JP2018518152A5 - - Google Patents
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- JP2018518152A5 JP2018518152A5 JP2017550493A JP2017550493A JP2018518152A5 JP 2018518152 A5 JP2018518152 A5 JP 2018518152A5 JP 2017550493 A JP2017550493 A JP 2017550493A JP 2017550493 A JP2017550493 A JP 2017550493A JP 2018518152 A5 JP2018518152 A5 JP 2018518152A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- acid sequence
- equivalent
- lhr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 54
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 41
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 37
- 102000023108 LH Receptors Human genes 0.000 claims description 31
- 108010011942 LH Receptors Proteins 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 30
- 229920001184 polypeptide Polymers 0.000 claims description 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 29
- 206010028980 Neoplasm Diseases 0.000 claims description 22
- 150000007523 nucleic acids Chemical group 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 19
- 239000013598 vector Substances 0.000 claims description 17
- 239000000427 antigen Substances 0.000 claims description 16
- 102000036639 antigens Human genes 0.000 claims description 16
- 108091007433 antigens Proteins 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 16
- 239000000523 sample Substances 0.000 claims description 16
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 12
- 239000012472 biological sample Substances 0.000 claims description 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 11
- 108020004707 nucleic acids Proteins 0.000 claims description 9
- 102000039446 nucleic acids Human genes 0.000 claims description 9
- 108091035707 Consensus sequence Proteins 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 206010060862 Prostate cancer Diseases 0.000 claims description 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 5
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 claims description 4
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 230000001575 pathological effect Effects 0.000 claims description 4
- 230000011664 signaling Effects 0.000 claims description 4
- 230000004614 tumor growth Effects 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 3
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 2
- 102000003735 Mesothelin Human genes 0.000 claims description 2
- 108090000015 Mesothelin Proteins 0.000 claims description 2
- 102100023123 Mucin-16 Human genes 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 230000000139 costimulatory effect Effects 0.000 claims description 2
- 239000003623 enhancer Substances 0.000 claims description 2
- 108091008039 hormone receptors Proteins 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 229940040129 luteinizing hormone Drugs 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 238000003364 immunohistochemistry Methods 0.000 description 4
- 206010033128 Ovarian cancer Diseases 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000713666 Lentivirus Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562139623P | 2015-03-27 | 2015-03-27 | |
| US62/139,623 | 2015-03-27 | ||
| PCT/US2016/024354 WO2016160618A2 (en) | 2015-03-27 | 2016-03-25 | Car t-cell therapy directed to lhr for the treatment of solid tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018518152A JP2018518152A (ja) | 2018-07-12 |
| JP2018518152A5 true JP2018518152A5 (cg-RX-API-DMAC7.html) | 2019-05-09 |
Family
ID=57007252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017550493A Pending JP2018518152A (ja) | 2015-03-27 | 2016-03-25 | 充実性腫瘍を処置するためのｌｈｒに指向されたｃａｒ ｔ細胞治療 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11136401B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3273994B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018518152A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107530427A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016243124A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2981142A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2904573T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL254701A0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016160618A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2904573T3 (es) | 2015-03-27 | 2022-04-05 | Univ Southern California | Terapia con células T dirigida a LHR para el tratamiento de tumores sólidos |
| CN107847601A (zh) | 2015-06-04 | 2018-03-27 | 南加利福尼亚大学 | Lym‑1和lym‑2靶向的car细胞免疫疗法 |
| US10501775B2 (en) | 2016-07-12 | 2019-12-10 | Kite Pharma, Inc. | Antigen binding molecules and methods of use thereof |
