JP2021534762A5 - - Google Patents
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- Publication number
- JP2021534762A5 JP2021534762A5 JP2021510019A JP2021510019A JP2021534762A5 JP 2021534762 A5 JP2021534762 A5 JP 2021534762A5 JP 2021510019 A JP2021510019 A JP 2021510019A JP 2021510019 A JP2021510019 A JP 2021510019A JP 2021534762 A5 JP2021534762 A5 JP 2021534762A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence numbers
- sequence
- numbers
- isolated polynucleotide
- antigen
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018103050 | 2018-08-29 | ||
| CNPCT/CN2018/103050 | 2018-08-29 | ||
| CNPCT/CN2019/083918 | 2019-04-23 | ||
| CN2019083918 | 2019-04-23 | ||
| PCT/CN2019/103215 WO2020043152A1 (en) | 2018-08-29 | 2019-08-29 | Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021534762A JP2021534762A (ja) | 2021-12-16 |
| JP2021534762A5 true JP2021534762A5 (https=) | 2022-09-01 |
| JPWO2020043152A5 JPWO2020043152A5 (https=) | 2022-09-01 |
| JP7490915B2 JP7490915B2 (ja) | 2024-05-28 |
Family
ID=69643948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510019A Active JP7490915B2 (ja) | 2018-08-29 | 2019-08-29 | 抗メソテリンキメラ抗原受容体(car)構築物及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11932698B2 (https=) |
| EP (1) | EP3844282A4 (https=) |
| JP (1) | JP7490915B2 (https=) |
| KR (1) | KR102879284B1 (https=) |
| CN (1) | CN112639102B (https=) |
| AU (1) | AU2019327913A1 (https=) |
| CA (1) | CA3111087A1 (https=) |
| IL (1) | IL281098A (https=) |
| SG (1) | SG11202101773WA (https=) |
| TW (1) | TW202024330A (https=) |
| WO (1) | WO2020043152A1 (https=) |
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|---|---|---|---|---|
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| WO2018140573A1 (en) * | 2017-01-26 | 2018-08-02 | Sangamo Therapeutics, Inc. | B-cell engineering |
| EP3715368A1 (en) * | 2019-03-28 | 2020-09-30 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors, vectors coding for such receptors and their use in the modification of t cells |
| KR20220078568A (ko) * | 2019-08-14 | 2022-06-10 | 모드맵 테라퓨틱스 인코포레이티드 | Lrp5 단백질에 결합하는 항체 및 사용 방법 |
| CN110964750A (zh) * | 2019-11-13 | 2020-04-07 | 沣潮医药科技(上海)有限公司 | 携带基因元件组合的嵌合抗原受体细胞文库、制备和筛选方法及用途 |
| US12264190B2 (en) * | 2020-04-24 | 2025-04-01 | Astrazeneca Ab | Compositions and methods of treating cancer with chimeric antigen receptors |
| US20240252641A1 (en) * | 2020-05-05 | 2024-08-01 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using cd70 specific fusion proteins |
| GB202006820D0 (en) * | 2020-05-07 | 2020-06-24 | Autolus Ltd | Cell |
| GB202008688D0 (en) * | 2020-06-09 | 2020-07-22 | Cancer Research Tech Ltd | Chimeric antigen receptor cell |
| JP2023532347A (ja) * | 2020-06-29 | 2023-07-27 | セル メディカ,インコーポレイテッド | キメラ抗原受容体の緊張性シグナル伝達を減少させる方法および組成物 |
| JP7138989B1 (ja) | 2020-08-04 | 2022-09-20 | セレンジーン インコーポレイテッド | メソテリンに特異的に結合する抗メソテリンキメラ抗原受容体 |
| GB202012181D0 (en) * | 2020-08-05 | 2020-09-16 | Autolus Ltd | Chimeric receptor |
| WO2022037562A1 (en) * | 2020-08-17 | 2022-02-24 | Nanjing Legend Biotech Co., Ltd. | Engineered immunoresponsive cells and uses thereof |
