|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4537776A
(en)
|
1983-06-21 |
1985-08-27 |
The Procter & Gamble Company |
Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
ATE122238T1
(de)
|
1987-06-10 |
1995-05-15 |
Dana Farber Cancer Inst Inc |
Bifunktionelle antikörperkonstruktionen und verfahren zur selektiven tötung von zellbeständen.
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
ES2055445T3
(es)
|
1989-08-22 |
1994-08-16 |
Immunex Corp |
Proteinas de fusion que comprenden gm-csf e il-3.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
EP0786469B1
(en)
|
1990-06-11 |
2006-03-01 |
Gilead Sciences, Inc. |
Methods of use of nucleic acid ligands
|
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
SE9201966D0
(sv)
|
1992-06-25 |
1992-06-25 |
Trion Forskning & Utveckling |
Interleukin-1beta deletion mutant
|
|
AU701578B2
(en)
|
1992-08-21 |
1999-02-04 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
US5914254A
(en)
|
1993-08-02 |
1999-06-22 |
Celtrix Pharmaceuticals, Inc. |
Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
|
|
SE9400088D0
(sv)
|
1994-01-14 |
1994-01-14 |
Kabi Pharmacia Ab |
Bacterial receptor structures
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
WO1996002561A1
(en)
|
1994-07-20 |
1996-02-01 |
The General Hospital Corporation |
Interaction trap systems for detecting protein interactions
|
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
AU6961796A
(en)
|
1995-09-12 |
1997-04-01 |
Chiron Corporation |
Improved interleukin-6 receptor antagonist
|
|
EP0770397B1
(en)
|
1995-10-18 |
2004-04-21 |
Akzo Nobel N.V. |
Newcastle disease virus combination vaccine
|
|
US5986059A
(en)
|
1996-06-14 |
1999-11-16 |
Bayer Corporation |
T-cell selective interleukin-4 agonists
|
|
US6653104B2
(en)
|
1996-10-17 |
2003-11-25 |
Immunomedics, Inc. |
Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
WO1999037681A2
(en)
|
1998-01-26 |
1999-07-29 |
Unilever Plc |
Method for producing antibody fragments
|
|
AUPP221098A0
(en)
|
1998-03-06 |
1998-04-02 |
Diatech Pty Ltd |
V-like domain binding molecules
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
DE60013767T3
(de)
|
1999-01-19 |
2009-07-09 |
Unilever N.V. |
Verfahren zur herstellung von antikörperfragmenten
|
|
EP1696038B1
(en)
|
1999-05-05 |
2010-06-02 |
Phylogica Limited |
Isolating biological modulators from biodiverse gene fragment libraries
|
|
AU4761100A
(en)
|
1999-05-26 |
2000-12-18 |
Kalle Saksela |
Methods and materials for generating sh3 domains with tailored binding properties
|
|
US7101974B2
(en)
|
2000-03-02 |
2006-09-05 |
Xencor |
TNF-αvariants
|
|
SE0001877D0
(sv)
|
2000-05-22 |
2000-05-22 |
Klaus Mosbach |
Molecular imprinting
|
|
WO2001090190A2
(en)
|
2000-05-26 |
2001-11-29 |
National Research Council Of Canada |
Single-domain antigen-binding antibody fragments derived from llama antibodies
|
|
DE60142479D1
(de)
|
2000-08-30 |
2010-08-12 |
Penn State Res Found |
Aminosäureaustauschmutanten von interleukin 13
|
|
DE60140474D1
(de)
|
2000-09-08 |
2009-12-24 |
Univ Zuerich |
Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
|
|
DE10053224A1
(de)
|
2000-10-26 |
2002-05-08 |
Univ Goettingen Georg August |
Verfahren zur Exposition von Peptiden und Polypeptiden auf der Zelloberfläche von Bakterien
|
|
US20040132094A1
(en)
|
2000-12-13 |
2004-07-08 |
Michael Etzerodt |
Combinatorial libraries of proteins having the scaffold structure of c-type lectinlike domains
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
RU2004109222A
(ru)
|
2001-08-30 |
2005-10-20 |
Байорексис Фармасьютикал Корпорейшн (Us) |
Слитые белки модифицированного трансферрина
|
|
EP1433793A4
(en)
|
2001-09-13 |
2006-01-25 |
Inst Antibodies Co Ltd |
METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY
|
|
JP2005289809A
(ja)
|
2001-10-24 |
2005-10-20 |
Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) |
突然変異重鎖抗体
|
|
ES2350687T3
(es)
|
2002-07-03 |
2011-01-26 |
Ono Pharmaceutical Co., Ltd. |
Composiciones de inmunopotenciación.
