JP2018512873A5 - - Google Patents
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- JP2018512873A5 JP2018512873A5 JP2017554902A JP2017554902A JP2018512873A5 JP 2018512873 A5 JP2018512873 A5 JP 2018512873A5 JP 2017554902 A JP2017554902 A JP 2017554902A JP 2017554902 A JP2017554902 A JP 2017554902A JP 2018512873 A5 JP2018512873 A5 JP 2018512873A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- protein
- group
- actriib
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004169 proteins and genes Human genes 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 206010028289 Muscle atrophy Diseases 0.000 claims 7
- 201000000585 muscular atrophy Diseases 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 102000037280 Growth Differentiation Factor 2 Human genes 0.000 claims 4
- 108010090290 Growth Differentiation Factor 2 Proteins 0.000 claims 4
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 4
- 208000029578 Muscle disease Diseases 0.000 claims 4
- 108010056852 Myostatin Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 108010023082 activin A Proteins 0.000 claims 4
- 208000007502 anemia Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 108010059616 Activins Proteins 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 3
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 claims 3
- 239000000488 activin Substances 0.000 claims 3
- 230000032683 aging Effects 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000020832 chronic kidney disease Diseases 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000004761 fibrosis Effects 0.000 claims 3
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 208000030159 metabolic disease Diseases 0.000 claims 3
- 230000020763 muscle atrophy Effects 0.000 claims 3
- 208000001076 sarcopenia Diseases 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000037157 Azotemia Diseases 0.000 claims 2
- 208000010392 Bone Fractures Diseases 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 208000016097 disease of metabolism Diseases 0.000 claims 2
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- 102000018358 immunoglobulin Human genes 0.000 claims 2
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- 208000017169 kidney disease Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
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- 238000002360 preparation method Methods 0.000 claims 2
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- 208000024891 symptom Diseases 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 208000009852 uremia Diseases 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
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- 206010014561 Emphysema Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 201000004939 Fanconi anemia Diseases 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims 1
- 208000002260 Keloid Diseases 0.000 claims 1
- 206010023330 Keloid scar Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000002720 Malnutrition Diseases 0.000 claims 1
- 208000001826 Marfan syndrome Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000009525 Myocarditis Diseases 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000025584 Pericardial disease Diseases 0.000 claims 1
- 208000031845 Pernicious anaemia Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 238000009167 androgen deprivation therapy Methods 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 208000005980 beta thalassemia Diseases 0.000 claims 1
- 208000022806 beta-thalassemia major Diseases 0.000 claims 1
- 208000037877 cardiac atrophy Diseases 0.000 claims 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 208000028208 end stage renal disease Diseases 0.000 claims 1
- 201000000523 end stage renal failure Diseases 0.000 claims 1
- 238000005265 energy consumption Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 208000010706 fatty liver disease Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000018578 heart valve disease Diseases 0.000 claims 1
- 208000007475 hemolytic anemia Diseases 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 210000001117 keloid Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000001071 malnutrition Effects 0.000 claims 1
- 235000000824 malnutrition Nutrition 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000005486 microgravity Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 206010028537 myelofibrosis Diseases 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 208000015380 nutritional deficiency disease Diseases 0.000 claims 1
- 238000011275 oncology therapy Methods 0.000 claims 1
- 230000033667 organ regeneration Effects 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 208000007056 sickle cell anemia Diseases 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 230000017423 tissue regeneration Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021139606A JP7320571B2 (ja) | 2015-04-22 | 2021-08-30 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562150994P | 2015-04-22 | 2015-04-22 | |
