JP2020510659A5 - - Google Patents
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- Publication number
- JP2020510659A5 JP2020510659A5 JP2019546903A JP2019546903A JP2020510659A5 JP 2020510659 A5 JP2020510659 A5 JP 2020510659A5 JP 2019546903 A JP2019546903 A JP 2019546903A JP 2019546903 A JP2019546903 A JP 2019546903A JP 2020510659 A5 JP2020510659 A5 JP 2020510659A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- cd16a
- acid residues
- binding molecule
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17158566 | 2017-02-28 | ||
| EP17158566.4 | 2017-02-28 | ||
| EP17174407 | 2017-06-02 | ||
| EP17174407.1 | 2017-06-02 | ||
| PCT/EP2018/054989 WO2018158349A1 (en) | 2017-02-28 | 2018-02-28 | Tandem diabody for cd16a-directed nk-cell engagement |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510659A JP2020510659A (ja) | 2020-04-09 |
| JP2020510659A5 true JP2020510659A5 (https=) | 2021-04-01 |
| JP7115758B2 JP7115758B2 (ja) | 2022-08-09 |
Family
ID=61569251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019546903A Active JP7115758B2 (ja) | 2017-02-28 | 2018-02-28 | Ｃｄ１６ａ指向性ｎｋ細胞エンゲージメント用タンデムダイアボディ |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11180558B2 (https=) |
| EP (1) | EP3589655B1 (https=) |
| JP (1) | JP7115758B2 (https=) |
| CN (1) | CN110382539B (https=) |
| AU (1) | AU2018228719B2 (https=) |
| CA (1) | CA3051062C (https=) |
| DK (1) | DK3589655T3 (https=) |
| WO (1) | WO2018158349A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3095373A1 (en) * | 2018-04-13 | 2019-10-17 | Affimed Gmbh | Nk cell engaging antibody fusion constructs |
| CN116368154A (zh) * | 2020-10-08 | 2023-06-30 | 阿菲姆德股份有限公司 | 三特异性结合剂 |
| CR20230229A (es) * | 2020-11-06 | 2023-09-05 | Amgen Res Munich Gmbh | Moléculas de unión a antígeno biespecíficas con múltiples dianas de selectividad aumentada |
| JP2024503933A (ja) * | 2021-01-27 | 2024-01-29 | イノベント バイオロジクス（スーチョウ）カンパニー，リミティド | Ｃｄ１６ａに対する単一ドメイン抗体およびその使用 |
| WO2023274183A1 (zh) * | 2021-06-29 | 2023-01-05 | 江苏先声药业有限公司 | Cd16抗体及其应用 |
| IL312515A (en) * | 2021-11-03 | 2024-07-01 | Affimed Gmbh | Bispecific cd16a binders |
| US20260070986A1 (en) * | 2021-11-03 | 2026-03-12 | Affimed Gmbh | Bispecific cd16a binders |
| CN114262382B (zh) * | 2021-12-20 | 2023-09-19 | 上海恩凯细胞技术有限公司 | 双特异性抗体及其应用 |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| CN115960234B (zh) * | 2022-10-27 | 2023-12-29 | 合肥天港免疫药物有限公司 | 抗cd16a的抗体及其应用 |
| EP4640700A1 (en) | 2022-12-19 | 2025-10-29 | Harbour Biomed (Shanghai) Co., Ltd | "kappa/lambda" fab-fab series-connection multi-specific binding protein, preparation thereof, and use thereof |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| CN121591895A (zh) * | 2024-08-23 | 2026-03-03 | 安升（上海）医药科技有限公司 | 一种抗CD16a的单域抗体及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19819846B4 (de) * | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalente Antikörper-Konstrukte |
| WO2002066516A2 (en) | 2001-02-20 | 2002-08-29 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
| ES2283368T3 (es) * | 2001-11-14 | 2007-11-01 | Affimed Therapeutics Ag | Anticuerpos biespecificos anti-cd19 y anti-cd16 y usos de los mismos. |
| GB0510790D0 (en) | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
| EP2158221B1 (en) * | 2007-06-21 | 2018-08-29 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
| MX341884B (es) | 2009-03-10 | 2016-09-07 | Biogen Ma Inc | Anticuerpos anti-antigeno de maduracion de celulas b (bcma). |
| EP2361936B1 (en) * | 2010-02-25 | 2016-04-20 | Affimed GmbH | Antigen-binding molecule and uses thereof |
| US20110206672A1 (en) * | 2010-02-25 | 2011-08-25 | Melvyn Little | Antigen-Binding Molecule And Uses Thereof |
| KR101972446B1 (ko) | 2011-05-27 | 2019-04-25 | 글락소 그룹 리미티드 | Ｂｃｍａ（ｃｄ２６９／ｔｎｆｒｓｆ１７）결합 단백질 |
| WO2013013700A1 (en) * | 2011-07-22 | 2013-01-31 | Affimed Therapeutics Ag | Multivalent antigen-binding fv molecule |
| TWI679212B (zh) | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| WO2014068079A1 (en) | 2012-11-01 | 2014-05-08 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| WO2014122143A1 (en) | 2013-02-05 | 2014-08-14 | Engmab Ag | Method for the selection of antibodies against bcma |
| AR095374A1 (es) | 2013-03-15 | 2015-10-14 | Amgen Res Munich Gmbh | Moléculas de unión para bcma y cd3 |
| LT3030581T (lt) | 2013-08-07 | 2021-05-25 | Affimed Gmbh | Antikūno surišimo vietos specifiškos egfrviii |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| LT3292153T (lt) * | 2015-05-04 | 2019-11-11 | Affimed Gmbh | Cd30xcd16a antikūno derinys su antagonistiniu antikūnu prieš pd-1 skirtas terapijai |
| CN105367660B (zh) * | 2015-12-22 | 2018-12-21 | 深圳市北科生物科技有限公司 | 一种抗cd16a抗原和抗muc1抗原的双特异性抗体 |
-
2018
- 2018-02-28 WO PCT/EP2018/054989 patent/WO2018158349A1/en not_active Ceased
- 2018-02-28 CN CN201880014655.0A patent/CN110382539B/zh active Active
- 2018-02-28 CA CA3051062A patent/CA3051062C/en active Active
- 2018-02-28 DK DK18708967.7T patent/DK3589655T3/da active
- 2018-02-28 EP EP18708967.7A patent/EP3589655B1/en active Active
- 2018-02-28 AU AU2018228719A patent/AU2018228719B2/en active Active
- 2018-02-28 JP JP2019546903A patent/JP7115758B2/ja active Active
-
2019
- 2019-07-23 US US16/520,218 patent/US11180558B2/en active Active
-
2021
- 2021-10-26 US US17/510,738 patent/US12264198B2/en active Active
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