|
|
CA2501295A1
(en)
|
2002-10-02 |
2004-04-15 |
Jack Nguyen |
Methods of generating and screening for proteases with altered specificity
|
|
CA2505316C
(en)
|
2002-11-08 |
2014-08-05 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
|
GB0228210D0
(en)
|
2002-12-03 |
2003-01-08 |
Babraham Inst |
Single chain antibodies
|
|
WO2004060965A2
(en)
|
2002-12-31 |
2004-07-22 |
Nektar Therapeutics Al, Corporation |
Hydrolytically stable maleimide-terminated polymers
|
|
DK1587907T3
(da)
|
2003-01-07 |
2011-04-04 |
Dyax Corp |
Kunitz-domænebibliotek
|
|
TW200526780A
(en)
|
2004-01-06 |
2005-08-16 |
Hayashibara Biochem Lab |
TNF antagonists and TNF inhibitors comprising the same as the active ingredient
|
|
US20060008844A1
(en)
|
2004-06-17 |
2006-01-12 |
Avidia Research Institute |
c-Met kinase binding proteins
|
|
DE102004049479A1
(de)
|
2004-10-11 |
2006-04-13 |
Scil Proteins Gmbh |
Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie
|
|
CA2585549A1
(en)
|
2004-11-18 |
2006-05-26 |
Vib Vzw |
Novel type leptin receptor antagonist
|
|
WO2006115800A2
(en)
|
2005-04-15 |
2006-11-02 |
The Regents Of The University Of California |
Enhanced wound healing utilizing an anti-her2 antibody coupled to a tnf alpha
|
|
WO2006122787A1
(en)
|
2005-05-18 |
2006-11-23 |
Ablynx Nv |
Serum albumin binding proteins
|
|
WO2008014612A1
(en)
|
2006-08-02 |
2008-02-07 |
Mcgill University |
Fusion proteins and methods for modulation of immune response
|
|
EP1892248A1
(en)
|
2006-08-21 |
2008-02-27 |
Eidgenössische Technische Hochschule Zürich |
Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase
|
|
US9023352B2
(en)
|
2007-02-20 |
2015-05-05 |
Tufts University |
Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein
|
|
US11535673B2
(en)
|
2007-04-05 |
2022-12-27 |
President and Fellows of Harvard CoHege |
Chimeric activators: quantitatively designed protein therapeutics and uses thereof
|
|
CN101835802B
(zh)
|
2007-06-01 |
2014-04-09 |
马里兰大学巴尔的摩分校 |
免疫球蛋白恒定区Fc受体结合剂
|
|
US20110038865A1
(en)
|
2007-06-26 |
2011-02-17 |
University Of Miami |
Antibody- endostatin fusion protein and its variants
|
|
ES2536772T3
(es)
|
2007-09-21 |
2015-05-28 |
The Regents Of The University Of California |
El interferón dirigido demuestra potentes actividades apoptóticas y antitumorales
|
|
WO2010030671A1
(en)
|
2008-09-09 |
2010-03-18 |
University Of Medicine And Dentistry Of New Jersey |
Type i interferon antagonists
|
|
US8334101B2
(en)
|
2008-09-26 |
2012-12-18 |
University Of Massachusetts |
Intracellular DNA receptor
|
|
JP2012510806A
(ja)
|
2008-12-08 |
2012-05-17 |
コンプリクス エン ヴェー |
単鎖逆平行コイルドコイルタンパク質
|
|
ES2534085T3
(es)
|
2009-08-17 |
2015-04-17 |
Roche Glycart Ag |
Inmunoconjugados dirigidos
|
|
US20130115189A1
(en)
|
2009-09-10 |
2013-05-09 |
Cytos Biotechnology Ag |
Use of Interleukin-1 Beta Mutein Conjugates in the Treatment of Diabetes
|
|
US20110262348A1
(en)
|
2010-03-29 |
2011-10-27 |
Vrije Universiteit Brussel |
Selective targeting of intratumoral cells
|
|
EP2663331A4
(en)
|
2011-01-10 |
2015-07-15 |
Glaxosmithkline Intellectual Property Man Ltd |
NEW USES
|
|
HUE029139T2
(hu)
|
2011-02-10 |
2017-02-28 |
Roche Glycart Ag |
Mutáns interleukin-2 polipeptidek
|
|
EP2718457A4
(en)
|
2011-06-06 |
2014-12-24 |
Immungene Inc |
GENETICALLY MODIFIED FUSION MOLECULES LIGAND TNFSF-ANTIBODY ELEMENT
|
|
SE535863C2
(sv)
|
2011-07-18 |
2013-01-22 |
Atlas Copco Ind Tech Ab |
Hållare för motordrivet verktyg innefattande klämdelar med genomgående hål
|
|
SG10201603411WA
(en)
|
2011-10-28 |
2016-07-28 |
Teva Pharmaceuticals Australia Pty Ltd |
Polypeptide constructs and uses thereof
|
|
CN104245734B
(zh)
|
2012-01-20 |
2017-09-05 |
非营利性组织佛兰芒综合大学生物技术研究所 |
靶向突变体α‑螺旋束细胞因子
|
|
ES2800426T3
(es)
|
2012-03-03 |
2020-12-30 |
Immungene Inc |
Moléculas de fusión anticuerpos-mutante de interferón modificadas
|
|
RS60280B1
(sr)
*
|
2013-03-12 |
2020-06-30 |
Molecular Templates Inc |
Citotoksični proteini koji sadrže ciljane vezujuće regione za ćelije i regioni shiga toksina a podjedinice za selektivno ubijanje određenih vrsta ćelija
|
|
WO2015007536A2
(en)
|
2013-07-18 |
2015-01-22 |
Vib Vzw |
Fusokines involving cytokines with strongly reduced receptor binding affinities
|
|
DK3022226T3
(en)
|
2013-07-19 |
2019-03-25 |
Vib Vzw |
TARGETED MODIFIED IL-1 FAMILY MEMBERS
|
|
JP6595988B2
(ja)
|
2013-07-19 |
2019-10-23 |
ヴィブ ブイゼットダブリュー |
ターゲットされる修飾ｔｎｆファミリーメンバー
|
|
CA2918119C
(en)
*
|
2013-07-19 |
2022-11-29 |
Centre Hospitalier Regional Universitaire De Montpellier |
Targeting of ifn.alpha.2 antagonists to treat autoimmune diseases
|
|
US11702477B2
(en)
|
2015-11-06 |
2023-07-18 |
Orionis Biosciences BV |
Bi-functional chimeric proteins and uses thereof
|