CA3111087A1 - Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof - Google Patents
Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof Download PDFInfo
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- CA3111087A1 CA3111087A1 CA3111087A CA3111087A CA3111087A1 CA 3111087 A1 CA3111087 A1 CA 3111087A1 CA 3111087 A CA3111087 A CA 3111087A CA 3111087 A CA3111087 A CA 3111087A CA 3111087 A1 CA3111087 A1 CA 3111087A1
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A61K40/31—Chimeric antigen receptors [CAR]
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- C—CHEMISTRY; METALLURGY
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
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- Immunology (AREA)
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- Molecular Biology (AREA)
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- Zoology (AREA)
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- General Engineering & Computer Science (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Hematology (AREA)
- Neurology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018103050 | 2018-08-29 | ||
| CNPCT/CN2018/103050 | 2018-08-29 | ||
| CNPCT/CN2019/083918 | 2019-04-23 | ||
| CN2019083918 | 2019-04-23 | ||
| PCT/CN2019/103215 WO2020043152A1 (en) | 2018-08-29 | 2019-08-29 | Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3111087A1 true CA3111087A1 (en) | 2020-03-05 |
Family
ID=69643948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3111087A Pending CA3111087A1 (en) | 2018-08-29 | 2019-08-29 | Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11932698B2 (https=) |
| EP (1) | EP3844282A4 (https=) |
| JP (1) | JP7490915B2 (https=) |
| KR (1) | KR102879284B1 (https=) |
| CN (1) | CN112639102B (https=) |
| AU (1) | AU2019327913A1 (https=) |
| CA (1) | CA3111087A1 (https=) |
| IL (1) | IL281098A (https=) |
| SG (1) | SG11202101773WA (https=) |
| TW (1) | TW202024330A (https=) |
| WO (1) | WO2020043152A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| WO2018140573A1 (en) * | 2017-01-26 | 2018-08-02 | Sangamo Therapeutics, Inc. | B-cell engineering |
| EP3715368A1 (en) * | 2019-03-28 | 2020-09-30 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors, vectors coding for such receptors and their use in the modification of t cells |
| KR20220078568A (ko) * | 2019-08-14 | 2022-06-10 | 모드맵 테라퓨틱스 인코포레이티드 | Lrp5 단백질에 결합하는 항체 및 사용 방법 |
| CN110964750A (zh) * | 2019-11-13 | 2020-04-07 | 沣潮医药科技(上海)有限公司 | 携带基因元件组合的嵌合抗原受体细胞文库、制备和筛选方法及用途 |
| US12264190B2 (en) * | 2020-04-24 | 2025-04-01 | Astrazeneca Ab | Compositions and methods of treating cancer with chimeric antigen receptors |
| US20240252641A1 (en) * | 2020-05-05 | 2024-08-01 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using cd70 specific fusion proteins |
| GB202006820D0 (en) * | 2020-05-07 | 2020-06-24 | Autolus Ltd | Cell |
| GB202008688D0 (en) * | 2020-06-09 | 2020-07-22 | Cancer Research Tech Ltd | Chimeric antigen receptor cell |
| JP2023532347A (ja) * | 2020-06-29 | 2023-07-27 | セル メディカ,インコーポレイテッド | キメラ抗原受容体の緊張性シグナル伝達を減少させる方法および組成物 |
| JP7138989B1 (ja) | 2020-08-04 | 2022-09-20 | セレンジーン インコーポレイテッド | メソテリンに特異的に結合する抗メソテリンキメラ抗原受容体 |
| GB202012181D0 (en) * | 2020-08-05 | 2020-09-16 | Autolus Ltd | Chimeric receptor |
| WO2022037562A1 (en) * | 2020-08-17 | 2022-02-24 | Nanjing Legend Biotech Co., Ltd. | Engineered immunoresponsive cells and uses thereof |
| EP4263612A4 (en) * | 2020-12-18 | 2025-04-02 | Bioardis LLC | Mesothelin binding molecules and uses thereof |
| AU2022222688B2 (en) * | 2021-02-16 | 2025-11-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Molecules that bind to mesothelin polypeptides |
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| JP2021534762A (ja) | 2021-12-16 |
| EP3844282A1 (en) | 2021-07-07 |
| EP3844282A4 (en) | 2022-06-01 |
| CN112639102B (zh) | 2024-03-01 |
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