JP2020516305A5 - - Google Patents
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- Publication number
- JP2020516305A5 JP2020516305A5 JP2019556339A JP2019556339A JP2020516305A5 JP 2020516305 A5 JP2020516305 A5 JP 2020516305A5 JP 2019556339 A JP2019556339 A JP 2019556339A JP 2019556339 A JP2019556339 A JP 2019556339A JP 2020516305 A5 JP2020516305 A5 JP 2020516305A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- seq
- tumor
- motomeko
- immunomodulatory polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000040430 polynucleotide Human genes 0.000 claims 12
- 108091033319 polynucleotide Proteins 0.000 claims 12
- 239000002157 polynucleotide Substances 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 230000002519 immonomodulatory effect Effects 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 5
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 201000000053 blastoma Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 201000008184 embryoma Diseases 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 230000002518 glial effect Effects 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 238000000375 direct analysis in real time Methods 0.000 claims 1
- 238000012063 dual-affinity re-targeting Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 210000004882 non-tumor cell Anatomy 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002626 targeted therapy Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical group [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710251198.4 | 2017-04-18 | ||
| CN201710251198.4A CN108728444A (zh) | 2017-04-18 | 2017-04-18 | 免疫调节性多核苷酸及其应用 |
| PCT/CN2018/083435 WO2018192505A1 (en) | 2017-04-18 | 2018-04-17 | Immunomodulatory polynucleotides and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020516305A JP2020516305A (ja) | 2020-06-11 |
| JP2020516305A5 true JP2020516305A5 (https=) | 2021-05-27 |
| JP7251017B2 JP7251017B2 (ja) | 2023-04-04 |
Family
ID=63855596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019556339A Active JP7251017B2 (ja) | 2017-04-18 | 2018-04-17 | 免疫調節ポリヌクレオチド及びその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11326170B2 (https=) |
| EP (1) | EP3612633A4 (https=) |
| JP (1) | JP7251017B2 (https=) |
| CN (2) | CN108728444A (https=) |
| WO (1) | WO2018192505A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210122778A1 (en) * | 2019-10-21 | 2021-04-29 | Northwestern University | Spherical nucleic acids with dendritic ligands |
| CN113058033B (zh) * | 2019-12-16 | 2024-07-09 | 远大赛威信生命科学(南京)有限公司 | 一种用于预防和治疗乙型肝炎的药物组合物及其用途 |
| CN113521267B (zh) * | 2020-04-17 | 2024-06-25 | 北京科兴中维生物技术有限公司 | 一种covid-19重组蛋白疫苗组合物及应用 |
| CN113521274B (zh) * | 2020-04-17 | 2024-06-25 | 北京科兴中维生物技术有限公司 | 一种covid-19灭活疫苗组合物及应用 |
| CN113521275B (zh) * | 2020-04-17 | 2024-06-25 | 北京科兴中维生物技术有限公司 | 一种复合佐剂及使用该复合佐剂的新冠covid-19重组蛋白疫苗 |
| CN113521273B (zh) * | 2020-04-17 | 2026-04-10 | 北京科兴中维生物技术有限公司 | 一种使用含有CpG寡聚脱氧核苷酸的复合佐剂的新冠COVID-19灭活疫苗 |
| WO2021249011A1 (en) | 2020-06-10 | 2021-12-16 | Sichuan Clover Biopharmaceuticals, Inc. | Hiv vaccine compositions, methods, and uses thereof |
| WO2021249116A1 (en) | 2020-06-10 | 2021-12-16 | Sichuan Clover Biopharmaceuticals, Inc. | Coronavirus vaccine compositions, methods, and uses thereof |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
| CN115252772A (zh) * | 2021-04-30 | 2022-11-01 | 华普生物技术(江苏)股份有限公司 | 人工合成的含CpG单链脱氧寡核苷酸在疫苗中的应用 |
