ATE412177T1 - Millisekunden-aktivationsschalter für 7- transmembran-proteine - Google Patents

Millisekunden-aktivationsschalter für 7- transmembran-proteine

Info

Publication number
ATE412177T1
ATE412177T1 AT03789370T AT03789370T ATE412177T1 AT E412177 T1 ATE412177 T1 AT E412177T1 AT 03789370 T AT03789370 T AT 03789370T AT 03789370 T AT03789370 T AT 03789370T AT E412177 T1 ATE412177 T1 AT E412177T1
Authority
AT
Austria
Prior art keywords
compounds
recombinant
labels
present
terminus
Prior art date
Application number
AT03789370T
Other languages
English (en)
Inventor
Moritz Buenemann
Jean-Pierre Vilardaga
Carsten Hoffmann
Martin Lohse
Original Assignee
Univ Wuerzburg J Maximilians
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wuerzburg J Maximilians filed Critical Univ Wuerzburg J Maximilians
Application granted granted Critical
Publication of ATE412177T1 publication Critical patent/ATE412177T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Electrotherapy Devices (AREA)
AT03789370T 2002-12-20 2003-12-19 Millisekunden-aktivationsschalter für 7- transmembran-proteine ATE412177T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10259874 2002-12-20
EP03004394 2003-03-03

Publications (1)

Publication Number Publication Date
ATE412177T1 true ATE412177T1 (de) 2008-11-15

Family

ID=32683463

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789370T ATE412177T1 (de) 2002-12-20 2003-12-19 Millisekunden-aktivationsschalter für 7- transmembran-proteine

Country Status (6)

Country Link
US (1) US8084575B2 (de)
EP (1) EP1581811B1 (de)
AT (1) ATE412177T1 (de)
AU (1) AU2003293959A1 (de)
DE (1) DE60324331D1 (de)
WO (1) WO2004057333A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2890446B1 (fr) 2005-09-05 2008-04-18 Cis Bio Internat Sa Methode de detection d'interaction intracellulaire entre bio-molecules
WO2007100618A2 (en) * 2006-02-23 2007-09-07 Atto Bioscience Novel cell-based phosphodiesterase assays
EP2036986A4 (de) * 2006-05-26 2010-01-20 Noacell Science Co Ltd Kontinuierliches testverfahren zur messung der rezeptor- und ionenkanalvermittelten calciumantwort und nachfolgender genexpression
US10203320B2 (en) 2008-11-11 2019-02-12 Corning Incorporated Label free method for assessing chemical cardiotoxicity
DE102008064164A1 (de) * 2008-12-22 2010-07-01 Leica Microsystems Cms Gmbh Verfahren zur räumlich hochauflösenden stochastischen Untersuchung einer mit einer Substanz markierten Struktur einer Probe
AU2010207880B2 (en) * 2009-01-29 2012-03-29 Commonwealth Scientific Industrial Research Organisation Measuring G protein coupled receptor activation
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
US10001470B2 (en) * 2009-12-04 2018-06-19 Sanford-Burnham Medical Research Institute Method, system and composition for optically inducing cardiomyocyte contraction
CN105899948A (zh) 2013-11-28 2016-08-24 联邦科学技术研究组织 检测疟原虫感染的方法
EP3056902B1 (de) * 2015-02-16 2020-04-01 Universite De Bordeaux Neuartige spannungsabhängige Ionenkanalfusionen und Verwendungsverfahren dafür
CN105671118A (zh) * 2016-03-02 2016-06-15 昆明理工大学 一种基于腺苷受体a2a分子探针的药物活性成分筛选方法
CN108586620B (zh) * 2018-05-10 2021-11-23 山东大学 筛选昆虫性信息素受体的配体的传感器分子以及筛选方法
CN114450310A (zh) * 2019-10-15 2022-05-06 瑞士苏黎世联邦理工学院 用于检测胞内或囊内生物分子相互作用的人工跨膜蛋白

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69840146D1 (de) 1997-03-14 2008-12-04 Univ California Fluoreszenzprotein-sensoren zur erkennung von analyten
US6376257B1 (en) * 1997-04-24 2002-04-23 University Of Rochester Detection by fret changes of ligand binding by GFP fusion proteins
US6277627B1 (en) * 1997-12-31 2001-08-21 Duke University Biosensor
EP1088233B9 (de) 1998-06-16 2006-05-17 PerkinElmer BioSignal Inc. Biolumineszentes resonanz-energie-transfersystem (bret) und seine anwendung
ES2329850T3 (es) * 1998-07-17 2009-12-01 University Of Maryland, Baltimore Proteinas manipuladas para la deteccion de analitos.
US7018846B1 (en) * 1998-08-10 2006-03-28 Science & Technology Corporation @ Unm Display of receptors and analysis of binding interactions and drug libraries
WO2000034318A1 (en) 1998-12-11 2000-06-15 Clontech Laboratories, Inc. Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof
ES2272309T3 (es) 1999-08-03 2007-05-01 Millennium Pharmaceuticals, Inc. 15571, una nueva molecula de tipo gpcr de la familia de tipo secretina y sus usos.
US20020048811A1 (en) * 2000-10-16 2002-04-25 Devreotes Peter N. Receptor mediated activation of heterotrimeric G-proteins

Also Published As

Publication number Publication date
WO2004057333A1 (en) 2004-07-08
US8084575B2 (en) 2011-12-27
AU2003293959A1 (en) 2004-07-14
DE60324331D1 (de) 2008-12-04
EP1581811A1 (de) 2005-10-05
EP1581811B1 (de) 2008-10-22
US20060272037A1 (en) 2006-11-30

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Legal Events

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