JP2017500018A5 - - Google Patents
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- Publication number
- JP2017500018A5 JP2017500018A5 JP2016532590A JP2016532590A JP2017500018A5 JP 2017500018 A5 JP2017500018 A5 JP 2017500018A5 JP 2016532590 A JP2016532590 A JP 2016532590A JP 2016532590 A JP2016532590 A JP 2016532590A JP 2017500018 A5 JP2017500018 A5 JP 2017500018A5
- Authority
- JP
- Japan
- Prior art keywords
- apelin
- seq
- antigen
- binding fragment
- aplnr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000027455 binding Effects 0.000 claims 34
- 239000000427 antigen Substances 0.000 claims 31
- 102000036639 antigens Human genes 0.000 claims 31
- 108091007433 antigens Proteins 0.000 claims 31
- 239000012634 fragment Substances 0.000 claims 31
- 108010052412 Apelin Proteins 0.000 claims 27
- 108091008803 APLNR Proteins 0.000 claims 24
- 102000016555 Apelin receptors Human genes 0.000 claims 24
- 102000018746 Apelin Human genes 0.000 claims 22
- BWVPHIKGXQBZPV-QKFDDRBGSA-N apelin Chemical compound NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCSC)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(O)=O)CCC1 BWVPHIKGXQBZPV-QKFDDRBGSA-N 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 19
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 230000001404 mediated effect Effects 0.000 claims 12
- 238000003556 assay Methods 0.000 claims 9
- 238000000338 in vitro Methods 0.000 claims 9
- 230000005764 inhibitory process Effects 0.000 claims 7
- 230000001593 cAMP accumulation Effects 0.000 claims 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 101000793362 Homo sapiens Apelin receptor Proteins 0.000 claims 3
- 102000047215 human APLNR Human genes 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 208000017442 Retinal disease Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 108010040480 apelin-13 peptide Proteins 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102400000252 Apelin-13 Human genes 0.000 claims 1
- 102400000253 Apelin-31 Human genes 0.000 claims 1
- 101800001805 Apelin-31 Proteins 0.000 claims 1
- 102400000251 Apelin-36 Human genes 0.000 claims 1
- 101800001808 Apelin-36 Proteins 0.000 claims 1
- 101100246550 Caenorhabditis elegans pyr-1 gene Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000034038 Pathologic Neovascularization Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- QZNKGTRFBWGADN-SLUWFFAESA-N apelin-12 Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCSC)C(=O)N3CCC[C@H]3C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)N QZNKGTRFBWGADN-SLUWFFAESA-N 0.000 claims 1
- 108010006026 apelin-12 peptide Proteins 0.000 claims 1
- XXCCRHIAIBQDPX-PEWBXTNBSA-N apelin-13 Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCC(N)=O)C1=CN=CN1 XXCCRHIAIBQDPX-PEWBXTNBSA-N 0.000 claims 1
- 108010062131 apelin-14 Proteins 0.000 claims 1
- SVWSKJCJNAIKNH-MJZUAXFLSA-N apelin-17 Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](N)CCCCN)C1=CN=CN1 SVWSKJCJNAIKNH-MJZUAXFLSA-N 0.000 claims 1
- BVTLGARMSLXAHI-VDEROMQGSA-N apelin-36 Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)C(C)C)C1=CN=CN1 BVTLGARMSLXAHI-VDEROMQGSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- BPGBAEXPBQHBSV-UHFFFAOYSA-N pyr1 Chemical compound C1=C2C3=C(C)C(C(NC=C4)=O)=C4C(C)=C3NC2=CC=C1OC(=O)C1=CC=CC=C1 BPGBAEXPBQHBSV-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361906568P | 2013-11-20 | 2013-11-20 | |
| US61/906,568 | 2013-11-20 | ||
| PCT/US2014/066687 WO2015077491A1 (en) | 2013-11-20 | 2014-11-20 | Aplnr modulators and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019022363A Division JP6738449B2 (ja) | 2013-11-20 | 2019-02-12 | Ａｐｌｎｒモジュレーター及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017500018A JP2017500018A (ja) | 2017-01-05 |
| JP2017500018A5 true JP2017500018A5 (https=) | 2017-12-28 |
| JP6483117B2 JP6483117B2 (ja) | 2019-03-13 |
Family
ID=52021453
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016532590A Active JP6483117B2 (ja) | 2013-11-20 | 2014-11-20 | Ａｐｌｎｒモジュレーター及びその使用 |
| JP2019022363A Active JP6738449B2 (ja) | 2013-11-20 | 2019-02-12 | Ａｐｌｎｒモジュレーター及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019022363A Active JP6738449B2 (ja) | 2013-11-20 | 2019-02-12 | Ａｐｌｎｒモジュレーター及びその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (7) | US10155811B2 (https=) |
| EP (1) | EP3071600B1 (https=) |
| JP (2) | JP6483117B2 (https=) |
| KR (1) | KR20160086942A (https=) |
| CN (1) | CN105916881A (https=) |
| AU (1) | AU2014352962B2 (https=) |
| BR (1) | BR112016011401A2 (https=) |
| CA (1) | CA2931299C (https=) |
| CL (1) | CL2016001212A1 (https=) |
| EA (1) | EA201691027A1 (https=) |
| IL (1) | IL245733A0 (https=) |
