JP2020515508A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020515508A5 JP2020515508A5 JP2019528825A JP2019528825A JP2020515508A5 JP 2020515508 A5 JP2020515508 A5 JP 2020515508A5 JP 2019528825 A JP2019528825 A JP 2019528825A JP 2019528825 A JP2019528825 A JP 2019528825A JP 2020515508 A5 JP2020515508 A5 JP 2020515508A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- amino acid
- antibody fragment
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 21
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 6
- 102000045309 human NT5E Human genes 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 5
- 230000037430 deletion Effects 0.000 claims 5
- 238000012217 deletion Methods 0.000 claims 5
- 230000037431 insertion Effects 0.000 claims 5
- 238000003780 insertion Methods 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 239000000783 alginic acid Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2017/072445 | 2017-01-24 | ||
| CN2017072445 | 2017-01-24 | ||
| PCT/CN2018/073746 WO2018137598A1 (en) | 2017-01-24 | 2018-01-23 | Anti-cd73 antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515508A JP2020515508A (ja) | 2020-05-28 |
| JP2020515508A5 true JP2020515508A5 (https=) | 2021-03-04 |
| JP7206193B2 JP7206193B2 (ja) | 2023-01-17 |
Family
ID=62978102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019528825A Active JP7206193B2 (ja) | 2017-01-24 | 2018-01-23 | 抗ｃｄ７３抗体およびその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US10584169B2 (https=) |
| EP (2) | EP4050030A1 (https=) |
| JP (1) | JP7206193B2 (https=) |
| KR (3) | KR20200108915A (https=) |
| CN (2) | CN112279918A (https=) |
| AU (3) | AU2018213549B2 (https=) |
| BR (1) | BR112019012040A2 (https=) |
| CA (1) | CA3045376C (https=) |
| CL (1) | CL2019001756A1 (https=) |
| CO (1) | CO2019006657A2 (https=) |
| DK (1) | DK3383916T3 (https=) |
| EA (1) | EA201991099A1 (https=) |
| ES (1) | ES2908662T3 (https=) |
| HR (1) | HRP20220629T1 (https=) |
| HU (1) | HUE058975T2 (https=) |
| IL (3) | IL290842B2 (https=) |
| LT (1) | LT3383916T (https=) |
| MX (1) | MX391656B (https=) |
| MY (1) | MY188386A (https=) |
| NZ (1) | NZ753714A (https=) |
| PE (1) | PE20191208A1 (https=) |
| PH (1) | PH12019550087A1 (https=) |
| PL (1) | PL3383916T3 (https=) |
| PT (1) | PT3383916T (https=) |
| RS (1) | RS63195B1 (https=) |
| SI (1) | SI3383916T1 (https=) |
| UA (1) | UA126571C2 (https=) |
| WO (1) | WO2018137598A1 (https=) |
| ZA (1) | ZA201904619B (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7066696B2 (ja) | 2016-10-11 | 2022-05-13 | アジェナス インコーポレイテッド | 抗ｌａｇ－３抗体及びその使用方法 |
| TWI877770B (zh) | 2018-02-27 | 2025-03-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶 |
| WO2019173692A2 (en) | 2018-03-09 | 2019-09-12 | Agenus Inc. | Anti-cd73 antibodies and methods of use thereof |
| EP3810610A1 (en) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| WO2020010197A1 (en) | 2018-07-05 | 2020-01-09 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
| WO2020020307A1 (en) * | 2018-07-25 | 2020-01-30 | I-Mab Biopharma Co., Ltd. | Anti-cd73 anti-pd-l1 bispecific antibodies |
| US20220220218A1 (en) * | 2018-11-12 | 2022-07-14 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-cd73 antibody, antigen-binding fragment thereof and application thereof |
