|
EP0368684B2
(en)
|
1988-11-11 |
2004-09-29 |
Medical Research Council |
Cloning immunoglobulin variable domain sequences.
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
SE509359C2
(sv)
|
1989-08-01 |
1999-01-18 |
Cemu Bioteknik Ab |
Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
|
|
CA2090126C
(en)
|
1990-08-02 |
2002-10-22 |
John W. Schrader |
Methods for the production of proteins with a desired function
|
|
US5440021A
(en)
|
1991-03-29 |
1995-08-08 |
Chuntharapai; Anan |
Antibodies to human IL-8 type B receptor
|
|
ATE194385T1
(de)
|
1991-03-29 |
2000-07-15 |
Genentech Inc |
Menschliche pf4a rezeptoren und ihre verwendung
|
|
US5374506A
(en)
|
1991-09-13 |
1994-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Amino acid sequence for a functional human interleukin-8 receptor
|
|
AU687010B2
(en)
|
1992-07-17 |
1998-02-19 |
Dana-Farber Cancer Institute |
Method of intracellular binding of target molecules
|
|
DK1621554T4
(da)
|
1992-08-21 |
2012-12-17 |
Univ Bruxelles |
Immunoglobuliner blottet for lette kæder
|
|
ES2155854T3
(es)
|
1993-06-09 |
2001-06-01 |
Unilever Nv |
Procedimiento de produccion de proteinas de fusion que comprende fragmentos de scfv con la ayuda de un molde transformado.
|
|
US6091639A
(en)
|
1993-08-27 |
2000-07-18 |
Kabushiki Kaisha Toshiba |
Non-volatile semiconductor memory device and data programming method
|
|
US6448379B1
(en)
|
1993-09-14 |
2002-09-10 |
Chiron Corporation |
IL8 inhibitors
|
|
US5595756A
(en)
*
|
1993-12-22 |
1997-01-21 |
Inex Pharmaceuticals Corporation |
Liposomal compositions for enhanced retention of bioactive agents
|
|
EP0745134A1
(en)
|
1994-02-22 |
1996-12-04 |
Danafarber Cancer Institute |
Nucleic acid delivery system, method of synthesis and uses thereof
|
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
AU7298398A
(en)
|
1996-11-19 |
1998-06-10 |
Sangstat Medical Corporation |
Enhanced effects for hapten conjugated therapeutics
|
|
US6329516B1
(en)
|
1997-04-28 |
2001-12-11 |
Fmc Corporation |
Lepidopteran GABA-gated chloride channels
|
|
DK1027439T3
(da)
|
1997-10-27 |
2010-05-10 |
Bac Ip Bv |
Multivalente antigenbindende proteiner
|
|
KR20010034512A
(ko)
|
1998-02-19 |
2001-04-25 |
베렌슨, 론 |
림프구 활성화 조절을 위한 조성물 및 그 방법
|
|
EP0967284A1
(en)
|
1998-05-28 |
1999-12-29 |
Pfizer Limited |
Phosphodiesterases
|
|
GB9824632D0
(en)
|
1998-11-10 |
1999-01-06 |
Celltech Therapeutics Ltd |
Biological compounds
|
|
CA2361678A1
(en)
|
1999-02-05 |
2000-08-10 |
Rijksuniversiteit Leiden |
Method of modulating metabolite biosynthesis in recombinant cells
|
|
DE60035163T2
(de)
|
1999-03-15 |
2008-02-21 |
University Of British Columbia, Vancouver |
Abc1 polypeptide und verfahren und reagenzien zur modulation des cholesterolgehalts
|
|
CN100513570C
(zh)
|
1999-06-18 |
2009-07-15 |
Cv治疗公司 |
结合框运输蛋白abc1的调节作用
|
|
IL147920A0
(en)
|
1999-08-02 |
2002-08-14 |
Keygene Nv |
Method for generating cgmmv resistant plants, genetic constructs, and the obtained cgmmv-resistant plants
|
|
US20040214783A1
(en)
|
2002-05-08 |
2004-10-28 |
Terman David S. |
Compositions and methods for treatment of neoplastic disease
|
|
GB9922124D0
(en)
|
1999-09-17 |
1999-11-17 |
Pfizer Ltd |
Phosphodiesterase enzymes
|
|
DE19955408A1
(de)
|
1999-11-18 |
2001-05-23 |
Bayer Ag |
GABA-B-Rezeptoren
|
|
EP1240337B1
(en)
|
1999-12-24 |
2006-08-23 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