| US62/150,994 | 2015-04-22 | ||
| US201562262356P | 2015-12-02 | 2015-12-02 | |
| US62/262,356 | 2015-12-02 | ||
| PCT/US2016/027046 WO2016171948A1 (en) | 2015-04-22 | 2016-04-12 | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139606A Division JP7320571B2 (ja) | 2015-04-22 | 2021-08-30 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512873A JP2018512873A (ja) | 2018-05-24 |
| JP2018512873A5 true JP2018512873A5 (https=) | 2019-11-14 |
| JP6959487B2 JP6959487B2 (ja) | 2021-11-02 |
Family
ID=57144520
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554902A Active JP6959487B2 (ja) | 2015-04-22 | 2016-04-12 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
| JP2021139606A Active JP7320571B2 (ja) | 2015-04-22 | 2021-08-30 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139606A Active JP7320571B2 (ja) | 2015-04-22 | 2021-08-30 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10913782B2 (https=) |
| EP (2) | EP3286206B1 (https=) |
| JP (2) | JP6959487B2 (https=) |
| KR (1) | KR102777477B1 (https=) |
| CN (1) | CN107683287B (https=) |
| AU (2) | AU2016251640B2 (https=) |
| CA (1) | CA2983440C (https=) |
| CY (1) | CY1124124T1 (https=) |
| DK (1) | DK3286206T3 (https=) |
| ES (1) | ES2856001T3 (https=) |
| HR (1) | HRP20210725T1 (https=) |
| HU (1) | HUE054232T2 (https=) |
| IL (1) | IL255070B (https=) |
| LT (1) | LT3286206T (https=) |
| MX (1) | MX2017013520A (https=) |
| PL (1) | PL3286206T3 (https=) |
| PT (1) | PT3286206T (https=) |
| RS (1) | RS61881B1 (https=) |
| RU (1) | RU2733492C2 (https=) |
| SG (2) | SG11201708351XA (https=) |
| SI (1) | SI3286206T1 (https=) |
| SM (1) | SMT202100294T1 (https=) |
| WO (1) | WO2016171948A1 (https=) |
| ZA (2) | ZA201707821B (https=) |
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| US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| CN114699529A (zh) | 2014-06-13 | 2022-07-05 | 阿塞勒隆制药公司 | 用于治疗溃疡的方法和组合物 |
| US10358476B2 (en) | 2015-04-06 | 2019-07-23 | Acceleron Pharma Inc. | Single arm type I and type II receptor fusion proteins and uses thereof |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| MA41920B1 (fr) | 2015-04-06 | 2021-05-31 | Acceleron Pharma Inc | Protéines de fusion de récepteur type i et type ii à bras unique et leurs utilisations |
| DK3496739T3 (da) | 2016-07-15 | 2021-05-10 | Acceleron Pharma Inc | Sammensætninger omfattende actriia-polypeptider til brug i behandlingen af pulmonal hypertension |
| MA45811A (fr) | 2016-07-27 | 2019-06-05 | Acceleron Pharma Inc | Méthodes et compositions de traitement de maladie. |
| CA3039573A1 (en) | 2016-10-05 | 2018-04-12 | Acceleron Pharma Inc. | Alk4:actriib heteromultimers and uses thereof |
| CN110036025B (zh) | 2016-10-05 | 2024-03-22 | 阿塞勒隆制药公司 | 变体ActRIIB蛋白及其用途 |
| JOP20190085A1 (ar) * | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| NZ754161A (en) | 2016-11-10 | 2025-11-28 | Keros Therapeutics Inc | Activin receptor type iia variants and methods of use thereof |
| LT3600415T (lt) * | 2017-03-24 | 2025-12-29 | Novartis Ag | Antikūnas prieš ii tipo aktivino receptorių, skirtas naudoti širdies nepakankamumo gydymui |
| CA3082146A1 (en) | 2017-11-09 | 2019-05-16 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| IL320014A (en) * | 2018-01-12 | 2025-06-01 | Keros Therapeutics Inc | Activin receptor type iib variants and methods of use thereof |
| KR20250133994A (ko) | 2018-05-09 | 2025-09-09 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
| JP7669291B2 (ja) * | 2019-05-30 | 2025-04-28 | アクセレロン ファーマ インコーポレーテッド | Ａｃｔｒｉｉ結合性タンパク質及びその使用 |
| US20220372135A1 (en) | 2019-09-27 | 2022-11-24 | Disc Medicine, Inc. | Methods for treating myelofibrosis and related conditions |
| US20230129812A1 (en) * | 2020-02-03 | 2023-04-27 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| MX2022009553A (es) * | 2020-02-03 | 2022-11-07 | Acceleron Pharma Inc | Proteínas actriib variantes y sus usos. |
| WO2021189010A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| WO2021189019A1 (en) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Activin receptor type ii chimeras and methods of use thereof |
| US20230181690A1 (en) * | 2020-04-13 | 2023-06-15 | Celgene Corporation | Methods for treating anemia using an actriib ligand trap and fedratinib |
| US20230174620A1 (en) | 2020-04-28 | 2023-06-08 | Acceleron Pharma Inc. | Actrii proteins and use in treating post-capillary pulmonary hypertension |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| JP2023539107A (ja) * | 2020-08-20 | 2023-09-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アクチビンａアンタゴニストによる心機能障害及びｃｏｖｉｄ－１９の予防及び治療方法 |
| WO2022150590A1 (en) * | 2021-01-08 | 2022-07-14 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
| US11945856B2 (en) | 2022-01-28 | 2024-04-02 | 35Pharma Inc. | Activin receptor type IIB variants and uses thereof |
| US20260092096A1 (en) * | 2024-05-14 | 2026-04-02 | 35Pharma Inc. | Activin receptor type iib variants and uses thereof |
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