| CN111499747B (zh) * | 2019-01-11 | 2022-03-18 | 康诺亚生物医药科技（成都）有限公司 | 一种抗cd73单克隆抗体及其应用 |
| MX2021008094A (es) | 2019-01-11 | 2021-09-21 | Omeros Corp | Metodos y composiciones para el tratamiento del cancer. |
| CN111434688A (zh) * | 2019-01-11 | 2020-07-21 | 上海开拓者生物医药有限公司 | Cd73抗体及其制备方法和应用 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| CN113795267A (zh) | 2019-03-12 | 2021-12-14 | 艾库斯生物科学有限公司 | 致癌基因驱动的癌症的治疗 |
| WO2020205527A1 (en) * | 2019-03-29 | 2020-10-08 | Arcus Biosciences, Inc. | Treatment of cancer utilizing an identified adenosine fingerprint |
| JP7623706B2 (ja) * | 2019-06-06 | 2025-01-29 | ジャコバイオ ファーマスーティカルズ カンパニー リミテッド | Ｃｄ７３に特異的な結合分子と結合分子の使用 |
| CN117946274B (zh) * | 2019-06-19 | 2026-02-17 | 杭州博之锐生物制药有限公司 | 抗cd73抗体及其应用 |
| CN112300279A (zh) | 2019-07-26 | 2021-02-02 | 上海复宏汉霖生物技术股份有限公司 | 针对抗cd73抗体和变体的方法和组合物 |
| JP7471016B2 (ja) * | 2019-08-21 | 2024-04-19 | ハーバー・バイオメド・（シャンハイ）・カンパニー・リミテッド | 抗ｃｄ７３抗体およびその適用 |
| UA130408C2 (uk) | 2019-09-06 | 2026-02-11 | Ле Лаборатуар Сервьє | Антитіла до cd73 |
| CA3161717A1 (en) * | 2019-11-15 | 2021-05-20 | Dana LORD | Biparatopic cd73 antibodies |
| PE20221409A1 (es) * | 2020-01-03 | 2022-09-20 | Incyte Corp | Anticuerpos anti-cd73 y usos de estos |
| TW202135823A (zh) | 2020-01-03 | 2021-10-01 | 美商英塞特公司 | Ｃｄ７３抑制劑及ａ２ａ／ａ２ｂ腺苷受體抑制劑組合療法 |
| TWI890283B (zh) | 2020-02-14 | 2025-07-11 | 美商基利科學股份有限公司 | 結合ccr8之抗體及融合蛋白及其用途 |
| CA3174033A1 (en) * | 2020-04-09 | 2021-10-14 | Sang Hoon Cha | Monoclonal antibodies and antigen binding fragments thereof for suppressing cd73 immune checkpoint and uses thereof |
| US20230159655A1 (en) * | 2020-04-22 | 2023-05-25 | Akeso Biopharma, Inc | Anti-cd73 antibody and use thereof |
| CN115551888B (zh) * | 2020-05-12 | 2026-04-28 | 百欧恩泰(珠海)医药研发有限公司 | 抗cd73抗体及其用途 |
| JP2023532234A (ja) | 2020-06-22 | 2023-07-27 | イノベント バイオロジクス（スーチョウ）カンパニー，リミティド | 抗ｃｄ７３抗体とその用途 |
| KR20230050378A (ko) | 2020-08-13 | 2023-04-14 | 이나뜨 파르마 에스.에이. | 항-cd73 항체를 사용하여 암을 치료하는 방법 |
| US20240218074A1 (en) * | 2020-08-17 | 2024-07-04 | Akeso Biopharma, Inc. | Anti-cd73 antibody and use thereof |
| WO2022083049A1 (zh) * | 2020-10-19 | 2022-04-28 | 中山康方生物医药有限公司 | 抗cd73的抗体及其用途 |
| CN120590533A (zh) * | 2020-10-23 | 2025-09-05 | 中山康方生物医药有限公司 | 抗cd73的抗体及其用途 |
| TWI900705B (zh) * | 2020-12-11 | 2025-10-11 | 大陸商上海華奧泰生物藥業股份有限公司 | Ｃｄ７３的抗原結合蛋白及其應用 |
| TW202241441A (zh) | 2020-12-29 | 2022-11-01 | 美商英塞特公司 | 包含ａ２ａ／ａ２ｂ抑制劑、ｐｄ－１／ｐｄ－ｌ１抑制劑及抗ｃｄ７３抗體之組合療法 |
| WO2022142053A1 (en) * | 2020-12-30 | 2022-07-07 | I-Mab Biopharma Co., Ltd | Formulations of anti-cd73 antibodies |
| EP4288455A1 (en) | 2021-02-03 | 2023-12-13 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
| US20240174763A1 (en) * | 2021-02-24 | 2024-05-30 | Novoprotein Scientific Inc. | Anti-human cd73 antibody and use thereof |
| CN112552406B (zh) * | 2021-02-24 | 2021-05-11 | 吴江近岸蛋白质科技有限公司 | 抗人cd73抗体 |
| CN112574313B (zh) * | 2021-02-25 | 2021-05-11 | 吴江近岸蛋白质科技有限公司 | 抗cd73抗体及其用途 |
| EP4349867A4 (en) * | 2021-05-28 | 2026-01-07 | Harbour Biomed Shanghai Co Ltd | SPECIFIC BINDING PROTEIN TARGETING PD-L1 AND CD73 |
| WO2023076876A1 (en) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation of immune responses to viral vectors |
| KR20240139053A (ko) | 2022-01-25 | 2024-09-20 | 씨에스피씨 메가리스 바이오파마슈티칼 씨오., 엘티디. | 항-cd73 항체 및 이의 용도 |
