PE20001367A1 - Sintesis recombinante de beta-lipotropina y otros peptidos - Google Patents
Sintesis recombinante de beta-lipotropina y otros peptidosInfo
- Publication number
- PE20001367A1 PE20001367A1 PE1999001290A PE00129099A PE20001367A1 PE 20001367 A1 PE20001367 A1 PE 20001367A1 PE 1999001290 A PE1999001290 A PE 1999001290A PE 00129099 A PE00129099 A PE 00129099A PE 20001367 A1 PE20001367 A1 PE 20001367A1
- Authority
- PE
- Peru
- Prior art keywords
- protein
- fusion protein
- lipotropin
- beta
- host cell
- Prior art date
Links
- 102100027467 Pro-opiomelanocortin Human genes 0.000 title abstract 2
- 108010042362 beta-Lipotropin Proteins 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 2
- 101100121955 Tanacetum cinerariifolium GLIP gene Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/67—Lipotropins, e.g. beta, gamma lipotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
SE REFIERE A UNA PROTEINA DE FUSION, QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS DE PROPEPTIDO DE PROCARBOXIPEPTIDASA B Y UNA PROTEINA HETEROLOGA TAL COMO BETA-LIPOTROPINA hPTH O GLIP. TAMBIEN SE REFIERE A UN ADN QUE CODIFICA DICHA PROTEINA, UN VECTOR, UNA CELULA HUESPED, UNA PROTEINA PARA CONSTRUIR UNA CELULA HUESPED RECOMBINANTE; UN PROCEDIMIENTO PARA EXPRESAR UNA PROTEINA DE FUSION EN UNA CELULA HUESPED RECOMBINANTE, UN PROCEDIMIENTO PARA PREPARAR UNA PROTEINA DE INTERES QUE COMPRENDE a)TRANSFORMAR UN HUESPED CON UN VECTOR DE EXPRESION QUE CODIFICA UNA PROTEINA DE FUSION DE PROCARBOXIPEPTIDASA QUE COMPRENDE DICHA PROTEINA DE INTERES; b)CULTIVAR EL HUESPED TRANSFORMADO EN CONDICIONES QUE PERMITAN LA EXPRESION DE DICHA PROTEINA DE FUSION; c)PURIFICAR POR CUALQUIER MEDIO, LA PROTEINA DE FUSION A PARTIR DE DICHO HUESPED TRANSFORMADO; d)LIBERAR DICHA PROTEINA DE INTERES DE DICHA PROTEINA DE FUSION MEDIANTE CUALQUIER ESCISION QUIMICA O ENZIMATICA ADECUADA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11305898P | 1998-12-21 | 1998-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001367A1 true PE20001367A1 (es) | 2000-12-15 |
Family
ID=22347391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001290A PE20001367A1 (es) | 1998-12-21 | 1999-12-17 | Sintesis recombinante de beta-lipotropina y otros peptidos |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1016723A1 (es) |
| JP (1) | JP2002533072A (es) |
| AU (1) | AU2186900A (es) |
| CA (1) | CA2355402A1 (es) |
| PE (1) | PE20001367A1 (es) |
| WO (1) | WO2000037615A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005203925A1 (en) * | 2004-01-08 | 2005-07-21 | Theratechnologies Inc. | Glucagon-Like Peptide-1 analogs with long duration of action |
| AR094276A1 (es) * | 2012-12-21 | 2015-07-22 | Alkem Laboratories Ltd | Marcadores de fusion y sistema de vector de expresion para la expresion de hormona paratiroides humana (rhpth) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5892695A (ja) * | 1981-11-26 | 1983-06-02 | Mitsubishi Chem Ind Ltd | ハイブリツドプラスミド |
| CA2206848A1 (en) * | 1994-12-07 | 1996-06-13 | Bionebraska, Inc. | Production of peptides using recombinant fusion protein constructs |
| EP0844885A2 (en) * | 1995-08-16 | 1998-06-03 | Zeneca Limited | Chemical compounds |
| HUP9901562A3 (en) * | 1996-05-04 | 2000-06-28 | Astrazeneca Ab | Monoclonal antibody to cea, conjugates comprising said antibody, and their therapeutic use in an adept system |
| AU6000698A (en) * | 1997-02-14 | 1998-09-08 | Zeneca Limited | Proteins |
-
1999
- 1999-12-15 JP JP2000589671A patent/JP2002533072A/ja not_active Withdrawn
- 1999-12-15 AU AU21869/00A patent/AU2186900A/en not_active Abandoned
- 1999-12-15 WO PCT/US1999/029837 patent/WO2000037615A1/en active Application Filing
- 1999-12-15 CA CA002355402A patent/CA2355402A1/en not_active Abandoned
- 1999-12-17 EP EP99310191A patent/EP1016723A1/en not_active Withdrawn
- 1999-12-17 PE PE1999001290A patent/PE20001367A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000037615A1 (en) | 2000-06-29 |
| EP1016723A1 (en) | 2000-07-05 |
| CA2355402A1 (en) | 2000-06-29 |
| AU2186900A (en) | 2000-07-12 |
| JP2002533072A (ja) | 2002-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |