ATE500270T1 - Materialien und methoden die sich auf g-protein gekoppelte rezeptor oligomere beziehen - Google Patents

Materialien und methoden die sich auf g-protein gekoppelte rezeptor oligomere beziehen

Info

Publication number
ATE500270T1
ATE500270T1 AT04733584T AT04733584T ATE500270T1 AT E500270 T1 ATE500270 T1 AT E500270T1 AT 04733584 T AT04733584 T AT 04733584T AT 04733584 T AT04733584 T AT 04733584T AT E500270 T1 ATE500270 T1 AT E500270T1
Authority
AT
Austria
Prior art keywords
coupled receptor
protein coupled
materials
methods related
oligomers
Prior art date
Application number
AT04733584T
Other languages
English (en)
Inventor
Graeme Davidson Milligan
Dominic Behan
Original Assignee
Univ Glasgow
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Glasgow filed Critical Univ Glasgow
Application granted granted Critical
Publication of ATE500270T1 publication Critical patent/ATE500270T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04733584T 2003-05-20 2004-05-18 Materialien und methoden die sich auf g-protein gekoppelte rezeptor oligomere beziehen ATE500270T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47202503P 2003-05-20 2003-05-20
PCT/GB2004/002150 WO2004104041A1 (en) 2003-05-20 2004-05-18 Materials and methods relating to g-protein coupled receptor oligomers

Publications (1)

Publication Number Publication Date
ATE500270T1 true ATE500270T1 (de) 2011-03-15

Family

ID=33476913

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04733584T ATE500270T1 (de) 2003-05-20 2004-05-18 Materialien und methoden die sich auf g-protein gekoppelte rezeptor oligomere beziehen

Country Status (11)

Country Link
US (2) US7405053B2 (de)
EP (1) EP1625159B1 (de)
JP (1) JP4932486B2 (de)
CN (1) CN1809587B (de)
AT (1) ATE500270T1 (de)
AU (1) AU2004241193B2 (de)
CA (1) CA2525286C (de)
DE (1) DE602004031605D1 (de)
MX (1) MXPA05012546A (de)
TW (1) TWI334871B (de)
WO (1) WO2004104041A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006011133A1 (de) * 2006-03-10 2007-09-13 Raumedic Ag Chimäres Polypeptidmolekül
EP2004675A1 (de) * 2006-03-16 2008-12-24 Protagonists Ltd. Kombination von cytokin und cytokinrezeptor zur modulation der funktion des immunsystems
US9284363B2 (en) * 2006-07-26 2016-03-15 Case Western Reserve University System and method for controlling G-protein coupled receptor pathways
KR20090083925A (ko) * 2006-11-10 2009-08-04 디메릭스 바이오사이언스 피티와이 엘티디 탐지시스템 및 그 이용
EP3926045A1 (de) * 2007-03-22 2021-12-22 Heptares Therapeutics Limited Mutante proteine und verfahren zur auswahl davon
EP2048503A1 (de) * 2007-10-09 2009-04-15 Universität Konstanz Prüfung zur Überwachung der Aktivität von Frizzled-Rezeptoren
TWI426459B (zh) * 2007-10-26 2014-02-11 Hon Hai Prec Ind Co Ltd 自動識別模具出庫和入庫動作的系統及方法
WO2010003170A1 (en) * 2008-06-17 2010-01-14 Dimerix Bioscience Pty Ltd Novel receptor hetero-dimers/-oligomers
US20110160081A1 (en) * 2008-07-01 2011-06-30 Javitch Jonathan A functional complementation assay for defined gpcr oligomers
WO2010031114A1 (en) * 2008-09-18 2010-03-25 Dimerix Bioscience Pty Ltd Novel receptor hetero-dimers/-oligomers
US20100120063A1 (en) * 2008-10-10 2010-05-13 Discoverx Corporation GPCR Arrestin Assays
EP2411813A4 (de) * 2009-03-27 2012-06-13 Dimerix Bioscience Pty Ltd Neue rezeptor-hetero-dimere/-oligomere
JP6093946B2 (ja) * 2014-02-25 2017-03-15 国立大学法人東北大学 Ｇタンパク質共役型受容体のシグナル伝達の検出方法
CN111741752A (zh) 2017-12-19 2020-10-02 Gpcr治疗公司 Gpcr异聚体抑制剂及其用途
WO2020043152A1 (en) * 2018-08-29 2020-03-05 Nanjing Legend Biotech Co., Ltd. Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof
US20210318305A1 (en) * 2018-09-05 2021-10-14 Yamasa Corporation Method and Kit for Rapid Measurement of Autoantibody Activity with Respect to TSH Receptor
US20220002357A1 (en) * 2018-12-04 2022-01-06 The University Of North Carolina At Chapel Hill G protein-coupled receptor screening systems

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
NZ336479A (en) 1997-04-14 2001-10-26 Arena Pharm Inc A method of identifying modulators of cell surface membrane receptors useful in the treatment of disease
US7119190B2 (en) 1997-04-14 2006-10-10 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human G protein-coupled receptors
US6555339B1 (en) 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
US6221660B1 (en) 1999-02-22 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding SNORF25 receptor
US6365356B1 (en) 1999-03-17 2002-04-02 Cornell Research Foundation, Inc. Receptors that regulate cell signaling relating to chemokines
US20020137054A1 (en) 1999-11-02 2002-09-26 Smithkline Beecham Corporation & Smithkline Beecham Plc AXOR35, a G-protein coupled receptor
US20010053848A1 (en) 2000-03-10 2001-12-20 Patel Yogesh C. Hetero-oligomeric G protein-coupled receptors as novel drug targets
CN1672054A (zh) 2002-07-25 2005-09-21 阿克拉若生物科学公司 检测受体寡聚化

Also Published As

Publication number Publication date
JP2007537707A (ja) 2007-12-27
AU2004241193A1 (en) 2004-12-02
DE602004031605D1 (de) 2011-04-14
TW200510456A (en) 2005-03-16
JP4932486B2 (ja) 2012-05-16
US7741064B2 (en) 2010-06-22
WO2004104041A1 (en) 2004-12-02
US7405053B2 (en) 2008-07-29
TWI334871B (en) 2010-12-21
EP1625159B1 (de) 2011-03-02
AU2004241193B2 (en) 2011-03-10
CN1809587A (zh) 2006-07-26
CN1809587B (zh) 2010-11-10
CA2525286C (en) 2012-09-11
EP1625159A1 (de) 2006-02-15
MXPA05012546A (es) 2006-05-25
US20070099263A1 (en) 2007-05-03
CA2525286A1 (en) 2004-12-02
US20080286828A1 (en) 2008-11-20

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