|
AU2001250412A1
(en)
|
2000-03-31 |
2001-10-08 |
Ipf Pharmaceuticals Gmbh |
Diagnostic and medicament for analysing the cell surface proteome of tumour and inflammatory cells and for treating tumorous and inflammatory diseases, preferably using specific chemokine receptor analysis and the chemokine receptor-ligand interaction
|
|
EP2213743A1
(en)
|
2000-04-12 |
2010-08-04 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
CA2441903C
(en)
|
2000-05-26 |
2012-07-31 |
National Research Council Of Canada |
Single-domain brain-targeting antibody fragments derived from llama antibodies
|
|
US6741957B1
(en)
|
2000-07-21 |
2004-05-25 |
Daimlerchrysler Corporation |
Analytical tire model for vehicle durability and ride comfort analysis
|
|
RU2420537C2
(ru)
|
2001-01-17 |
2011-06-10 |
Трабьон Фармасьютикалз Инк. |
Слитые белки связывающий домен-иммуноглобулин
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
AU2002335930B2
(en)
|
2001-03-09 |
2005-07-28 |
Morphosys Ag |
Serum albumin binding moieties
|
|
US20030017150A1
(en)
|
2001-03-14 |
2003-01-23 |
Torphy Theodore J. |
Chronic obstructive pulmonary disease-related immunglobulin derived proteins, compositions, methods and uses
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
DK1399484T3
(da)
|
2001-06-28 |
2010-11-08 |
Domantis Ltd |
Dobbelt-specifik ligand og anvendelse af denne
|
|
AU2002355477B2
(en)
|
2001-08-03 |
2008-09-25 |
Medical Research Council |
Method of identifying a consensus sequence for intracellular antibodies
|
|
AU2002339863A1
(en)
|
2001-08-31 |
2003-03-18 |
Abmaxis, Inc. |
Multivalent protein conjugate with multiple ligand-binding domains of receptors
|
|
KR100599789B1
(ko)
|
2001-12-03 |
2006-07-12 |
삼성에스디아이 주식회사 |
방열효율이 향상된 플라즈마 디스플레이 장치 및 그 제조방법
|
|
CA2471645A1
(en)
|
2002-01-03 |
2003-07-10 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Immunoconjugates useful for treatment of tumours
|
|
AU2003244817B2
(en)
|
2002-06-28 |
2010-08-26 |
Domantis Limited |
Antigen-binding immunoglobulin single variable domains and dual-specific constructs
|
|
US7004940B2
(en)
|
2002-10-10 |
2006-02-28 |
Ethicon, Inc. |
Devices for performing thermal ablation having movable ultrasound transducers
|
|
BRPI0315666B8
(pt)
|
2002-10-23 |
2021-05-25 |
Ludwig Inst For Cancer Res Ltd |
dna de a34 e a33 do tipo 3, proteínas, seus anticorpos e métodos de tratamento usando os mesmos
|
|
EP1578367A4
(en)
|
2002-11-01 |
2012-05-02 |
Genentech Inc |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE DISEASES
|
|
EP1558645B1
(en)
|
2002-11-08 |
2011-07-27 |
Ablynx N.V. |
Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
|
|
WO2004041863A2
(en)
|
2002-11-08 |
2004-05-21 |
Ablynx N.V. |
Single domain antibodies directed against interferon- gamma and uses therefor
|
|
ES2374068T3
(es)
|
2002-12-03 |
2012-02-13 |
Ucb Pharma, S.A. |
Ensayo para identificar células productoras de anticuerpos.
|
|
GB0228210D0
(en)
|
2002-12-03 |
2003-01-08 |
Babraham Inst |
Single chain antibodies
|
|
NZ541050A
(en)
|
2002-12-16 |
2010-06-25 |
Genmab As |
Human monoclonal antibodies against interleukin 8 (IL-8)
|
|
GB0230203D0
(en)
|
2002-12-27 |
2003-02-05 |
Domantis Ltd |
Fc fusion
|
|
MXPA05007151A
(es)
|
2002-12-31 |
2005-09-21 |
Nektar Therapeutics Al Corp |
Polimeros terminados en maleimida hidroliticamente estables.
