JP2018512873A5 - - Google Patents
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- JP2018512873A5 JP2018512873A5 JP2017554902A JP2017554902A JP2018512873A5 JP 2018512873 A5 JP2018512873 A5 JP 2018512873A5 JP 2017554902 A JP2017554902 A JP 2017554902A JP 2017554902 A JP2017554902 A JP 2017554902A JP 2018512873 A5 JP2018512873 A5 JP 2018512873A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- protein
- group
- actriib
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000004169 proteins and genes Human genes 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 26
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 206010028289 Muscle atrophy Diseases 0.000 claims 7
- 201000000585 muscular atrophy Diseases 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 102000037280 Growth Differentiation Factor 2 Human genes 0.000 claims 4
- 108010090290 Growth Differentiation Factor 2 Proteins 0.000 claims 4
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 4
- 208000029578 Muscle disease Diseases 0.000 claims 4
- 108010056852 Myostatin Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 108010023082 activin A Proteins 0.000 claims 4
- 208000007502 anemia Diseases 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 108010059616 Activins Proteins 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 3
- 102100026818 Inhibin beta E chain Human genes 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 claims 3
- 239000000488 activin Substances 0.000 claims 3
- 230000032683 aging Effects 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
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- 229940079593 drug Drugs 0.000 claims 1
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- 230000008030 elimination Effects 0.000 claims 1
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- 208000028208 end stage renal disease Diseases 0.000 claims 1
- 201000000523 end stage renal failure Diseases 0.000 claims 1
- 238000005265 energy consumption Methods 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 208000010706 fatty liver disease Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000018578 heart valve disease Diseases 0.000 claims 1
- 208000007475 hemolytic anemia Diseases 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 210000001117 keloid Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000001071 malnutrition Effects 0.000 claims 1
- 235000000824 malnutrition Nutrition 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000005486 microgravity Effects 0.000 claims 1
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- 230000002107 myocardial effect Effects 0.000 claims 1
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- 238000011275 oncology therapy Methods 0.000 claims 1
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- 239000008194 pharmaceutical composition Substances 0.000 claims 1
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- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
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- 201000002793 renal fibrosis Diseases 0.000 claims 1
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- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
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- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021139606A JP7320571B2 (ja) | 2015-04-22 | 2021-08-30 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562150994P | 2015-04-22 | 2015-04-22 | |
| US62/150,994 | 2015-04-22 | ||
| US201562262356P | 2015-12-02 | 2015-12-02 | |
| US62/262,356 | 2015-12-02 | ||
| PCT/US2016/027046 WO2016171948A1 (en) | 2015-04-22 | 2016-04-12 | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139606A Division JP7320571B2 (ja) | 2015-04-22 | 2021-08-30 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512873A JP2018512873A (ja) | 2018-05-24 |
| JP2018512873A5 true JP2018512873A5 (https=) | 2019-11-14 |
| JP6959487B2 JP6959487B2 (ja) | 2021-11-02 |
Family
ID=57144520
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554902A Active JP6959487B2 (ja) | 2015-04-22 | 2016-04-12 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