| JP2020501512A (ja) * | 2016-09-23 | 2020-01-23 | ユニバーシティ オブ サザン カリフォルニア | キメラ抗原受容体およびその組成物ならびにそれらの使用の方法 |
| IL266892B2 (en) | 2016-12-02 | 2025-10-01 | Univ Southern California | Artificial immune receptors and methods of using them |
| CA3056227A1 (en) * | 2017-03-13 | 2018-09-20 | Poseida Therapeutics, Inc. | Compositions and methods for selective elimination and replacement of hematopoietic stem cells |
| CN107354199A (zh) * | 2017-07-04 | 2017-11-17 | 武汉波睿达生物科技有限公司 | 一种检测靶向cd30的cart细胞中car表达的荧光定量试剂盒 |
| US10844371B2 (en) | 2017-09-22 | 2020-11-24 | Kite Pharma, Inc. | Antigen binding molecules and methods of use thereof |
| EP3675878A4 (en) | 2017-10-02 | 2021-06-16 | Fred Hutchinson Cancer Research Center | LUTEINIZING HORMONE RECEPTOR BINDERS AND LUTEINIZING HORMONAGONISTS FOR IDENTIFICATION, EXPANSION, ABLATION AND MODIFICATION OF PRIMITIVE STEM CELL POPULATIONS |
| EP3802615A4 (en) | 2018-06-04 | 2022-04-13 | Precigen, Inc. | Muc16 specific chimeric antigen receptors and uses thereof |
| CN112639102B (zh) * | 2018-08-29 | 2024-03-01 | 南京传奇生物科技有限公司 | 抗间皮素嵌合抗原受体(car)构建体及其用途 |
| CA3116130A1 (en) | 2018-10-13 | 2020-04-16 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for identifying and treating subjects at risk for poor car t cell therapy response |
| BR112021013180A2 (pt) * | 2019-01-06 | 2022-04-12 | Abintus Bio Inc | Composição farmacêutica, vetor viral não replicante, e, método para prover terapia celular adotiva |
| JP2022520106A (ja) | 2019-02-15 | 2022-03-28 | ユニバーシティ オブ サザン カリフォルニア | Ｌｙｍ－１およびｌｙｍ－２抗体組成物ならびに改善されたｃａｒ構築物 |
| US20200384029A1 (en) * | 2019-06-07 | 2020-12-10 | The Trustees Of The University Of Pennsylvania | Dual car expressing t cells individually linked to cd28 and 4-1bb |
| WO2021142413A1 (en) * | 2020-01-12 | 2021-07-15 | Vanderbilt University | Human antibodies to crimean congo hemorrhagic fever virus |
| WO2022008471A1 (en) * | 2020-07-07 | 2022-01-13 | THERMOSOME GmbH | Liposome formulations |
| WO2022081436A1 (en) * | 2020-10-15 | 2022-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス，インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| US12144827B2 (en) | 2021-02-25 | 2024-11-19 | Lyell Immunopharma, Inc. | ROR1 targeting chimeric antigen receptor |
| CN113156142B (zh) * | 2021-04-16 | 2024-09-27 | 苏州才博医学科技有限公司 | 一种针对异体cart细胞特异性抗体的检测方法 |
| WO2025117530A2 (en) * | 2023-11-27 | 2025-06-05 | The Trustees Of Columbia University In The City Of New York | Tmem106b(120-254) aggregate-binding antibody |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US707993A (en) | 1901-05-16 | 1902-08-26 | Clinton J Warren | Machine for corking bottles. |
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| WO1991010737A1 (en) | 1990-01-11 | 1991-07-25 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| DK0564531T3 (da) | 1990-12-03 | 1998-09-28 | Genentech Inc | Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber |
| DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
| CA2110799A1 (en) | 1991-06-14 | 1992-12-23 | Arnold H. Horwitz | Microbially-produced antibody fragments and their conjugates |
| DE69233745D1 (de) | 1991-12-02 | 2008-10-23 | Cambridge Antibody Tech | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| JPH09506262A (ja) | 1993-12-08 | 1997-06-24 | ジェンザイム・コーポレイション | 特異的抗体の製造方法 |
| DE69534347T2 (de) | 1994-01-31 | 2006-05-24 | Trustees Of Boston University, Boston | Bibliotheken aus Polyklonalen Antikörpern |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| GB9416721D0 (en) | 1994-08-18 | 1994-10-12 | Short Brothers Plc | A bias yarn assembly forming device |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| DK1143006T3 (da) | 1995-08-18 | 2008-07-14 | Morphosys Ip Gmbh | Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| US6924123B2 (en) | 1996-10-29 | 2005-08-02 | Oxford Biomedica (Uk) Limited | Lentiviral LTR-deleted vector |
| PT1144607E (pt) | 1999-07-20 | 2009-04-22 | Morphosys Ag | Novos métodos para apresentar (poli)peptídeos/ proteínas em partículas bacteriofágicas através de ligações dissulfureto |
| AT411997B (de) | 1999-09-14 | 2004-08-26 | Baxter Ag | Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate |
| AU780825B2 (en) | 1999-09-27 | 2005-04-21 | Clifford L. Librach | Detection of HLA-G |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| AU2001243288B2 (en) | 2000-02-24 | 2005-11-24 | Life Technologies Corporation | Simultaneous stimulation and concentration of cells |
| US7419829B2 (en) | 2000-10-06 | 2008-09-02 | Oxford Biomedica (Uk) Limited | Vector system |