|
|
GB0312481D0
(en)
|
2003-05-30 |
2003-07-09 |
Celltech R&D Ltd |
Antibodies
|
|
DE602004017726D1
(de)
|
2003-06-30 |
2008-12-24 |
Domantis Ltd |
Pegylierte Single-domain-antikörper (dAb)
|
|
ES2385829T3
(es)
|
2003-08-20 |
2012-08-01 |
Ucb Pharma, S.A. |
Métodos para obtener anticuerpos
|
|
WO2005103702A2
(en)
|
2004-04-20 |
2005-11-03 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with cxc chemokine receptor 2 (cxcr2)
|
|
US20060008601A1
(en)
|
2004-06-25 |
2006-01-12 |
Zeik Douglas B |
Flexible laminate having an integrated pressure release valve
|
|
US7882839B2
(en)
|
2004-06-25 |
2011-02-08 |
Ambis Jr Edward J |
Custom mouthguard
|
|
KR101151957B1
(ko)
|
2004-07-22 |
2012-06-01 |
로저 킹돈 크레이그 |
결합 분자
|
|
WO2006040153A2
(en)
|
2004-10-13 |
2006-04-20 |
Ablynx N.V. |
Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
|
|
WO2006040154A2
(en)
|
2004-10-14 |
2006-04-20 |
Dublin City University |
Prokaryotic two hybrid system
|
|
AU2005325801A1
(en)
|
2005-01-31 |
2006-08-03 |
Ablynx N.V. |
Method for generating variable domain sequences of heavy chain antibodies
|
|
US8188223B2
(en)
|
2005-05-18 |
2012-05-29 |
Ablynx N.V. |
Serum albumin binding proteins
|
|
ES2694247T3
(es)
|
2005-05-20 |
2018-12-19 |
Ablynx N.V. |
NanobodiesTM mejorados para el tratamiento de trastornos mediados por agregación
|
|
WO2007005605A2
(en)
|
2005-07-01 |
2007-01-11 |
Washington University In St. Louis |
Phosphospecific chemokine receptor antibodies
|
|
NZ612578A
(en)
|
2005-08-19 |
2014-11-28 |
Abbvie Inc |
Dual variable domain immunoglobin and uses thereof
|
|
WO2007112940A2
(en)
|
2006-03-31 |
2007-10-11 |
Ablynx N.V. |
Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same
|
|
AU2007237501A1
(en)
|
2006-04-14 |
2007-10-25 |
Ablynx N.V. |
DP-78-like nanobodies
|
|
CN101070346A
(zh)
*
|
2006-05-08 |
2007-11-14 |
陈正贤 |
一种制备双功能抗体的方法
|
|
EP2040995A1
(en)
|
2006-06-26 |
2009-04-01 |
Aida Centre, S.L. |
Blister package integrating rfid based tags
|
|
CA2656620C
(en)
|
2006-07-04 |
2018-03-13 |
Genmab A/S |
Cd20 binding molecules for the treatment of copd
|
|
WO2008020079A1
(en)
|
2006-08-18 |
2008-02-21 |
Ablynx N.V. |
Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling
|
|
WO2008028044A2
(en)
|
2006-08-30 |
2008-03-06 |
Centocor, Inc. |
Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel
|
|
AU2007293614A1
(en)
|
2006-09-08 |
2008-03-13 |
Ablynx N.V. |
Serum albumin binding proteins with long half-lives
|
|
ATE536369T1
(de)
|
2006-10-11 |
2011-12-15 |
Ablynx Nv |
Im wesentlichen ph-wert-unabhängigerweise an serumproteine bindende aminosäuresequenzen, verbindungen, die diese enthalten, und deren verwendung
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
CA2673331A1
(en)
|
2006-12-19 |
2008-06-26 |
Ablynx N.V. |
Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
|
|
US20100087371A1
(en)
|
2007-02-22 |
2010-04-08 |
Sean Hu |
Transglutaminase Variants with Improved Specificity
|
|
US8865875B2
(en)
|
2007-08-22 |
2014-10-21 |
Medarex, L.L.C. |
Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
|
|
CA2712432C
(en)
|
2008-01-29 |
2018-09-25 |
Ablynx N.V. |
Methods to stabilize single variable domains
|
|
EP2285833B1
(en)
*
|
2008-05-16 |
2014-12-17 |
Ablynx N.V. |
AMINO ACID SEQUENCES DIRECTED AGAINST CXCR4 AND OTHER GPCRs AND COMPOUNDS COMPRISING THE SAME
|
|
US9005963B2
(en)
|
2008-10-14 |
2015-04-14 |
Ablynx N.V. |
Amino acid sequences directed against cellular receptors for viruses and bacteria
|
|
AU2010217120B2
(en)
|
2009-02-24 |
2014-11-20 |
Novartis Ag |
Methods for identifying immunobinders of cell-surface antigens
|
|
WO2011003622A1
(en)
|
2009-07-10 |
2011-01-13 |
Ablynx N.V. |
Method for the production of variable domains
|
|
CN102725311A
(zh)
|
2009-09-23 |
2012-10-10 |
卡罗勒斯治疗公司 |
治疗发炎的方法
|
|
CA2784498A1
(en)
|
2009-12-18 |
2011-06-23 |
Sanofi |
Novel antagonist antibodies and their fab fragments against gpvi and uses thereof
|
|
KR101721187B1
(ko)
|
2009-12-23 |
2017-03-29 |
에스바테크 - 어 노바티스 컴파니 엘엘씨 |
면역원성의 감소 방법
|
|
WO2011083140A1
(en)
*
|
2010-01-08 |
2011-07-14 |
Ablynx Nv |
Immunoglobulin single variable domain directed against human cxcr4
|
|
AU2011328246B2
(en)
*
|
2010-11-08 |
2016-06-30 |
Ablynx N.V. |
CXCR2 binding polypeptides
|
|
SG10201805064SA
(en)
|
2011-06-23 |
2018-07-30 |
Ablynx Nv |
Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
|
|
PE20141522A1
(es)
|
2011-08-17 |
2014-11-17 |
Glaxo Group Ltd |
Proteinas y peptidos modificados
|
|
US9328174B2
(en)
|
2012-05-09 |
2016-05-03 |
Novartis Ag |
Chemokine receptor binding polypeptides
|
|
EP3087394A2
(en)
|
2013-12-27 |
2016-11-02 |
Merrimack Pharmaceuticals, Inc. |
Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
|