| JP2021139606A Active JP7320571B2 (ja) | 2015-04-22 | 2021-08-30 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021139606A Active JP7320571B2 (ja) | 2015-04-22 | 2021-08-30 | 筋消耗疾患治療用の新規なハイブリッドａｃｔｒｉｉｂリガンド捕集タンパク質 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US10913782B2 (https=) |
| EP (2) | EP3878857A1 (https=) |
| JP (2) | JP6959487B2 (https=) |
| KR (1) | KR102777477B1 (https=) |
| CN (1) | CN107683287B (https=) |
| AU (2) | AU2016251640B2 (https=) |
| CA (1) | CA2983440C (https=) |
| CY (1) | CY1124124T1 (https=) |
| DK (1) | DK3286206T3 (https=) |
| ES (1) | ES2856001T3 (https=) |
| HR (1) | HRP20210725T1 (https=) |
| HU (1) | HUE054232T2 (https=) |
| IL (1) | IL255070B (https=) |
| LT (1) | LT3286206T (https=) |
| MX (1) | MX2017013520A (https=) |
| PL (1) | PL3286206T3 (https=) |
| PT (1) | PT3286206T (https=) |
| RS (1) | RS61881B1 (https=) |
| RU (1) | RU2733492C2 (https=) |
| SG (2) | SG11201708351XA (https=) |
| SI (1) | SI3286206T1 (https=) |
| SM (1) | SMT202100294T1 (https=) |
| WO (1) | WO2016171948A1 (https=) |
| ZA (2) | ZA201707821B (https=) |
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| US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| WO2015192111A1 (en) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| US10227392B2 (en) | 2015-04-06 | 2019-03-12 | Acceleron Pharma Inc. | ALK7:ActRIIB heteromultimers and uses thereof |
| CN107849114B (zh) | 2015-04-06 | 2021-08-20 | 阿塞勒隆制药公司 | 单臂i型和ii型受体融合蛋白和其用途 |
| HRP20210694T1 (hr) | 2016-07-15 | 2021-09-17 | Acceleron Pharma, Inc. | Pripravci koji sadrže actriia polipeptide za uporabu za liječenje plućne hipertenzije |
| PL3490582T3 (pl) | 2016-07-27 | 2024-09-23 | Acceleron Pharma Inc. | Kompozycje do zastosowania w leczeniu mielofibrozy |
| BR112019006993A2 (pt) | 2016-10-05 | 2019-09-03 | Acceleron Pharma Inc | heteromultímeros de alk4:actriib e usos dos mesmos |
| JP7280182B2 (ja) | 2016-10-05 | 2023-05-23 | アクセルロン ファーマ インコーポレイテッド | バリアントＡｃｔＲＩＩＢタンパク質およびその使用 |
| JOP20190085A1 (ar) * | 2016-10-20 | 2019-04-17 | Biogen Ma Inc | طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة |
| CN110430890B (zh) | 2016-11-10 | 2024-09-10 | 科乐斯疗法公司 | 激活素受体iia型变体及其使用方法 |
| FI3600415T3 (fi) * | 2017-03-24 | 2025-12-05 | Novartis Ag | Aktiviinireseptorin tyypin ii reseptorin vastainen vasta-aine käytettäväksi sydämen vajaatoiminnan hoidossa |
| EP3706777B1 (en) | 2017-11-09 | 2024-05-22 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| IL320014A (en) * | 2018-01-12 | 2025-06-01 | Keros Therapeutics Inc | Activin receptor type iib variants and methods of use thereof |
| JP7405772B2 (ja) | 2018-05-09 | 2023-12-26 | ケロス セラピューティクス インコーポレイテッド | アクチビンｉｉａ型受容体変異体および同変異体を含む医薬組成物 |
| AU2020284038A1 (en) * | 2019-05-30 | 2021-12-02 | Acceleron Pharma Inc. | ActRII-binding proteins and uses thereof |
| CN114761013A (zh) | 2019-09-27 | 2022-07-15 | 迪斯克医药公司 | 治疗骨髓纤维化和相关病症的方法 |
| EP4100430A4 (en) * | 2020-02-03 | 2024-04-03 | Acceleron Pharma Inc. | COMPOSITIONS AND METHODS FOR TREATING PULMONARY HYPERTENSION |
| EP4100431A4 (en) * | 2020-02-03 | 2024-10-16 | Acceleron Pharma Inc. | Variant actriib proteins and uses thereof |
| IL296394A (en) * | 2020-03-20 | 2022-11-01 | Keros Therapeutics Inc | Type ii activin receptor chimeras and methods of using them |
| WO2021189010A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| WO2021211418A1 (en) * | 2020-04-13 | 2021-10-21 | Celgene Corporation | Methods for treating anemia using an actriib ligand trap and fedratinib |
| EP4142769A4 (en) | 2020-04-28 | 2024-05-15 | Acceleron Pharma Inc. | ACTRII PROTEINS AND USE IN THE TREATMENT OF POSTCAPILLARY PULMONARY HYPERTENSION |
| WO2021231798A1 (en) | 2020-05-13 | 2021-11-18 | Disc Medicine, Inc. | Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis |
| IL300362A (en) * | 2020-08-20 | 2023-04-01 | Regeneron Pharma | Methods to prevent and treat poor cardiac function and covid-19 with activin A antagonists |
| EP4274600A4 (en) * | 2021-01-08 | 2024-11-20 | Acceleron Pharma Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PULMONARY HYPERTENSION |
| KR20240150761A (ko) | 2022-01-28 | 2024-10-16 | 35파마 인크. | 액티빈 수용체 유형 iib 변이체 및 이의 용도 |
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