| US12187806B2 (en) | 2022-03-04 | 2025-01-07 | Development Center For Biotechnology | Anti-CD73 antibodies and use thereof |
| TW202400242A (zh) * | 2022-03-14 | 2024-01-01 | 大陸商上海華奧泰生物藥業股份有限公司 | 抗體藥物偶聯物及其應用 |
| JP2025512384A (ja) | 2022-04-13 | 2025-04-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｒｏｐ－２発現がんを治療するための併用療法 |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
| EP4626552A1 (en) | 2022-12-01 | 2025-10-08 | MedImmune Limited | Combination therapy for treatment of cancer comprising anti-pd-l1 and anti-cd73 antibodies |
| WO2024217447A1 (zh) * | 2023-04-17 | 2024-10-24 | 上海鑫湾生物科技有限公司 | 特异性结合cd73的抗体及其制备方法和应用 |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025076113A1 (en) | 2023-10-05 | 2025-04-10 | Capstan Therapeutics, Inc. | Ionizable cationic lipids with conserved spacing and lipid nanoparticles |
| US20250127728A1 (en) | 2023-10-05 | 2025-04-24 | Capstan Therapeutics, Inc. | Constrained Ionizable Cationic Lipids and Lipid Nanoparticles |
| WO2025135233A1 (ko) * | 2023-12-21 | 2025-06-26 | ㈜지아이이노베이션 | Cd73에 특이적으로 결합하는 항체 및 이의 용도 |
| WO2025137640A1 (en) | 2023-12-22 | 2025-06-26 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025162964A1 (en) | 2024-01-30 | 2025-08-07 | Institut National de la Santé et de la Recherche Médicale | Methods for the treatment of endometriosis |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| WO2025217452A1 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Constrained ionizable cationic lipids and lipid nanoparticles |
| WO2025217454A2 (en) | 2024-04-11 | 2025-10-16 | Capstan Therapeutics, Inc. | Ionizable cationic lipids and lipid nanoparticles |
| WO2025233264A1 (en) | 2024-05-07 | 2025-11-13 | Innate Pharma | Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers |
Family Cites Families (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4694778A (en) | 1984-05-04 | 1987-09-22 | Anicon, Inc. | Chemical vapor deposition wafer boat |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5120764A (en) | 1988-11-01 | 1992-06-09 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US4997854A (en) | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| WO1996033735A1 (en) | 1995-04-27 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| US5756096A (en) | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| US6420140B1 (en) | 1996-10-11 | 2002-07-16 | Abgenix, Inc. | Production of multimeric protein by cell fusion method |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| BRPI9809391B8 (pt) | 1997-04-14 | 2021-05-25 | Amgen Res Munich Gmbh | processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| WO1999004705A1 (en) | 1997-07-25 | 1999-02-04 | Tsui Ban C H | Devices, systems and methods for determining proper placement of epidural catheters |
| AU776910B2 (en) | 1998-12-08 | 2004-09-23 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Modifying protein immunogenicity |
| WO2000067796A1 (en) | 1999-05-07 | 2000-11-16 | Genentech, Inc. | Treatment of autoimmune diseases with antagonists which bind to b cell surface markers |
| FR2828206B1 (fr) | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
| WO2005113556A1 (en) | 2004-05-13 | 2005-12-01 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
| US20090142345A1 (en) | 2005-03-15 | 2009-06-04 | Takeda Pharmaceutical Company Limited | Prophylactic/therapeutic agent for cancer |
| JP5382692B2 (ja) * | 2006-07-10 | 2014-01-08 | 学校法人藤田学園 | 抗体の分類法、抗原の同定法、抗体又は抗体セットの取得法、抗体パネルの作成法、並びに抗体又は抗体セット及びその用途 |
| ES2700141T3 (es) | 2007-08-02 | 2019-02-14 | Gilead Biologics Inc | Anticuerpos inhibidores LOXL2 y usos de los mismos |
| US7982016B2 (en) | 2007-09-10 | 2011-07-19 | Amgen Inc. | Antigen binding proteins capable of binding thymic stromal lymphopoietin |
| US8652843B2 (en) | 2008-08-12 | 2014-02-18 | Oncomed Pharmaceuticals, Inc. | DDR1-binding agents and methods of use thereof |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| TWI598347B (zh) | 2009-07-13 | 2017-09-11 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| BR112012019693A2 (pt) | 2010-02-04 | 2017-06-20 | Gilead Biologics Inc | anticorpos que se ligam à lisil oxidase-like 2 (loxl2) e métodos de uso para eles. |
| EP2608809B1 (en) | 2010-08-27 | 2019-05-22 | Gilead Biologics, Inc. | Antibodies to matrix metalloproteinase 9 |
| US9550835B2 (en) | 2011-08-23 | 2017-01-24 | Chugai Seiyaku Kabushiki Kaisha | Anti-DDR1 antibody having anti-tumor activity |
| GB201115529D0 (en) | 2011-09-08 | 2011-10-26 | Imp Innovations Ltd | Antibodies, uses and methods |
| HK1201065A1 (en) | 2011-10-04 | 2015-08-21 | Gilead Calistoga Llc | Novel quinoxaline inhibitors of pi3k |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| WO2013116562A1 (en) | 2012-02-03 | 2013-08-08 | Gilead Calistoga Llc | Compositions and methods of treating a disease with (s)-4 amino-6-((1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile |
| WO2014047624A1 (en) | 2012-09-24 | 2014-03-27 | Gilead Sciences, Inc. | Anti-ddr1 antibodies |
| JP6207100B2 (ja) | 2012-12-21 | 2017-10-04 | ギリアード カリストガ エルエルシー | イソキノリノンまたはキナゾリノンホスファチジルイノシトール３−キナーゼ阻害剤 |
| AU2013364068B2 (en) | 2012-12-21 | 2016-10-20 | Gilead Calistoga Llc | Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors |
| US9388243B2 (en) | 2013-05-29 | 2016-07-12 | Samsung Electronics Co., Ltd. | Method of target membrane protein depletion |
| PL3008053T3 (pl) | 2013-06-14 | 2018-08-31 | Gilead Calistoga Llc | Inhibitory 3-kinazy fosfatydyloinozytolu |
| WO2016131950A1 (en) * | 2015-02-20 | 2016-08-25 | Innate Pharma | Cd73 blockade |
| EP3204417B1 (en) * | 2014-10-10 | 2020-07-22 | Innate Pharma | Cd73 blockade |
| GB2537445A (en) | 2014-11-10 | 2016-10-19 | Medimmune Ltd | Binding molecules specific for CD73 and uses thereof |
| GB2538120A (en) | 2014-11-11 | 2016-11-09 | Medimmune Ltd | Therapeutic combinations comprising anti-CD73 antibodies and uses thereof |
| JP6668345B2 (ja) | 2014-11-21 | 2020-03-18 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 修飾された重鎖定常領域を含む抗体 |
| AU2015349878A1 (en) * | 2014-11-21 | 2017-05-25 | Bristol-Myers Squibb Company | Antibodies against CD73 and uses thereof |
| CN114805575B (zh) | 2015-12-09 | 2024-07-23 | 科尔沃斯制药股份有限公司 | 人源化抗cd73抗体 |
| MY204117A (en) | 2017-06-22 | 2024-08-08 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| WO2019173692A2 (en) | 2018-03-09 | 2019-09-12 | Agenus Inc. | Anti-cd73 antibodies and methods of use thereof |
-
2018
- 2018-01-23 CA CA3045376A patent/CA3045376C/en active Active
- 2018-01-23 EA EA201991099A patent/EA201991099A1/ru unknown
- 2018-01-23 KR KR1020207026020A patent/KR20200108915A/ko not_active Ceased
- 2018-01-23 KR KR1020197025714A patent/KR102156199B1/ko active Active
- 2018-01-23 NZ NZ753714A patent/NZ753714A/en unknown
- 2018-01-23 HR HRP20220629TT patent/HRP20220629T1/hr unknown
- 2018-01-23 CN CN202011018748.6A patent/CN112279918A/zh active Pending
- 2018-01-23 IL IL290842A patent/IL290842B2/en unknown
- 2018-01-23 RS RS20220443A patent/RS63195B1/sr unknown
- 2018-01-23 EP EP22150866.6A patent/EP4050030A1/en active Pending
- 2018-01-23 DK DK18733153.3T patent/DK3383916T3/da active
- 2018-01-23 EP EP18733153.3A patent/EP3383916B1/en active Active
- 2018-01-23 PT PT187331533T patent/PT3383916T/pt unknown
- 2018-01-23 SI SI201830661T patent/SI3383916T1/sl unknown
- 2018-01-23 UA UAA201906244A patent/UA126571C2/uk unknown
- 2018-01-23 MX MX2019008758A patent/MX391656B/es unknown
- 2018-01-23 ES ES18733153T patent/ES2908662T3/es active Active
- 2018-01-23 HU HUE18733153A patent/HUE058975T2/hu unknown
- 2018-01-23 US US16/069,144 patent/US10584169B2/en active Active
- 2018-01-23 MY MYPI2019003100A patent/MY188386A/en unknown
- 2018-01-23 LT LTEPPCT/CN2018/073746T patent/LT3383916T/lt unknown
- 2018-01-23 KR KR1020187022273A patent/KR20180093088A/ko not_active Abandoned
- 2018-01-23 AU AU2018213549A patent/AU2018213549B2/en active Active
- 2018-01-23 PE PE2019001312A patent/PE20191208A1/es unknown
- 2018-01-23 WO PCT/CN2018/073746 patent/WO2018137598A1/en not_active Ceased
- 2018-01-23 CN CN201880000859.9A patent/CN109476755B/zh active Active
- 2018-01-23 BR BR112019012040-8A patent/BR112019012040A2/pt active IP Right Grant
- 2018-01-23 PL PL18733153.3T patent/PL3383916T3/pl unknown
- 2018-01-23 JP JP2019528825A patent/JP7206193B2/ja active Active
-
2019
- 2019-05-20 PH PH12019550087A patent/PH12019550087A1/en unknown
- 2019-06-21 CL CL2019001756A patent/CL2019001756A1/es unknown
- 2019-06-21 CO CONC2019/0006657A patent/CO2019006657A2/es unknown
- 2019-07-09 IL IL267942A patent/IL267942B/en unknown
- 2019-07-15 ZA ZA2019/04619A patent/ZA201904619B/en unknown
-
2020
- 2020-02-10 US US16/785,953 patent/US11613577B2/en active Active
-
2022
- 2022-04-29 AU AU2022202847A patent/AU2022202847A1/en not_active Abandoned
-
2025
- 2025-04-28 AU AU2025202949A patent/AU2025202949A1/en active Pending
- 2025-10-19 IL IL324062A patent/IL324062A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020515508A5 (https=) | ||
| PH12019550087A1 (en) | Anti-cd73 antibodies and uses thereof | |
| JP2021503455A5 (https=) | ||
| JP2019535763A5 (https=) | ||
| JP2023509196A5 (https=) | ||
| JP2022502371A5 (https=) | ||
| RU2022102446A (ru) | Биспецифические связывающие белки и пути их применения | |
| JP2014530017A5 (https=) | ||
| JP2021534096A5 (https=) | ||
| JP2021508469A5 (https=) | ||
| FI3328893T3 (fi) | Mesoteliinia ja cd3:a sitovia bispesifisiä vasta-ainekonstrukteja | |
| JP2020526478A5 (https=) | ||
| JP2021510521A5 (https=) | ||
| JP2018502050A5 (https=) | ||
| JP2019533719A5 (https=) | ||
| JP2019502712A5 (https=) | ||
| JP2022530404A5 (https=) | ||
| JP2021522162A5 (https=) | ||
| JP2018523493A5 (https=) | ||
| JP2020501532A5 (https=) | ||
| JP2020510653A5 (ja) | Ｃｅａを標的にする多重特異性結合タンパク質 | |
| JP2023548443A5 (https=) | ||
| JP2019507762A5 (https=) | ||
| JP2011505146A5 (https=) | ||
| JP2020510659A5 (https=) |