| CN114807153A (zh) * | 2022-05-13 | 2022-07-29 | 南京吉盛澳玛生物医药有限公司 | 多种具有免疫刺激活性的CpG寡聚脱氧核苷酸及其应用 |
| US20230404642A1 (en) * | 2022-06-01 | 2023-12-21 | Syncromune, Inc. | Method for the treatment of cancer via tumor cell lysis and intratumoral administration of combinations of immunotherapeutic ingredients |
| CN115368463B (zh) * | 2022-07-19 | 2025-12-19 | 合肥天港免疫药物有限公司 | 双特异性抗体及其应用 |
| CN118356486A (zh) * | 2023-01-19 | 2024-07-19 | 华普生物技术(河北)股份有限公司 | CpG佐剂在制备新型冠状病毒疫苗中的应用 |
| CN117568339A (zh) * | 2023-01-19 | 2024-02-20 | 华普生物技术(河北)股份有限公司 | CpG寡核苷酸及其应用 |
| AU2024287014A1 (en) | 2023-06-07 | 2026-01-22 | Sichuan Clover Biopharmaceuticals, Inc. | Rsv vaccine composition, method and use thereof |
| CN120053634A (zh) * | 2023-11-30 | 2025-05-30 | 华普石家庄医药有限公司 | 一种水痘带状疱疹疫苗组合物及其用途 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
| US5658738A (en) | 1994-05-31 | 1997-08-19 | Becton Dickinson And Company | Bi-directional oligonucleotides that bind thrombin |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| IL149820A0 (en) | 2002-05-23 | 2002-11-10 | Curetech Ltd | Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency |
| AR040996A1 (es) * | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| MY159370A (en) * | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| WO2007119815A1 (ja) | 2006-04-14 | 2007-10-25 | Kyowa Hakko Kirin Co., Ltd. | Ｔｏｌｌ様受容体９作動薬 |
| MX2009006230A (es) * | 2006-12-12 | 2009-06-22 | Idera Pharmaceuticals Inc | Agonistas sinteticos de receptores de tipo toll 9. |
| EP2170353B1 (en) * | 2007-05-18 | 2015-06-03 | AdiuTide Pharmaceuticals GmbH | Phosphate-modified oligonucleotide analogs with immunostimulatory activity |
| HRP20131167T1 (hr) | 2007-06-18 | 2014-01-03 | Merck Sharp & Dohme B.V. | Antitijela za humani receptor programirane smrti pd-1 |
| CA2697032C (en) | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| KR101814408B1 (ko) | 2008-09-26 | 2018-01-04 | 다나-파버 캔서 인스티튜트 인크. | 인간 항-ｐｄ-１, ｐｄ-ｌ１, 및 ｐｄ-ｌ2 항체 및 그의 용도 |
| US8895702B2 (en) | 2008-12-08 | 2014-11-25 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies |
| US20100189651A1 (en) | 2009-01-12 | 2010-07-29 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| NZ628923A (en) | 2009-11-24 | 2016-02-26 | Medimmune Ltd | Targeted binding agents against b7-h1 |
| KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | Ｂ7-ｈ1 및 ｐｄ-1과 결합하는 항체 및 다른 분자들 |
| JP6240600B2 (ja) | 2011-07-24 | 2017-11-29 | キュアテク リミテッド | ヒト化免疫モノクローナル抗体の変異体 |
| HRP20201595T1 (hr) | 2011-11-28 | 2020-12-11 | Merck Patent Gmbh | Anti-pd-l1 protutijela i njihova uporaba |
| CN102719436A (zh) * | 2012-06-27 | 2012-10-10 | 南开大学 | 一种寡核苷酸及其制备在防治心肌肥大与心力衰竭药物中的用途 |
| AR095882A1 (es) * | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
| ES2699410T3 (es) * | 2014-05-28 | 2019-02-11 | Univ Dresden Tech | Ensayo basado en células y métodos de cribado de moduladores de la señalización de p75NTR |
| KR102230325B1 (ko) * | 2015-09-30 | 2021-03-19 | 시오노기 앤드 컴파니, 리미티드 | 면역 부활 활성을 갖는 핵산 유도체 |
-
2017
- 2017-04-18 CN CN201710251198.4A patent/CN108728444A/zh not_active Withdrawn
-
2018
- 2018-04-17 US US16/484,090 patent/US11326170B2/en active Active
- 2018-04-17 WO PCT/CN2018/083435 patent/WO2018192505A1/en not_active Ceased
- 2018-04-17 CN CN201880025806.2A patent/CN110753756B/zh active Active
- 2018-04-17 JP JP2019556339A patent/JP7251017B2/ja active Active
- 2018-04-17 EP EP18787826.9A patent/EP3612633A4/en active Pending
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