| EP4263612A4 (en) * | 2020-12-18 | 2025-04-02 | Bioardis LLC | Mesothelin binding molecules and uses thereof |
| AU2022222688B2 (en) * | 2021-02-16 | 2025-11-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Molecules that bind to mesothelin polypeptides |
| WO2022232277A1 (en) * | 2021-04-27 | 2022-11-03 | TCR2 Therapeutics Inc. | COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND TGFβR SWITCH |
| JP7487989B2 (ja) * | 2021-05-26 | 2024-05-21 | セレンジーン インコーポレイテッド | 抗メソテリンscFvを含むキメリック抗原受容体及びその用途 |
| WO2022257984A1 (zh) * | 2021-06-08 | 2022-12-15 | 南京驯鹿医疗技术有限公司 | 一种增强型嵌合抗原受体(car)细胞的制备及其应用 |
| WO2023020472A1 (en) * | 2021-08-16 | 2023-02-23 | Utc Therapeutics (Shanghai) Co., Ltd. | Mesothelin-targetting antibodies and uses thereof in cancer therapies |
| CN115724942A (zh) * | 2021-09-02 | 2023-03-03 | 广东菲鹏制药股份有限公司 | TGFβRII活性改造突变体及其应用 |
| CN115746123A (zh) * | 2021-09-02 | 2023-03-07 | 广东菲鹏制药股份有限公司 | TGFβRII突变体及其应用 |
| CN114015720A (zh) * | 2021-09-29 | 2022-02-08 | 昆明市延安医院 | 具有靶向高强度杀瘤活性的Mesothelin嵌合抗原受体修饰的T细胞的制备方法 |
| KR20240109293A (ko) * | 2021-10-06 | 2024-07-10 | 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 | 암 치료에서 fshr을 표적으로 하는 이중특이 t세포 활성제와 사용 방법 |
| TW202323281A (zh) * | 2021-10-14 | 2023-06-16 | 美商泰尼歐生物公司 | 間皮素結合蛋白及其用途 |
| AU2022366987A1 (en) | 2021-10-14 | 2024-05-16 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
| US20250242023A1 (en) * | 2021-10-22 | 2025-07-31 | Regents Of The University Of Minnesota | Genetically engineered t cell receptors |
| EP4461747A4 (en) * | 2022-01-06 | 2026-04-15 | Oricell Therapeutics Co Ltd | ANTIGEN-BINDING PROTEIN TARGETTING MSLN AND ITS USE |
| CN114560949B (zh) * | 2022-03-07 | 2023-09-26 | 中国人民解放军空军军医大学 | 一种具有增强car-t细胞抗肿瘤能力的嵌合抗原受体、d-car-t细胞及其应用 |
| CN116284409A (zh) * | 2022-07-08 | 2023-06-23 | 上海优替济生生物医药有限公司 | Gpc3 car-t细胞及其在制备治疗癌症的药物中的用途 |
| WO2024088371A1 (zh) * | 2022-10-28 | 2024-05-02 | 原启生物科技(上海)有限责任公司 | 靶向msln的抗原结合蛋白 |
| WO2024096592A1 (ko) * | 2022-11-02 | 2024-05-10 | 주식회사 셀렌진 | 메소텔린에 대한 친화도가 상승된 키메릭 항원 수용체 및 이의 용도 |
| CN116019939A (zh) * | 2022-11-24 | 2023-04-28 | 华中科技大学同济医学院附属协和医院 | 靶向msln的分子探针以及用途 |
| KR20250163331A (ko) * | 2023-03-23 | 2025-11-20 | 내셔날 리서치 카운실 오브 캐나다 | 항-메소텔린 (msln) 단일 도메인 항체 및 치료 작제물 |
| CN118109416B (zh) * | 2023-03-30 | 2024-11-22 | 广州百吉生物制药有限公司 | 功能增强型工程化免疫细胞及其制备和应用 |
| WO2024259305A1 (en) * | 2023-06-14 | 2024-12-19 | The Broad Institute, Inc. | Vhh polypeptides that bind to mesothelin, compositions and methods of use thereof |
| WO2024259070A2 (en) * | 2023-06-14 | 2024-12-19 | Merck Sharp & Dohme Llc | Chimeric antigen receptors and use thereof |
| CN119708251A (zh) * | 2023-09-27 | 2025-03-28 | 北京大学 | 一种利用cd27逆转t和car-t细胞pd1信号的工程化细胞方法 |
| CN118147105B (zh) * | 2024-05-09 | 2024-08-02 | 西宝生物科技(上海)股份有限公司 | 一种蔗糖磷酸化酶的高效制备方法 |
| CN119859615A (zh) * | 2024-12-31 | 2025-04-22 | 广州安捷生物医学技术有限公司 | 一种靶向成纤维细胞激活蛋白的car-msc细胞及其制备方法和应用 |
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| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| CA2406864A1 (en) | 2000-02-24 | 2001-08-30 | Life Technologies Corporation | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US7405053B2 (en) * | 2003-05-20 | 2008-07-29 | The University Court Of The University Of Glasgow | Materials and methods relating to G-protein coupled receptor oligomers |
