JP2018519245A - 癌の治療のためのインドールアミン−2,3−ジオキシゲナーゼの阻害剤およびそれらの使用方法 - Google Patents
癌の治療のためのインドールアミン−2,3−ジオキシゲナーゼの阻害剤およびそれらの使用方法 Download PDFInfo
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- JP2018519245A JP2018519245A JP2017551628A JP2017551628A JP2018519245A JP 2018519245 A JP2018519245 A JP 2018519245A JP 2017551628 A JP2017551628 A JP 2017551628A JP 2017551628 A JP2017551628 A JP 2017551628A JP 2018519245 A JP2018519245 A JP 2018519245A
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Classifications
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| US20200188482A1 (en) * | 2017-04-28 | 2020-06-18 | The Brigham And Women`S Hospital, Inc. | Targeting gamma-delta t cells in obesity and cachexia |
| CA3062294A1 (en) | 2017-05-03 | 2018-11-08 | Vivace Therapeutics, Inc. | Non-fused tricyclic compounds |
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| US11192865B2 (en) | 2017-08-21 | 2021-12-07 | Vivace Therapeutics, Inc. | Benzosulfonyl compounds |
| WO2019078968A2 (en) * | 2017-10-18 | 2019-04-25 | Angex Pharmaceutical, Inc. | CYCLIC COMPOUNDS AS IMMUNOMODULATORS |
| CN109836356B (zh) * | 2017-11-24 | 2022-03-08 | 沈阳化工研究院有限公司 | 一种芳甲醚衍生物及其应用 |
| WO2019113236A1 (en) | 2017-12-06 | 2019-06-13 | Vivace Therapeutics, Inc. | Benzocarbonyl compounds |
| AU2019205904A1 (en) | 2018-01-05 | 2020-06-18 | Dicerna Pharmaceuticals, Inc. | Reducing beta-catenin and IDO expression to potentiate immunotherapy |
| US11447449B2 (en) | 2018-01-05 | 2022-09-20 | Bristol-Myers Squibb Company | Inhibitors of indoleamine 2,3-dioxygenase and methods of their use |
| US11661403B2 (en) | 2018-05-16 | 2023-05-30 | Vivace Therapeutics, Inc. | Oxadiazole compounds |
| CN112384283B (zh) * | 2018-07-06 | 2023-08-15 | 吉利德科学公司 | 治疗性的杂环化合物 |
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| US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
| CN109608334B (zh) * | 2019-01-11 | 2021-07-13 | 盐城通海生物科技有限公司 | 一种合成4-甲氧基巴豆酸甲酯的方法 |
| BR112021014911A2 (pt) * | 2019-02-01 | 2021-11-23 | Glaxosmithkline Ip Dev Ltd | Belantamabe mafodotina em combinação com pembrolizumabe para tratamento de câncer |
| KR102386849B1 (ko) * | 2019-10-14 | 2022-04-13 | 포항공과대학교 산학협력단 | 면역치료를 위한 환경 반응형 접착성 항체전달체 및 이의 제조방법 |
| WO2021102618A1 (en) | 2019-11-25 | 2021-06-03 | InventisBio Co., Ltd. | Novel salts of indoleamine 2,3-dioxygenase inhibitors |
| CN113214138A (zh) * | 2020-02-04 | 2021-08-06 | 中国医学科学院药物研究所 | 苯丙酸类衍生物、及其制法和药物组合物与用途 |
| US11839659B2 (en) | 2020-07-02 | 2023-12-12 | Northwestern University | Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein |
| CN112174891B (zh) * | 2020-11-02 | 2022-02-01 | 浙江省农业科学院 | 一种氟唑菌苯胺代谢物的制备方法 |
| JP2024016314A (ja) * | 2020-12-24 | 2024-02-07 | 小野薬品工業株式会社 | 一般式(i-a)で示される化合物、その薬学的に許容される塩、またはそれらの水和物と免疫チェックポイント阻害薬および/またはep4受容体拮抗薬との組み合わせ |
| EP4052705A1 (en) | 2021-03-05 | 2022-09-07 | Universität Basel Vizerektorat Forschung | Compositions for the treatment of ebv associated diseases or conditions |
| KR20230152715A (ko) | 2021-03-05 | 2023-11-03 | 유니버시타트 바셀 | Ebv 관련 질환 또는 질병의 치료용 조성물 |
Family Cites Families (40)
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|---|---|---|---|---|
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| US4252894A (en) * | 1975-10-22 | 1981-02-24 | Gaf Corporation | Hydrophilic color coupler composition containing diepoxide |
| WO2003099276A1 (en) | 2002-05-10 | 2003-12-04 | Bristol-Myers Squibb Company | 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors |
| CN101445469B (zh) * | 2003-09-24 | 2013-02-13 | 梅特希尔基因公司 | 组蛋白脱乙酰基酶抑制剂 |
