JP2020515508A5 - - Google Patents
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- JP2020515508A5 JP2020515508A5 JP2019528825A JP2019528825A JP2020515508A5 JP 2020515508 A5 JP2020515508 A5 JP 2020515508A5 JP 2019528825 A JP2019528825 A JP 2019528825A JP 2019528825 A JP2019528825 A JP 2019528825A JP 2020515508 A5 JP2020515508 A5 JP 2020515508A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- amino acid
- antibody fragment
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 21
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 21
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 6
- 102000045309 human NT5E Human genes 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 5
- 230000037430 deletion Effects 0.000 claims 5
- 238000012217 deletion Methods 0.000 claims 5
- 230000037431 insertion Effects 0.000 claims 5
- 238000003780 insertion Methods 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 239000000783 alginic acid Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017072445 | 2017-01-24 | ||
| CNPCT/CN2017/072445 | 2017-01-24 | ||
| PCT/CN2018/073746 WO2018137598A1 (en) | 2017-01-24 | 2018-01-23 | Anti-cd73 antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515508A JP2020515508A (ja) | 2020-05-28 |
| JP2020515508A5 true JP2020515508A5 (https=) | 2021-03-04 |
| JP7206193B2 JP7206193B2 (ja) | 2023-01-17 |
Family
ID=62978102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019528825A Active JP7206193B2 (ja) | 2017-01-24 | 2018-01-23 | 抗ｃｄ７３抗体およびその使用 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US10584169B2 (https=) |
| EP (2) | EP3383916B1 (https=) |
| JP (1) | JP7206193B2 (https=) |
| KR (3) | KR20180093088A (https=) |
| CN (2) | CN112279918A (https=) |
| AU (3) | AU2018213549B2 (https=) |
| BR (1) | BR112019012040A2 (https=) |
| CA (1) | CA3045376C (https=) |
| CL (1) | CL2019001756A1 (https=) |
| CO (1) | CO2019006657A2 (https=) |
| DK (1) | DK3383916T3 (https=) |
| EA (1) | EA201991099A1 (https=) |
| ES (1) | ES2908662T3 (https=) |
| HR (1) | HRP20220629T1 (https=) |
| HU (1) | HUE058975T2 (https=) |
| IL (3) | IL290842B2 (https=) |
| LT (1) | LT3383916T (https=) |
| MX (1) | MX391656B (https=) |
| MY (1) | MY188386A (https=) |
| NZ (1) | NZ753714A (https=) |
| PE (1) | PE20191208A1 (https=) |
| PH (1) | PH12019550087A1 (https=) |
| PL (1) | PL3383916T3 (https=) |
| PT (1) | PT3383916T (https=) |
| RS (1) | RS63195B1 (https=) |
| SI (1) | SI3383916T1 (https=) |
| UA (1) | UA126571C2 (https=) |
| WO (1) | WO2018137598A1 (https=) |
| ZA (1) | ZA201904619B (https=) |
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| BR122023024273A2 (pt) | 2018-02-27 | 2024-02-20 | Incyte Corporation | Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos |
| TWI823906B (zh) | 2018-03-09 | 2023-12-01 | 美商艾吉納斯公司 | 抗-cd73 抗體及其使用方法 |
| WO2019222677A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| GEP20237548B (en) | 2018-07-05 | 2023-10-10 | Incyte Corp | Fused pyrazine derivatives as a2a /a2b inhibitors |
| WO2020020307A1 (en) * | 2018-07-25 | 2020-01-30 | I-Mab Biopharma Co., Ltd. | Anti-cd73 anti-pd-l1 bispecific antibodies |
| MX2021005396A (es) * | 2018-11-12 | 2021-07-06 | Jiangsu Hengrui Medicine Co | Anticuerpo anti-cd73, fragmento de union a antigeno y aplicacion del mismo. |
| CN111499747B (zh) * | 2019-01-11 | 2022-03-18 | 康诺亚生物医药科技（成都）有限公司 | 一种抗cd73单克隆抗体及其应用 |
| CN111434688A (zh) * | 2019-01-11 | 2020-07-21 | 上海开拓者生物医药有限公司 | Cd73抗体及其制备方法和应用 |
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| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
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| WO2022083049A1 (zh) * | 2020-10-19 | 2022-04-28 | 中山康方生物医药有限公司 | 抗cd73的抗体及其用途 |
| US20240018254A1 (en) * | 2020-10-23 | 2024-01-18 | Akeso Biopharma, Inc | Anti-cd73 antibody and use thereof |
| TWI900705B (zh) * | 2020-12-11 | 2025-10-11 | 大陸商上海華奧泰生物藥業股份有限公司 | Ｃｄ７３的抗原結合蛋白及其應用 |
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