| CN110200997A (zh) | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| KR102437522B1 (ko) | 2012-05-25 | 2022-08-26 | 셀렉티스 | 면역요법을 위한 동종이형 및 면역억제제 저항성인 t 세포의 조작 방법 |
| US20150017136A1 (en) | 2013-07-15 | 2015-01-15 | Cellectis | Methods for engineering allogeneic and highly active t cell for immunotherapy |
| US20140004121A1 (en) * | 2012-06-27 | 2014-01-02 | Amgen Inc. | Anti-mesothelin binding proteins |
| CN104769103B (zh) | 2012-09-04 | 2018-06-08 | 塞勒克提斯公司 | 多链嵌合抗原受体和其用途 |
| CN104955845B (zh) * | 2012-09-27 | 2018-11-16 | 美国政府(由卫生和人类服务部的部长所代表) | 间皮素抗体和引起有效的抗肿瘤活性的方法 |
| CN102875685B (zh) | 2012-09-29 | 2013-12-25 | 郑骏年 | 嵌合抗原受体hFⅦL-CD8-OX40-CD3ζ及其用途 |
| TW201446794A (zh) | 2013-02-20 | 2014-12-16 | Novartis Ag | 利用抗-cd123嵌合抗原受體工程化t細胞之初級人類白血病有效靶向 |
| PL3546572T3 (pl) | 2013-05-13 | 2024-07-22 | Cellectis | Chimeryczny receptor antygenowy swoisty względem cd19 i jego zastosowania |
| MX2015015638A (es) | 2013-05-13 | 2016-10-28 | Cellectis | Metodos para diseñar celulas t altamente activas para inmunoterapia. |
| WO2014191128A1 (en) | 2013-05-29 | 2014-12-04 | Cellectis | Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system |
| ES2918501T3 (es) | 2013-12-19 | 2022-07-18 | Novartis Ag | Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos |
| ES2928000T3 (es) | 2014-06-06 | 2022-11-14 | Memorial Sloan Kettering Cancer Center | Receptores de antígeno quimérico dirigidos a mesotelina y usos de los mismos |
| KR20250067191A (ko) | 2014-09-17 | 2025-05-14 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| AU2016243124A1 (en) * | 2015-03-27 | 2017-11-02 | University Of Southern California | CAR T-cell therapy directed to LHR for the treatment of solid tumors |
| CN104877032B (zh) * | 2015-06-26 | 2018-12-11 | 中国医学科学院血液病医院(血液学研究所) | Cd33特异性嵌合抗原受体及其应用 |
| AU2016317936A1 (en) | 2015-09-04 | 2018-03-08 | Tocagen Inc. | Recombinant vectors comprising 2A peptide |
| CN110352068A (zh) * | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
| WO2018132695A1 (en) | 2017-01-13 | 2018-07-19 | Celdara Medical, Llc | Chimeric antigen receptors targeting tim-1 |
-
2019
- 2019-08-29 SG SG11202101773WA patent/SG11202101773WA/en unknown
- 2019-08-29 CN CN201980055889.4A patent/CN112639102B/zh active Active
- 2019-08-29 WO PCT/CN2019/103215 patent/WO2020043152A1/en not_active Ceased
- 2019-08-29 KR KR1020217009330A patent/KR102879284B1/ko active Active
- 2019-08-29 JP JP2021510019A patent/JP7490915B2/ja active Active
- 2019-08-29 US US17/270,970 patent/US11932698B2/en active Active
- 2019-08-29 CA CA3111087A patent/CA3111087A1/en active Pending
- 2019-08-29 TW TW108131105A patent/TW202024330A/zh unknown
- 2019-08-29 AU AU2019327913A patent/AU2019327913A1/en not_active Abandoned
- 2019-08-29 EP EP19854280.5A patent/EP3844282A4/en active Pending
-
2021
- 2021-02-24 IL IL281098A patent/IL281098A/en unknown
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