2018-10-31
ES2778933T3 (es) 2020-08-12
EA037459B1 (ru) 2021-03-30
EP3393478B1 (en) 2020-03-04
AU2016375861A1 (en) 2018-07-05

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Legal Events

Date Code Title Description
MM4A Patent for invention definitely lapsed due to non-payment of fees