| MA (1) | MA39061A1 (https=) |
| MX (1) | MX377716B (https=) |
| PH (1) | PH12016500943A1 (https=) |
| WO (1) | WO2015077491A1 (https=) |
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| TWI687439B (zh) | 2011-06-30 | 2020-03-11 | 中外製藥股份有限公司 | 異源二聚化多胜肽 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR20230143201A (ko) | 2011-11-30 | 2023-10-11 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| SG10201709559PA (en) | 2012-08-24 | 2017-12-28 | Chugai Pharmaceutical Co Ltd | Fcγriib-specific fc region variant |
| ES2876009T3 (es) | 2012-12-27 | 2021-11-11 | Chugai Pharmaceutical Co Ltd | Polipéptido heterodimerizado |
| US9353163B2 (en) | 2013-03-14 | 2016-05-31 | Regeneron Pharmaceuticals, Inc. | Apelin fusion proteins and uses thereof |
| CN105246914B (zh) | 2013-04-02 | 2021-08-27 | 中外制药株式会社 | Fc区变体 |
| US11104730B2 (en) | 2013-11-20 | 2021-08-31 | Regeneren Pharmaceuticals, Inc. | Methods of treating eye disorders with APLNR antagonists and VEGF inhibitors |
| WO2015077491A1 (en) | 2013-11-20 | 2015-05-28 | Regeneron Pharmaceuticals, Inc. | Aplnr modulators and uses thereof |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
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| EA201992630A1 (ru) * | 2017-05-06 | 2020-04-29 | Ридженерон Фармасьютикалз, Инк. | Способы лечения заболеваний глаз антагонистами aplnr и ингибиторами vegf |
| EP4640703A3 (en) | 2017-11-14 | 2026-04-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibodies and methods of use |
| CN110655577A (zh) * | 2018-06-13 | 2020-01-07 | 鸿运华宁（杭州）生物医药有限公司 | APJ抗体及其与Elabela的融合蛋白质，以及其药物组合物和应用 |
| KR102259473B1 (ko) | 2018-08-10 | 2021-06-02 | 추가이 세이야쿠 가부시키가이샤 | 항cd137 항원 결합 분자 및 그의 사용 |
| EP4696320A2 (en) | 2019-05-15 | 2026-02-18 | Chugai Seiyaku Kabushiki Kaisha | Anti-c1s antibody |
| WO2020257460A2 (en) * | 2019-06-19 | 2020-12-24 | Ab Initio Biotherapeutics, Inc. | Apj modulators and uses thereof |
| GB202015755D0 (en) * | 2020-10-05 | 2020-11-18 | Rogers Arpi | Coronavirus therapy |
| CN117065020A (zh) * | 2023-02-17 | 2023-11-17 | 山东大学 | 抑制aplnr表达或降低aplnr活性的物质在制备治疗瘢痕药物中的应用 |
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| EP4660299A1 (en) | 2024-06-06 | 2025-12-10 | Philipps-Universität Marburg | Production of blood and immune cell progenitors |
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| US9353163B2 (en) | 2013-03-14 | 2016-05-31 | Regeneron Pharmaceuticals, Inc. | Apelin fusion proteins and uses thereof |
| HK1218252A1 (zh) | 2013-07-25 | 2017-02-10 | Novartis Ag | 合成apelin多肽之生物结合物 |
| WO2015077491A1 (en) | 2013-11-20 | 2015-05-28 | Regeneron Pharmaceuticals, Inc. | Aplnr modulators and uses thereof |
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2014
- 2014-11-20 WO PCT/US2014/066687 patent/WO2015077491A1/en not_active Ceased
- 2014-11-20 AU AU2014352962A patent/AU2014352962B2/en active Active
- 2014-11-20 MA MA39061A patent/MA39061A1/fr unknown
- 2014-11-20 CN CN201480073192.7A patent/CN105916881A/zh active Pending
- 2014-11-20 EA EA201691027A patent/EA201691027A1/ru unknown
- 2014-11-20 CA CA2931299A patent/CA2931299C/en active Active
- 2014-11-20 KR KR1020167016410A patent/KR20160086942A/ko not_active Withdrawn
- 2014-11-20 MX MX2016006709A patent/MX377716B/es active IP Right Grant
- 2014-11-20 BR BR112016011401A patent/BR112016011401A2/pt not_active IP Right Cessation
- 2014-11-20 JP JP2016532590A patent/JP6483117B2/ja active Active
- 2014-11-20 US US15/038,202 patent/US10155811B2/en active Active
- 2014-11-20 EP EP14810088.6A patent/EP3071600B1/en active Active
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2015
- 2015-05-20 US US14/717,914 patent/US9644018B2/en active Active
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2016
- 2016-05-19 CL CL2016001212A patent/CL2016001212A1/es unknown
- 2016-05-19 IL IL245733A patent/IL245733A0/en unknown
- 2016-05-20 PH PH12016500943A patent/PH12016500943A1/en unknown
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2017
- 2017-04-05 US US15/480,199 patent/US10189901B2/en active Active
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2018
- 2018-10-30 US US16/175,357 patent/US10626173B2/en active Active
- 2018-12-13 US US16/218,862 patent/US10947310B2/en active Active
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2019
- 2019-02-12 JP JP2019022363A patent/JP6738449B2/ja active Active
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2021
- 2021-02-04 US US17/167,990 patent/US11642390B2/en active Active
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2023
- 2023-03-23 US US18/125,353 patent/US20240091301A1/en not_active Abandoned
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