| AU2004276337B2 (en) | 2003-09-24 | 2009-11-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
| TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ox40l抗體 |
| US7812135B2 (en) | 2005-03-25 | 2010-10-12 | Tolerrx, Inc. | GITR-binding antibodies |
| DK2559690T3 (en) | 2005-05-10 | 2016-04-25 | Incyte Holdings Corp | Modulators of indoleamine 2,3-dioxygenase and methods of use thereof |
| AU2006265108C1 (en) | 2005-07-01 | 2013-01-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (PD-L1) |
| ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
| MX2008013400A (es) * | 2006-04-19 | 2008-11-10 | Astellas Pharma Inc | Derivado de azolcarboxamida. |
| JP5319532B2 (ja) | 2006-09-19 | 2013-10-16 | インサイト・コーポレイション | インドールアミン2,3−ジオキシゲナーゼのモジュレーターとしてのn−ヒドロキシアミジノヘテロサイクル |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| EP2175884B8 (en) | 2007-07-12 | 2017-02-22 | GITR, Inc. | Combination therapies employing gitr binding molecules |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| CA2932121A1 (en) | 2007-11-30 | 2009-06-11 | Newlink Genetics Corporation | Ido inhibitors |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| PT2376535T (pt) | 2008-12-09 | 2017-06-23 | Hoffmann La Roche | Anticorpos anti-pd-l1 e a sua utilização para a melhoria do funcionamento das células t |
| HUE049825T2 (hu) | 2009-09-03 | 2020-10-28 | Merck Sharp & Dohme | Anti-GITR antitestek |
| EP2493862B1 (en) | 2009-10-28 | 2016-10-05 | Newlink Genetics Corporation | Imidazole derivatives as ido inhibitors |
| MY159679A (en) | 2009-12-10 | 2017-01-13 | Hoffmann La Roche | Antibodies binding preferentially human csf1r extracellular domain 4 and their use |
| BR112012022210B1 (pt) | 2010-03-04 | 2021-08-17 | Macrogenics, Inc | Anticorpo isolado ou seu fragmento imunorreativo, molécula de ácido nucleico, composição farmacêutica, e, uso do anticorpo isolado |
| MX336682B (es) | 2010-03-05 | 2016-01-27 | Hoffmann La Roche | Anticuerpos contra csf-1r humanos y usos de los mismos. |
| RU2617971C2 (ru) | 2010-03-05 | 2017-04-28 | Ф.Хоффманн-Ля Рош Аг | Антитела против csf-1r человека и их применение |
| KR20200044999A (ko) | 2010-05-04 | 2020-04-29 | 파이브 프라임 테라퓨틱스, 인크. | Csf1r에 결합하는 항체들 |
| SI2614082T1 (sl) | 2010-09-09 | 2018-12-31 | Pfizer Inc. | Molekule, ki vežejo 4-1BB |
| NO2694640T3 (enExample) | 2011-04-15 | 2018-03-17 | ||
| RS57324B1 (sr) | 2011-04-20 | 2018-08-31 | Medimmune Llc | Antitela i drugi molekuli koji vezuju b7-h1 i pd-1 |
| CA2856895C (en) | 2011-11-28 | 2021-10-26 | Merck Patent Gmbh | Anti-pd-l1 antibodies and uses thereof |
| CN104159921B (zh) | 2011-12-15 | 2018-05-04 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
| CA2861122A1 (en) | 2012-02-06 | 2013-08-15 | Genentech, Inc. | Compositions and methods for using csf1r inhibitors |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| EP3539984A1 (en) | 2012-05-11 | 2019-09-18 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| TWI713436B (zh) | 2012-08-31 | 2020-12-21 | 美商戊瑞治療有限公司 | 用結合群落刺激因子1受體(csf1r)之抗體治療病狀之方法 |
| HRP20180971T1 (hr) * | 2013-03-15 | 2018-08-10 | Bristol-Myers Squibb Company | Inhibitori indolamin 2,3-dioksigenaze (ido) |
| HK1220442A1 (zh) * | 2013-03-15 | 2017-05-05 | Bristol-Myers Squibb Company | Ido抑制剂 |
| MX2016002075A (es) * | 2013-08-27 | 2016-05-26 | Squibb Bristol Myers Co | Inhibidores de indolamina 2,3-dioxigenasa (ido). |
| US10399933B2 (en) * | 2015-04-03 | 2019-09-03 | Bristol-Myers Squibb Company | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer |
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