| EP1967590A3 (en) | 2001-03-13 | 2008-09-17 | Novartis AG | Lentiviral packaging constructs |
| US7429382B2 (en) | 2002-10-16 | 2008-09-30 | Corixa Corporation | Antibodies that bind cell-associated CA 125/O772P and methods of use thereof |
| EA013225B1 (ru) | 2003-01-07 | 2010-04-30 | Симфоген А/С | Способ получения линии клеток, продуцирующей рекомбинантный поликлональный белок, способ получения поликлонального белка, линия клеток, продуцирующая рекомбинантный поликлональный белок, библиотека векторов, популяция клеток |
| CA2518552A1 (en) | 2003-03-11 | 2004-09-23 | Genentech, Inc. | Novel compositions and methods for the treatment of immune related disease |
| GB0408449D0 (en) | 2004-04-15 | 2004-05-19 | Banerjee Subhasis | Diagnostic and therapeutic applications of soluble lhcge protein |
| EP1789087A4 (en) | 2004-08-20 | 2009-10-21 | Univ California | GENETICALLY MODIFIED ANTIBODY FRAGMENT WHICH LINKS TO ANTIGEN IRREVERSIBLELY |
| CN1331887C (zh) | 2004-08-20 | 2007-08-15 | 上海美恩生物技术有限公司 | 抗hla－dr10的淋巴瘤特异性嵌合单抗 |
| JP5173426B2 (ja) | 2004-10-25 | 2013-04-03 | メルク・シャープ・エンド・ドーム・コーポレイション | 抗ａｄｄｌ抗体およびこの使用 |
| WO2007058725A2 (en) | 2005-10-12 | 2007-05-24 | The Regents Of The University Of California | Engineered antibody fragment that irreversibly binds an antigen |
| US7858752B2 (en) | 2006-12-05 | 2010-12-28 | Abbott Laboratories | Recombinant antibodies against hepatitis C virus and methods of obtaining and using same |
| JP2012501180A (ja) | 2008-08-26 | 2012-01-19 | シティ・オブ・ホープ | Ｔ細胞の抗腫瘍エフェクター機能増進のための方法および組成物 |
| US9855291B2 (en) | 2008-11-03 | 2018-01-02 | Adc Therapeutics Sa | Anti-kidney associated antigen 1 (KAAG1) antibodies |
| CA2800182A1 (en) | 2009-05-26 | 2010-12-02 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| US8680055B2 (en) * | 2009-06-03 | 2014-03-25 | University Of Southern California | Methods for decreasing steroidogenesis in prostate cancer cells |
| CN102574915B (zh) * | 2009-08-06 | 2014-10-22 | 伊缪纳斯制药株式会社 | 特异性结合Aβ寡聚体的抗体及其用途 |
| WO2012047427A2 (en) * | 2010-08-31 | 2012-04-12 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2651442B1 (en) | 2010-12-14 | 2020-04-22 | University of Maryland, Baltimore | Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer |
| SG11201404769UA (en) | 2012-02-22 | 2014-11-27 | Univ Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| EP2836239A1 (en) | 2012-04-11 | 2015-02-18 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Chimeric antigen receptors targeting b-cell maturation antigen |
| US20130280220A1 (en) * | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
| WO2014059028A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
| EP2730588A1 (en) | 2012-11-12 | 2014-05-14 | Intelectys | Antibodies and fragments thereof raised against the alpha-3 domain of HLA-G protein, methods and means for their preparation, and uses thereof |
| US9534044B2 (en) | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
| US20140348744A1 (en) | 2013-05-24 | 2014-11-27 | Jacek K. Pinski | Compositions and methods for regulating cancer-related signaling pathways |
| JP6288621B2 (ja) | 2013-08-23 | 2018-03-07 | 学校法人藤田学園 | インフルエンザウイルスに対する抵抗力の判定方法 |
| KR101605421B1 (ko) | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
| ES2904573T3 (es) | 2015-03-27 | 2022-04-05 | Univ Southern California | Terapia con células T dirigida a LHR para el tratamiento de tumores sólidos |
| US20190031759A1 (en) | 2015-04-30 | 2019-01-31 | Technion Research & Development Foundation Limited | Chimeric antigen receptors and methods of their use |
| EP3568469A4 (en) | 2017-02-21 | 2020-11-11 | Eutilex Co., Ltd. | COMPOSITIONS OF CAR-T CELLS DIRECTED AGAINST HLA-DR AND THEIR MANUFACTURING AND USE PROCEDURES |
-
2016
- 2016-03-25 ES ES16773871T patent/ES2904573T3/es active Active
- 2016-03-25 EP EP16773871.5A patent/EP3273994B1/en not_active Not-in-force
- 2016-03-25 JP JP2017550493A patent/JP2018518152A/ja active Pending
- 2016-03-25 CN CN201680024480.2A patent/CN107530427A/zh active Pending
- 2016-03-25 US US15/561,967 patent/US11136401B2/en active Active
- 2016-03-25 CA CA2981142A patent/CA2981142A1/en not_active Abandoned
- 2016-03-25 AU AU2016243124A patent/AU2016243124A1/en not_active Abandoned
- 2016-03-25 WO PCT/US2016/024354 patent/WO2016160618A2/en not_active Ceased
-
2017
- 2017-09-26 IL IL254701A patent/IL254701A0/en unknown
-
2021
- 2021-08-31 US US17/462,987 patent/US20210403585A1/en not_active Abandoned
-
2024
- 2024-05-20 US US18/669,185 patent/US20250129171A1/en active Pending
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